JP2017501202A5 - - Google Patents
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- Publication number
- JP2017501202A5 JP2017501202A5 JP2016544410A JP2016544410A JP2017501202A5 JP 2017501202 A5 JP2017501202 A5 JP 2017501202A5 JP 2016544410 A JP2016544410 A JP 2016544410A JP 2016544410 A JP2016544410 A JP 2016544410A JP 2017501202 A5 JP2017501202 A5 JP 2017501202A5
- Authority
- JP
- Japan
- Prior art keywords
- nicotinamide
- pyridin
- cyano
- fluoro
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(C)[n](c1n2)ncc1cc(*)c2[Rh] Chemical compound CC(C)[n](c1n2)ncc1cc(*)c2[Rh] 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461923403P | 2014-01-03 | 2014-01-03 | |
| US61/923,403 | 2014-01-03 | ||
| PCT/US2015/010006 WO2015103453A1 (en) | 2014-01-03 | 2015-01-02 | Heteroaryl substituted nicotinamide compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017501202A JP2017501202A (ja) | 2017-01-12 |
| JP2017501202A5 true JP2017501202A5 (OSRAM) | 2018-12-13 |
| JP6475252B2 JP6475252B2 (ja) | 2019-02-27 |
Family
ID=52355270
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016544410A Expired - Fee Related JP6475252B2 (ja) | 2014-01-03 | 2015-01-02 | ヘテロアリール置換のニコチンアミド化合物 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9169252B2 (OSRAM) |
| EP (1) | EP3089973B1 (OSRAM) |
| JP (1) | JP6475252B2 (OSRAM) |
| KR (1) | KR20160101191A (OSRAM) |
| CN (1) | CN106061967B (OSRAM) |
| AR (1) | AR098991A1 (OSRAM) |
| AU (1) | AU2015204045A1 (OSRAM) |
| CA (1) | CA2935329A1 (OSRAM) |
| CL (1) | CL2016001706A1 (OSRAM) |
| EA (1) | EA201691343A1 (OSRAM) |
| ES (1) | ES2804707T3 (OSRAM) |
| IL (1) | IL246474A0 (OSRAM) |
| MA (1) | MA39162A1 (OSRAM) |
| MX (1) | MX2016008723A (OSRAM) |
| PE (1) | PE20161292A1 (OSRAM) |
| PH (1) | PH12016501164A1 (OSRAM) |
| SG (1) | SG11201605340QA (OSRAM) |
| TN (1) | TN2016000271A1 (OSRAM) |
| TW (1) | TW201609693A (OSRAM) |
| UY (1) | UY35935A (OSRAM) |
| WO (1) | WO2015103453A1 (OSRAM) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201503397YA (en) | 2012-11-08 | 2015-05-28 | Bristol Myers Squibb Co | Heteroaryl substituted pyridyl compounds useful as kinase modulators |
| US9546153B2 (en) | 2012-11-08 | 2017-01-17 | Bristol-Myers Squibb Company | Bicyclic heterocycle substituted pyridyl compounds useful as kinase modulators |
| GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
| GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| CA2935392C (en) | 2014-01-01 | 2022-07-26 | Medivation Technologies, Inc. | Amino pyridine derivatives for the treatment of conditions associated with excessive tgf.beta activity |
| US20180228907A1 (en) | 2014-04-14 | 2018-08-16 | Arvinas, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
| CN109641906B (zh) * | 2015-06-24 | 2021-10-01 | 百时美施贵宝公司 | 杂芳基取代的氨基吡啶化合物 |
| CN107849039B (zh) | 2015-06-24 | 2020-07-03 | 百时美施贵宝公司 | 经杂芳基取代的氨基吡啶化合物 |
| AR105114A1 (es) | 2015-06-24 | 2017-09-06 | Bristol Myers Squibb Co | Compuestos de aminopiridina sustituida con heteroarilo |
