JP2017501694A5 - - Google Patents
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- JP2017501694A5 JP2017501694A5 JP2016536918A JP2016536918A JP2017501694A5 JP 2017501694 A5 JP2017501694 A5 JP 2017501694A5 JP 2016536918 A JP2016536918 A JP 2016536918A JP 2016536918 A JP2016536918 A JP 2016536918A JP 2017501694 A5 JP2017501694 A5 JP 2017501694A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- item
- isolating
- exosome
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 238000000034 method Methods 0.000 claims description 105
- 210000001808 exosome Anatomy 0.000 claims description 46
- 206010028980 Neoplasm Diseases 0.000 claims description 43
- 201000011510 cancer Diseases 0.000 claims description 40
- 108090000623 proteins and genes Proteins 0.000 claims description 28
- 102000004169 proteins and genes Human genes 0.000 claims description 17
- 210000004027 cell Anatomy 0.000 claims description 14
- 108020004414 DNA Proteins 0.000 claims description 12
- 210000001124 body fluid Anatomy 0.000 claims description 12
- 239000000107 tumor biomarker Substances 0.000 claims description 12
- 230000035772 mutation Effects 0.000 claims description 11
- 239000010839 body fluid Substances 0.000 claims description 10
- 102000010956 Glypican Human genes 0.000 claims description 8
- 108050001154 Glypican Proteins 0.000 claims description 8
- 108050007238 Glypican-1 Proteins 0.000 claims description 8
- 206010005003 Bladder cancer Diseases 0.000 claims description 6
- 208000003174 Brain Neoplasms Diseases 0.000 claims description 6
- 206010006187 Breast cancer Diseases 0.000 claims description 6
- 208000026310 Breast neoplasm Diseases 0.000 claims description 6
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 6
- 206010009944 Colon cancer Diseases 0.000 claims description 6
- 102000053602 DNA Human genes 0.000 claims description 6
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims description 6
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 6
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims description 6
- 206010033128 Ovarian cancer Diseases 0.000 claims description 6
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 6
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 6
- 206010060862 Prostate cancer Diseases 0.000 claims description 6
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 6
- 208000015634 Rectal Neoplasms Diseases 0.000 claims description 6
- 208000000453 Skin Neoplasms Diseases 0.000 claims description 6
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 6
- 208000024313 Testicular Neoplasms Diseases 0.000 claims description 6
- 206010057644 Testis cancer Diseases 0.000 claims description 6
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 6
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 6
- 201000010881 cervical cancer Diseases 0.000 claims description 6
- 208000029742 colonic neoplasm Diseases 0.000 claims description 6
- 201000004101 esophageal cancer Diseases 0.000 claims description 6
- 206010017758 gastric cancer Diseases 0.000 claims description 6
- 201000010536 head and neck cancer Diseases 0.000 claims description 6
- 208000014829 head and neck neoplasm Diseases 0.000 claims description 6
- 201000007270 liver cancer Diseases 0.000 claims description 6
- 208000014018 liver neoplasm Diseases 0.000 claims description 6
- 201000005202 lung cancer Diseases 0.000 claims description 6
