JP2017501694A5 - - Google Patents
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- JP2017501694A5 JP2017501694A5 JP2016536918A JP2016536918A JP2017501694A5 JP 2017501694 A5 JP2017501694 A5 JP 2017501694A5 JP 2016536918 A JP2016536918 A JP 2016536918A JP 2016536918 A JP2016536918 A JP 2016536918A JP 2017501694 A5 JP2017501694 A5 JP 2017501694A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- item
- isolating
- exosome
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 238000000034 method Methods 0.000 claims description 105
- 210000001808 exosome Anatomy 0.000 claims description 46
- 206010028980 Neoplasm Diseases 0.000 claims description 43
- 201000011510 cancer Diseases 0.000 claims description 40
- 108090000623 proteins and genes Proteins 0.000 claims description 28
- 102000004169 proteins and genes Human genes 0.000 claims description 17
- 210000004027 cell Anatomy 0.000 claims description 14
- 108020004414 DNA Proteins 0.000 claims description 12
- 210000001124 body fluid Anatomy 0.000 claims description 12
- 239000000107 tumor biomarker Substances 0.000 claims description 12
- 230000035772 mutation Effects 0.000 claims description 11
- 239000010839 body fluid Substances 0.000 claims description 10
- 102000010956 Glypican Human genes 0.000 claims description 8
- 108050001154 Glypican Proteins 0.000 claims description 8
- 108050007238 Glypican-1 Proteins 0.000 claims description 8
- 206010005003 Bladder cancer Diseases 0.000 claims description 6
- 208000003174 Brain Neoplasms Diseases 0.000 claims description 6
- 206010006187 Breast cancer Diseases 0.000 claims description 6
- 208000026310 Breast neoplasm Diseases 0.000 claims description 6
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 6
- 206010009944 Colon cancer Diseases 0.000 claims description 6
- 102000053602 DNA Human genes 0.000 claims description 6
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims description 6
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 6
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims description 6
- 206010033128 Ovarian cancer Diseases 0.000 claims description 6
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 6
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 6
- 206010060862 Prostate cancer Diseases 0.000 claims description 6
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 6
- 208000015634 Rectal Neoplasms Diseases 0.000 claims description 6
- 208000000453 Skin Neoplasms Diseases 0.000 claims description 6
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 6
- 208000024313 Testicular Neoplasms Diseases 0.000 claims description 6
- 206010057644 Testis cancer Diseases 0.000 claims description 6
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 6
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 6
- 201000010881 cervical cancer Diseases 0.000 claims description 6
- 208000029742 colonic neoplasm Diseases 0.000 claims description 6
- 201000004101 esophageal cancer Diseases 0.000 claims description 6
- 206010017758 gastric cancer Diseases 0.000 claims description 6
- 201000010536 head and neck cancer Diseases 0.000 claims description 6
- 208000014829 head and neck neoplasm Diseases 0.000 claims description 6
- 201000007270 liver cancer Diseases 0.000 claims description 6
- 208000014018 liver neoplasm Diseases 0.000 claims description 6
- 201000005202 lung cancer Diseases 0.000 claims description 6
- 208000020816 lung neoplasm Diseases 0.000 claims description 6
- 210000002751 lymph Anatomy 0.000 claims description 6
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 6
- 201000002528 pancreatic cancer Diseases 0.000 claims description 6
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 6
- 206010038038 rectal cancer Diseases 0.000 claims description 6
- 201000001275 rectum cancer Diseases 0.000 claims description 6
- 210000003296 saliva Anatomy 0.000 claims description 6
- 210000002966 serum Anatomy 0.000 claims description 6
- 201000000849 skin cancer Diseases 0.000 claims description 6
