JPWO2014185461A1 - Hair restorer composition - Google Patents
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- JPWO2014185461A1 JPWO2014185461A1 JP2015517114A JP2015517114A JPWO2014185461A1 JP WO2014185461 A1 JPWO2014185461 A1 JP WO2014185461A1 JP 2015517114 A JP2015517114 A JP 2015517114A JP 2015517114 A JP2015517114 A JP 2015517114A JP WO2014185461 A1 JPWO2014185461 A1 JP WO2014185461A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4993—Derivatives containing from 2 to 10 oxyalkylene groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
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Abstract
(A)育毛有効成分と、(B)ヒドロキシエチルキトサン及びヒドロキシプロピルキトサンから選ばれる少なくとも1種と、(C)エチレンオキサイドの平均付加モル数が6〜60モルであるポリオキシエチレンソルビット脂肪酸エステルと、(D)エタノールとを含有する育毛剤組成物。(A) a hair-growth active ingredient, (B) at least one selected from hydroxyethyl chitosan and hydroxypropyl chitosan, and (C) a polyoxyethylene sorbite fatty acid ester having an average added mole number of ethylene oxide of 6 to 60 mol (D) A hair restorer composition containing ethanol.
Description
本発明は、頭髪に十分なボリュームを付与することができる育毛剤組成物に関する。 The present invention relates to a hair restorer composition capable of imparting a sufficient volume to hair.
育毛剤は、通常、継続使用することによって育毛効果(脱毛抑制、発毛促進)を得ることができる。そのため、脱毛症の症状である、頭髪のボリュームダウン(薄毛の外観)を短期間に改善するのは難しく、育毛剤の使用期間よりも短い使用期間でふんわり感を付与する機能を持った育毛養毛剤が望まれていた。 The hair-growth agent can usually obtain a hair-growth effect (suppression of hair loss, promotion of hair growth) by continuous use. For this reason, it is difficult to improve hair volume reduction (appearance of thin hair), which is a symptom of alopecia, in a short period of time, and a hair growth nourishing agent with a function that gives a soft feeling in a shorter period of use than the period of use of the hair restoration agent Was desired.
ふんわり感の付与に関しては、これまでにコラーゲン誘導体や、ケラチン誘導体等の毛髪と類似した成分を毛髪に浸透・補充する方法(特許文献1、2:特開昭60−243010号公報、特開平2−53712号公報)や、毛髪表面を天然高分子等によりコートする方法(特許文献3〜7:特開昭59−65008号公報、特開昭62−36308号公報、特開昭64−9911号公報、特開平4−308525号公報、特開平1−249711号公報)等が知られている。 With regard to imparting a soft feeling, a method of penetrating and supplementing hair with components similar to hair such as collagen derivatives and keratin derivatives so far (Patent Documents 1 and 2: JP-A-60-243010, JP-A-2) No. -53712) and methods for coating the hair surface with natural polymers, etc. (Patent Documents 3 to 7: JP 59-65008 A, JP 62-36308 A, and JP 64-9911 A). Japanese Laid-Open Patent Publication No. 4-308525 and Japanese Laid-Open Patent Publication No. 1-249711) are known.
これらの成分を適量配合することで、薄毛の外観は改善する傾向にあるものの、十分に満足できるものではなかった。薄毛の外観をさらに向上させるために、これらの成分の配合量を多くすると、使用感として、地肌のべたつきが生じたり、髪が重くなることでふんわり感が低下するという問題が生じる。そのため、配合量を少なくすると、使用感は優れるものの、十分なふんわり感は付与できなくなる不具合が生じていた。 By blending appropriate amounts of these components, the appearance of thinning hair tends to improve, but it is not fully satisfactory. If the blending amount of these components is increased in order to further improve the appearance of thinning hair, there is a problem that the skin feels sticky as a feeling of use, or the feeling of fluffiness decreases due to the hair becoming heavier. For this reason, when the blending amount is reduced, the usability is excellent, but there is a problem that a sufficient soft feeling cannot be imparted.
本発明は、上記事情に鑑みなされたもので、育毛効果の発現前にふんわり感が得られることで薄毛の外観を改善でき、更にこれに育毛、脱毛抑制効果が加わることで頭髪全体に十分なボリュームを回復することができ、しかも地肌のべたつきがなく、優れた使用感を有する育毛剤組成物を提供することを目的とする。 The present invention has been made in view of the above circumstances, and it is possible to improve the appearance of thin hair by obtaining a fluffy feeling before the onset of the hair growth effect. An object of the present invention is to provide a hair restorer composition that can restore the volume, has no stickiness of the background, and has an excellent feeling of use.
