JP2017501715A5 - - Google Patents
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- Publication number
- JP2017501715A5 JP2017501715A5 JP2016541634A JP2016541634A JP2017501715A5 JP 2017501715 A5 JP2017501715 A5 JP 2017501715A5 JP 2016541634 A JP2016541634 A JP 2016541634A JP 2016541634 A JP2016541634 A JP 2016541634A JP 2017501715 A5 JP2017501715 A5 JP 2017501715A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- endopeptidase
- pain
- composition
- derived
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010059378 Endopeptidases Proteins 0.000 claims 24
- 102000005593 Endopeptidases Human genes 0.000 claims 24
- 108010055044 Tetanus Toxin Proteins 0.000 claims 11
- 229920001184 polypeptide Polymers 0.000 claims 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims 10
- 238000000034 method Methods 0.000 claims 9
- 230000005945 translocation Effects 0.000 claims 9
- 108030001720 Bontoxilysin Proteins 0.000 claims 8
- 208000002193 Pain Diseases 0.000 claims 8
- 231100001102 clostridial toxin Toxicity 0.000 claims 6
- 208000000094 Chronic Pain Diseases 0.000 claims 5
- 102000035195 Peptidases Human genes 0.000 claims 5
- 108091005804 Peptidases Proteins 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 101710138657 Neurotoxin Proteins 0.000 claims 4
- 238000003776 cleavage reaction Methods 0.000 claims 4
- 239000002581 neurotoxin Substances 0.000 claims 4
- 231100000618 neurotoxin Toxicity 0.000 claims 4
- 230000007017 scission Effects 0.000 claims 4
- 239000004365 Protease Substances 0.000 claims 3
- 208000004296 neuralgia Diseases 0.000 claims 3
- 208000021722 neuropathic pain Diseases 0.000 claims 3
- 230000004962 physiological condition Effects 0.000 claims 3
- 229920002704 polyhistidine Polymers 0.000 claims 3
- 235000019419 proteases Nutrition 0.000 claims 3
- 206010027476 Metastases Diseases 0.000 claims 2
- 208000001294 Nociceptive Pain Diseases 0.000 claims 2
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 230000009401 metastasis Effects 0.000 claims 2
- 235000019833 protease Nutrition 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 206010006002 Bone pain Diseases 0.000 claims 1
- 206010058019 Cancer Pain Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 206010036376 Postherpetic Neuralgia Diseases 0.000 claims 1
- 208000004550 Postoperative Pain Diseases 0.000 claims 1
- 241000687919 Rodinia Species 0.000 claims 1
- 102000000583 SNARE Proteins Human genes 0.000 claims 1
- 108010041948 SNARE Proteins Proteins 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000002917 arthritic effect Effects 0.000 claims 1
- 231100001103 botulinum neurotoxin Toxicity 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 229960002504 capsaicin Drugs 0.000 claims 1
- 235000017663 capsaicin Nutrition 0.000 claims 1
- 210000000170 cell membrane Anatomy 0.000 claims 1
- 210000000172 cytosol Anatomy 0.000 claims 1
- 230000002526 effect on cardiovascular system Effects 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 210000001044 sensory neuron Anatomy 0.000 claims 1
- 210000002027 skeletal muscle Anatomy 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 108700012359 toxins Proteins 0.000 claims 1
- 208000009935 visceral pain Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361920053P | 2013-12-23 | 2013-12-23 | |
| US61/920,053 | 2013-12-23 | ||
| US14/244,162 | 2014-04-03 | ||
| US14/244,162 US9216210B2 (en) | 2013-12-23 | 2014-04-03 | Multiprotease therapeutics for chronic pain |
| PCT/EP2014/078732 WO2015097087A1 (en) | 2013-12-23 | 2014-12-19 | Multiprotease therapeutics for chronic pain |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017501715A JP2017501715A (ja) | 2017-01-19 |
| JP2017501715A5 true JP2017501715A5 (https=) | 2018-02-01 |
| JP6378772B2 JP6378772B2 (ja) | 2018-08-22 |
Family
