CN107708659A - It is compounded with the face skin preparations for extenal use of amino acid - Google Patents
It is compounded with the face skin preparations for extenal use of amino acid Download PDFInfo
- Publication number
- CN107708659A CN107708659A CN201680038189.0A CN201680038189A CN107708659A CN 107708659 A CN107708659 A CN 107708659A CN 201680038189 A CN201680038189 A CN 201680038189A CN 107708659 A CN107708659 A CN 107708659A
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- amino acid
- compounded
- extenal use
- skin preparations
- mass
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- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 241000213996 Melilotus Species 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 206010035039 Piloerection Diseases 0.000 description 1
- 244000203593 Piper nigrum Species 0.000 description 1
- 235000008184 Piper nigrum Nutrition 0.000 description 1
- 229920001030 Polyethylene Glycol 4000 Polymers 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- 235000006886 Zingiber officinale Nutrition 0.000 description 1
- USNWAMPROKAEIT-UHFFFAOYSA-N [Na].C(C=C)(=O)O Chemical compound [Na].C(C=C)(=O)O USNWAMPROKAEIT-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 125000003647 acryloyl group Chemical group O=C([*])C([H])=C([H])[H] 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- TUFYVOCKVJOUIR-UHFFFAOYSA-N alpha-Thujaplicin Natural products CC(C)C=1C=CC=CC(=O)C=1O TUFYVOCKVJOUIR-UHFFFAOYSA-N 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000001153 anti-wrinkle effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 description 1
- 229940089116 arnica extract Drugs 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- 150000003851 azoles Chemical class 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- QKSKPIVNLNLAAV-UHFFFAOYSA-N bis(2-chloroethyl) sulfide Chemical compound ClCCSCCCl QKSKPIVNLNLAAV-UHFFFAOYSA-N 0.000 description 1
- 235000013614 black pepper Nutrition 0.000 description 1
- 229930006711 bornane-2,3-dione Natural products 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229930008380 camphor Natural products 0.000 description 1
- 229960000846 camphor Drugs 0.000 description 1
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 description 1
- 229960002504 capsaicin Drugs 0.000 description 1
- 229940007061 capsicum extract Drugs 0.000 description 1
- 239000001943 capsicum frutescens fruit extract Substances 0.000 description 1
- 239000001390 capsicum minimum Substances 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 1
- YSMODUONRAFBET-UHFFFAOYSA-N delta-DL-hydroxylysine Natural products NCC(O)CCC(N)C(O)=O YSMODUONRAFBET-UHFFFAOYSA-N 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 1
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- YSMODUONRAFBET-UHNVWZDZSA-N erythro-5-hydroxy-L-lysine Chemical compound NC[C@H](O)CC[C@H](N)C(O)=O YSMODUONRAFBET-UHNVWZDZSA-N 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- FODTZLFLDFKIQH-FSVGXZBPSA-N gamma-Oryzanol (TN) Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)O[C@@H]2C([C@@H]3CC[C@H]4[C@]5(C)CC[C@@H]([C@@]5(C)CC[C@@]54C[C@@]53CC2)[C@H](C)CCC=C(C)C)(C)C)=C1 FODTZLFLDFKIQH-FSVGXZBPSA-N 0.000 description 1
- 235000008397 ginger Nutrition 0.000 description 1
- 235000020710 ginseng extract Nutrition 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- 238000002169 hydrotherapy Methods 0.000 description 1
- QJHBJHUKURJDLG-UHFFFAOYSA-N hydroxy-L-lysine Natural products NCCCCC(NO)C(O)=O QJHBJHUKURJDLG-UHFFFAOYSA-N 0.000 description 1
- 229960002591 hydroxyproline Drugs 0.000 description 1
- NFIDBGJMFKNGGQ-UHFFFAOYSA-N isopropylmethylphenol Natural products CC(C)CC1=CC=CC=C1O NFIDBGJMFKNGGQ-UHFFFAOYSA-N 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000001617 migratory effect Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 235000010460 mustard Nutrition 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 229940116257 pepper extract Drugs 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- AVSXGQJYEFAQNK-UHFFFAOYSA-N prop-2-enamide;hydrate Chemical compound O.NC(=O)C=C AVSXGQJYEFAQNK-UHFFFAOYSA-N 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 229940119485 safflower extract Drugs 0.000 description 1
- 235000019515 salmon Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000006104 solid solution Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
- 229930007845 β-thujaplicin Natural products 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
The high amino acid compounding face skin preparations for extenal use of the improvement of the low stimulation of present invention offer and the facial wrinkles including eye circumference.A kind of face skin preparations for extenal use for being compounded with amino acid, it contains:(A) amino acid and (B) vanillyl alcohol butyl ether, foregoing (A) amino acid is valine, leucine and isoleucine.As (A) amino acid, the mass % of valine 0.1~2.0, the mass % of leucine 0.1~4.0 and the mass % of isoleucine 0.1~2.0 are preferably comprised, preferably comprises the mass % of (B) vanillyl alcohol butyl ether 0.001~1.0.