- 208000020816 lung neoplasm Diseases 0.000 claims description 6
- 210000002751 lymph Anatomy 0.000 claims description 6
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 6
- 201000002528 pancreatic cancer Diseases 0.000 claims description 6
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 6
- 206010038038 rectal cancer Diseases 0.000 claims description 6
- 201000001275 rectum cancer Diseases 0.000 claims description 6
- 210000003296 saliva Anatomy 0.000 claims description 6
- 210000002966 serum Anatomy 0.000 claims description 6
- 201000000849 skin cancer Diseases 0.000 claims description 6
- 201000011549 stomach cancer Diseases 0.000 claims description 6
- 201000003120 testicular cancer Diseases 0.000 claims description 6
- 206010044285 tracheal cancer Diseases 0.000 claims description 6
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 6
- 210000002700 urine Anatomy 0.000 claims description 6
- 210000004291 uterus Anatomy 0.000 claims description 6
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 4
- 210000001185 bone marrow Anatomy 0.000 claims description 4
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims description 4
- 210000000416 exudates and transudate Anatomy 0.000 claims description 4
- 238000012300 Sequence Analysis Methods 0.000 claims description 3
- 201000008129 pancreatic ductal adenocarcinoma Diseases 0.000 claims description 3
- 238000001356 surgical procedure Methods 0.000 claims description 3
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims description 2
- 230000004913 activation Effects 0.000 claims description 2
- 238000003205 genotyping method Methods 0.000 claims description 2
- 238000002955 isolation Methods 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 description 12
- 201000010099 disease Diseases 0.000 description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
- 108020004707 nucleic acids Proteins 0.000 description 7
- 102000039446 nucleic acids Human genes 0.000 description 7
- 150000007523 nucleic acids Chemical class 0.000 description 7
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 6
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 6
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 description 5
- 238000011319 anticancer therapy Methods 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- 238000002512 chemotherapy Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001794 hormone therapy Methods 0.000 description 1
- 238000009169 immunotherapy Methods 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 238000002626 targeted therapy Methods 0.000 description 1
- 239000003104 tissue culture media Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361911863P | 2013-12-04 | 2013-12-04 | |
| US61/911,863 | 2013-12-04 | ||
| PCT/US2014/068630 WO2015085096A1 (en) | 2013-12-04 | 2014-12-04 | Analysis of genomic dna, rna, and proteins in exosomes for diagnosis and theranosis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019148579A Division JP2019198327A (ja) | 2013-12-04 | 2019-08-13 | 診断および療法のためのエキソソーム中のゲノムｄｎａ、ｒｎａおよびタンパク質の分析 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017501694A JP2017501694A (ja) | 2017-01-19 |
| JP2017501694A5 true JP2017501694A5 (https=) | 2017-12-21 |
Family
ID=53274132
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016536918A Ceased JP2017501694A (ja) | 2013-12-04 | 2014-12-04 | 診断および療法のためのエキソソーム中のゲノムｄｎａ、ｒｎａおよびタンパク質の分析 |