| GB201518456D0 (en) * | 2015-10-19 | 2015-12-02 | Galapagos Nv | Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory, autoimmune and/or proliferative diseases |
| WO2017133667A1 (en) * | 2016-02-05 | 2017-08-10 | Savira Pharmaceuticals Gmbh | Pyrimidine and pyridine derivatives and use in treatment, amelioration or prevention of influenza thereof |
| WO2017133657A1 (en) * | 2016-02-05 | 2017-08-10 | Savira Pharmaceuticals Gmbh | Pyridine and pyrimidine derivatives and their use in treatment, amelioration or prevention of influenza |
| WO2018005863A1 (en) * | 2016-07-01 | 2018-01-04 | G1 Therapeutics, Inc. | Pyrimidine-based compounds for the treatment of cancer |
| JOP20180011A1 (ar) * | 2017-02-16 | 2019-01-30 | Gilead Sciences Inc | مشتقات بيرولو [1، 2-b]بيريدازين |
| WO2019028301A1 (en) * | 2017-08-04 | 2019-02-07 | Bristol-Myers Squibb Company | INDOLE COMPOUNDS SUBSTITUTED WITH [1,2,4] TRIAZOLO [4,3-A] PYRIDINYL |
| NZ763299A (en) | 2017-09-14 | 2025-09-26 | Daiichi Sankyo Co Ltd | Compound having cyclic structure |
| WO2019060742A1 (en) | 2017-09-22 | 2019-03-28 | Kymera Therapeutics, Inc | AGENTS FOR DEGRADING PROTEINS AND USES THEREOF |
| EP3684366A4 (en) | 2017-09-22 | 2021-09-08 | Kymera Therapeutics, Inc. | CRBN LIGANDS AND USES OF THE LATEST |
| KR20190043437A (ko) | 2017-10-18 | 2019-04-26 | 씨제이헬스케어 주식회사 | 단백질 키나제 억제제로서의 헤테로고리 화합물 |
| US11065231B2 (en) | 2017-11-17 | 2021-07-20 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of interleukin-1 receptor- associated kinase 4 polypeptides |
| WO2019111218A1 (en) | 2017-12-08 | 2019-06-13 | Cadila Healthcare Limited | Novel heterocyclic compounds as irak4 inhibitors |
| TW201927769A (zh) * | 2017-12-18 | 2019-07-16 | 德商歌林達有限公司 | 經取代之吡咯啶醯胺ｉｉ |
| IL315310A (en) | 2017-12-26 | 2024-10-01 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
| WO2019140380A1 (en) | 2018-01-12 | 2019-07-18 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| EP3737675A4 (en) | 2018-01-12 | 2022-01-05 | Kymera Therapeutics, Inc. | Crbn ligands and uses thereof |
| EP3752504A4 (en) | 2018-02-14 | 2021-06-09 | Dana Farber Cancer Institute, Inc. | IRAQ DEGRADER AND USES THEREOF |
| US11292792B2 (en) | 2018-07-06 | 2022-04-05 | Kymera Therapeutics, Inc. | Tricyclic CRBN ligands and uses thereof |
| WO2020010227A1 (en) | 2018-07-06 | 2020-01-09 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| TWI842978B (zh) * | 2018-07-13 | 2024-05-21 | 美商基利科學股份有限公司 | 衍生物 |
| TWI727392B (zh) * | 2018-08-13 | 2021-05-11 | 美商基利科學股份有限公司 | 噻二唑irak4抑制劑 |
| KR102195348B1 (ko) | 2018-11-15 | 2020-12-24 | 에이치케이이노엔 주식회사 | 단백질 키나제 억제제로서의 신규 화합물 및 이를 포함하는 약제학적 조성물 |
| US11352350B2 (en) | 2018-11-30 | 2022-06-07 | Kymera Therapeutics, Inc. | IRAK degraders and uses thereof |
| CN114174279B (zh) * | 2019-08-06 | 2024-07-02 | 百时美施贵宝公司 | 可用作irak4抑制剂的双环杂环化合物 |