Description
Technical field
The present invention relates to the face skin preparations for extenal use for being compounded with amino acid, more particularly to low stimulation and including eye circumference
Facial wrinkles the high face skin preparations for extenal use for being compounded with amino acid of improvement.
Background technology
Valine, leucine and isoleucine are known as branched-chain amino acid (BCAA:Branched Chain Amino
Acids one kind in essential amino acid), all the time, be compounded in by exercise induced anemia, set up for the purpose of food etc.
In.Further, since being the composition for forming people's epidermal protein matter, therefore also it is compounded in the external preparations such as cosmetics, medicine.
For example, as food applications, Patent Document 1 discloses by valine, isoleucine, leucine this 3 kinds of amino
The solid solution that acid is formed;Patent Document 2 discloses a kind of oral amino acid composition for improving skin state, its feature exists
In containing L- essence ammonia respectively with the ratio of 10~40 parts by weight, 5~20 parts by weight, 8~30 parts by weight and 10~35 parts by weight
This 5 kinds of amino acid of acid, Pidolidone, Valine, ILE and L-Leu.
In addition, the purposes as external preparation, Patent Document 3 discloses a kind of collagen to generate accelerator, and it is included by sweet
Propylhomoserin, alanine, valine, leucine, isoleucine, serine, threonine, aspartic acid, glutamic acid acid, methionine, rely
The amino acid mixing that propylhomoserin, hydroxylysine, arginine, histidine, phenylalanine, tyrosine, proline and hydroxyproline are formed
Thing;Patent Document 4 discloses a kind of NMF, it is characterised in that it contains selected from composition (A) hydrophilic index
(Hydropathy Index) be a kind or 2 kinds in positive amino acid and (B) menthol, menthol derivative or camphorquinone with
It is upper to be used as active ingredient.
On the other hand, vanillyl alcohol butyl ether is generally synthesized by the composition included in vanilla bean, therefore has excellent warming
Effect, all the time, for body Shou body cosmetics etc..
For example, Patent Document 5 discloses the cooling agent composition that a kind of creeping chill lasting effect is excellent, it contains specifically
Menthol or at least one kind of in the carboxylate of its analog shown in formula;Patent Document 6 discloses a kind of liquid oral use
Composition, it contains:(A) isopropyl methyl phenol, (B) allantoin, the average addition molal quantity of (C) ethylene oxide are 40~100
Mole Crodaret, (D) combination citric acid and citrate or citrate beyond alkaline agent or combination lemon
The material that acid beyond lemon hydrochlorate and citric acid or citric acid forms, the compounding amount of composition (C) is 0.10~1.0 mass %, and
(C)/(B) mass ratio is 5~30, and the pH of composition is 4.0~6.2, and it is also selected from spilanthol, vanillyl alcohol fourth containing (E)
It is at least one kind of in ether and capsaicine;Patent Document 7 discloses a kind of dentifrice composition, and it contains:(a) sodium chloride, (b) choosing
From at least one kind of, (c) monomenthyl succinate in menthol, peppermint oil dementholized and peppermint oil, (d) surfactant, and (c)
The compounding amount of monomenthyl succinate is 0.03~1 mass %, and the composition also contains at least 1 selected from (e-1) and (e-2)
Kind, (e-1) vanillyl alcohol butyl ether and/or spilanthol, (e-2) be selected from black pepper, capsicum, ginger plant essential oil or extraction
Thing;Patent Document 8 discloses Yi Zhong Shou body compositions, and it contains blood circulation accelerant and amino acid, and blood circulation promotees
It is selected from Ah rice celery extract, pepper extract, rough gentian extract, mustard extract, Capsicum Extract, ginger extraction to enter agent
Thing, ginseng extract, biloba extract thing, Arnica extract, safflower extract, the green rough gentian extract of Japan, Melilotus sweetclover are planted
Thing extract, horsetail extract, camphor and its derivative, Hinokitiol and its derivative and their salt, tocopherol and its spread out
1 kind or 2 in biology, nicotinic acid and its derivative and their salt, gamma oryzanol its derivative, vanillyl alcohol butyl ether, sodium acid carbonate
More than kind, amino acid is selected from leucine, isoleucine, valine, tryptophan, lysine, methionine, phenylalanine, Soviet Union's ammonia
It is one kind or two or more in acid, valine, leucine, isoleucine, histidine, arginine.