本発明者らは、上記目的を達成するために鋭意検討した結果、(A)育毛有効成分と、(B)ヒドロキシエチルキトサン及びヒドロキシプロピルキトサンから選ばれる少なくとも1種と、(C)エチレンオキサイドの平均付加モル数が6〜60モルであるポリオキシエチレンソルビット脂肪酸エステルと、(D)エタノールとを配合した育毛剤組成物とすることで、(C)成分による毛髪の内部補修により毛髪強度(ハリコシ)を上げ、かつ毛髪外部を(B)成分で適度にコートすることで、育毛、脱毛抑制効果が発現する前にふんわり感が得られるため、細くて薄くなった毛髪の外観を改善でき、更にこれに育毛、脱毛抑制効果が加わり頭髪全体に十分なボリュームを回復することができ、しかも使用感(地肌のべたつきのなさ)にも優れることを見出し、本発明をなすに至った。 As a result of intensive studies to achieve the above object, the present inventors have found that (A) a hair-growth active ingredient, (B) at least one selected from hydroxyethyl chitosan and hydroxypropyl chitosan, and (C) ethylene oxide By preparing a hair-restoring composition containing polyoxyethylene sorbite fatty acid ester having an average addition mole number of 6 to 60 moles and (D) ethanol, hair strength (harkoshi by the internal repair of hair with component (C)) ) And moderately coating the outside of the hair with the component (B) gives a soft feeling before the hair growth and hair loss inhibiting effects are manifested, thus improving the appearance of thin and thin hair. Hair growth and hair loss suppression effects are added to this, so that the entire volume of the hair can be restored, and the feeling of use (non-stickiness of the background) is also excellent. Found that were able to complete the present invention.
従って、本発明は、下記育毛剤組成物を提供する。
[1]
(A)育毛有効成分と、
(B)ヒドロキシエチルキトサン及びヒドロキシプロピルキトサンから選ばれる少なくとも1種と、
(C)エチレンオキサイドの平均付加モル数が6〜60モルであるポリオキシエチレンソルビット脂肪酸エステルと、
(D)エタノールと
を含有することを特徴とする育毛剤組成物。
[2]
(B)成分の配合量が0.11〜0.19質量%である[1]記載の育毛剤組成物。
[3]
(C)成分が、エチレンオキサイドの平均付加モル数が30〜40モルであるテトラオレイン酸ポリオキシエチレンソルビットである[1]又は[2]記載の育毛剤組成物。
[4]
(C)成分の配合量が0.1〜1.0質量%である[1]〜[3]のいずれかに記載の育毛剤組成物。
[5]
(A)成分が、6−ベンジルアミノプリン、ペンタデカン酸グリセリド及びミノキシジルから選ばれる少なくとも1種である[1]〜[4]のいずれかに記載の育毛剤組成物。Accordingly, the present invention provides the following hair restorer composition.
[1]
(A) a hair-growth active ingredient;
(B) at least one selected from hydroxyethyl chitosan and hydroxypropyl chitosan;
(C) a polyoxyethylene sorbite fatty acid ester having an average addition mole number of ethylene oxide of 6 to 60 moles;
(D) A hair restorer composition comprising ethanol.
[2]
(B) The hair-restoring agent composition as described in [1] whose compounding quantity of a component is 0.11-0.19 mass%.
[3]
(C) The hair restorer composition according to [1] or [2], wherein the component is polyoxyethylene sorbite tetraoleate having an average addition mole number of ethylene oxide of 30 to 40 moles.
[4]
(C) The hair restorer composition in any one of [1]-[3] whose compounding quantity of component is 0.1-1.0 mass%.
[5]
(A) The hair restorer composition according to any one of [1] to [4], wherein the component is at least one selected from 6-benzylaminopurine, pentadecanoic acid glyceride and minoxidil.
本発明の育毛剤組成物は、育毛効果の発現前にふんわり感が得られることで薄毛の外観を改善でき、更にこれに育毛、脱毛抑制効果が加わり頭髪全体に十分なボリュームを回復することができ、しかも地肌のべたつきがなく、優れた使用感を有する。 The hair restorer composition of the present invention can improve the appearance of thin hair by obtaining a soft feeling before the onset of the hair-growth effect, and can further increase the volume of the entire hair by adding hair-growth and hair loss inhibiting effects. It can be done without any stickiness of the surface and has an excellent feeling of use.