| WO2021127283A2 (en) | 2019-12-17 | 2021-06-24 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| EP4076520A4 (en) | 2019-12-17 | 2024-03-27 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| US12421230B2 (en) | 2020-02-03 | 2025-09-23 | Bristol-Myers Squibb Company | Tricyclic heteroaryl compounds useful as IRAK4 inhibitors |
| TW202210483A (zh) | 2020-06-03 | 2022-03-16 | 美商凱麥拉醫療公司 | Irak降解劑之結晶型 |
| TW202241891A (zh) | 2020-12-30 | 2022-11-01 | 美商凱麥拉醫療公司 | Irak降解劑及其用途 |
| JP2024506656A (ja) | 2021-02-15 | 2024-02-14 | カイメラ セラピューティクス， インコーポレイテッド | Ｉｒａｋ４分解剤およびその使用 |
| US12097261B2 (en) | 2021-05-07 | 2024-09-24 | Kymera Therapeutics, Inc. | CDK2 degraders and uses thereof |
| KR20230019396A (ko) * | 2021-07-29 | 2023-02-08 | 프라비바이오 주식회사 | 신규 벤젠 유도체 및 이의 면역억제 관련 용도 |
| PT4367118T (pt) | 2021-08-18 | 2025-04-16 | Gilead Sciences Inc | Degradadores bifuncionais de quinases associadas ao recetor de interleucina-1 e sua utilização terapêutica |
| WO2023076556A1 (en) | 2021-10-29 | 2023-05-04 | Kymera Therapeutics, Inc. | Irak4 degraders and synthesis thereof |
| JP2025504059A (ja) | 2022-01-31 | 2025-02-06 | カイメラ セラピューティクス， インコーポレイテッド | Ｉｒａｋデグレーダー及びその使用 |
| WO2025151602A1 (en) * | 2024-01-11 | 2025-07-17 | Bristol-Myers Squibb Company | Heteroaryl compounds as ligand directed degraders of irak4 |
| WO2025151728A1 (en) * | 2024-01-12 | 2025-07-17 | Bristol-Myers Squibb Company | Ligand directed degrader of irak4 |
| CN118388401B (zh) * | 2024-06-28 | 2024-08-20 | 成都凯斯坦生物医药有限公司 | 一种4-氨基-2-氯烟醛的制备方法 |
| CN118641677B (zh) * | 2024-08-16 | 2024-11-05 | 北京京丰制药集团有限公司 | 尼可刹米原料中杂质的检测方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7273868B2 (en) * | 2000-04-28 | 2007-09-25 | Tanabe Seiyaku Co., Ltd. | Pyrazine derivatives |
| EP1399440B1 (en) | 2001-06-15 | 2009-06-03 | Vertex Pharmaceuticals Incorporated | 5-(2-aminopyrimidin-4-yl)benzisoxazoles as protein kinase inhibitors |
| AUPR688101A0 (en) | 2001-08-08 | 2001-08-30 | Luminis Pty Limited | Protein domains and their ligands |
| GB0211019D0 (en) | 2002-05-14 | 2002-06-26 | Syngenta Ltd | Novel compounds |
| AU2003244098A1 (en) | 2002-06-28 | 2004-01-19 | Yamanouchi Pharmaceutical Co., Ltd. | Diaminopyrimidinecarboxa mide derivative |
| WO2004065378A1 (en) | 2003-01-17 | 2004-08-05 | Warner-Lambert Company Llc | 2-aminopyridine substituted heterocycles as inhibitors of cellular proliferation |
| EP1651636A1 (en) | 2003-07-10 | 2006-05-03 | Neurogen Corporation | Substituted heterocyclic diarylamine analogues |
| GB0402653D0 (en) | 2004-02-06 | 2004-03-10 | Cyclacel Ltd | Compounds |
| US7521457B2 (en) | 2004-08-20 | 2009-04-21 | Boehringer Ingelheim International Gmbh | Pyrimidines as PLK inhibitors |
| FR2896503B1 (fr) | 2006-01-23 | 2012-07-13 | Aventis Pharma Sa | Nouveaux derives soufres d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases |
| CA2685588A1 (en) | 2007-06-08 | 2008-12-11 | Bayer Cropscience Sa | Fungicide heterocyclyl-pyrimidinyl-amino derivatives |
| WO2009046416A1 (en) | 2007-10-05 | 2009-04-09 | Targegen Inc. | Anilinopyrimidines as jak kinase inhibitors |
| EA021367B1 (ru) * | 2008-11-28 | 2015-06-30 | Кова Компани, Лтд. | Производное пиридин-3-карбоксамида |