- 201000011549 stomach cancer Diseases 0.000 claims description 6
- 201000003120 testicular cancer Diseases 0.000 claims description 6
- 206010044285 tracheal cancer Diseases 0.000 claims description 6
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 6
- 210000002700 urine Anatomy 0.000 claims description 6
- 210000004291 uterus Anatomy 0.000 claims description 6
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 4
- 210000001185 bone marrow Anatomy 0.000 claims description 4
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims description 4
- 210000000416 exudates and transudate Anatomy 0.000 claims description 4
- 238000012300 Sequence Analysis Methods 0.000 claims description 3
- 201000008129 pancreatic ductal adenocarcinoma Diseases 0.000 claims description 3
- 238000001356 surgical procedure Methods 0.000 claims description 3
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims description 2
- 230000004913 activation Effects 0.000 claims description 2
- 238000003205 genotyping method Methods 0.000 claims description 2
- 238000002955 isolation Methods 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 description 12
- 201000010099 disease Diseases 0.000 description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
- 108020004707 nucleic acids Proteins 0.000 description 7
- 102000039446 nucleic acids Human genes 0.000 description 7
- 150000007523 nucleic acids Chemical class 0.000 description 7
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 6
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 6
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 description 5
- 238000011319 anticancer therapy Methods 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- 238000002512 chemotherapy Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001794 hormone therapy Methods 0.000 description 1
- 238000009169 immunotherapy Methods 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 238000002626 targeted therapy Methods 0.000 description 1
- 239000003104 tissue culture media Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361911863P | 2013-12-04 | 2013-12-04 | |
| US61/911,863 | 2013-12-04 | ||
| PCT/US2014/068630 WO2015085096A1 (en) | 2013-12-04 | 2014-12-04 | Analysis of genomic dna, rna, and proteins in exosomes for diagnosis and theranosis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019148579A Division JP2019198327A (ja) | 2013-12-04 | 2019-08-13 | 診断および療法のためのエキソソーム中のゲノムｄｎａ、ｒｎａおよびタンパク質の分析 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017501694A JP2017501694A (ja) | 2017-01-19 |
| JP2017501694A5 true JP2017501694A5 (https=) | 2017-12-21 |
Family
ID=53274132
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016536918A Ceased JP2017501694A (ja) | 2013-12-04 | 2014-12-04 | 診断および療法のためのエキソソーム中のゲノムｄｎａ、ｒｎａおよびタンパク質の分析 |
| JP2019148579A Withdrawn JP2019198327A (ja) | 2013-12-04 | 2019-08-13 | 診断および療法のためのエキソソーム中のゲノムｄｎａ、ｒｎａおよびタンパク質の分析 |
| JP2021110830A Active JP7138372B2 (ja) | 2013-12-04 | 2021-07-02 | 診断および療法のためのエキソソーム中のゲノムｄｎａ、ｒｎａおよびタンパク質の分析 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019148579A Withdrawn JP2019198327A (ja) | 2013-12-04 | 2019-08-13 | 診断および療法のためのエキソソーム中のゲノムｄｎａ、ｒｎａおよびタンパク質の分析 |
| JP2021110830A Active JP7138372B2 (ja) | 2013-12-04 | 2021-07-02 | 診断および療法のためのエキソソーム中のゲノムｄｎａ、ｒｎａおよびタンパク質の分析 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US9921223B2 (https=) |
| EP (1) | EP3076949B1 (https=) |
| JP (3) | JP2017501694A (https=) |
| AU (3) | AU2014360344B2 (https=) |
| CA (1) | CA2936100A1 (https=) |
| DK (1) | DK3076949T3 (https=) |
| HR (1) | HRP20192131T1 (https=) |
| HU (1) | HUE046489T2 (https=) |
| LT (1) | LT3076949T (https=) |
| NZ (1) | NZ721720A (https=) |
| SI (1) | SI3076949T1 (https=) |
| WO (1) | WO2015085096A1 (https=) |
| ZA (1) | ZA201604468B (https=) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
| WO2006116362A2 (en) | 2005-04-25 | 2006-11-02 | The Trustees Of Boston University | Structured substrates for optical surface profiling |