本発明の育毛剤組成物は、
(A)育毛有効成分と、
(B)ヒドロキシエチルキトサン及びヒドロキシプロピルキトサンから選ばれる少なくとも1種と、
(C)エチレンオキサイドの平均付加モル数が6〜60モルであるポリオキシエチレンソルビット脂肪酸エステルと、
(D)エタノールと
を含有する。The hair restorer composition of the present invention comprises:
(A) a hair-growth active ingredient;
(B) at least one selected from hydroxyethyl chitosan and hydroxypropyl chitosan;
(C) a polyoxyethylene sorbite fatty acid ester having an average addition mole number of ethylene oxide of 6 to 60 moles;
(D) contains ethanol.
[(A)育毛有効成分]
本発明で用いられる(A)成分は、育毛効果、脱毛抑制効果を有する公知の育毛有効成分であって、例えば、6−ベンジルアミノプリン、ペンタデカン酸グリセリド、ミノキシジル、塩化カプロニウム、t−フラバノン、アデノシン、センブリ抽出液、ビタミンE誘導体、D−パントテニルアルコ−ル、ニコチン酸アミド、ヒノキチオ−ル、β−グリチルレチン酸、フォルスコリン(コレウスエキスに含有)等が挙げられ、1種単独で又は2種以上を適宜組み合わせて用いることができる。これらのなかでも特に、育毛効果の点から、6−ベンジルアミノプリン、ペンタデカン酸グリセリド、ミノキシジルが好ましく、より好ましくは、6−ベンジルアミノプリン、ペンタデカン酸グリセリドである。[(A) Hair-growth active ingredient]
The component (A) used in the present invention is a known hair-growth active ingredient having a hair-growth effect and a hair loss inhibitory effect, such as 6-benzylaminopurine, pentadecanoic acid glyceride, minoxidil, capronium chloride, t-flavanone, adenosine , Assembly extract, vitamin E derivative, D-pantothenyl alcohol, nicotinamide, hinokitiol, β-glycyrrhetinic acid, forskolin (contained in Coleus extract), etc. The above can be used in appropriate combination. Among these, 6-benzylaminopurine, pentadecanoic acid glyceride, and minoxidil are preferable from the viewpoint of hair growth effect, and 6-benzylaminopurine and pentadecanoic acid glyceride are more preferable.
(A)成分の配合量は、抜け毛改善、地肌のべたつきのなさ、ふんわり感、育毛効果の点から、組成物全量に対して0.1〜5質量%(センブリ抽出液やコレウスエキス等の植物エキスについては、エキス純分の配合量)が好ましく、より好ましくは0.5〜3質量%である。上記範囲とすることで抜け毛改善、育毛効果がより高まり、地肌のべたつきのなさ、ふんわり感をより向上させることができる。 Component (A) is blended in an amount of 0.1 to 5% by weight (plants such as assembly extract and coleus extract) based on the total amount of the composition in terms of hair loss improvement, non-stickiness of the skin, soft feeling, and hair growth effect. About extract, the compounding quantity of a pure extract) is preferable, More preferably, it is 0.5-3 mass%. By setting it as the said range, hair loss improvement and the hair-growth effect increase more, and the non-stickiness of a ground surface and a soft feeling can be improved more.
[(B)キトサン]
(B)成分は、ヒドロキシエチルキトサン及びヒドロキシプロピルキトサンから選ばれる少なくとも1種であり、(C)成分と共に用いることでふんわり感を顕著に向上させることができる。また、溶解性に優れ、良好な外観安定性を得ることができる。[(B) Chitosan]
(B) component is at least 1 sort (s) chosen from hydroxyethyl chitosan and hydroxypropyl chitosan, and a soft feeling can be improved notably by using with (C) component. Moreover, it is excellent in solubility and good appearance stability can be obtained.