Prior art literature
Patent document
Patent document 1:No. 2010/050168 pamphlet of International Publication No.
Patent document 2:Japanese Unexamined Patent Publication 2005-247738 publications
Patent document 3:Japanese Unexamined Patent Publication 2007-51087 publications
Patent document 4:Japanese Unexamined Patent Publication 2013-227286 publications
Patent document 5:Japanese Unexamined Patent Publication 2015-38204 publications
Patent document 6:Japanese Unexamined Patent Publication 2010-143889 publications
Patent document 7:Japanese Unexamined Patent Publication 2010-37318 publications
Patent document 8:Japanese Unexamined Patent Publication 2008-69134 publications
The content of the invention
Problems to be solved by the invention
However, the technology described in patent document 1~4 is related to the amino acid such as valine, isoleucine, leucine, for
With being applied in combination for vanillyl alcohol butyl ether, then do not studied completely.In addition, the technology described in patent document 1~4 is not can
To provide, the improvement of low stimulation and the facial wrinkles including eye circumference is high to be compounded with outside the face skin of amino acid
With the invention of agent.
In addition, the technology described in patent document 5 is conceived to the warming effect of vanillyl alcohol butyl ether, rather than for including eye
The invention that the improvement of facial wrinkles including week can be improved.And then the technology described in patent document 6 and 7 relates to
And composition for oral cavity, dentifrice composition, its do not refer to by the assemblage zone with amino acid come the face including eye circumference
The improvement of portion's wrinkle.Moreover, although the technology described in patent document 8 describes valine, isoleucine, leucine etc.
The combination of amino acid and vanillyl alcohol butyl ether, but be only Shou body compositions all the time, only has described in the claims, and implements
Specific effect not on the books in example etc., and do not refer to the improvement of the facial wrinkles including eye circumference.
Therefore, it is an object of the invention to solve foregoing problem of the prior art point, and it is an object of the present invention to provide it is low stimulation and
The high face skin preparations for extenal use for being compounded with amino acid of the improvements of facial wrinkles including eye circumference.
The solution used to solve the problem
The present inventor has made intensive studies to solve aforementioned problems, as a result finds by being compounded specific amino acid
With vanillyl alcohol butyl ether, so as to realize object defined above, the present invention is so far completed.
That is, the face skin preparations for extenal use for being compounded with amino acid of the invention is characterised by that it contains:(A) amino acid
(B) vanillyl alcohol butyl ether, foregoing (A) amino acid are valine, leucine and isoleucine.
In addition, the face skin preparations for extenal use for being compounded with amino acid of the present invention is preferred:As foregoing (A) amino acid, contain
There are the mass % of valine 0.1~2.0, the mass % of leucine 0.1~4.0 and the mass % of isoleucine 0.1~2.0, containing foregoing
(B) the mass % of vanillyl alcohol butyl ether 0.001~1.0.
And then the face for being compounded with amino acid of the invention preferably comprises (C) imidazole peptide with skin preparations for extenal use, preferably comprises
(D) elastin laminin.
Moreover, the face for being compounded with amino acid of the present invention is preferably that eye circumference is used with skin preparations for extenal use.
The effect of invention
It is compounded with according to the present invention it is possible to which the improvement for providing low stimulation and facial wrinkles including eye circumference is high
The face skin preparations for extenal use of amino acid.
Embodiment
The face for being compounded with amino acid of 1 embodiment according to the present invention is carried out specifically with skin preparations for extenal use below
It is bright.
The face skin preparations for extenal use for being compounded with amino acid of the present embodiment is characterised by, its contain (A) amino acid and
(B) vanillyl alcohol butyl ether, (A) amino acid are valine, leucine and isoleucine.Thus, it is possible to provide low stimulation and including eye
The high face skin preparations for extenal use for being compounded with amino acid of the improvements of facial wrinkles including week.It should be noted that this
In embodiment, " containing " is unrelated with adding method, step as long as referring to contain in formula.
In the present embodiment, as valine, leucine and isoleucine, as long as can be used for common external preparation etc.
Material is just not particularly limited, such as can include:Ajinomoto Healthy Supply Co., Ltd. L-
Valine (trade name), L-Leucine (trade name), L-Isoleucine (trade name) etc..
In addition, in the present embodiment, as (B) vanillyl alcohol butyl ether, as long as can be used for the vanilla of common external preparation etc.
