JP2017210428A - ゼラチンカプセルおよび該ゼラチンカプセルの製造方法 - Google Patents
ゼラチンカプセルおよび該ゼラチンカプセルの製造方法 Download PDFInfo
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- JP2017210428A JP2017210428A JP2016103846A JP2016103846A JP2017210428A JP 2017210428 A JP2017210428 A JP 2017210428A JP 2016103846 A JP2016103846 A JP 2016103846A JP 2016103846 A JP2016103846 A JP 2016103846A JP 2017210428 A JP2017210428 A JP 2017210428A
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- Prior art keywords
- capsule
- gelatin
- transglutaminase
- gelatin capsule
- solution
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Abstract
Description
前記カプセル被膜が、トランスグルタミナーゼと、ヒドロキシプロピルメチルセルロースおよびヒドロキシプロピルセルロースからなる群より選ばれる1種以上とを有することを特徴とするものである。
前記カプセル被膜に、トランスグルタミナーゼ溶液と、ヒドロキシプロピルメチルセルロース溶液およびヒドロキシプロピルセルロース溶液からなる群より選ばれる1種以上とを、塗布、噴霧、浸漬およびそれらの組合せからなる群より選ばれる1種以上の方法により、前記カプセル被膜に、前記トランスグルタミナーゼと、ヒドロキシプロピルメチルセルロースおよびヒドロキシプロピルセルロースからなる群より選ばれる1種以上とを有することを特徴とするものである。
本発明のゼラチンカプセルは、ゼラチンを含有するカプセル被膜が、内容物を内包するゼラチンカプセルであって、前記カプセル被膜が、トランスグルタミナーゼと、ヒドロキシプロピルメチルセルロースおよびヒドロキシプロピルセルロースからなる群より選ばれる1種以上とを有することを特徴とするものである。これにより、カプセル同士の付着や凝集、変形を防止できるゼラチンカプセルを提供することができる。ここで、「カプセル同士の付着や凝集、変形を防止できる」とは、完全に相互付着がなく塊化していない状態だけでなく、わずかに相互付着がある状態や一部塊化しても簡単に解れる状態を含み、カプセルの変形、崩壊および溶解を防止できることをも含むものである。
ロータリーダイ式成形装置(株式会社カマタ製製:WH−1)を使用して、下記表1の処方に従って、魚由来のゼラチンでソフトカプセルを作製した。次いで、カプセル被膜に対し、下記表2および表3記載の割合(W/W%)のトランスグルタミナーゼ(味の素株式会社製:アクティバTG−S(商品名))溶液と、ヒドロキシプロピルセルロース(日本曹達株式会社製のセルニー SSL(商品名))溶液と、ヒドロキシプロピルメチルセルロース(信越化学工業株式会社製のメトローズ SE−06(商品名))溶液と、を噴霧法によりコーティングして、OVAL−5、内容量300mg、皮膜170mgで総重量470mgの実施例1〜4のソフトカプセルを作製した。内容量の詳細は、株式会社マルハニチロ食品製のDHA−46MK(商品名)を280.6mg、RIMFROST社製のRIMFROST SUBLIME(商品名)を9.7mg、株式会社スピルリナ研究所製の精製ハープシールオイル(商品名)を9.7mgである。得られた実施例1〜4のソフトカプセルについて、下記の経時付着防止性試験、硬度試験および崩壊試験を行い、結果を下記表2および表3中に併記した。
作製したゼラチンのソフトカプセルを、40℃、湿度75%の環境下で保存し、経時的な状態変化を測定し、下記表4に従って、評価した。なお、表中の経時を表す「w」は「週」を示し、図1は本発明のゼラチンカプセルである実施例10の4週間後の状態を示す図で、表4中の評価「+」の状態を示す図あり、図2は表3中の評価「−3」の状態を示す図である。
株式会社サン科学製のRHEO METERCR−500DX−S型の圧力・弾性用感圧軸(寸法:15mm)を定深測定モードで使用して、R/H HOLD:2.0mm、P/T PRESS:5mm/mの条件で、作製したソフトカプセルの硬度を測定した。