| JP2019148579A Withdrawn JP2019198327A (ja) | 2013-12-04 | 2019-08-13 | 診断および療法のためのエキソソーム中のゲノムｄｎａ、ｒｎａおよびタンパク質の分析 |
| JP2021110830A Active JP7138372B2 (ja) | 2013-12-04 | 2021-07-02 | 診断および療法のためのエキソソーム中のゲノムｄｎａ、ｒｎａおよびタンパク質の分析 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019148579A Withdrawn JP2019198327A (ja) | 2013-12-04 | 2019-08-13 | 診断および療法のためのエキソソーム中のゲノムｄｎａ、ｒｎａおよびタンパク質の分析 |
| JP2021110830A Active JP7138372B2 (ja) | 2013-12-04 | 2021-07-02 | 診断および療法のためのエキソソーム中のゲノムｄｎａ、ｒｎａおよびタンパク質の分析 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US9921223B2 (https=) |
| EP (1) | EP3076949B1 (https=) |
| JP (3) | JP2017501694A (https=) |
| AU (3) | AU2014360344B2 (https=) |
| CA (1) | CA2936100A1 (https=) |
| DK (1) | DK3076949T3 (https=) |
| HR (1) | HRP20192131T1 (https=) |
| HU (1) | HUE046489T2 (https=) |
| LT (1) | LT3076949T (https=) |
| NZ (1) | NZ721720A (https=) |
| SI (1) | SI3076949T1 (https=) |
| WO (1) | WO2015085096A1 (https=) |
| ZA (1) | ZA201604468B (https=) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
| WO2006116362A2 (en) | 2005-04-25 | 2006-11-02 | The Trustees Of Boston University | Structured substrates for optical surface profiling |
| US11286463B2 (en) | 2012-03-08 | 2022-03-29 | Advanced ReGen Medical Technologies, LLC | Reprogramming of aged adult stem cells |
| EP3563859B1 (en) | 2012-08-13 | 2021-10-13 | Cedars-Sinai Medical Center | Cardiosphere-derived exosomes for tissue regeneration |
| WO2014028862A1 (en) | 2012-08-17 | 2014-02-20 | Cornell University | Use of dna in circulating exosomes as a diagnostic marker for metastasic disease |
| BR112015023275B1 (pt) | 2013-03-15 | 2022-06-21 | Board Of Regents, The University Of Texas System | Método in vitro de detecção de biomarcador de câncer |
| US9921223B2 (en) * | 2013-12-04 | 2018-03-20 | Board Of Regents, The University Of Texas System | Analysis of genomic DNA, RNA, and proteins in exosomes for diagnosis and theranosis |
| US20150174166A1 (en) | 2013-12-20 | 2015-06-25 | Advanced ReGen Medical Technologies, LLC | Compositions for Cellular Restoration and Methods of Making and Using Same |
| US10772911B2 (en) | 2013-12-20 | 2020-09-15 | Advanced ReGen Medical Technologies, LLC | Cell free compositions for cellular restoration and methods of making and using same |
| EP3125907A4 (en) * | 2014-04-01 | 2017-11-29 | Cornell University | Use of double-stranded dna in exosomes: a novel biomarker in cancer detection |
| EP4494699A3 (en) | 2014-10-03 | 2025-04-30 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy |
| US11397182B2 (en) | 2014-10-07 | 2022-07-26 | Cornell University | Methods for prognosing and preventing metastatic liver disease |
| US11971402B2 (en) | 2015-04-24 | 2024-04-30 | Cornell University | Methods and reagents for determination and treatment of organotropic metastasis |
| US11339441B2 (en) * | 2015-05-12 | 2022-05-24 | The Research Foundation For The State University Of New York | Profiling chemically modified DNA/RNA units for disease and cancer diagnosis |
| CA2988771A1 (en) | 2015-06-09 | 2016-12-15 | The Board Of Regents Of The University Of Texas System | Diagnostic test for early stage cancer |
| EP3307890A1 (en) | 2015-06-10 | 2018-04-18 | Board of Regents, The University of Texas System | Use of exosomes for the treatment of disease |
| AU2016327573B2 (en) | 2015-09-22 | 2022-07-14 | Trustees Of Boston University | Multiplexed phenotyping of nanovesicles |