(B)成分の配合量は、ふんわり感、地肌のべたつきのなさの点から、組成物全量に対して0.11〜0.19質量%が好ましく、より好ましくは0.13〜0.17質量%である。0.11質量%未満では、ふんわり感が劣る場合があり、0.19質量%を超えると地肌のべたつきのなさ、ふんわり感が劣る場合がある。 The blending amount of the component (B) is preferably from 0.11 to 0.19% by mass, more preferably from 0.13 to 0.17% by mass, based on the total amount of the composition, from the point of softness and non-stickiness of the background. %. If it is less than 0.11% by mass, the soft feeling may be inferior, and if it exceeds 0.19% by mass, the non-stickiness of the background and the soft feeling may be inferior.
[(C)ポリオキシエチレンソルビット脂肪酸エステル]
(C)成分は、エチレンオキサイドの平均付加モル数が6〜60モル、特に30〜40であるポリオキシエチレンソルビット脂肪酸エステルであり、(B)成分と共に用いることでふんわり感を飛躍的に高めることができる。(C)成分としては、モノラウリン酸ポリオキシエチレンソルビット、ヘキサステアリン酸ポリオキシエチレンソルビット、テトラオレイン酸ポリオキシエチレンソルビット等が挙げられ、1種単独で又は2種以上を適宜組み合わせて用いることができる。これらのなかでも特に、ふんわり感付与の点からエチレンオキサイドの平均付加モル数が6〜60モルであるテトラオレイン酸ポリオキシエチレンソルビットが好ましく、より好ましくはエチレンオキサイドの平均付加モル数が30〜40のテトラオレイン酸ポリオキシエチレンソルビットである。エチレンオキサイドの付加モル数が60を超えるとふんわり感が劣り、入手のし易さの点から6モル以上である。[(C) Polyoxyethylene sorbite fatty acid ester]
Component (C) is a polyoxyethylene sorbite fatty acid ester having an average added mole number of ethylene oxide of 6 to 60 mol, particularly 30 to 40, and when used together with component (B), drastically increases the soft feeling. Can do. Examples of the component (C) include monolauric acid polyoxyethylene sorbit, hexastearic acid polyoxyethylene sorbit, tetraoleic acid polyoxyethylene sorbit, etc., which may be used alone or in combination of two or more. . Among these, tetraoxyoleic acid polyoxyethylene sorbite having an average added mole number of ethylene oxide of 6 to 60 moles is preferable from the viewpoint of giving a soft feeling, and more preferably an average added mole number of ethylene oxide is 30 to 40. This is a polyoxyethylene sorbite of tetraoleate. When the added mole number of ethylene oxide exceeds 60, the soft feeling is inferior, and it is 6 moles or more from the viewpoint of availability.
(C)成分の配合量は、ふんわり感、地肌のべたつきのなさの点から、組成物全量に対して0.1〜1.0質量%が好ましく、0.2〜0.5質量%がより好ましい。0.1質量%未満では、ふんわり感が劣る場合があり、1.0質量%を超えると地肌のべたつきのなさ、ふんわり感が劣る場合がある。 Component (C) is preferably blended in an amount of 0.1 to 1.0% by weight, more preferably 0.2 to 0.5% by weight, based on the total amount of the composition, in terms of softness and non-stickiness of the background. preferable. If it is less than 0.1% by mass, the soft feeling may be inferior, and if it exceeds 1.0% by mass, the stickiness of the background and the soft feeling may be inferior.
[(D)エタノール]
(D)エタノールは、育毛有効成分等の溶解性を高めると共に、地肌のべたつきのなさを向上させるために配合する。(D)エタノールとしては、無水エタノールや95体積%エタノールを挙げることができる。育毛有効成分の溶解性とそれに伴う抜け毛改善、ふんわり感、育毛効果、さらには地肌のべたつきのなさの点から、(D)成分の配合量は、組成物全量に対して無水エタノールとして60〜90質量%が好ましく、より好ましくは65〜80質量%である。なお、この配合量は、植物エキス等のエキス類を配合した場合、これらエキス類から持ち込まれるエタノールを含む配合量である。[(D) ethanol]
(D) Ethanol is blended in order to enhance the solubility of hair growth active ingredients and the like, and to improve the non-stickiness of the background. (D) Examples of ethanol include absolute ethanol and 95% by volume ethanol. From the viewpoints of solubility of hair growth active ingredient and associated hair loss improvement, soft feeling, hair growth effect, and non-stickiness of the skin, the blending amount of component (D) is 60 to 90 as absolute ethanol with respect to the total amount of the composition. % By mass is preferable, and more preferably 65 to 80% by mass. In addition, this compounding quantity is a compounding quantity containing the ethanol brought in from these extracts, when extracts, such as a plant extract, are mix | blended.