Alcohol butyl ether is just not particularly limited, such as can include:" the Vanillyl butyl of Takasago spices Industry Co
ether”。
And then in the present embodiment, preferably as (A) amino acid, contain the mass % of valine 0.1~2.0, leucine 0.1
~the 4.0 mass % and mass % of isoleucine 0.1~2.0 and preferably comprise the mass % of (B) vanillyl alcohol butyl ether 0.001~1.0;It is excellent
Choosing contains the mass % of valine 0.5~1.0, the mass % of leucine 0.5~2.0 and the matter of isoleucine 0.5~1.0 with following ranges
Measure % and contain the mass % of (B) vanillyl alcohol butyl ether 0.01~0.7.In addition, particularly preferably contain (B) vanillyl alcohol butyl ether 0.1~0.5
Quality %.By the way that content is set into above range, so as to provide lower stimulation and facial wrinkles including eye circumference
The higher face skin preparations for extenal use for being compounded with amino acid of improvement.In addition, when the compounding quantitative change of (B) vanillyl alcohol butyl ether is more
May turn into stimulate the reason for, but by within the above range with combination of amino acids and can suppress stimulate generation.
In addition, the preferred valine of face skin preparations for extenal use for being compounded with amino acid of the present embodiment, leucine and different bright
Propylhomoserin contains than for 1:2:1;Special further preferably the mass % of valine 0.5, the mass % of leucine 1.0 and isoleucine
0.5 mass %.By the way that leucine to be set to about 2 times of mix ratio of valine and isoleucine, so as to further improve
Be compounded with by coating the face skin preparations for extenal use of amino acid etc. the anti-muscle brought etc. tired effect, it is possible to increase wrinkle
Line improvement.
And then the face for being compounded with amino acid of the present embodiment preferably comprises (C) imidazole peptide with skin preparations for extenal use.(C) miaow
Azoles peptide is the material being rich in the muscle of the birds such as stripped tuna, tuna or migratory bird.As above-mentioned (C) imidazole peptide, as long as energy
The imidazole peptide for being enough in common external preparation etc. is just not particularly limited, such as can include:Carnosine, anserine, snake carnosine
Deng the one kind or two or more of them can be contained.Specifically, can include:H.Holstein GmbH&Co.KG company systems
Amelox (trade name), Symrise Co., Ltd. DRAGOSINE (trade name) etc. or carnosine, the goose flesh of monomer
Peptide, snake carnosine etc..By containing (C) imidazole peptide, so as to further improve effect improving wrinkles.
In addition, the compounding amount as (C) imidazole peptide, preferably 0.01~5 mass %, more preferably 0.1~3 mass %, entering one
Walk preferably 1~2 mass %.Thereby, it is possible to further improve effect improving wrinkles.
And then the face for being compounded with amino acid of the present embodiment preferably comprises (D) elastin laminin with skin preparations for extenal use.(D)
Elastin laminin is the protein of elastotic, as above-mentioned (D) elastin laminin, as long as can be used for common external preparation etc.
Elastin laminin be just not particularly limited, such as the elastin laminin for being derived from the fishes such as animal, tuna, the salmon such as ox can be used.
Height can be used to grind Hydrolysis Elastin (trade name), the Hydrolysis α-Elastin (commodity of Co. Ltd. system
Name), Elasocean (trade name) or the elastin laminin from animal, the powdery of fish.By containing (D) elastin laminin, from
And it can further improve effect improving wrinkles.
In addition, the compounding amount as (D) elastin laminin, preferably 0.001~5 mass %, more preferably 0.1~2 mass %.By
This, can further improve effect improving wrinkles.
