JP2017109927A - Amino acid formulated facial skin external preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an amino acid formulated facial skin external preparation that is low in stimulus and has a high effect of improving the appearance of wrinkles on a face including a skin around eyes.SOLUTION: The present invention relates to the amino acid formulated facial skin external preparation containing (A) amino acids, and (B) vanillyl butyl ether, wherein (A) amino acids are valine, leucine, and isoleucine. Preferably, as (A) amino acids, 0.1 to 2.0 mass% of valine, 0.1 to 4.0 mass% of leucine, and 0.1 to 2.0 mass% of isoleucine are contained, and (B) 0.001 to 1.0 mass% of vanillyl butyl ether is contained.SELECTED DRAWING: None

Description

  The present invention relates to an amino acid-containing facial skin external preparation, and more particularly, to an amino acid-containing facial skin external preparation having a low irritation and a high effect of improving wrinkles in the face including the eyes.

  Valine, leucine and isoleucine are one of the essential amino acids called BCAA (Branched Chain Amino Acids) and have been conventionally incorporated into foods and the like for the purpose of sports anemia and recovery from fatigue. In addition, since it is a component constituting the protein of human epidermis, it has also been incorporated into external preparations such as cosmetics and pharmaceuticals.

  For example, for food use, Patent Document 1 discloses a solid solution composed of three amino acids of valine, isoleucine and leucine, and Patent Document 2 discloses L-arginine, L-glutamine, L-valine, L-isoleucine and 5 types of amino acids of L-leucine are contained in a ratio of 10 to 40 parts by weight, 10 to 40 parts by weight, 5 to 20 parts by weight, 8 to 30 parts by weight and 10 to 35 parts by weight, respectively. An oral amino acid composition for improving skin condition is disclosed.

  As the use of the external preparation, Patent Document 3 includes glycine, alanine, valine, leucine, isoleucine, serine, threonine, aspartic acid, glutamic acid, methionine, lysine, oxylysine, arginine, histidine, phenylalanine, tyrosine, proline and oxy. A collagen production promoter comprising an amino acid mixture composed of proline is disclosed, and Patent Document 4 discloses that component (A) an amino acid having a positive Hydropathy Index and (B) one type selected from menthol, menthol derivatives, or camphor A moisturizing agent containing at least two kinds as active ingredients is disclosed.

  On the other hand, vanillyl butyl ether is generally synthesized from components contained in vanilla beans and has been used for slimming cosmetics for the body because of its excellent warm feeling effect.

  For example, Patent Document 5 discloses a cooling sensation agent composition excellent in cooling sensation sustaining effect, which contains at least one carboxylic acid ester of menthol or an analog thereof represented by a specific formula. 6 includes (A) isopropylmethylphenol, (B) allantoin, (C) polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 40 to 100 mol, (D) citric acid and citrate or citric acid. An alkali agent other than acid salt, or a combination of citrate and citric acid or an acid other than citric acid, and the blending amount of component (C) is 0.10 to 1.0% by mass, And the mass ratio of (C) / (B) is 5-30, the pH of the composition is 4.0-6.2, and (E) from spirantol, vanillyl butyl ether, and capsaicin A liquid oral composition containing at least one kind is disclosed, and Patent Document 7 discloses (a) sodium chloride, (b) at least one kind selected from menthol, peppermint oil, and peppermint oil, and (c) amber. Monomentyl acid, (d) a surfactant, (c) the amount of monomenthyl succinate is 0.03 to 1% by mass, and (e-1) vanillyl butyl ether and / or spirantol, (e -2) A dentifrice composition containing at least one selected from an essential oil or extract of a plant selected from black pepper, pepper, and ginger is disclosed. Patent Document 8 contains a blood circulation promoter and an amino acid. , Blood circulation promoters, Ambibis Naga extract, Salamander extract, Gentian extract, Eggplant extract, Chili extract, Ginger extract, Panax ginseng Extracts, ginkgo biloba extract, arnica extract, safflower extract, assembly extract, merirot extract, horse chestnut extract, camphor and its derivatives, hinokitiol and its derivatives and their salts, tocopherol and its derivatives, nicotinic acid and Derivatives thereof and salts thereof, γ-oryzanol and derivatives thereof, vanillyl butyl ether, one or more selected from sodium bicarbonate, and amino acids are leucine, isoleucine, valine, tryptophan, lysine, methionine, phenylalanine, A slimming composition that is one or more selected from threonine, valine, leucine, isoleucine, histidine, arginine is disclosed.