[その他の成分]
本発明の育毛剤組成物には、本発明の効果を損なわない範囲で、通常育毛剤組成物に配合される上記成分以外の任意成分を1種単独で又は2種以上を適宜組み合わせて用いることができる。このような成分としては、(C)成分以外のノニオン界面活性剤、半極性界面活性剤、両性界面活性剤、アニオン性高分子、ノニオン性高分子、ポリオール類、有機塩類、保湿剤、トニック剤、可溶化剤、ジブチルヒドロキシトルエン(BHT)等の酸化防止剤、トリクロサン、トリクロロカルバン等の殺菌剤、脂肪酸モノエタノールアミド、脂肪酸ジエタノールアミド等の粘度調整剤、紫外線吸収剤、酸化防止剤、タンパク誘導体、動植物抽出液、ピロクトンオラミン、ジンクピリチオン等のフケ防止剤、グリチルリチン酸ジカリウムやサリチル酸グリコール等の抗炎症剤、安息香酸及びその塩、ポリエチレングリコールや乳酸ラウリル等の経皮吸収促進剤、パラベン類、ケーソンCG等の防腐剤、クエン酸、トリエタノールアミン等のpH調整剤、エチレングリコールジ脂肪酸エステル等のパール化剤、乳濁剤、ハイドロトロープ、ビタミン類、揮発性油分、疎水性溶媒、希釈性溶媒、ショウキョウエキスやトウガラシチンキ等のエキス類、l−メントール等の清涼剤、色素、香料等が挙げられる。[Other ingredients]
In the hair restorer composition of the present invention, an optional component other than the above-mentioned components that are usually blended in the hair restorer composition is used alone or in combination of two or more, as long as the effects of the present invention are not impaired. Can do. Examples of such components include nonionic surfactants other than the component (C), semipolar surfactants, amphoteric surfactants, anionic polymers, nonionic polymers, polyols, organic salts, humectants, and tonic agents. , Solubilizers, antioxidants such as dibutylhydroxytoluene (BHT), bactericides such as triclosan and trichlorocarban, viscosity modifiers such as fatty acid monoethanolamide and fatty acid diethanolamide, UV absorbers, antioxidants, protein derivatives Animal and plant extracts, anti-dandruff agents such as piroctone olamine, zinc pyrithione, anti-inflammatory agents such as dipotassium glycyrrhizinate and glycol salicylate, benzoic acid and its salts, transdermal absorption promoters such as polyethylene glycol and lauryl lactate, parabens , P of antiseptics such as caisson CG, citric acid, triethanolamine, etc. Conditioners, pearlizing agents such as ethylene glycol difatty acid esters, emulsions, hydrotropes, vitamins, volatile oils, hydrophobic solvents, diluting solvents, extracts such as pepper extract and pepper tincture, l-menthol And other refreshing agents, pigments, and fragrances.
[用途]
本発明の育毛剤組成物は、育毛剤、養毛剤、血行促進剤、抜け毛改善剤として広く利用でき、特に育毛剤として使用することが好ましい。この場合、育毛トニック、頭皮用エッセンス、育毛スプレー、育毛ヘアジェル等の形態で外用に使用することができ、頭皮及び毛髪(特に薄毛部分や毛髪の根元部分)の両方に塗布することで、育毛効果と根本からのふんわり感効果により頭髪全体に十分なボリュームを付与することができる。本発明の育毛剤組成物は、上記必須成分及び任意成分を混合して、常法に基づいて得ることができる。[Usage]
The hair restorer composition of the present invention can be widely used as a hair restorer, a hair nourishing agent, a blood circulation promoter, and a hair loss improving agent, and is particularly preferably used as a hair restorer. In this case, it can be used for external use in the form of hair-growth tonic, scalp essence, hair-growth spray, hair-growth hair gel, etc., and it can be applied to both the scalp and hair (especially thin hair and hair root) to achieve hair-growth effect. A sufficient volume can be given to the entire hair by the soft feeling effect from the root. The hair restorer composition of the present invention can be obtained based on a conventional method by mixing the above essential components and optional components.