In addition, the face for being compounded with amino acid of the present embodiment preferably comprises acrylamide water solubility with skin preparations for extenal use
Thickener.As acrylamide water-soluble thickener, as long as can be used for the material of common external preparation etc. just without spy
Do not limit, such as can include:(hydroxy-ethyl acrylate/acryloyl dimethyl tauric acid sodium) copolymer, (PAA/
Acryloyl dimethyl tauric acid sodium) copolymer, (acryloyl dimethyl tauric acid ammonium/VP) copolymer, (acryloyl group diformazan
Base taurine ammonium methacrylic acid behenyl alcohol polyethers -25) cross-linked polymer etc., wherein, particularly preferred (hydroxy-ethyl acrylate/the third
Enoyl- dimethyltaurine sodium) copolymer, (PAA/acryloyl dimethyl tauric acid sodium) copolymer, can use
It is one kind or two or more in acrylamide water-soluble thickener.And then as acrylamide water-soluble thickener, tool
For body, as (hydroxy-ethyl acrylate/acryloyl dimethyl tauric acid sodium) copolymer, SEPPIC company systems can be included
SEPIPLUS S (trade name), SEPINOV EMT10 (trade name), SIMULGEL NS (trade name) etc., as (acrylic acid
Sodium/acryloyl dimethyl tauric acid sodium) copolymer, the SIMULGEL EG (trade name) of SEPPIC company systems can be included
Deng as (acryloyl dimethyl tauric acid ammonium/VP) copolymer, the Aristoflex of Clariant company systems can be included
AVC (trade name), can as (acryloyl dimethyl tauric acid ammonium methacrylic acid behenyl alcohol polyethers -25) cross-linked polymer
To include:Aristoflex HMB (trade name) of Clariant company systems etc..By being compounded, acrylamide is water-soluble to be increased
Thick dose, so as to the molten of the valine, leucine and the isoleucine that make to be compounded with the face skin preparations for extenal use of amino acid
Numerical solution is good, can further improve the wrinkle that face skin preparations for extenal use that amino acid is compounded with by coating etc. is brought
Line improvement, antifatigue effect etc..
And then the face for being compounded with amino acid of the present embodiment is preferably compounded with skin preparations for extenal use and dissolved selected from by PEG-
More than a kind in the group of 20 methyl sesquistearates and PEG-20 methyls dioleate composition.As PEG-20
Methyl sesquistearate and PEG-20 methyl dioleates, as long as can be used for the thing of common external preparation etc.
Matter is just not particularly limited, such as can include:Japan Lubrizol Corporation Glucamate SSE-
20 (trade names), Glucamate DOE-120 (trade name) etc..Thereby, it is possible to make to be compounded with outside the face skin of amino acid
Steady dissolution with the valine in agent, leucine and isoleucine is good, can further improve and is compounded by being coated with
Effect improving wrinkles that face skin preparations for extenal use of amino acid etc. is brought, antifatigue effect etc..
In addition, the present embodiment be compounded with amino acid face with skin preparations for extenal use be it is low stimulation and wrinkle improvement
High material, therefore it is suitable for the skin preparations for extenal use of facial (face), it is especially preferred as the eye circumference that wrinkle significantly occurs, energy
It is enough in eye cream, eye circumference beautifying liquid etc.., can will and then skin preparations for extenal use refers to the material that can be used in human body etc.
Cosmetics, quasi- medicine, medicine etc. are used as object.Therefore, cosmetics etc. refer to include basic cosmetics, the coloured silks such as face film agent (pack)
The material of cosmetics etc..
In addition, in the present embodiment, in the range of effect as described above is not damaged, other compositions can also be suitably added
Deng.As the above-mentioned composition that can be arbitrarily compounded in addition, can include generally with the composition example being mixed in skin preparations for extenal use etc.
Such as:Oil components, NMF, antioxidant, preservative, spices, various vitamin preparations, chelating agent, colouring agent, ultraviolet radiation absorption
Agent, effective component, inorganic salts etc..
Embodiment 1~10 used below illustrates in further detail, but the present invention is not limited to these embodiments.Need
Illustrate, the numerical value in formula represents quality %.
Embodiment
(embodiment 1, comparative example 1 and 2)
According to the formula of table 1 below, the skin preparations for extenal use of embodiment 1 and comparative example 1 has been made.For obtained embodiment
1st, the skin preparations for extenal use of comparative example 1 and comparative example 2, carrying out following wrinkles improves experiment, is shown in table 1 in the lump.In addition, carry out following
Skin irritation test.It should be noted that the numerical value in formula represents quality %.In addition, in table 1, ※ 1 is SEPPIC companies
The SEPIPULUS S (trade name) of system.
[table 1]
(wrinkle improves experiment)
According to " be used for obtain new effect anti-wrinkle product interpretational criteria (Japanese perfuming cosmetic association will (Vol.30,
No.4, p.316-332,2006) " is tested, and using the adult female 20 of wrinkle grade 1~3 as examinee, will be implemented
The continuous one month skin for being used for hemifacial canthus daily of skin preparations for extenal use of example and comparative example, the then improvement to wrinkle are imitated
Fruit is investigated.Evaluation method is carried out according to above-mentioned criterion, and professional inspector observes the variable condition of wrinkle grade by visual observation.
Comparison based on coating position with uncoated position, by observing that the number of improvement have rated wrinkle after continued use
Improvement.Metewand is as follows.