International Publication No. 2010/050168 Pamphlet JP 2005-247738 A JP 2007-51087 A JP2013-227286A JP2015-38204A JP 2010-143889 A JP 2010-37318 A JP 2008-69134 A

  However, the techniques described in Patent Documents 1 to 4 relate to amino acids such as valine, isoleucine, and leucine, and the combined use with vanillyl butyl ether has not been studied at all. In addition, the techniques described in Patent Literatures 1 to 4 cannot provide an amino acid-containing facial skin external preparation with low irritation and high wrinkle improvement effect on the face including the eyes.

  Further, the technique described in Patent Document 5 focuses on the warming effect of vanillyl butyl ether, and cannot improve the wrinkle improving effect on the face including the eyes. Furthermore, the techniques described in Patent Documents 6 and 7 relate to oral compositions and dentifrice compositions, and did not mention the effect of improving wrinkles on the face including the eyes by a combination with amino acids. Furthermore, the technique described in Patent Document 8 is a composition for slimming to the last although there is a description of a combination of an amino acid such as valine, isoleucine, leucine and vanillyl butyl ether. There is no description of specific effects in Examples and the like, and no mention is made of the effect of improving wrinkles on the face including the eyes.

  Accordingly, an object of the present invention is to solve the above-described problems of the prior art and provide an amino acid-containing facial skin external preparation with a low irritation and a high effect of improving wrinkles on the face including the eyes.

  As a result of intensive studies to solve the above problems, the present inventor has found that the object can be achieved by blending a specific amino acid and vanillyl butyl ether, and has completed the present invention.

  That is, the amino acid-containing facial skin external preparation of the present invention is characterized in that (A) the amino acid is valine, leucine and isoleucine, and contains (A) the amino acid and (B) vanillyl butyl ether. Is.

  Moreover, the amino acid-containing facial skin external preparation of the present invention has, as the amino acid (A), 0.1 to 2.0% by mass of valine, 0.1 to 4.0% by mass of leucine and 0.1 to 2 of isoleucine. It is preferable to contain 0% by mass and 0.001 to 1.0% by mass of the (B) vanillyl butyl ether.

  Furthermore, the amino acid-containing facial skin external preparation of the present invention preferably contains (C) an imidazole peptide, and preferably contains (D) elastin.

  Furthermore, it is preferable that the amino acid-containing facial skin external preparation of the present invention is for the eyes.

  ADVANTAGE OF THE INVENTION According to this invention, it can provide the skin external preparation for amino acid combinations with a low irritation | stimulation and a high effect of improving wrinkles in the face including the eyes.

Hereinafter, the amino acid-containing facial skin external preparation of the present invention will be specifically described.
The amino acid-containing facial skin external preparation of the present invention is characterized in that (A) the amino acid is valine, leucine and isoleucine, and contains the (A) amino acid and (B) vanillyl butyl ether. is there. Thereby, it is possible to provide an amino acid-containing facial skin external preparation with low irritation and high effect of improving wrinkles on the face including the eyes. In the present invention, “containing” may be included in the formulation, and the addition method and procedure are not limited.

  In the present invention, the valine, the leucine, and the isoleucine are not limited as long as they can be used for ordinary external preparations. For example, L-valine (trade name) manufactured by Ajinomoto Healthy Supply Co., Ltd., L- Examples include leucine (trade name) and L-isoleucine (trade name).

  Further, in the present invention, the (B) vanillyl butyl ether is not limited as long as it can be used for ordinary external preparations, etc., and examples thereof include “vanillyl butyl ether” manufactured by Takasago International Corporation. Can do.

  Furthermore, in the present invention, the amino acid (A) contains 0.1 to 2.0% by mass of valine, 0.1 to 4.0% by mass of leucine and 0.1 to 2.0% by mass of isoleucine, (B) It is preferable to contain 0.001-1.0 mass% of vanillyl butyl ether, the said valine 0.5-1.0 mass%, the said leucine 0.5-2.0 mass%, and the said isoleucine 0. It is preferable to contain 5-1.0 mass% and to contain the said (B) vanillyl butyl ether 0.01-0.7 mass%. Moreover, it is preferable to contain 0.1-0.5 mass% of said (B) vanillyl butyl ether especially. By setting the content in such a range, it is possible to provide an amino acid-containing facial skin external preparation with a lower irritation and a higher wrinkle improving effect on the face including the eyes. Moreover, although the said (B) vanillyl butyl ether may cause irritation when the compounding quantity increases, generation | occurrence | production of irritation | stimulation can be suppressed by combining with the said amino acid in the said range.