日本薬局方 一般試験法 崩壊試験法に基づき、崩壊試験器(富山産業株式会社製のDISINTEGRATION TESTER NT−1(M))(電動機)、TMB−8(恒温槽)(補助盤あり)を用いて、作製したソフトカプセルの崩壊試験を行い、得られた結果の平均値を数値として使用した。
ロータリーダイ式成形装置(株式会社カマタ製製:WH−1)を使用して、上記表1の処方に従って、魚由来のゼラチンでソフトカプセルを作製した。次いで、カプセル被膜に対し、下記表5および表6記載の割合(W/W%)のトランスグルタミナーゼ(味の素株式会社製:アクティバTG−S(商品名))溶液と、ヒドロキシプロピルメチルセルロース(信越化学工業株式会社製のメトローズ SE−06(商品名))溶液と、ヒドロキシプロピルセルロース(日本曹達株式会社製のセルニー SSL(商品名))溶液と、を噴霧法によりコーティングして、OVAL−6、内容量340mg、皮膜190mgで総重量530mgの実施例5および実施例6のソフトカプセルを作製した。内容量の詳細は、株式会社マルハニチロ食品製のDHA−46MK(商品名)を318.0mg、RIMFROST社製のRIMFROST SUBLIME(商品名)を11.0mg、株式会社スピルリナ研究所製の精製ハープシールオイル(商品名)を11.0mgである。得られた実施例5および実施例6のソフトカプセルについて、上記の経時付着防止性試験および硬度試験を行い、結果を下記表5および表6中に併記した。
ロータリーダイ式成形装置(株式会社カマタ製製:WH−1)を使用して、上記表1の処方に従って、魚由来のゼラチンでソフトカプセルを作製した。次いで、カプセル被膜に対し、下記表7記載の割合(W/W%)のトランスグルタミナーゼ(味の素株式会社製:アクティバTG−S(商品名))溶液と、ヒドロキシプロピルメチルセルロース(信越化学工業株式会社製のメトローズ SE−06(商品名))溶液と、ヒドロキシプロピルセルロース(日本曹達株式会社製のセルニー SL(商品名))溶液と、を噴霧法によりコーティングして、OVAL−5、内容量300mg、皮膜170mgで総重量470mgの実施例7および実施例8のソフトカプセルを作製した。内容量の詳細は、株式会社マルハニチロ食品製のDHA−46MK(商品名)を280.6mg、RIMFROST社製のRIMFROST SUBLIME(商品名)を9.7mg、株式会社スピルリナ研究所製の精製ハープシールオイル(商品名)を9.7mgである。得られた実施例7および実施例8のソフトカプセルについて、上記の経時付着防止性試験、硬度試験および崩壊試験を行い、結果を下記表7中に併記した。
ロータリーダイ式成形装置(株式会社カマタ製製:WH−1)を使用して、上記表1の処方に従って、魚由来のゼラチンでソフトカプセルを作製した。次いで、カプセル被膜に対し、下記表8記載の割合(W/W%)のトランスグルタミナーゼ(味の素株式会社製:アクティバTG−K(商品名))溶液と、ヒドロキシプロピルメチルセルロース(信越化学工業株式会社製のメトローズ SE−06(商品名))溶液と、ヒドロキシプロピルセルロース(日本曹達株式会社製のセルニー SL(商品名))溶液と、を噴霧法によりコーティングして、OVAL−5、内容量300mg、皮膜170mgで総重量470mgの実施例9のソフトカプセルを作製した。内容量の詳細は、株式会社マルハニチロ食品製のDHA−46MK(商品名)を280.6mg、RIMFROST社製のRIMFROST SUBLIME(商品名)を9.7mg、株式会社スピルリナ研究所製の精製ハープシールオイル(商品名)を9.7mgである。得られた実施例9のソフトカプセルについて、上記の経時付着防止性試験、硬度試験および崩壊試験を行い、結果を下記表8中に併記した。
ロータリーダイ式成形装置(株式会社カマタ製製:WH−1)を使用して、上記表1の処方に従って、魚由来のゼラチンでソフトカプセルを作製した。次いで、カプセル被膜に対し、下記表9記載の割合(W/W%)のトランスグルタミナーゼ(味の素株式会社製:アクティバTG−S(商品名))溶液と、ヒドロキシプロピルメチルセルロース(信越化学工業株式会社製のメトローズ SE−06(商品名))溶液と、ヒドロキシプロピルセルロース(日本曹達株式会社製のセルニー SL(商品名))溶液と、を噴霧法によりコーティングして、OVAL−5、内容量300mg、皮膜170mgで総重量470mgの実施例10のソフトカプセルを作製した。内容量の詳細は、株式会社マルハニチロ食品製のDHA−46MK(商品名)を280.6mg、RIMFROST社製のRIMFROST SUBLIME(商品名)を9.7mg、株式会社スピルリナ研究所製の精製ハープシールオイル(商品名)を9.7mgである。得られた実施例10のソフトカプセルについて、上記の経時付着防止性試験、硬度試験および崩壊試験を行い、結果を下記表9中に併記した。