[容器、容器材質]
本発明の育毛剤組成物を充填する容器としては、機械的又は差圧によるディスペンサー容器及びスクイーズ容器、ラミネートフィルム容器、スポイト容器、ボトル容器等が挙げられる。ボトルの材質としては、ポリエチレン、ポリプロピレン、ポリエチレンテレフタレート、ポリスチレン、ポリ塩化ビニル、エチレン−ビニルアルコール樹脂、アクリロニトリル・スチレン樹脂、ABS樹脂、ポリアミド、ガラス等を単層ないし二層以上組み合わせて用いることができ、特にポリエチレンが好ましい。[Container, container material]
Examples of the container filled with the hair growth composition of the present invention include a dispenser container and a squeeze container by mechanical or differential pressure, a laminate film container, a dropper container, a bottle container and the like. As the bottle material, polyethylene, polypropylene, polyethylene terephthalate, polystyrene, polyvinyl chloride, ethylene-vinyl alcohol resin, acrylonitrile / styrene resin, ABS resin, polyamide, glass, etc. can be used in a single layer or in combination of two or more layers. In particular, polyethylene is preferred.
以下、実施例及び比較例を示し、本発明を具体的に説明するが、本発明は下記の実施例に制限されるものではない。なお、(D)エタノールは無水エタノールとしての量であり、(D)エタノールの配合量は、組成物中に含まれる全量を示す。実施例25、26の「その他の成分」の植物エキスに関しては有姿の配合量を示し、それ以外の植物エキスに関してはエキス純分の配合量を示した。(D)エタノール及び植物エキス以外の成分の配合量は全て純分換算量である。 EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In addition, (D) ethanol is the quantity as absolute ethanol, and the compounding quantity of (D) ethanol shows the whole quantity contained in a composition. For the plant extracts of “Other components” in Examples 25 and 26, the solid blending amount was shown, and for the other plant extracts, the blending amount of the extract was shown. (D) The compounding quantity of components other than ethanol and a plant extract is a pure part conversion amount.
[実施例1〜26、比較例1〜9]
下記表に示す組成の育毛剤組成物を常法に準じて調製し、下記方法で評価した。結果を表中に併記する。[Examples 1 to 26, Comparative Examples 1 to 9]
A hair restorer composition having the composition shown in the following table was prepared according to a conventional method and evaluated by the following method. The results are also shown in the table.
[抜け毛改善]
<評価方法>
50〜60歳代の女性40名に対して、育毛剤組成物を1日2回(間隔をあけて1回ずつ合計2回)、1ヶ月間連続使用し、使用前に比べて使用後の抜け毛の本数が減ったか否かについて評価を行った。
評価点が3点以上であれば、抜け毛改善効果は良好である。
<評価基準>
5点:40名中36名以上が、抜け毛が減ったと回答した
4点:40名中28名以上35名以下が、抜け毛が減ったと回答した
3点:40名中20名以上27名以下が、抜け毛が減ったと回答した
2点:40名中12名以上19名以下が、抜け毛が減ったと回答した
1点:40名中11名以下が、抜け毛が減ったと回答した[Improve hair loss]
<Evaluation method>
For 40 women in their 50s and 60s, use hair restorer composition twice a day (twice at a time for a total of 2 times) for 1 month, after use, compared to before use It was evaluated whether or not the number of hair loss was reduced.
If the evaluation score is 3 or more, the hair loss improving effect is good.
<Evaluation criteria>
5 points: 36 or more out of 40 responded that hair loss was reduced. 4 points: 28 to 35 out of 40 responded that hair loss was reduced. 3 points: 20 to 27 or less out of 40 persons. 2 points: 12 to 19 out of 40 people answered that hair loss was reduced 1 point: 11 or less of 40 people answered that hair loss was reduced
[育毛効果]
<評価方法>
50〜60歳代の女性40名に対して、育毛剤組成物を1日2回(間隔をあけて1回ずつ合計2回)、1ヶ月間連続使用し、使用前に比べて使用後の髪が増えた感じがあるか否かについて評価を行った。
評価点が3点以上であれば、育毛効果は良好である。
<基準>
5点:40名中36名以上が、髪が増えた感じがあると回答した
4点:40名中28名以上35名以下が、髪が増えた感じがあると回答した
3点:40名中20名以上27名以下が、髪が増えた感じがあると回答した
2点:40名中12名以上19名以下が、髪が増えた感じがあると回答した
1点:40名中11名以下が、髪が増えた感じがあると回答した[Hair growth effect]
<Evaluation method>
For 40 women in their 50s and 60s, use hair restorer composition twice a day (twice at a time for a total of 2 times) for 1 month, after use, compared to before use An evaluation was made as to whether or not there was a feeling of increased hair.