  In addition, in the amino acid-containing facial skin external preparation of the present invention, the content ratio of the valine, the leucine and the isoleucine is preferably 1: 2: 1, and in particular, the valine 0.5% by mass and the leucine More preferably, 1.0% by mass and 0.5% by mass of the isoleucine are contained. By setting leucine to a blending ratio of about 2 times, the effect of preventing fatigue of muscles and the like due to the application of amino acids and the like can be further enhanced, and the effect of improving wrinkles can be enhanced.

  Furthermore, the amino acid-containing facial skin external preparation of the present invention preferably contains (C) an imidazole peptide. The (C) imidazole peptide is a substance that is abundant in muscles of birds such as skipjack, tuna, or migratory birds. Such (C) imidazole peptide is not limited as long as it can be used for usual external preparations and the like, and examples thereof include carnosine, anserine, and valenin, which contain one or more of these. be able to. Specific examples include Ameriox (trade name) manufactured by H. Holstein GmbH & Co. KG, DRAGOSINE (trade name) manufactured by Simrise Co., Ltd., or a single carnosine, anserine, and valenin. By containing the (C) imidazole peptide, the wrinkle improving effect can be further enhanced.

  Moreover, as a compounding quantity of the said (C) imidazole peptide, 0.01-5 mass% is preferable, 0.1-3 mass% is more preferable, 1-2 mass% is still more preferable. Thereby, a wrinkle improvement effect can be heightened more.

  Furthermore, the amino acid-containing facial skin external preparation of the present invention preferably contains (D) elastin. (D) Elastin is an elastic fiber protein, and the (D) elastin is not limited as long as it can be used for ordinary external preparations. For example, animals such as cattle and fish such as tuna and salmon The origin can be used. Hydrolyzed elastin (trade name), hydrolyzed α-elastin (trade name), elastocean (trade name) manufactured by Koken Co., Ltd., or powdered elastin derived from animals or fish can be used. By containing the (D) elastin, the wrinkle improving effect can be further enhanced.

  Moreover, as a compounding quantity of the said (D) elastin, 0.001-5 mass% is preferable, and 0.1-2 mass% is more preferable. Thereby, a wrinkle improvement effect can be heightened more.

  Moreover, it is preferable that the amino acid-containing facial skin external preparation of the present invention contains an acrylic acid amide water-soluble thickener. The acrylic amide-based water-soluble thickener is not limited as long as it can be used for ordinary external preparations. For example, (hydroxyethyl acrylate / acryloyldimethyltaurine Na) copolymer, (Na acrylate / acryloyl) Dimethyl taurine Na) copolymer, (acryloyl dimethyl taurine ammonium / VP) copolymer, (acryloyl dimethyl taurine ammonium methacrylate behenes-25) crosspolymer, etc., among which (hydroxyethyl acrylate / acryloyl dimethyl taurine Na) copolymer , (Na acrylate / acryloyl dimethyl taurine Na) copolymer is particularly preferable, and one or two or more kinds selected from the acrylic amide water-soluble thickeners can be used. Furthermore, as the acrylic acid amide-based water-soluble thickener, specifically, as (Hydroxyethyl acrylate / acryloyldimethyltaurine Na) copolymer, SEPPIC S (trade name), SEPINOV EMT10 (product) Name), SIMULGEL NS (trade name) and the like, and (acrylic acid Na / acryloyldimethyltaurine Na) copolymer can include SIMULGEL EG (trade name) manufactured by SEPPIC, and (acryloyldimethyl). As the taurine ammonium / VP) copolymer, there may be mentioned Aristoflex AVC (trade name) manufactured by Clariant Co., Ltd. (acryloyldimethyl taurine ammonium behenes methacrylate-25) cross-polymer and Examples thereof include Aristoflex HMB (trade name) manufactured by Clariant. By blending the acrylic acid amide-based water-soluble thickener, the dissolution stability of the valine, the leucine and the isoleucine in the amino acid-blended facial skin preparation can be improved. The wrinkle improvement effect by application etc., the fatigue prevention effect, etc. can be heightened further.