| GB201518466D0 (en) * | 2015-10-19 | 2015-12-02 | Cizzle Biotechnology Ltd | Use |
| WO2017123662A1 (en) | 2016-01-11 | 2017-07-20 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction |
| WO2017136676A1 (en) | 2016-02-05 | 2017-08-10 | Nanoview Diagnostics Inc. | Detection of exosomes having surface markers |
| CA3017586A1 (en) * | 2016-03-15 | 2017-09-21 | Codiak Biosciences, Inc. | Therapeutic membrane vesicles |
| US11203754B2 (en) | 2016-04-29 | 2021-12-21 | Advanced ReGen Medical Technologies, LLC | Microrna compositions and methods of making and using same |
| WO2017210652A1 (en) | 2016-06-03 | 2017-12-07 | Cedars-Sinai Medical Center | Cdc-derived exosomes for treatment of ventricular tachyarrythmias |
| WO2017223186A1 (en) * | 2016-06-21 | 2017-12-28 | Nant Holdings Ip, Llc | Exosome-guided treatment of cancer |
| CN106124282B (zh) * | 2016-07-26 | 2019-07-16 | 广州海力特生物科技有限公司 | 一种叠层离心过滤分离提取外泌体的方法 |
| US20180067121A1 (en) * | 2016-09-06 | 2018-03-08 | Nanoco Technologies Ltd. | Exosome-conjugated quantum dot nanoparticles and methods of detecting exosomes and cancer using same |
| US11541078B2 (en) | 2016-09-20 | 2023-01-03 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders |
| US11629176B2 (en) | 2017-03-21 | 2023-04-18 | Exoprother Medical Ltd. | Native cell derived vesicles containing tumor suppressor proteins for therapy |
| GB2560897A (en) * | 2017-03-23 | 2018-10-03 | Lotvall Jan | Tissue-derived extracellular vesicles and their use as diagnostics |
| JP7336769B2 (ja) | 2017-04-19 | 2023-09-01 | シーダーズ―シナイ メディカル センター | 骨格筋ジストロフィーを治療する方法及び組成物 |
| CN107338306A (zh) * | 2017-07-23 | 2017-11-10 | 嘉兴允英医学检验有限公司 | 一种用于GPC1mRNA表达检测的试剂盒 |
| EP4218775A1 (en) * | 2017-08-04 | 2023-08-02 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and their extracellular vesicles for treatment and prevention of cancer |
| GB2574785A (en) | 2017-09-15 | 2019-12-25 | Jan Loetvall | Method and system for identifying membrane proteins on extracellular vesicles |
| JP2021503077A (ja) | 2017-11-09 | 2021-02-04 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 細胞外小胞タンパク質、ならびに癌診断、療法に対する応答予測、および治療をするためのそれらの使用 |
| EP3716986A4 (en) * | 2017-12-01 | 2022-02-09 | Cornell University | NANOPARTICLES AND VARIOUS EXOSOME SUBSETS FOR CANCER DETECTION AND TREATMENT |
| AU2018386215B2 (en) | 2017-12-15 | 2024-11-28 | Board Of Regents, The University Of Texas System | Methods and compositions for treating cancer using exosomes-associated gene editing |
| WO2019126068A1 (en) | 2017-12-20 | 2019-06-27 | Cedars-Sinai Medical Center | Engineered extracellular vesicles for enhanced tissue delivery |
| CN111655271B (zh) * | 2017-12-28 | 2025-09-23 | 隆萨销售股份公司 | 用于免疫肿瘤学和抗炎疗法的外来体 |
| EP3740576A4 (en) | 2018-01-18 | 2021-10-20 | Advanced Regen Medical Technologies, LLC | THERAPEUTIC COMPOSITIONS AND THEIR PREPARATION AND USE METHODS |
| EP3749344A4 (en) | 2018-02-05 | 2022-01-26 | Cedars-Sinai Medical Center | METHODS OF THERAPEUTIC USE OF EXOSOMES AND Y-RNAS |
| WO2019178317A1 (en) | 2018-03-14 | 2019-09-19 | Children's Medical Center Corporation | Platform for assessment of the transcytosis of extracellular vesicles across endothelial barriers and uses thereof |
| EP3775258A4 (en) * | 2018-03-28 | 2022-01-26 | Board of Regents, The University of Texas System | IDENTIFICATION OF EPIGENETIC ALTERATIONS IN DNA ISOLATED FROM EXOSOMES |
