JP2017500057A5 - - Google Patents
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- JP2017500057A5 JP2017500057A5 JP2016553248A JP2016553248A JP2017500057A5 JP 2017500057 A5 JP2017500057 A5 JP 2017500057A5 JP 2016553248 A JP2016553248 A JP 2016553248A JP 2016553248 A JP2016553248 A JP 2016553248A JP 2017500057 A5 JP2017500057 A5 JP 2017500057A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims description 164
- 239000000427 antigen Substances 0.000 claims description 79
- 102000036639 antigens Human genes 0.000 claims description 79
- 108091007433 antigens Proteins 0.000 claims description 79
- 238000000034 method Methods 0.000 claims description 47
- 210000004027 cell Anatomy 0.000 claims description 40
- 206010028980 Neoplasm Diseases 0.000 claims description 38
- 230000005867 T cell response Effects 0.000 claims description 31
- 239000012642 immune effector Substances 0.000 claims description 21
- 229940121354 immunomodulator Drugs 0.000 claims description 21
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims description 16
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 16
- 239000012634 fragment Substances 0.000 claims description 14
- 230000004936 stimulating effect Effects 0.000 claims description 14
- 201000010099 disease Diseases 0.000 claims description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 13
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 12
- 210000003162 effector t lymphocyte Anatomy 0.000 claims description 12
- 210000003071 memory t lymphocyte Anatomy 0.000 claims description 12
- 210000004986 primary T-cell Anatomy 0.000 claims description 12
- 231100000433 cytotoxic Toxicity 0.000 claims description 9
- 230000001472 cytotoxic effect Effects 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 6
- 150000007523 nucleic acids Chemical class 0.000 claims description 6
- 102000039446 nucleic acids Human genes 0.000 claims description 6
- 108020004707 nucleic acids Proteins 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims description 4
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims description 4
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims description 4
- 101710160107 Outer membrane protein A Proteins 0.000 claims description 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 3
- 206010000830 Acute leukaemia Diseases 0.000 claims description 3
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims description 3
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims description 3
- 206010006187 Breast cancer Diseases 0.000 claims description 3
- 208000026310 Breast neoplasm Diseases 0.000 claims description 3
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims description 3
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims description 3
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims description 3
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims description 3
- 102000003735 Mesothelin Human genes 0.000 claims description 3
- 108090000015 Mesothelin Proteins 0.000 claims description 3
- 206010027406 Mesothelioma Diseases 0.000 claims description 3
- 208000034578 Multiple myelomas Diseases 0.000 claims description 3
- 101100346932 Mus musculus Muc1 gene Proteins 0.000 claims description 3
- 101100155997 Mus musculus Vmn1r51 gene Proteins 0.000 claims description 3
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims description 3
- 206010033128 Ovarian cancer Diseases 0.000 claims description 3
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 3
- 206010060862 Prostate cancer Diseases 0.000 claims description 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 3
- 101150109474 TMEM37 gene Proteins 0.000 claims description 3
- 201000011510 cancer Diseases 0.000 claims description 3
- 208000024207 chronic leukemia Diseases 0.000 claims description 3
- 208000005017 glioblastoma Diseases 0.000 claims description 3
- 201000000050 myeloid neoplasm Diseases 0.000 claims description 3
- 229920001481 poly(stearyl methacrylate) Polymers 0.000 claims description 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims description 2
- 210000000612 antigen-presenting cell Anatomy 0.000 claims description 2
- 210000001185 bone marrow Anatomy 0.000 claims description 2
- 210000004556 brain Anatomy 0.000 claims description 2
- 230000000139 costimulatory effect Effects 0.000 claims description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 2
- 210000004185 liver Anatomy 0.000 claims description 2
- 210000004072 lung Anatomy 0.000 claims description 2
- 210000002540 macrophage Anatomy 0.000 claims description 2
- 210000000952 spleen Anatomy 0.000 claims description 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 208000025113 myeloid leukemia Diseases 0.000 claims 1
- 108010047041 Complementarity Determining Regions Proteins 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- -1 Tert Proteins 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 208000032839 leukemia Diseases 0.000 description 2