ID=53398919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016541634A Expired - Fee Related JP6378772B2 (ja) | 2013-12-23 | 2014-12-19 | 慢性疼痛のためのマルチプロテアーゼ（ｍｕｌｔｉｐｒｏｔｅａｓｅ）治療薬 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9216210B2 (https=) |
| EP (1) | EP3087089B1 (https=) |
| JP (1) | JP6378772B2 (https=) |
| KR (1) | KR101900582B1 (https=) |
| CN (2) | CN112708630A (https=) |
| AU (1) | AU2014372689B2 (https=) |
| CA (1) | CA2934986C (https=) |
| DK (1) | DK3087089T3 (https=) |
| ES (1) | ES2671493T3 (https=) |
| PL (1) | PL3087089T3 (https=) |
| PT (1) | PT3087089T (https=) |
| WO (1) | WO2015097087A1 (https=) |
| ZA (1) | ZA201605051B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100266638A1 (en) | 2004-02-26 | 2010-10-21 | Allergan, Inc. | Headache treatment method |
| US9216210B2 (en) * | 2013-12-23 | 2015-12-22 | Dublin City University | Multiprotease therapeutics for chronic pain |
| PT3274364T (pt) * | 2015-03-26 | 2021-11-05 | Harvard College | Neurotoxina botulínica manipulada |
| GB201517450D0 (en) | 2015-10-02 | 2015-11-18 | Ipsen Biopharm Ltd | Method |
| GB201607901D0 (en) | 2016-05-05 | 2016-06-22 | Ipsen Biopharm Ltd | Chimeric neurotoxins |
| EP3504226A1 (en) | 2016-08-24 | 2019-07-03 | President and Fellows of Harvard College | Engineered botulinum neurotoxin |
| WO2018060351A1 (en) * | 2016-09-29 | 2018-04-05 | Ipsen Biopharm Limited | Hybrid neurotoxins |
| EP3752128B1 (de) * | 2018-02-16 | 2025-01-15 | preclinics discovery GmbH | Nukleinsäure-basiertes botulinum neurotoxin zur therapeutischen anwendung |
| GB201815844D0 (en) * | 2018-09-28 | 2018-11-14 | Ipsen Biopharm Ltd | Therapeutic & comestic uses of botulinum neurotoxin serotype e |
| FR3114739B1 (fr) * | 2020-10-06 | 2022-08-26 | Centre Nat Rech Scient | Nouveaux peptoides et leur utilisation dans la prevention ou le traitement de la douleur chronique |
| WO2023105289A1 (en) | 2021-12-06 | 2023-06-15 | Dublin City University | Methods and compositions for the treatment of pain |
Family Cites Families (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1099445A3 (en) | 1993-06-10 | 2001-09-05 | Allergan, Inc. | Treatment of neuromuscular disorders and conditions with different botulinum serotype |
| US5437291A (en) | 1993-08-26 | 1995-08-01 | Univ Johns Hopkins | Method for treating gastrointestinal muscle disorders and other smooth muscle dysfunction |
| US6974578B1 (en) | 1993-12-28 | 2005-12-13 | Allergan, Inc. | Method for treating secretions and glands using botulinum toxin |
| US8187612B2 (en) | 1993-12-28 | 2012-05-29 | Allergan, Inc. | Use of the neurotoxic component of a botulinum toxin for treating a spastic muscle |
| US20040126396A1 (en) | 1993-12-28 | 2004-07-01 | Allergan, Inc. | Botulinum toxin treatment for strabismus |
| US5670484A (en) | 1994-05-09 | 1997-09-23 | Binder; William J. | Method for treatment of skin lesions associated with cutaneous cell-proliferative disorders |
| PT1086702E (pt) | 1994-05-09 | 2005-08-31 | William J Binder | Neurotoxinas pre-sinapticas para tratamento da dor de cabeca devida a enxaqueca |
| EP0760681B1 (en) | 1994-05-31 | 1999-09-01 | Allergan, Inc | Modification of clostridial toxins for use as transport proteins |
| GB9508204D0 (en) | 1995-04-21 | 1995-06-07 | Speywood Lab Ltd | A novel agent able to modify peripheral afferent function |
| US7192596B2 (en) | 1996-08-23 | 2007-03-20 | The Health Protection Agency Ipsen Limited | Recombinant toxin fragments |
| GB9617671D0 (en) | 1996-08-23 | 1996-10-02 | Microbiological Res Authority | Recombinant toxin fragments |
| US6063768A (en) | 1997-09-04 | 2000-05-16 | First; Eric R. | Application of botulinum toxin to the management of neurogenic inflammatory disorders |
| GB9721189D0 (en) | 1997-10-08 | 1997-12-03 | Speywood Lab The Limited | Analgesic conjugates |