If the evaluation score is 3 points or more, the hair-growth effect is good.
<Standard>
5 points: More than 36 out of 40 responded that there was a feeling of increased hair 4 points: 28 to 35 out of 40 responded that there was a feeling of increased hair 3 points: 40 20 to 27 of them answered that they had increased hair 2 points: 12 to 19 of 40 people answered that they had increased hair 1 point: 11 of 40 The people below the name replied that their hair increased.
[ふんわり感]
<評価方法>
40〜60歳代の女性10名に対して、育毛剤組成物を14日間、洗髪後に使用し、使用前に比べて使用後の髪がふんわりした感じがあるか否かについて評価を行った。
評価点が3点以上であれば、ふんわり感は良好である。
<評価基準>
5点:10名中9名以上が、髪がふんわりした感じがあると回答した
4点:10名中7名以上8名以下が、髪がふんわりした感じがあると回答した
3点:10名中5名以上6名以下が、髪がふんわりした感じがあると回答した
2点:10名中3名以上4名以下が、髪がふんわりした感じがあると回答した
1点:10名中2名以下が、髪がふんわりした感じがあると回答した[Soft feeling]
<Evaluation method>
For 10 women in their 40s and 60s, the hair restorer composition was used for 14 days after shampooing, and an evaluation was made as to whether or not the hair after use had a soft feel compared to before use.
If the evaluation score is 3 points or more, the soft feeling is good.
<Evaluation criteria>
5 points: 9 or more out of 10 responded that their hair feels fluffy 4 points: 7 to 8 out of 10 respondents that their hair feels fluffy 3 points: 10 5 to 6 of them answered that their hair was soft 2 points: 3 to 4 of 10 people said that their hair was soft 1 point: 2 out of 10 The following people replied that their hair feels soft
[地肌のべたつきのなさ]
<評価方法>
40〜60歳代の女性10名に対して、育毛剤組成物を14日間、洗髪後に使用して乾燥後、育毛剤使用前に比べて地肌(頭皮)がべたつくか否かについて評価を行った。
評価点が3点以上であれば、地肌のべたつきのなさは良好である。
<評価基準>
5点:10名中9名以上が、地肌にべたつきを感じないと回答した
4点:10名中7名以上8名以下が、地肌にべたつきを感じないと回答した
3点:10名中5名以上6名以下が、地肌にべたつきを感じないと回答した
2点:10名中3名以上4名以下が、地肌にべたつきを感じないと回答した
1点:10名中2名以下が、地肌にべたつきを感じないと回答した[No stickiness of the skin]
<Evaluation method>
For 10 women in their 40s and 60s, the hair growth composition was used for 14 days after washing the hair and dried, and then evaluated whether the scalp (scalp) was sticky compared to before using the hair growth agent. .
If the evaluation score is 3 points or more, the non-stickiness of the background is good.
<Evaluation criteria>
5 points: 9 or more out of 10 responded that they did not feel sticky on the ground 4 points: 7 to 8 out of 10 responded that they did not feel sticky on the ground 3 points: 5 out of 10 6 or more people answered that they did not feel sticky on the skin 2 points: 3 or more of 10 people answered that they did not feel sticky on the skin 1 point: 2 or less people out of 10 Answer that the skin is not sticky
[溶解性]
<評価方法>
配合直後の外観を目視評価した。
<評価基準>
○:沈殿物なし
×:沈殿物あり[Solubility]
<Evaluation method>
The appearance immediately after blending was visually evaluated.
<Evaluation criteria>
○: No precipitate ×: Precipitate
実施例及び比較例で使用した原料を下記に示す。
従って、本発明は、下記育毛剤組成物を提供する。
[1]
(A)6−ベンジルアミノプリン、ペンタデカン酸グリセリド及びミノキシジルから選ばれる少なくとも1種の育毛有効成分と、
(B)ヒドロキシエチルキトサン及びヒドロキシプロピルキトサンから選ばれる少なくとも1種:0.11〜0.19質量%と、
(C)エチレンオキサイドの平均付加モル数が6〜60モルであるポリオキシエチレンソルビット脂肪酸エステルと、
(D)エタノールと
を含有することを特徴とする育毛剤組成物。
[2]
(C)成分が、エチレンオキサイドの平均付加モル数が30〜40モルであるテトラオレイン酸ポリオキシエチレンソルビットである[1]記載の育毛剤組成物。
[3]
(C)成分の配合量が0.1〜1.0質量%である[1]又は[2]記載の育毛剤組成物。
[4]
(D)成分の配合量が60〜90質量%である[1]〜[3]のいずれかに記載の育毛剤組成物。
Accordingly, the present invention provides the following hair restorer composition.
