JP2017197539A - ５−アザシチジン類の糖部シリルエーテル誘導体 - Google Patents
５−アザシチジン類の糖部シリルエーテル誘導体 Download PDFInfo
- Publication number
- JP2017197539A JP2017197539A JP2017092160A JP2017092160A JP2017197539A JP 2017197539 A JP2017197539 A JP 2017197539A JP 2017092160 A JP2017092160 A JP 2017092160A JP 2017092160 A JP2017092160 A JP 2017092160A JP 2017197539 A JP2017197539 A JP 2017197539A
- Authority
- JP
- Japan
- Prior art keywords
- group
- azacytidine
- compound
- formula
- silyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- NMUSYJAQQFHJEW-WATOWXBHSA-N NC(N=CN1C([C@@H]2O)OC(CO)[C@H]2O)=NC1=O Chemical compound NC(N=CN1C([C@@H]2O)OC(CO)[C@H]2O)=NC1=O NMUSYJAQQFHJEW-WATOWXBHSA-N 0.000 description 1
- XAUDJQYHKZQPEU-KVQBGUIXSA-N NC(N=CN1[C@@H](C2)O[C@H](CO)[C@H]2O)=NC1=O Chemical compound NC(N=CN1[C@@H](C2)O[C@H](CO)[C@H]2O)=NC1=O XAUDJQYHKZQPEU-KVQBGUIXSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/12—Triazine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016085145 | 2016-04-21 | ||
| JP2016085145 | 2016-04-21 | ||
| PCT/JP2016/065660 WO2017183215A1 (ja) | 2016-04-21 | 2016-05-27 | ５－アザシチジン類の糖部シリルエーテル誘導体 |
| JPPCT/JP2016/065660 | 2016-05-27 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016565699A Division JP6162349B1 (ja) | 2016-04-21 | 2016-07-27 | ５−アザシチジン類の糖部シリルエーテル誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017197539A true JP2017197539A (ja) | 2017-11-02 |
| JP2017197539A5 JP2017197539A5 (enExample) | 2019-06-13 |
Family
ID=60115962
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017092160A Pending JP2017197539A (ja) | 2016-04-21 | 2017-05-08 | ５−アザシチジン類の糖部シリルエーテル誘導体 |
Country Status (5)
| Country | Link |
|---|---|
| EP (2) | EP3543249A1 (enExample) |
| JP (1) | JP2017197539A (enExample) |
| KR (1) | KR102579485B1 (enExample) |
| CN (1) | CN108368148B (enExample) |
| WO (2) | WO2017183215A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019160127A1 (ja) * | 2018-02-19 | 2019-08-22 | 大原薬品工業株式会社 | Ｄｎｍｔ阻害剤の用途 |
| CN112638422B (zh) * | 2018-10-30 | 2023-03-17 | 大原药品工业株式会社 | 医药组合物 |
| JPWO2021060341A1 (enExample) * | 2019-09-26 | 2021-04-01 | ||
| WO2022031759A1 (en) * | 2020-08-04 | 2022-02-10 | Herophilus, Inc. | Decitabine induced mecp2 expression and uses thereof |
| WO2022181514A1 (ja) * | 2021-02-23 | 2022-09-01 | 大原薬品工業株式会社 | 慢性骨髄性白血病幹細胞阻害剤 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009509531A (ja) * | 2005-09-29 | 2009-03-12 | スーパージェン インコーポレイテッド | ５−アザ−シトシンを組み込んだオリゴヌクレオチドアナログ |
| WO2016057828A1 (en) * | 2014-10-08 | 2016-04-14 | Epigenetics Pharma Llc | Silylated pyrimidine prodrugs and methods of their use |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3816619A (en) * | 1965-08-25 | 1974-06-11 | Upjohn Co | Ladakamycin and process for preparing same |
| CH527207A (de) | 1968-05-08 | 1972-08-31 | Ceskoslovenska Akademie Ved | Verfahren zur Herstellung von 1-Glycosyl-5-azacytosinen |
| AU2003302624A1 (en) * | 2002-11-29 | 2004-06-23 | Amedis Pharmaceuticals Ltd. | Silicon compounds |
| GB0227906D0 (en) * | 2002-11-29 | 2003-01-08 | Amedis Pharm Ltd | Compounds and their use |
| KR100897924B1 (ko) | 2002-12-10 | 2009-05-18 | 엘지엔시스(주) | 금융통합단말기 프린터부의 용지가이드 장치 |
| KR100866399B1 (ko) | 2002-12-10 | 2008-11-03 | 엘지엔시스(주) | 매체자동지급기의 모듈부 스톱퍼장치 |
| CN102010455B (zh) * | 2009-09-05 | 2012-07-11 | 山东新时代药业有限公司 | 一种地西他滨的制备方法 |
| JP6289361B2 (ja) * | 2011-03-31 | 2018-03-07 | セルジーン インターナショナル サルル | ５−アザシチジンの合成 |
| WO2013036846A2 (en) * | 2011-09-09 | 2013-03-14 | Koronis Pharmaceuticals, Incorporated | N4 derivatives of deoxycytidine prodrugs |
| KR101922702B1 (ko) | 2016-05-10 | 2018-11-29 | 주식회사 씨엔제이 | 기판용 필름의 재활용 칩 제작방법 및 장치 |
-
2016
- 2016-05-27 WO PCT/JP2016/065660 patent/WO2017183215A1/ja not_active Ceased
- 2016-07-27 KR KR1020187018429A patent/KR102579485B1/ko active Active
- 2016-07-27 WO PCT/JP2016/072010 patent/WO2017183217A1/ja not_active Ceased
- 2016-07-27 EP EP19160835.5A patent/EP3543249A1/en not_active Withdrawn
- 2016-07-27 EP EP16797711.5A patent/EP3252067B1/en active Active
- 2016-07-27 CN CN201680072731.4A patent/CN108368148B/zh active Active
-
2017
- 2017-05-08 JP JP2017092160A patent/JP2017197539A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009509531A (ja) * | 2005-09-29 | 2009-03-12 | スーパージェン インコーポレイテッド | ５−アザ−シトシンを組み込んだオリゴヌクレオチドアナログ |
| WO2016057828A1 (en) * | 2014-10-08 | 2016-04-14 | Epigenetics Pharma Llc | Silylated pyrimidine prodrugs and methods of their use |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108368148A (zh) | 2018-08-03 |
| WO2017183215A1 (ja) | 2017-10-26 |
| CN108368148B (zh) | 2021-11-05 |
| EP3252067A1 (en) | 2017-12-06 |
| EP3252067A4 (en) | 2017-12-06 |
| WO2017183217A1 (ja) | 2017-10-26 |
| EP3543249A1 (en) | 2019-09-25 |
| KR102579485B1 (ko) | 2023-09-20 |
| EP3252067B1 (en) | 2019-05-29 |
| KR20180134835A (ko) | 2018-12-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190509 |
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| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20190509 |
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| A977 | Report on retrieval |
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| A131 | Notification of reasons for refusal |
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| A02 | Decision of refusal |
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