  Furthermore, it is preferable that the amino acid-containing facial skin external preparation of the present invention is dissolved by blending one or more selected from the group consisting of PEG-20 sesquistearate and PEG-20 methyl glucose. The sesquistearic acid PEG-20 and dioleic acid PEG-20 methylglucose are not limited as long as they can be used for ordinary external preparations and the like. For example, Glucamate SSE-20 (trade name) manufactured by Nippon Lubrizol Co., Ltd. , Glucamate DOE-120 (trade name) and the like. Thereby, the dissolution stability of the valine, the leucine and the isoleucine in the amino acid-containing facial skin external preparation can be improved, and the wrinkle improving effect, the fatigue preventing effect, etc. by applying the amino acid-containing facial skin external preparation etc. It can be further enhanced.

  In addition, the facial skin preparation for amino acid composition of the present invention is a skin external preparation for the face (face) because it is low in irritation and has a high wrinkle improving effect. It is preferable that it can be used for eye cream, eye lotion and the like. Furthermore, the external preparation for skin can be used on the human body and the like, and can be used for cosmetics, quasi drugs, pharmaceuticals, and the like. Here, cosmetics and the like include basic cosmetics such as pack agents, makeup cosmetics, and the like.

  Further, in the present invention, other components and the like can be appropriately added as long as the effects of the present invention are not impaired. Arbitrary ingredients other than the above can be blended in the qualitative and quantitative ranges, and ingredients that are usually blended in external preparations for skin, such as oily ingredients, moisturizers, antioxidants, preservatives, fragrances, various vitamins Agents, chelating agents, colorants, ultraviolet absorbers, medicinal ingredients, inorganic salts and the like can be blended.

  EXAMPLES Hereinafter, although this invention is demonstrated further in detail using an Example, this invention is not limited to these Examples. In addition, the numerical value in prescription shows the mass%.

(Example 1, Comparative Examples 1 and 2)
According to the formulation shown in Table 1 below, the skin external preparations of Example 1 and Comparative Example 1 were prepared. The obtained skin external preparations of Example 1 and Comparative Examples 1 and 2 were subjected to the following wrinkle improvement test and are also shown in Table 1. In addition, the following skin irritation test was conducted. In addition, the numerical value in prescription shows the mass%. In Table 1, * 1 is SEPIPULUS S (trade name) manufactured by SEPPIC.

(Wrinkle improvement test)
Anti-wrinkle product evaluation guidelines for acquiring new efficacy (Journal of Cosmetic Society of Japan (Vol. 30, No. 4, p. 316-332, 2006)) 20 female subjects were used, and the skin external preparations of Examples and Comparative Examples were used on the skin of one face of the face and eyes for 1 month, and then the wrinkle-improving effect was examined. A specialist inspector visually observed changes in the wrinkle grade, and evaluated the number of people who showed improvement after continuous use based on a comparison between the coated and uncoated areas.

(Evaluation criteria)
◎: Number of people who improved 15 or more ○: Number of people who improved 10 or more to less than 15 △: Number of people who improved 5 or more to less than 10 ×: Improvement was seen Less than 5

(Skin irritation test)
20 females in their twenties and thirties were examined for skin irritation after using the skin external preparations of Examples and Comparative Examples on the skin of one face of the face and eyes for one month every day. In the evaluation method, the presence or absence of stimulation was evaluated by the following five-step evaluation as compared with the non-coated portion, and the following criteria were determined from the average score.

(5-level evaluation)
5 points: Very good (no irritation)
4 points: Slightly good 3 points: Good 2 points: Normal 1 point: Bad (stimulated)

(Evaluation criteria 2)
Greater than average 4 points ◎
Greater than 3 points and less than 4 points ○
Greater than 2 average points and 3 points or less △
Less than 2 average points ×

  From the results shown in Table 1, the skin external preparation of Example 1 showed an improvement effect for 18 adult women and a good wrinkle improvement effect. On the other hand, the skin external preparations of Comparative Examples 1 and 2 showed an improvement effect only in two adult women, and no wrinkle improvement effect was obtained. In addition, the skin external preparation of Example 1 was hypoallergenic with an average score of 4.8 for evaluating skin irritation. On the other hand, the skin external preparation of Comparative Example 1 was low irritant with an average score of 4.9 for skin irritation, but Comparative Example 2 had an average score of 3.5 for skin irritation evaluation. It was more irritating than Example 1.

(Example 2)
The pack agent of Example 2 was produced according to the prescription in Table 2 below. The wrinkle improvement test and the skin irritation test described above were performed on the obtained pack agent of Example 2. In addition, the numerical value in prescription shows the mass%. In Table 2, * 2 is Tornale (trade name) manufactured by Hayashibara Co., Ltd.

  The pack preparation of Example 2 was effective in improving 19 wrinkles and was effective in improving wrinkles. In addition, the pack preparation of Example 2 was hypoallergenic with an average score of 4.9 skin irritation evaluation.