| US11286463B2 (en) | 2012-03-08 | 2022-03-29 | Advanced ReGen Medical Technologies, LLC | Reprogramming of aged adult stem cells |
| AU2013302799B2 (en) | 2012-08-13 | 2018-03-01 | Cedars-Sinai Medical Center | Exosomes and micro-ribonucleic acids for tissue regeneration |
| US11180812B2 (en) | 2012-08-17 | 2021-11-23 | Cornell University | Use of DNA in circulating exosomes as a diagnostic marker for metastatic disease |
| CN105264092B (zh) | 2013-03-15 | 2019-02-22 | 得克萨斯州大学系统董事会 | 用于诊断和疗法的外来体中的miRNA生物发生 |
| JP2017501694A (ja) * | 2013-12-04 | 2017-01-19 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | 診断および療法のためのエキソソーム中のゲノムｄｎａ、ｒｎａおよびタンパク質の分析 |
| US10772911B2 (en) | 2013-12-20 | 2020-09-15 | Advanced ReGen Medical Technologies, LLC | Cell free compositions for cellular restoration and methods of making and using same |
| CR20160307A (es) | 2013-12-20 | 2016-11-08 | Advanced Regen Medical Tech Llc | Composiciones para la restauración de células y métodos para la preparación y utilización de las mismas |
| US10844436B2 (en) * | 2014-04-01 | 2020-11-24 | Cornell University | Use of double-stranded DNA in exosomes: a novel biomarker in cancer detection |
| CA2962444C (en) | 2014-10-03 | 2023-09-05 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy |
| US11397182B2 (en) | 2014-10-07 | 2022-07-26 | Cornell University | Methods for prognosing and preventing metastatic liver disease |
| US11971402B2 (en) | 2015-04-24 | 2024-04-30 | Cornell University | Methods and reagents for determination and treatment of organotropic metastasis |
| US11339441B2 (en) * | 2015-05-12 | 2022-05-24 | The Research Foundation For The State University Of New York | Profiling chemically modified DNA/RNA units for disease and cancer diagnosis |
| WO2016201064A1 (en) | 2015-06-09 | 2016-12-15 | The Board Of Regents Of The University Of Texas System | Diagnostic test for early stage cancer |
| US20180177727A1 (en) | 2015-06-10 | 2018-06-28 | Board Of Regents, The University Of Texas System | Use of exosomes for the treatment of disease |
| CN114217058A (zh) | 2015-09-22 | 2022-03-22 | 波士顿大学董事会 | 纳米囊泡的多重表型分析 |
| GB201518466D0 (en) * | 2015-10-19 | 2015-12-02 | Cizzle Biotechnology Ltd | Use |
| EP3402543B1 (en) | 2016-01-11 | 2021-09-08 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction |
| JP7033082B2 (ja) * | 2016-02-05 | 2022-03-09 | ナノビュー バイオサイエンシズ インコーポレイテッド | 表面マーカーを有するエキソソームの検出 |
| RU2018136151A (ru) * | 2016-03-15 | 2020-04-15 | Кодиак Байосайнсиз, Инк. | Терапевтические мембранные везикулы |
| EP3436081A4 (en) | 2016-04-29 | 2019-07-24 | Advanced Regen Medical Technologies, LLC | Microrna compositions and methods of making and using same |
| WO2017210652A1 (en) | 2016-06-03 | 2017-12-07 | Cedars-Sinai Medical Center | Cdc-derived exosomes for treatment of ventricular tachyarrythmias |
| WO2017223186A1 (en) * | 2016-06-21 | 2017-12-28 | Nant Holdings Ip, Llc | Exosome-guided treatment of cancer |
| CN106124282B (zh) | 2016-07-26 | 2019-07-16 | 广州海力特生物科技有限公司 | 一种叠层离心过滤分离提取外泌体的方法 |
| US20180067121A1 (en) * | 2016-09-06 | 2018-03-08 | Nanoco Technologies Ltd. | Exosome-conjugated quantum dot nanoparticles and methods of detecting exosomes and cancer using same |
| US11541078B2 (en) | 2016-09-20 | 2023-01-03 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders |
| CN110650728B (zh) * | 2017-03-21 | 2023-06-23 | 埃索普罗瑟医疗有限公司 | 含有用于治疗的肿瘤抑制蛋白的天然细胞衍生的囊泡 |
| GB2560897A (en) | 2017-03-23 | 2018-10-03 | Lotvall Jan | Tissue-derived extracellular vesicles and their use as diagnostics |
| EP4699658A2 (en) | 2017-04-19 | 2026-02-25 | Cedars-Sinai Medical Center | Methods and compositions for treating skeletal muscular dystrophy |
| CN107338306A (zh) * | 2017-07-23 | 2017-11-10 | 嘉兴允英医学检验有限公司 | 一种用于GPC1mRNA表达检测的试剂盒 |
| JP2020529477A (ja) * | 2017-08-04 | 2020-10-08 | シーダーズ—シナイ メディカル センター | がんの治療及び防止のためのカルディオスフィア由来細胞及びその細胞外小胞 |
| GB2574785A (en) | 2017-09-15 | 2019-12-25 | Jan Loetvall | Method and system for identifying membrane proteins on extracellular vesicles |