(metewand)
◎ (good):Improved number is confirmed to be more than 15 people
Zero (slightly good):Confirm improved number for it is more than 10 people~be less than 15 people
△ (slightly worse):Confirm improved number for it is more than 5 people~be less than 10 people
× (poor):Confirm improved number and be less than 5 people
(skin irritation test)
For 20 women of 20 years old~30 years old, the skin preparations for extenal use of embodiment and comparative example is used for continuous one month daily
Skin in hemifacial canthus, is then investigated skin irritation.Compared with uncoated portion, for stimulation
There are useless following 5 level evaluations to be evaluated, based on its average mark, judged according to following benchmark.
(5 level evaluations)
5 points:Very good (non-stimulated)
4 points:It is slightly good
3 points:Can be with
2 points:Commonly
1 point:Poor (having stimulation)
(metewand 2)
Average mark is more than 4 points of ◎ (good)
Average mark is more than 3 points and less than 4 points zero (slightly good)
Average mark is more than 2 points and less than 3 points △ (slightly worse)
Average mark 2 divides following × (poor)
As shown in Table 1, the skin preparations for extenal use of embodiment 1 has 18 adult females to obtain improvement, and wrinkle changes
It is kind to work well.On the other hand, the skin preparations for extenal use of comparative example 1 and comparative example 2 only 2 adult females obtain improvement, wrinkle
Line improvement is poor.In addition, the skin irritation evaluation of the skin preparations for extenal use of embodiment 1 is equally divided into 4.8 points, it is low stimulation
Property.On the other hand, what the skin irritation of the skin preparations for extenal use of comparative example 1 was evaluated is equally divided into 4.9 points, though it is low irritant,
But the skin irritation evaluation of comparative example 2 is equally divided into 3.5 points, and the excitant than embodiment 1 is big.
(embodiment 2)
According to the formula of table 2 below, the face film agent of embodiment 2 has been made.For the face film agent of obtained embodiment 2, enter
Above-mentioned wrinkle of having gone improves experiment and skin irritation test.It should be noted that the numerical value in formula represents quality %.Separately
Outside, in table 2, ※ 2 is the Tornare (trade name) of woods original Co. Ltd. system.
[table 2]
Composition name | Compounding amount (quality %) |
Purified water | 81.70 |
Glycerine | 5.00 |
Pentanediol | 2.00 |
Carbomer | 0.50 |
Arginine | 0.70 |
Phenoxyethanol | 0.50 |
Tornare※2 | 5.00 |
Elastin laminin (powder) | 0.50 |
Anserine | 1.00 |
Carnosine | 1.00 |
Valine | 0.50 |
L-Leu | 1.00 |
ILE | 0.50 |
Vanillyl alcohol butyl ether | 0.10 |
Amount to | 100.00 |
The face film agent of embodiment 2 has 19 adult females to obtain improvement, and effect improving wrinkles are good.In addition, implement
The skin irritation evaluation of the face film agent of example 2 is equally divided into 4.9 points, is low irritant.
(embodiment 3)
According to the formula of Table 3 below, the skin preparations for extenal use of embodiment 3 has been made.Outside for the skin of obtained embodiment 3
With agent, carrying out above-mentioned wrinkle improves experiment.It should be noted that in table 3, ※ 1 is the SEPIPULUS S of SEPPIC company systems
(trade name).
[table 3]
The skin preparations for extenal use of embodiment 3 has 19 adult females to obtain improvement, and effect improving wrinkles are good.
(embodiment 4)
According to the formula of table 4 below, the face film agent of embodiment 4 has been made.For the face film agent of obtained embodiment 4, enter
The above-mentioned wrinkle of row improves experiment.It should be noted that in table 4, ※ 2 is the Tornare (trade name) of woods original Co. Ltd. system.
[table 4]
Composition name | Compounding amount (quality %) |
Purified water | 79.80 |
Glycerine | 5.00 |
Pentanediol | 2.00 |
Carbomer | 0.50 |
Arginine | 0.70 |
Phenoxyethanol | 0.50 |
Tornare※2 | 5.00 |
Elastin laminin (powder) | 0.50 |
Anserine | 1.00 |
Carnosine | 1.00 |
Valine | 0.50 |
L-Leu | 1.00 |
ILE | 0.50 |
N-acetyl-glucosamine | 1.00 |
Vanillyl alcohol butyl ether | 1.00 |
Amount to | 100.00 |
The face film agent of embodiment 4 has adult female 19 to obtain improvement, and effect improving wrinkles are good.
(embodiment 5)
According to the formula of table 5 below, the toner of embodiment 5 has been made.For the toner of obtained embodiment 5, enter
The above-mentioned wrinkle of row improves experiment and skin irritation test.