(Example 3)
A skin external preparation of Example 3 was prepared according to the formulation shown in Table 3 below. The above-described wrinkle improvement test was performed on the obtained skin external preparation of Example 3. In Table 3, * 1 is SEPIPULUS S (trade name) manufactured by SEPPIC.

  The skin external preparation of Example 3 was effective in improving 19 wrinkles and was effective in improving wrinkles.

Example 4
The pack agent of Example 4 was produced according to the prescription in Table 4 below. The wrinkle improvement test was performed on the pack agent of Example 4 obtained. In Table 4, * 2 is Tornale (trade name) manufactured by Hayashibara Co., Ltd.

  The pack agent of Example 4 showed an improvement effect in 19 adult women, and the wrinkle improvement effect was good.

(Example 5)
The lotion of Example 5 was produced according to the prescription in Table 5 below. The above-described wrinkle improvement test and skin irritation test were performed on the lotion obtained in Example 5.

  The lotion of Example 5 was effective in improving 17 wrinkles, and was effective in improving wrinkles. In addition, the lotion of Example 5 was hypoallergenic with an average score of 4.95 points for skin irritation evaluation.

(Example 6)
A lotion of Example 6 was prepared according to the formulation shown in Table 6 below. The wrinkle improvement test was performed on the lotion obtained in Example 6.

  The lotion of Example 6 showed an improvement effect for 17 adult women and a good wrinkle improvement effect.

(Example 7)
A cream of Example 7 was prepared according to the formulation shown in Table 7 below. The obtained wrinkle improvement test and skin irritation test were performed on the cream of Example 7.

  The cream of Example 7 showed an improvement effect for 18 adult women, and the wrinkle improvement effect was good. The cream of Example 7 was hypoallergenic with an average score of 4.7 for skin irritation evaluation.

(Example 8)
A cream of Example 8 was prepared according to the formulation in Table 8 below. The obtained cream of Example 8 was subjected to the above wrinkle improvement test and skin irritation test.

  The cream of Example 8 showed an improvement effect for 19 adult women, and the wrinkle improvement effect was good. The cream of Example 8 was hypoallergenic with an average score of 4.9 skin irritation evaluation.

Example 9
A cosmetic liquid of Example 9 was prepared according to the formulation shown in Table 9 below. The wrinkle improvement test and the skin irritation test were performed on the obtained beauty serum of Example 9.

  The essence of Example 9 showed an improvement effect for 17 adult women and a good wrinkle improvement effect. The serum of Example 9 was hypoallergenic with an average score of 4.7 for skin irritation evaluation.

(Example 10)
A cosmetic solution of Example 10 was prepared according to the formulation shown in Table 10 below. The wrinkle improvement test was performed on the obtained cosmetic liquid of Example 10.

The essence of Example 10 was effective in improving 18 wrinkles and was effective in improving wrinkles.

That is, the amino acid formulation facial skin external preparation of the present invention, (A) amino acids valine, leucine and isoleucine, containing the (A) and amino acids, and, (B) a vanillyl butyl ether, der for eyes It is characterized by that.

Hereinafter, the amino acid-containing facial skin external preparation of the present invention will be specifically described.
Amino blended facial skin external preparation of the present invention, (A) amino acids valine, leucine and isoleucine, wherein the (A) amino acids, containing, and (B) vanillyl butyl ether, der Rukoto for eyes It is characterized by. Thereby, it is possible to provide an amino acid-containing facial skin external preparation with low irritation and high effect of improving wrinkles on the face including the eyes. In the present invention, “containing” may be included in the formulation, and the addition method and procedure are not limited.

Claims (5)

(A) the amino acids are valine, leucine and isoleucine,
An amino acid-containing facial skin external preparation comprising the (A) amino acid and (B) vanillyl butyl ether. As the amino acid (A), 0.1 to 2.0% by mass of valine, 0.1 to 4.0% by mass of leucine and 0.1 to 2.0% by mass of isoleucine are contained,
The amino acid-containing facial skin external preparation according to claim 1, comprising 0.001 to 1.0% by mass of (B) vanillyl butyl ether.   (C) The amino acid-containing facial skin external preparation according to claim 1 or 2, which contains an imidazole peptide.   The amino acid-containing facial skin preparation for external use according to any one of claims 1 to 3, which contains (D) elastin. The amino acid-containing facial skin external preparation according to any one of claims 1 to 4, wherein the amino acid-containing facial skin external preparation is for eyes.