| WO2019094692A2 (en) | 2017-11-09 | 2019-05-16 | The Trustees Of The University Of Pennsylvania | Extracellular vesicle proteins and their use for cancer diagnosis, predicting response to therapy, and treatment |
| WO2019109077A1 (en) | 2017-12-01 | 2019-06-06 | Cornell University | Nanoparticles and distinct exosome subsets for detection and treatment of cancer |
| CA3084821A1 (en) | 2017-12-15 | 2019-06-20 | Board Of Regents, The University Of Texas System | Methods and compositions for treating cancer using exosomes-associated gene editing |
| US11660355B2 (en) | 2017-12-20 | 2023-05-30 | Cedars-Sinai Medical Center | Engineered extracellular vesicles for enhanced tissue delivery |
| AU2018394238A1 (en) * | 2017-12-28 | 2020-06-18 | Lonza Sales Ag | Exosomes for immuno-oncology and anti-inflammatory therapy |
| US10717981B2 (en) | 2018-01-18 | 2020-07-21 | Advanced ReGen Medical Technologies, LLC | Therapeutic compositions and methods of making and using the same |
| US12146137B2 (en) | 2018-02-05 | 2024-11-19 | Cedars-Sinai Medical Center | Methods for therapeutic use of exosomes and Y-RNAS |
| US12241888B2 (en) | 2018-03-14 | 2025-03-04 | Children's Medical Center Corporation | Platform for assessment of the transcytosis of extracellular vesicles across endothelial barriers and uses thereof |
| JP7813099B2 (ja) * | 2018-03-28 | 2026-02-12 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 治療用物質を標的送達するためのエキソソームの使用法 |
| EP3775258A4 (en) * | 2018-03-28 | 2022-01-26 | Board of Regents, The University of Texas System | IDENTIFICATION OF EPIGENETIC ALTERATIONS IN DNA ISOLATED FROM EXOSOMES |
| CN112236130A (zh) * | 2018-04-09 | 2021-01-15 | 得克萨斯州大学系统董事会 | 使用外排体对癌基因的治疗性靶向 |
| EP3788150A4 (en) * | 2018-05-04 | 2022-01-26 | Sigma-Aldrich Co. LLC | PRODUCTION OF RECOMBINANT PROTEINS WITH REDUCED LEVELS OF HOST CELL PROTEINS |
| EP3803332A1 (en) | 2018-06-01 | 2021-04-14 | NanoView Biosciences, Inc. | Compositions, systems, and methods for enhanced label-free and fluorescence - based detection of nanoparticles |
| IL269897B2 (en) | 2018-11-15 | 2023-08-01 | Sternum Ltd | Implementing control flow correctness verification in code intermediate files |
| US11766484B2 (en) | 2019-01-03 | 2023-09-26 | International Business Machines Corporation | Exosome vessels for delivery of molecular cargo |
| WO2020146390A1 (en) | 2019-01-09 | 2020-07-16 | Exocure Biosciences, Inc. | Bacteria-derived vesicles and uses thereof |
| US20220113313A1 (en) * | 2019-02-01 | 2022-04-14 | NanoView Biosciences, Inc. | Systems and methods for vesicle cargo labeling and detection |
| AU2020218358A1 (en) * | 2019-02-08 | 2021-08-26 | Board Of Regents, The University Of Texas System | Isolation and detection of exosome-associated microbiome for diagnostic and therapeutic purposes |
| CN114080232A (zh) * | 2019-03-21 | 2022-02-22 | 科迪亚克生物科学公司 | 用于疫苗递送的细胞外囊泡 |
| WO2020219699A1 (en) * | 2019-04-23 | 2020-10-29 | Children's Medical Center Corporation | Use of rab7 gtpase (rab7) inhibitors in enhancing permeability of the blood brain barrier (bbb) |
| EP4013392B1 (en) | 2019-09-13 | 2026-04-29 | Exocure Sweden AB | Use of ghost nanovesicles as therapeutics |
| JP7462452B2 (ja) * | 2020-03-27 | 2024-04-05 | 株式会社日立製作所 | 培養細胞の分化レベルを評価するための評価装置および評価方法、並びに自動細胞培養システム |
| CN112698033A (zh) * | 2020-12-09 | 2021-04-23 | 复旦大学附属中山医院 | 一种血源性外泌体her2的检测方法及其应用 |
| US20230340606A1 (en) * | 2021-09-09 | 2023-10-26 | The Regents Of The University Of California | Extracellular repetitive rna biomarkers of mutant kras cancers |
| WO2023081099A1 (en) * | 2021-11-02 | 2023-05-11 | Daniel Kim | Extracellular rna signatures of mutant kras(g12c) cancers |
| WO2023210644A1 (ja) * | 2022-04-26 | 2023-11-02 | 国立大学法人東京大学 | がん細胞由来細胞外小胞群の単離濃縮方法、分析方法、薬剤選択方法、キット、及び抗がん剤 |
| US20250290919A1 (en) * | 2022-05-06 | 2025-09-18 | The Trustees Of The University Of Pennsylvania | Ultrasensitive single extracellular vesicle detection using high throughput droplet digital enzyme-linked immunosorbent assay |