[1]
(A) at least one hair-growth active ingredient selected from 6-benzylaminopurine, pentadecanoic acid glyceride and minoxidil ;
(B) at least one selected from hydroxyethyl chitosan and hydroxypropyl chitosan : 0.11 to 0.19% by mass ;
(C) a polyoxyethylene sorbite fatty acid ester having an average addition mole number of ethylene oxide of 6 to 60 moles;
(D) A hair restorer composition comprising ethanol.
[ 2 ]
(C) component, the average addition mole number of ethylene oxide is polyoxyethylene sorbit tetraoleate 30-40 moles [1] Symbol placing the hair restorer composition.
[ 3 ]
(C) The hair restorer composition according to [1] or [2] , wherein the compounding amount of the component is 0.1 to 1.0% by mass.
[4]
(D) The hair restorer composition in any one of [1]-[3] whose compounding quantity of a component is 60-90 mass%.
Claims (5)
(B)ヒドロキシエチルキトサン及びヒドロキシプロピルキトサンから選ばれる少なくとも1種と、
(C)エチレンオキサイドの平均付加モル数が6〜60モルであるポリオキシエチレンソルビット脂肪酸エステルと、
(D)エタノールと
を含有することを特徴とする育毛剤組成物。(A) a hair-growth active ingredient;
(B) at least one selected from hydroxyethyl chitosan and hydroxypropyl chitosan;
(C) a polyoxyethylene sorbite fatty acid ester having an average addition mole number of ethylene oxide of 6 to 60 moles;
(D) A hair restorer composition comprising ethanol.
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CN111494265A (en) * | 2020-05-22 | 2020-08-07 | 广东创美抗衰老研究有限公司 | Tremella repairing and moisturizing mask |
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CN111110618B (en) * | 2020-02-11 | 2022-09-27 | 张运适 | A composition for promoting hair growth |
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JPS649911A (en) | 1987-06-30 | 1989-01-13 | Lion Corp | Hair cosmetic |
JP2598954B2 (en) | 1988-03-30 | 1997-04-09 | 三洋化成工業株式会社 | Hairdressing composition |
JP2878287B2 (en) | 1988-08-12 | 1999-04-05 | 株式会社成和化成 | Cosmetic base material |
JP2779555B2 (en) | 1991-04-05 | 1998-07-23 | 花王株式会社 | Hair cosmetics |
JPH11193219A (en) * | 1997-12-26 | 1999-07-21 | Ichimaru Pharcos Co Ltd | Hair growing and regenerating agent with formulated plant extract |
JP4133639B2 (en) * | 2003-07-16 | 2008-08-13 | ライオン株式会社 | Hair nourishing composition |
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JP2007169233A (en) * | 2005-12-26 | 2007-07-05 | Lion Corp | Hair growth tonic composition |
JP2008120792A (en) * | 2006-10-16 | 2008-05-29 | Hayashibara Biochem Lab Inc | Skin and hair cosmetic having moisture retention and hairdressing activity and method for producing the same |
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JP2007008867A (en) * | 2005-06-30 | 2007-01-18 | Lion Corp | Hair cosmetic |
JP2007191473A (en) * | 2005-12-21 | 2007-08-02 | Daiichi Sankyo Healthcare Co Ltd | New hair-growing composition |
WO2008035563A1 (en) * | 2006-09-21 | 2008-03-27 | Lion Corporation | Hair cosmetic |
JP2011529938A (en) * | 2008-08-04 | 2011-12-15 | ポリケム・エスエイ | Film-forming liquid formulation for drug release to the hair and scalp |
JP2012184220A (en) * | 2011-02-17 | 2012-09-27 | Lion Corp | Scalp and hair cosmetic |
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CN111494265A (en) * | 2020-05-22 | 2020-08-07 | 广东创美抗衰老研究有限公司 | Tremella repairing and moisturizing mask |
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CN105163717A (en) | 2015-12-16 |
WO2014185461A1 (en) | 2014-11-20 |
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