KR102579485B1 - 5-아자사이티딘류의 당 부분(糖部) 실릴에테르 유도체 - Google Patents

5-아자사이티딘류의 당 부분(糖部) 실릴에테르 유도체 Download PDF

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KR102579485B1
KR102579485B1 KR1020187018429A KR20187018429A KR102579485B1 KR 102579485 B1 KR102579485 B1 KR 102579485B1 KR 1020187018429 A KR1020187018429 A KR 1020187018429A KR 20187018429 A KR20187018429 A KR 20187018429A KR 102579485 B1 KR102579485 B1 KR 102579485B1
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azacytidine
compound
formula
substituted
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KR20180134835A (ko
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마고이치 사코
신페이 스기야먀
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오하라 야꾸힝 고교 가부시키가이샤
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
KR1020187018429A 2016-04-21 2016-07-27 5-아자사이티딘류의 당 부분(糖部) 실릴에테르 유도체 Active KR102579485B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2016085145 2016-04-21
JPJP-P-2016-085145 2016-04-21
JPPCT/JP2016/065660 2016-05-27
PCT/JP2016/065660 WO2017183215A1 (ja) 2016-04-21 2016-05-27 ５－アザシチジン類の糖部シリルエーテル誘導体
PCT/JP2016/072010 WO2017183217A1 (ja) 2016-04-21 2016-07-27 ５－アザシチジン類の糖部シリルエーテル誘導体

Publications (2)

Publication Number Publication Date
KR20180134835A KR20180134835A (ko) 2018-12-19
KR102579485B1 true KR102579485B1 (ko) 2023-09-20

Family

ID=60115962

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KR1020187018429A Active KR102579485B1 (ko) 2016-04-21 2016-07-27 5-아자사이티딘류의 당 부분(糖部) 실릴에테르 유도체

Country Status (7)

Country Link
US (1) US9901641B2 (enExample)
EP (2) EP3252067B1 (enExample)
JP (2) JP6162349B1 (enExample)
KR (1) KR102579485B1 (enExample)
CN (1) CN108368148B (enExample)
MY (1) MY182327A (enExample)
WO (2) WO2017183215A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10227374B2 (en) * 2016-04-21 2019-03-12 Ohara Pharmaceutical Co., Ltd. Silyl etherified derivatives of 5-azacytidines in carbohydrate moiety
JP6956937B2 (ja) * 2018-02-19 2021-11-02 大原薬品工業株式会社 Ｄｎｍｔ阻害剤の用途
WO2020090698A1 (ja) * 2018-10-30 2020-05-07 大原薬品工業株式会社 医薬組成物
US12472196B2 (en) * 2019-09-26 2025-11-18 Ohara Pharmaceutical Co., Ltd. Use of DNMT inhibitor
WO2022031759A1 (en) * 2020-08-04 2022-02-10 Herophilus, Inc. Decitabine induced mecp2 expression and uses thereof
JP7519657B2 (ja) * 2021-02-23 2024-07-22 大原薬品工業株式会社 慢性骨髄性白血病幹細胞阻害剤
WO2025142803A1 (ja) * 2023-12-25 2025-07-03 大原薬品工業株式会社 Ｄｎｍｔ阻害剤の経口投与用の医薬組成物
WO2025263591A1 (ja) * 2024-06-21 2025-12-26 大原薬品工業株式会社 経口用ｄｎｍｔ阻害剤の結晶形態

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004050665A1 (en) 2002-11-29 2004-06-17 Amedis Pharmaceuticals Ltd. Silicon compounds

Family Cites Families (12)

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US3816619A (en) 1965-08-25 1974-06-11 Upjohn Co Ladakamycin and process for preparing same
CH527207A (de) 1968-05-08 1972-08-31 Ceskoslovenska Akademie Ved Verfahren zur Herstellung von 1-Glycosyl-5-azacytosinen
DE2012888C3 (de) * 1970-03-14 1981-04-02 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von 5-Azapyrimidinnucleosiden
GB0227906D0 (en) * 2002-11-29 2003-01-08 Amedis Pharm Ltd Compounds and their use
KR100897924B1 (ko) 2002-12-10 2009-05-18 엘지엔시스(주) 금융통합단말기 프린터부의 용지가이드 장치
KR100866399B1 (ko) 2002-12-10 2008-11-03 엘지엔시스(주) 매체자동지급기의 모듈부 스톱퍼장치
US7700567B2 (en) * 2005-09-29 2010-04-20 Supergen, Inc. Oligonucleotide analogues incorporating 5-aza-cytosine therein
CN102010455B (zh) * 2009-09-05 2012-07-11 山东新时代药业有限公司 一种地西他滨的制备方法
WO2012135405A1 (en) * 2011-03-31 2012-10-04 Pharmion Llc Systhesis of 5-azacytidine
WO2013036846A2 (en) * 2011-09-09 2013-03-14 Koronis Pharmaceuticals, Incorporated N4 derivatives of deoxycytidine prodrugs
WO2016057828A1 (en) * 2014-10-08 2016-04-14 Epigenetics Pharma Llc Silylated pyrimidine prodrugs and methods of their use
KR101922702B1 (ko) 2016-05-10 2018-11-29 주식회사 씨엔제이 기판용 필름의 재활용 칩 제작방법 및 장치

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004050665A1 (en) 2002-11-29 2004-06-17 Amedis Pharmaceuticals Ltd. Silicon compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Oncology, 1974, 30, 405-422.

Also Published As

Publication number Publication date
CN108368148B (zh) 2021-11-05
KR20180134835A (ko) 2018-12-19
JPWO2017183217A1 (ja) 2018-04-26
US20170304337A1 (en) 2017-10-26
EP3252067A1 (en) 2017-12-06
JP2017197539A (ja) 2017-11-02
EP3252067A4 (en) 2017-12-06
JP6162349B1 (ja) 2017-07-12
MY182327A (en) 2021-01-19
US9901641B2 (en) 2018-02-27
EP3252067B1 (en) 2019-05-29
WO2017183215A1 (ja) 2017-10-26
CN108368148A (zh) 2018-08-03
EP3543249A1 (en) 2019-09-25
WO2017183217A1 (ja) 2017-10-26

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