| WO2024047441A1 (en) * | 2022-09-01 | 2024-03-07 | Fundação D. Anna De Sommer Champalimaud E Dr. Carlos Montez Champalimaud - Centro De Investigação Da Fundação Champalimaud | Method for monitoring tumor burden in subjects during therapeutic intervention |
| WO2024073671A1 (en) * | 2022-09-30 | 2024-04-04 | Foundation Medicine, Inc. | Systems and methods for processing clinico-genomic data |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5824311A (en) | 1987-11-30 | 1998-10-20 | Trustees Of The University Of Pennsylvania | Treatment of tumors with monoclonal antibodies against oncogene antigens |
| US4870287A (en) | 1988-03-03 | 1989-09-26 | Loma Linda University Medical Center | Multi-station proton beam therapy system |
| US5846945A (en) | 1993-02-16 | 1998-12-08 | Onyx Pharmaceuticals, Inc. | Cytopathic viruses for therapy and prophylaxis of neoplasia |
| US5801005A (en) | 1993-03-17 | 1998-09-01 | University Of Washington | Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated |
| GB9506466D0 (en) | 1994-08-26 | 1995-05-17 | Prolifix Ltd | Cell cycle regulated repressor and dna element |
| US5760395A (en) | 1996-04-18 | 1998-06-02 | Universities Research Assoc., Inc. | Method and apparatus for laser-controlled proton beam radiology |
| US5739169A (en) | 1996-05-31 | 1998-04-14 | Procept, Incorporated | Aromatic compounds for inhibiting immune response |
| US20030064949A1 (en) * | 1998-02-17 | 2003-04-03 | Loretta Nielsen | Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms |
| FR2766205B1 (fr) | 1997-07-16 | 2002-08-30 | Inst Nat Sante Rech Med | Nouveau procede de sensibilisation de cellules presentatrices d'antigene et nouveaux moyens pour la mise en oeuvre du procede |
| KR100519384B1 (ko) | 2002-08-13 | 2005-10-06 | (주)누백스 | 유전자 이입을 이용한 엑소좀의 제조방법 및 상기 엑소좀의 용도 |
| EP2245199B1 (en) * | 2008-02-01 | 2013-11-13 | The General Hospital Corporation | Use of microvesicles in diagnosis, prognosis and treatment of medical diseases and conditions |
| US20120196285A1 (en) * | 2011-01-31 | 2012-08-02 | Esoterix Genetic Laboratories, Llc | Methods for Enriching Microparticles or Nucleic Acids Using Binding Molecules |
| US9777042B2 (en) * | 2011-12-15 | 2017-10-03 | Morehouse School Of Medicine | Method of purifying HIV/SIV Nef from exosomal fusion proteins |
| US9309559B2 (en) * | 2013-04-15 | 2016-04-12 | Albert Einstein College Of Medicine, Inc. | Simultaneous extraction of DNA and RNA from FFPE tissues |
| JP2017501694A (ja) * | 2013-12-04 | 2017-01-19 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | 診断および療法のためのエキソソーム中のゲノムｄｎａ、ｒｎａおよびタンパク質の分析 |
-
2014
- 2014-12-04 JP JP2016536918A patent/JP2017501694A/ja not_active Ceased
- 2014-12-04 LT LT14867768T patent/LT3076949T/lt unknown
- 2014-12-04 WO PCT/US2014/068630 patent/WO2015085096A1/en not_active Ceased
- 2014-12-04 HU HUE14867768A patent/HUE046489T2/hu unknown
- 2014-12-04 HR HRP20192131TT patent/HRP20192131T1/hr unknown
- 2014-12-04 EP EP14867768.5A patent/EP3076949B1/en active Active
- 2014-12-04 CA CA2936100A patent/CA2936100A1/en active Pending
- 2014-12-04 NZ NZ721720A patent/NZ721720A/en not_active IP Right Cessation
- 2014-12-04 AU AU2014360344A patent/AU2014360344B2/en not_active Ceased
- 2014-12-04 US US15/101,857 patent/US9921223B2/en active Active
- 2014-12-04 DK DK14867768T patent/DK3076949T3/da active
- 2014-12-04 SI SI201431412T patent/SI3076949T1/sl unknown
-
2016
- 2016-06-30 ZA ZA2016/04468A patent/ZA201604468B/en unknown
-
2017
- 2017-11-01 US US15/801,269 patent/US10598665B2/en active Active
-
2019
- 2019-01-30 AU AU2019200573A patent/AU2019200573A1/en not_active Abandoned
- 2019-02-25 AU AU2019201290A patent/AU2019201290A1/en not_active Withdrawn
- 2019-08-13 JP JP2019148579A patent/JP2019198327A/ja not_active Withdrawn
-
2020
- 2020-03-04 US US16/809,300 patent/US20200200755A1/en not_active Abandoned
-
2021
- 2021-07-02 JP JP2021110830A patent/JP7138372B2/ja active Active
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