[table 5]
Composition name | Compounding amount (quality %) |
Purified water | 71.29 |
1,3 butylene glycol | 6.00 |
Glycerine | 4.00 |
Oleyl alcohol | 0.10 |
POE (20) sorbitan monostearate | 0.50 |
POE (15) lauryl alcohol | 0.50 |
Ethanol | 10.00 |
Methyl p-hydroxybenzoate | 0.30 |
Elastin laminin (powder) | 0.50 |
Anserine | 1.00 |
Carnosine | 1.00 |
Valine | 1.20 |
L-Leu | 2.40 |
ILE | 1.20 |
Vanillyl alcohol butyl ether | 0.01 |
Amount to | 100.00 |
The toner of embodiment 5 has 17 adult females to obtain improvement, and effect improving wrinkles are good.In addition, implement
The skin irritation evaluation of the toner of example 5 is equally divided into 4.95 points, is low irritant.
(embodiment 6)
According to the formula of table 6 below, the toner of embodiment 6 has been made.For the toner of obtained embodiment 6, enter
The above-mentioned wrinkle of row improves experiment.
[table 6]
Composition name | Compounding amount (quality %) |
Purified water | 64.20 |
1,3-BDO | 6.00 |
Glycerine | 5.00 |
PEG 4000 | 3.00 |
Olive oil | 0.50 |
POE (20) sorbitan monostearate | 1.50 |
POE (5) oleyl alcohol ether | 0.30 |
Ethanol | 10.00 |
Methyl p-hydroxybenzoate | 0.30 |
Elastin laminin (powder) | 0.50 |
Anserine | 1.00 |
Carnosine | 1.00 |
Valine | 1.00 |
L-Leu | 2.00 |
ILE | 1.00 |
N-acetyl-glucosamine | 2.00 |
Vanillyl alcohol butyl ether | 0.70 |
Amount to | 100.00 |
The toner of embodiment 6 has 17 adult females to obtain improvement, and effect improving wrinkles are good.
(embodiment 7)
According to the formula of table 7 below, the creams of embodiment 7 have been made.For the creams of obtained embodiment 7, carry out
Stating wrinkle improves experiment and skin irritation test.
[table 7]
Composition name | Compounding amount (quality %) |
Purified water | 48.80 |
1,3 butylene glycol | 6.00 |
PEG1500 | 4.00 |
Stearyl alcohol | 6.00 |
Stearic acid | 2.00 |
Hydrogenated lanolin | 4.00 |
Saualane | 9.00 |
Octyl dodecanol | 10.00 |
POE (25) spermaceti alcohol ether | 3.00 |
Glycerin monostearate | 2.00 |
Methyl p-hydroxybenzoate | 0.30 |
Phenoxyethanol | 0.30 |
Elastin laminin (powder) | 0.50 |
Anserine | 1.00 |
Carnosine | 1.00 |
Valine | 0.50 |
L-Leu | 1.00 |
ILE | 0.50 |
Vanillyl alcohol butyl ether | 0.10 |
Amount to | 100.00 |
The creams of embodiment 7 have 18 adult females to obtain improvement, and effect improving wrinkles are good.The breast of embodiment 7
The skin irritation evaluation of frost is equally divided into 4.7 points, is low irritant.
(embodiment 8)
According to the formula of table 8 below, the creams of embodiment 8 have been made.For the creams of obtained embodiment 8, carry out
Stating wrinkle improves experiment and skin irritation test.
[table 8]
Composition name | Compounding amount (quality %) |
Purified water | 65.49 |
1,3 butylene glycol | 5.00 |
Stearyl alcohol | 4.00 |
Stearic acid | 8.00 |
Butyl stearate | 6.00 |
Glycerin monostearate | 2.00 |
Potassium hydroxide | 0.40 |
Methyl p-hydroxybenzoate | 0.30 |
Phenoxyethanol | 0.30 |
Elastin laminin (powder) | 0.50 |
Anserine | 1.00 |
Carnosine | 1.00 |
Valine | 1.00 |
L-Leu | 2.00 |
ILE | 1.00 |
N-acetyl-glucosamine | 2.00 |
Vanillyl alcohol butyl ether | 0.01 |
Amount to | 100.00 |
The creams of embodiment 8 have 19 adult females to obtain improvement, and effect improving wrinkles are good.The breast of embodiment 8
The skin irritation evaluation of frost is equally divided into 4.9 points, is low irritant.
(embodiment 9)
According to the formula of table 9 below, the beautifying liquid of embodiment 9 has been made.For the beautifying liquid of obtained embodiment 9, enter
The above-mentioned wrinkle of row improves experiment and skin irritation test.