| JP2012529535A (ja) * | 2009-06-12 | 2012-11-22 | ブリストル−マイヤーズ スクイブ カンパニー | キナーゼモジュレーターとして有用なニコチンアミド化合物 |
| BR112012010220A2 (pt) | 2009-10-30 | 2021-02-23 | Janssen Pharmaceutical N.V. | piridinas fenóxi-substituídas como modulares do receptor opioide |
| KR20120130104A (ko) | 2010-02-01 | 2012-11-28 | 닛뽕 케미파 가부시키가이샤 | Ｇｐｒ119 작동약 |
| AU2012249240A1 (en) | 2011-04-29 | 2013-11-07 | Icahn School Of Medicine At Mount Sinai | Kinase inhibitors |
| US9074384B2 (en) * | 2011-07-27 | 2015-07-07 | Intex Recreation Corp. | Combined swimming pool ladder structure |
| US8987311B2 (en) | 2012-01-13 | 2015-03-24 | Bristol-Myers Squibb Company | Triazolyl-substituted pyridyl compounds useful as kinase inhibitors |
| CN104159896B (zh) * | 2012-01-13 | 2017-05-24 | 百时美施贵宝公司 | 用作激酶抑制剂的杂环取代的吡啶基化合物 |
| ES2575604T3 (es) | 2012-01-13 | 2016-06-29 | Bristol-Myers Squibb Company | Compuestos de piridilo sustituidos con tiazolilo o tiadiazolilo útiles como inhibidores cinasa |
| SG11201503397YA (en) * | 2012-11-08 | 2015-05-28 | Bristol Myers Squibb Co | Heteroaryl substituted pyridyl compounds useful as kinase modulators |
| US9546153B2 (en) | 2012-11-08 | 2017-01-17 | Bristol-Myers Squibb Company | Bicyclic heterocycle substituted pyridyl compounds useful as kinase modulators |
| AU2013341185B2 (en) | 2012-11-08 | 2017-07-13 | Bristol-Myers Squibb Company | Alkyl-amide-substituted pyridyl compounds useful as modulators of IL-12, IL-23 and/or IFNalpha responses |
-
2014
- 2014-12-29 TW TW103146137A patent/TW201609693A/zh unknown
- 2014-12-29 AR ARP140104949A patent/AR098991A1/es unknown
- 2014-12-29 UY UY0001035935A patent/UY35935A/es unknown
-
2015
- 2015-01-02 EP EP15700518.2A patent/EP3089973B1/en active Active
- 2015-01-02 MA MA39162A patent/MA39162A1/fr unknown
- 2015-01-02 ES ES15700518T patent/ES2804707T3/es active Active
- 2015-01-02 MX MX2016008723A patent/MX2016008723A/es unknown
- 2015-01-02 EA EA201691343A patent/EA201691343A1/ru unknown
- 2015-01-02 US US14/588,470 patent/US9169252B2/en active Active
- 2015-01-02 JP JP2016544410A patent/JP6475252B2/ja not_active Expired - Fee Related
- 2015-01-02 WO PCT/US2015/010006 patent/WO2015103453A1/en not_active Ceased
- 2015-01-02 SG SG11201605340QA patent/SG11201605340QA/en unknown
- 2015-01-02 TN TN2016000271A patent/TN2016000271A1/en unknown
- 2015-01-02 CA CA2935329A patent/CA2935329A1/en not_active Abandoned
- 2015-01-02 CN CN201580011617.6A patent/CN106061967B/zh active Active
- 2015-01-02 PE PE2016000991A patent/PE20161292A1/es not_active Application Discontinuation
- 2015-01-02 KR KR1020167020884A patent/KR20160101191A/ko not_active Withdrawn
- 2015-01-02 AU AU2015204045A patent/AU2015204045A1/en not_active Abandoned
-
2016
- 2016-06-16 PH PH12016501164A patent/PH12016501164A1/en unknown
- 2016-06-27 IL IL246474A patent/IL246474A0/en unknown
- 2016-07-01 CL CL2016001706A patent/CL2016001706A1/es unknown
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