- 230000004913 activation Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361901310P | 2013-11-07 | 2013-11-07 | |
| US61/901,310 | 2013-11-07 | ||
| US201462037875P | 2014-08-15 | 2014-08-15 | |
| US62/037,875 | 2014-08-15 | ||
| PCT/US2014/064621 WO2015070061A1 (en) | 2013-11-07 | 2014-11-07 | Anti-wt1/hla bi-specific antibody |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017500057A JP2017500057A (ja) | 2017-01-05 |
| JP2017500057A5 true JP2017500057A5 (cg-RX-API-DMAC7.html) | 2018-05-10 |
| JP6553069B2 JP6553069B2 (ja) | 2019-07-31 |
Family
ID=51987482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016553248A Expired - Fee Related JP6553069B2 (ja) | 2013-11-07 | 2014-11-07 | 抗wt1/hla二重特異性抗体 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP3066130B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6553069B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN106414500B (cg-RX-API-DMAC7.html) |
| ES (1) | ES2742224T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015070061A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL2014935B1 (en) | 2015-06-08 | 2017-02-03 | Applied Immune Tech Ltd | T cell receptor like antibodies having fine specificity. |
| JP6862435B2 (ja) * | 2015-10-09 | 2021-04-21 | イマティクス バイオテクノロジーズ ゲーエムベーハー | 抗wt1/hla特異的抗体 |
| CN107614519B (zh) | 2015-10-23 | 2022-08-05 | 优瑞科生物技术公司 | 抗体/t细胞受体嵌合构建体及其用途 |
| JP7022067B2 (ja) | 2016-01-14 | 2022-02-17 | メモリアル スローン ケタリング キャンサー センター | Foxp3由来のペプチドに特異的なt細胞受容体様抗体 |
| CA3221995C (en) | 2017-02-08 | 2024-05-28 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
| SG11201907646YA (en) | 2017-02-20 | 2019-09-27 | Dragonfly Therapeutics Inc | Proteins binding her2, nkg2d and cd16 |
| JP7538601B2 (ja) | 2017-04-26 | 2024-08-22 | ユーリカ セラピューティックス, インコーポレイテッド | キメラ活性化受容体及びキメラ刺激受容体を発現する細胞並びにその使用 |
| JP7072792B2 (ja) * | 2017-12-11 | 2022-05-23 | 国立大学法人神戸大学 | 二重特異性抗体 |
| TWI805665B (zh) | 2017-12-21 | 2023-06-21 | 瑞士商赫孚孟拉羅股份公司 | 結合hla-a2/wt1之抗體 |
| PT3749346T (pt) | 2018-02-08 | 2024-09-05 | Dragonfly Therapeutics Inc | Combinações de domínios variáveis de anticorpos dirigidas ao receptor nkg2d |
| KR20200118824A (ko) | 2018-02-08 | 2020-10-16 | 드래곤플라이 쎄라퓨틱스, 인크. | 자연 살해 세포를 활성화시키는 다중-특이성 결합 단백질을 수반하는 암의 병용 요법 |
| CN112041432A (zh) | 2018-02-15 | 2020-12-04 | 纪念斯隆-凯特林癌症中心 | Foxp3靶向剂组合物以及用于过继细胞疗法的使用方法 |
| CA3091424A1 (en) | 2018-02-20 | 2019-08-29 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind cd33, nkg2d, and cd16, and methods of use |
| US20230002730A1 (en) * | 2018-05-18 | 2023-01-05 | Children's National Medical Center | Improved targeted t-cell therapy |
| CA3108646A1 (en) | 2018-08-08 | 2020-02-13 | Dragonfly Therapeutics, Inc. | Proteins binding nkg2d, cd16 and a tumor-associated antigen |
| AU2019318083A1 (en) | 2018-08-08 | 2021-02-25 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind BCMA, NKG2D and CD16, and methods of use |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| US20240383999A1 (en) * | 2020-04-02 | 2024-11-21 | The Board Of Regents Of The University Of Texas System | Cd5l-binding antibodies and uses for the same |
| MX2022013944A (es) | 2020-05-06 | 2022-11-30 | Dragonfly Therapeutics Inc | Proteinas que se unen al receptor activador de celulas asesinas naturales grupo 2 miembro d (nkg2d), cumulo de diferenciacion (cd16) y miembro a de la familia de dominios de lectina tipo c 12 (clec12a). |
| KR20230074146A (ko) * | 2020-09-24 | 2023-05-26 | 에프. 호프만-라 로슈 아게 | T 세포 이중특이성 항체 관련 역효과의 예방 또는 완화 |
| JP2024500847A (ja) | 2020-12-18 | 2024-01-10 | センチュリー セラピューティクス,インコーポレイテッド | 適合可能な受容体特異性を有するキメラ抗原受容体システム |
| JP2024508894A (ja) | 2021-03-03 | 2024-02-28 | ドラゴンフライ セラピューティクス, インコーポレイテッド | Nkg2d、cd16、及び腫瘍関連抗原に結合する多特異性結合タンパク質を使用して癌を治療する方法 |
| AU2023240297A1 (en) * | 2022-03-22 | 2024-10-03 | Morphosys Ag | Deimmunized antibodies specific for cd3 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5885573A (en) * | 1993-06-01 | 1999-03-23 | Arch Development Corporation | Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies |
| KR20120125634A (ko) * | 2003-10-16 | 2012-11-16 | 마이크로메트 에이지 | 다중특이적 탈면역화된 cd3-바인더 |
| AU2006327175A1 (en) * | 2005-12-21 | 2007-06-28 | Medimmune, Llc | Epha2 bite molecules and uses thereof |
| EP3323833B1 (en) * | 2011-04-01 | 2019-12-04 | Memorial Sloan-Kettering Cancer Center | T cell receptor-like bispecific antibodies specific for a wt1 peptide presented by hla-a2 |
-
2014
- 2014-11-07 CN CN201480061156.9A patent/CN106414500B/zh not_active Expired - Fee Related
- 2014-11-07 ES ES14803300T patent/ES2742224T3/es active Active
- 2014-11-07 WO PCT/US2014/064621 patent/WO2015070061A1/en not_active Ceased
- 2014-11-07 JP JP2016553248A patent/JP6553069B2/ja not_active Expired - Fee Related
- 2014-11-07 EP EP14803300.4A patent/EP3066130B1/en active Active