| DE69911944T2 (de) | 1998-04-29 | 2004-07-22 | Allergan, Inc., Irvine | Zusammensetzungen und methode zum verlängung der wirkung des clostridiumsneurotoxins |
| GB9907429D0 (en) | 1999-03-31 | 1999-05-26 | Microbiological Res Authority | Modulation of C-fibre activity |
| US6776990B2 (en) | 1999-04-08 | 2004-08-17 | Allergan, Inc. | Methods and compositions for the treatment of pancreatitis |
| US6767544B2 (en) | 2002-04-01 | 2004-07-27 | Allergan, Inc. | Methods for treating cardiovascular diseases with botulinum toxin |
| US6358917B1 (en) | 1999-08-24 | 2002-03-19 | Jean D. A. Carruthers | Cosmetic use of botulinum toxin for treatment of downturned mouth |
| HK1046020B (en) * | 1999-08-25 | 2007-05-11 | Allergan, Inc. | Activatable recombinant neurotoxins |
| US7740868B2 (en) * | 1999-08-25 | 2010-06-22 | Allergan, Inc. | Activatable clostridial toxins |
| US20080032931A1 (en) * | 1999-08-25 | 2008-02-07 | Steward Lance E | Activatable clostridial toxins |
| US6113915A (en) | 1999-10-12 | 2000-09-05 | Allergan Sales, Inc. | Methods for treating pain |
| US6265379B1 (en) | 1999-10-13 | 2001-07-24 | Allergan Sales, Inc. | Method for treating otic disorders |
| US7838008B2 (en) | 1999-12-07 | 2010-11-23 | Allergan, Inc. | Methods for treating diverse cancers |
| US6139845A (en) | 1999-12-07 | 2000-10-31 | Allergan Sales, Inc. | Method for treating cancer with a neurotoxin |
| US6143306A (en) | 2000-01-11 | 2000-11-07 | Allergan Sales, Inc. | Methods for treating pancreatic disorders |
| US6337075B1 (en) | 2000-01-11 | 2002-01-08 | Allergan Sales, Inc. | Methods for treating diabetes |
| US6641820B1 (en) | 2000-01-19 | 2003-11-04 | Allergan, Inc. | Clostridial toxin derivatives and methods to treat pain |
| US6524580B1 (en) | 2000-02-15 | 2003-02-25 | Allergan Sales, Inc. | Method for treating thyroid disorders |
| US6464986B1 (en) | 2000-04-14 | 2002-10-15 | Allegan Sales, Inc. | Method for treating pain by peripheral administration of a neurotoxin |
| US6299893B1 (en) | 2000-04-17 | 2001-10-09 | Marvin Schwartz | Method to reduce hair loss and stimulate hair regrowth |
| US6565870B1 (en) | 2000-04-28 | 2003-05-20 | Allergan, Inc. | Methods for treating bone tumors |
| US6306403B1 (en) | 2000-06-14 | 2001-10-23 | Allergan Sales, Inc. | Method for treating parkinson's disease with a botulinum toxin |
| US6423319B1 (en) | 2000-10-04 | 2002-07-23 | Allergan Sales, Inc. | Methods for treating muscle injuries |
| US6827931B1 (en) | 2000-10-20 | 2004-12-07 | Allergan, Inc. | Method for treating endocrine disorders |
| US20020127247A1 (en) | 2000-11-17 | 2002-09-12 | Allergen Sales, Inc. | Modified clostridial neurotoxins with altered biological persistence |
| US7273722B2 (en) | 2000-11-29 | 2007-09-25 | Allergan, Inc. | Neurotoxins with enhanced target specificity |
| GB0111146D0 (en) | 2001-05-04 | 2001-06-27 | Imp College Innovations Ltd | Methods |
| US7255866B2 (en) | 2001-09-17 | 2007-08-14 | Allergan, Inc. | Botulinum toxin therapy for fibromyalgia |
| US6623742B2 (en) | 2001-09-17 | 2003-09-23 | Allergan, Inc. | Methods for treating fibromyalgia |
| US6921538B2 (en) | 2002-05-10 | 2005-07-26 | Allergan, Inc. | Therapeutic treatments for neuropsychiatric disorders |
| JP2006513994A (ja) | 2002-10-15 | 2006-04-27 | アラーガン、インコーポレイテッド | ボツリヌス毒素歯科治療および歯科措置 |
| US7238357B2 (en) | 2002-11-05 | 2007-07-03 | Allergan, Inc. | Methods for treating ulcers and gastroesophageal reflux disease |
| US8071550B2 (en) | 2003-03-03 | 2011-12-06 | Allergan, Inc. | Methods for treating uterine disorders |
| US6838434B2 (en) | 2003-05-02 | 2005-01-04 | Allergan, Inc. | Methods for treating sinus headache |
| US7220422B2 (en) | 2003-05-20 | 2007-05-22 | Allergan, Inc. | Methods and compositions for treating eye disorders |