| AU2019243179B2 (en) * | 2018-03-28 | 2025-09-18 | Board Of Regents, The University Of Texas System | Use of exosomes for targeted delivery of therapeutic agents |
| WO2019199803A1 (en) * | 2018-04-09 | 2019-10-17 | Board Of Regents, The University Of Texas System | Therapeutic targeting of oncogenes using exosomes |
| EP3788150A4 (en) * | 2018-05-04 | 2022-01-26 | Sigma-Aldrich Co. LLC | PRODUCTION OF RECOMBINANT PROTEINS WITH REDUCED LEVELS OF HOST CELL PROTEINS |
| WO2019232321A1 (en) | 2018-06-01 | 2019-12-05 | NanoView Biosciences, Inc. | Compositions, systems, and methods for enhanced label-free and fluorescence - based detection of nanoparticles |
| IL269897B2 (en) | 2018-11-15 | 2023-08-01 | Sternum Ltd | Implementing control flow correctness verification in code intermediate files |
| US11766484B2 (en) | 2019-01-03 | 2023-09-26 | International Business Machines Corporation | Exosome vessels for delivery of molecular cargo |
| US12397047B2 (en) | 2019-01-09 | 2025-08-26 | Exocure Sweden Ab | Bacteria-derived vesicles and uses thereof |
| WO2020160402A1 (en) * | 2019-02-01 | 2020-08-06 | NanoView Biosciences, Inc. | Systems and methods for vesicle cargo labeling and detection |
| EP3921325A4 (en) * | 2019-02-08 | 2022-11-23 | Board of Regents, The University of Texas System | ISOLATION AND DETECTION OF AN EXOSOME-ASSOCIATED MICROBIOME FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES |
| BR112021018694A2 (pt) * | 2019-03-21 | 2021-11-30 | Codiak Biosciences Inc | Vesículas extracelulares para distribuição de vacina |
| CA3137525A1 (en) * | 2019-04-23 | 2020-10-29 | Children's Medical Center Corporation | Use of rab7 gtpase (rab7) inhibitors in enhancing permeability of the blood brain barrier (bbb) |
| US20230313147A1 (en) * | 2019-06-04 | 2023-10-05 | Jerome Canady Research Institute for Advanced Biological and Technological Sciences | Cold plasma treatment mediated mutant specific t cell immunity |
| EP4013392B1 (en) | 2019-09-13 | 2026-04-29 | Exocure Sweden AB | Use of ghost nanovesicles as therapeutics |
| JP7462452B2 (ja) * | 2020-03-27 | 2024-04-05 | 株式会社日立製作所 | 培養細胞の分化レベルを評価するための評価装置および評価方法、並びに自動細胞培養システム |
| CN112698033A (zh) * | 2020-12-09 | 2021-04-23 | 复旦大学附属中山医院 | 一种血源性外泌体her2的检测方法及其应用 |
| US20230340606A1 (en) * | 2021-09-09 | 2023-10-26 | The Regents Of The University Of California | Extracellular repetitive rna biomarkers of mutant kras cancers |
| US20250011876A1 (en) * | 2021-11-02 | 2025-01-09 | The Regents Of The University Of California | Extracellular rna signatures of mutant kras(g12c) cancers |
| WO2023210644A1 (ja) * | 2022-04-26 | 2023-11-02 | 国立大学法人東京大学 | がん細胞由来細胞外小胞群の単離濃縮方法、分析方法、薬剤選択方法、キット、及び抗がん剤 |
| WO2023215820A1 (en) * | 2022-05-06 | 2023-11-09 | The Trustees Of The University Of Pennsylvania | Ultrasensitive single extracellular vesicle detection using high throughput droplet digital enzyme-linked immunosorbent assay |
| WO2024047441A1 (en) * | 2022-09-01 | 2024-03-07 | Fundação D. Anna De Sommer Champalimaud E Dr. Carlos Montez Champalimaud - Centro De Investigação Da Fundação Champalimaud | Method for monitoring tumor burden in subjects during therapeutic intervention |
| US20260100247A1 (en) * | 2022-09-30 | 2026-04-09 | Foundation Medicine, Inc. | Systems and methods for processing clinico-genomic data |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5824311A (en) | 1987-11-30 | 1998-10-20 | Trustees Of The University Of Pennsylvania | Treatment of tumors with monoclonal antibodies against oncogene antigens |