ロータリーダイ式成形装置(株式会社カマタ製製:WH−1)を使用して、上記表1の処方に従って、魚由来のゼラチンでソフトカプセルを作製した。次いで、カプセル被膜に対し、下記表10記載の割合(W/W%)のトランスグルタミナーゼ(味の素株式会社製:アクティバTG−K(商品名))溶液と、ヒドロキシプロピルメチルセルロース(信越化学工業株式会社製のメトローズ SE−06(商品名))溶液と、ヒドロキシプロピルセルロース(日本曹達株式会社製のセルニー SL(商品名))溶液と、を噴霧法によりコーティングして、OVAL−5、内容量300mg、皮膜170mgで総重量470mgの実施例11のソフトカプセルを作製した。内容量の詳細は、株式会社マルハニチロ食品製のDHA−46MK(商品名)を280.6mg、RIMFROST社製のRIMFROST SUBLIME(商品名)を9.7mg、株式会社スピルリナ研究所製の精製ハープシールオイル(商品名)を9.7mgである。得られた実施例11のソフトカプセルについて、上記の経時付着防止性試験、硬度試験および崩壊試験を行い、結果を下記表10中に併記した。
Claims (10)
- ゼラチンを含有するカプセル被膜が、内容物を内包するゼラチンカプセルであって、
前記カプセル被膜が、トランスグルタミナーゼと、ヒドロキシプロピルメチルセルロースおよびヒドロキシプロピルセルロースからなる群より選ばれる1種以上とを有することを特徴とするゼラチンカプセル。 - 前記カプセル被膜中の前記ヒドロキシプロピルメチルセルロースと前記ヒドロキシプロピルセルロースからなる群より選ばれる1種以上の成分の固形分の総量が、前記カプセル被膜の量の0.3〜7.0質量%である請求項1記載のゼラチンカプセル。
- 前記カプセル被膜中の前記トランスグルタミナーゼの配合量が、前記カプセル被膜の量の0.01〜2.0質量%である請求項1または2記載のゼラチンカプセル。
- 前記カプセル被膜が、前記トランスグルタミナーゼと、前記ヒドロキシプロピルメチルセルロースと、前記ヒドロキシプロピルセルロースとを有する請求項1〜3のうちいずれか一項に記載のゼラチンカプセル。
- 前記ゼラチンカプセルが、ソフトカプセルである請求項1〜4のうちいずれか一項に記載のゼラチンカプセル。
- 前記ゼラチンカプセルが、食品、化粧品および医薬品からなる群より選ばれる1種である請求項1〜5のうちいずれか一項に記載のゼラチンカプセル。
- ゼラチンを含有するカプセル被膜が内容物を内包するゼラチンカプセルの製造方法であって、
前記カプセル被膜に、トランスグルタミナーゼ溶液と、ヒドロキシプロピルメチルセルロース溶液およびヒドロキシプロピルセルロース溶液からなる群より選ばれる1種以上とを、塗布、噴霧、浸漬およびそれらの組合せからなる群より選ばれる1種以上の方法により、前記カプセル被膜に、前記トランスグルタミナーゼと、ヒドロキシプロピルメチルセルロースおよびヒドロキシプロピルセルロースからなる群より選ばれる1種以上とを有することを特徴とするゼラチンカプセルの製造方法。 - 前記カプセル被膜中の前記ヒドロキシプロピルメチルセルロースと前記ヒドロキシプロピルセルロースからなる群より選ばれる1種以上の成分の固形分の総量が、前記カプセル被膜の量の0.3〜7.0質量%である請求項7記載のゼラチンカプセルの製造方法。
- 前記カプセル被膜中の前記トランスグルタミナーゼの配合量が、前記カプセル被膜の量の0.01〜2.0質量%である請求項7または8記載のゼラチンカプセルの製造方法。
- 前記カプセル被膜に、トランスグルタミナーゼ溶液と、ヒドロキシプロピルメチルセルロース溶液と、ヒドロキシプロピルセルロース溶液とを、塗布、噴霧、浸漬およびそれらの組合せからなる群より選ばれる1種以上の方法により、前記カプセル被膜に、前記トランスグルタミナーゼと、前記ヒドロキシプロピルメチルセルロースと、前記ヒドロキシプロピルセルロースとを有する請求項7〜9のうちいずれか一項に記載のゼラチンカプセルの製造方法。
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