| US20040253274A1 (en) | 2003-06-11 | 2004-12-16 | Allergan, Inc. | Use of a clostridial toxin to reduce appetite |
| US20050169942A1 (en) | 2003-10-07 | 2005-08-04 | Allergan, Inc. | Novel DNA sequences of the botulinum neurotoxin complex of Clostridium botulinum type A-Hall (Allergan) strain for production of therapeutics |
| US7514088B2 (en) | 2005-03-15 | 2009-04-07 | Allergan, Inc. | Multivalent Clostridial toxin derivatives and methods of their use |
| WO2006011966A1 (en) | 2004-06-30 | 2006-02-02 | Allergan, Inc. | Optimizing expression of active botulinum toxin type e |
| US20060024331A1 (en) | 2004-08-02 | 2006-02-02 | Ester Fernandez-Salas | Toxin compounds with enhanced membrane translocation characteristics |
| CA2623874A1 (en) | 2004-09-30 | 2006-07-06 | Pro-Adn Diagnostic | Wnt4 in supporting lymphopoiesis |
| EP1871789B1 (en) * | 2005-03-15 | 2013-11-06 | Allergan, Inc. | Modified clostridial toxins with altered targeting capabilities for clostridial toxin target cells |
| GB0610868D0 (en) | 2006-06-01 | 2006-07-12 | Syntaxin Ltd | Treatment of pain |
| JP5799397B2 (ja) * | 2008-06-12 | 2015-10-28 | イプセン・バイオイノベーション・リミテッドＩｐｓｅｎ Ｂｉｏｉｎｎｏｖａｔｉｏｎ Ｌｉｍｉｔｅｄ | 癌の抑制 |
| EP2337790B1 (en) | 2008-08-29 | 2016-07-13 | Merz Pharma GmbH & Co. KGaA | Clostridial neurotoxins with altered persistency |
| ES2770033T3 (es) | 2009-03-13 | 2020-06-30 | Allergan Inc | Ensayos de actividad de endopeptidasa redirigida basados en inmunología |
| CA2758274C (en) * | 2009-04-14 | 2018-04-10 | Mcw Research Foundation, Inc. | Engineered botulinum neurotoxin |
| KR20120107988A (ko) | 2009-12-16 | 2012-10-04 | 알러간, 인코포레이티드 | 통합된 프로테아제 절단 부위 결합 도메인을 포함하는 변형 클로스트리듐 독소 |
| RU2561465C2 (ru) | 2010-05-20 | 2015-08-27 | Аллерган, Инк. | Разрушаемые клостридиальные токсины |
| US20130116794A1 (en) | 2010-08-04 | 2013-05-09 | Shaul Shohat | Shoulder implant |
| US9005628B2 (en) | 2012-10-04 | 2015-04-14 | Dublin City University | Biotherapy for pain |
| US20140177773A1 (en) * | 2012-12-20 | 2014-06-26 | Maria Christine KRETZING | Control rod drive apparatus utilizing alloys with low to zero cobalt content |
| US20160051644A1 (en) * | 2013-01-16 | 2016-02-25 | Bal Ram Singh | Botulinum Chimera Compositions for Axonal Regenerative Therapy During Spinal Cord Injury |
| US9447405B2 (en) * | 2013-03-08 | 2016-09-20 | Wisconsin Alumni Research Foundation | Regulation of specific spinal neurons regulating pain transmission via chimeric toxins |
| US9216210B2 (en) * | 2013-12-23 | 2015-12-22 | Dublin City University | Multiprotease therapeutics for chronic pain |
| WO2016180533A1 (en) * | 2015-05-12 | 2016-11-17 | Merz Pharma Gmbh & Co. Kgaa | Novel recombinant clostridial neurotoxins with increased duration of effect |
-
2014
- 2014-04-03 US US14/244,162 patent/US9216210B2/en active Active
- 2014-12-19 EP EP14821171.7A patent/EP3087089B1/en active Active
- 2014-12-19 KR KR1020167019888A patent/KR101900582B1/ko not_active Expired - Fee Related
- 2014-12-19 DK DK14821171.7T patent/DK3087089T3/en active
- 2014-12-19 CN CN202011545696.8A patent/CN112708630A/zh active Pending
- 2014-12-19 JP JP2016541634A patent/JP6378772B2/ja not_active Expired - Fee Related
- 2014-12-19 ES ES14821171.7T patent/ES2671493T3/es active Active
- 2014-12-19 PL PL14821171T patent/PL3087089T3/pl unknown
- 2014-12-19 AU AU2014372689A patent/AU2014372689B2/en not_active Ceased
- 2014-12-19 WO PCT/EP2014/078732 patent/WO2015097087A1/en not_active Ceased
- 2014-12-19 CA CA2934986A patent/CA2934986C/en active Active
- 2014-12-19 PT PT148211717T patent/PT3087089T/pt unknown
- 2014-12-19 CN CN201480073447.XA patent/CN105916875A/zh active Pending
-
2015
- 2015-12-22 US US14/978,478 patent/US10457927B2/en active Active
-
2016
- 2016-07-20 ZA ZA2016/05051A patent/ZA201605051B/en unknown
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