| US4870287A (en) | 1988-03-03 | 1989-09-26 | Loma Linda University Medical Center | Multi-station proton beam therapy system |
| US5801029A (en) | 1993-02-16 | 1998-09-01 | Onyx Pharmaceuticals, Inc. | Cytopathic viruses for therapy and prophylaxis of neoplasia |
| US5801005A (en) | 1993-03-17 | 1998-09-01 | University Of Washington | Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated |
| GB9506466D0 (en) | 1994-08-26 | 1995-05-17 | Prolifix Ltd | Cell cycle regulated repressor and dna element |
| US5760395A (en) | 1996-04-18 | 1998-06-02 | Universities Research Assoc., Inc. | Method and apparatus for laser-controlled proton beam radiology |
| US5739169A (en) | 1996-05-31 | 1998-04-14 | Procept, Incorporated | Aromatic compounds for inhibiting immune response |
| US20030064949A1 (en) * | 1998-02-17 | 2003-04-03 | Loretta Nielsen | Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms |
| FR2766205B1 (fr) | 1997-07-16 | 2002-08-30 | Inst Nat Sante Rech Med | Nouveau procede de sensibilisation de cellules presentatrices d'antigene et nouveaux moyens pour la mise en oeuvre du procede |
| KR100519384B1 (ko) * | 2002-08-13 | 2005-10-06 | (주)누백스 | 유전자 이입을 이용한 엑소좀의 제조방법 및 상기 엑소좀의 용도 |
| KR101810799B1 (ko) * | 2008-02-01 | 2017-12-19 | 더 제너럴 하스피탈 코포레이션 | 의학적 질환 및 병태의 진단, 예후, 및 치료에 있어서 미세소포체의 용도 |
| CA2821355A1 (en) * | 2011-01-31 | 2012-08-09 | Esoterix Genetic Laboratories, Llc | Methods for enriching microparticles or nucleic acids using binding molecules |
| US9777042B2 (en) * | 2011-12-15 | 2017-10-03 | Morehouse School Of Medicine | Method of purifying HIV/SIV Nef from exosomal fusion proteins |
| US9309559B2 (en) * | 2013-04-15 | 2016-04-12 | Albert Einstein College Of Medicine, Inc. | Simultaneous extraction of DNA and RNA from FFPE tissues |
| US9921223B2 (en) * | 2013-12-04 | 2018-03-20 | Board Of Regents, The University Of Texas System | Analysis of genomic DNA, RNA, and proteins in exosomes for diagnosis and theranosis |
-
2014
- 2014-12-04 US US15/101,857 patent/US9921223B2/en active Active
- 2014-12-04 SI SI201431412T patent/SI3076949T1/sl unknown
- 2014-12-04 CA CA2936100A patent/CA2936100A1/en active Pending
- 2014-12-04 EP EP14867768.5A patent/EP3076949B1/en active Active
- 2014-12-04 AU AU2014360344A patent/AU2014360344B2/en not_active Ceased
- 2014-12-04 HR HRP20192131TT patent/HRP20192131T1/hr unknown
- 2014-12-04 JP JP2016536918A patent/JP2017501694A/ja not_active Ceased
- 2014-12-04 LT LT14867768T patent/LT3076949T/lt unknown
- 2014-12-04 HU HUE14867768A patent/HUE046489T2/hu unknown
- 2014-12-04 DK DK14867768T patent/DK3076949T3/da active
- 2014-12-04 NZ NZ721720A patent/NZ721720A/en not_active IP Right Cessation
- 2014-12-04 WO PCT/US2014/068630 patent/WO2015085096A1/en not_active Ceased
-
2016
- 2016-06-30 ZA ZA2016/04468A patent/ZA201604468B/en unknown
-
2017
- 2017-11-01 US US15/801,269 patent/US10598665B2/en active Active
-
2019
- 2019-01-30 AU AU2019200573A patent/AU2019200573A1/en not_active Abandoned
- 2019-02-25 AU AU2019201290A patent/AU2019201290A1/en not_active Withdrawn
- 2019-08-13 JP JP2019148579A patent/JP2019198327A/ja not_active Withdrawn
-
2020
- 2020-03-04 US US16/809,300 patent/US20200200755A1/en not_active Abandoned
-
2021
- 2021-07-02 JP JP2021110830A patent/JP7138372B2/ja active Active
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