[table 9]
Composition name | Compounding amount (quality %) |
Purified water | 64.90 |
1,3 butylene glycol | 5.00 |
D-sorbite | 8.00 |
PEG1500 | 7.00 |
Olive oil | 0.20 |
POE oleyl alcohol ethers | 1.00 |
Ethanol | 7.00 |
Methyl p-hydroxybenzoate | 0.30 |
Elastin laminin (powder) | 0.50 |
Anserine | 1.00 |
Carnosine | 1.00 |
Valine | 1.00 |
L-Leu | 2.00 |
ILE | 1.00 |
Vanillyl alcohol butyl ether | 0.10 |
Amount to | 100.00 |
The beautifying liquid of embodiment 9 has 17 adult females to obtain improvement, and effect improving wrinkles are good.Embodiment 9
The skin irritation evaluation of beautifying liquid is equally divided into 4.7 points, is low irritant.
(embodiment 10)
According to the formula of table 10 below, the beautifying liquid of embodiment 10 has been made.For the beautifying liquid of obtained embodiment 10,
Carrying out above-mentioned wrinkle improves experiment.
[table 10]
Composition name | Compounding amount (quality %) |
Purified water | 64.70 |
1,3 butylene glycol | 6.00 |
Stearic acid | 3.00 |
Cetanol | 1.00 |
Hydrogenated lanolin | 3.00 |
Saualane | 5.00 |
Stearic acid -2- ethylhexyls | 3.00 |
POE spermaceti alcohol ethers | 2.00 |
Glycerin monostearate | 2.00 |
Triethanolamine | 1.00 |
Methyl p-hydroxybenzoate | 0.30 |
Elastin laminin (powder) | 0.50 |
Anserine | 1.00 |
Carnosine | 1.00 |
Valine | 1.00 |
L-Leu | 2.00 |
ILE | 1.00 |
N-acetyl-glucosamine | 2.00 |
Vanillyl alcohol butyl ether | 0.50 |
Amount to | 100.00 |
The beautifying liquid of embodiment 10 has 18 adult females to obtain improvement, and effect improving wrinkles are good.
Claims (5)
1. a kind of face skin preparations for extenal use for being compounded with amino acid, it is characterised in that it contains:(A) amino acid and (B) vanilla
Alcohol butyl ether,
(A) amino acid is valine, leucine and isoleucine.
2. the face skin preparations for extenal use according to claim 1 for being compounded with amino acid, it is characterised in that it also contains
(C) any one of imidazole peptide and (D) elastin laminin or both.
3. the face skin preparations for extenal use according to claim 1 or 2 for being compounded with amino acid, it is characterised in that as institute
(A) amino acid is stated, contains the mass % of valine 0.1~2.0, the mass % of leucine 0.1~4.0 and the matter of isoleucine 0.1~2.0
% is measured, contains the mass % of (B) vanillyl alcohol butyl ether 0.001~1.0.
4. the face skin preparations for extenal use according to claim 1 or 2 for being compounded with amino acid, it is characterised in that it is eye
Week skin preparations for extenal use.
5. the face skin preparations for extenal use according to claim 3 for being compounded with amino acid, it is characterised in that it is used for eye circumference
Skin preparations for extenal use.
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JP2015-242786 | 2015-12-14 | ||
JP2015242786A JP5966231B1 (en) | 2015-12-14 | 2015-12-14 | Amino acid-containing facial skin preparation |
PCT/JP2016/086566 WO2017104537A1 (en) | 2015-12-14 | 2016-12-08 | Amino acid-containing external skin preparation for face |
Publications (2)
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CN107708659B CN107708659B (en) | 2020-07-03 |
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CN201680038189.0A Expired - Fee Related CN107708659B (en) | 2015-12-14 | 2016-12-08 | External preparation for facial skin containing amino acids |
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JP (1) | JP5966231B1 (en) |
KR (1) | KR20180010255A (en) |
CN (1) | CN107708659B (en) |
HK (1) | HK1246172A1 (en) |
TW (1) | TWI641391B (en) |
WO (1) | WO2017104537A1 (en) |
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CN112188891A (en) * | 2018-04-04 | 2021-01-05 | 佛罗里达大学研究基金会公司 | Composition for treating skin |
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US11123272B2 (en) * | 2016-12-02 | 2021-09-21 | Symrise Ag | Cosmetic blends |
JPWO2022025109A1 (en) * | 2020-07-29 | 2022-02-03 |
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JP2008069134A (en) * | 2006-09-15 | 2008-03-27 | Noevir Co Ltd | Composition for slimming body |
CN101166427A (en) * | 2005-04-22 | 2008-04-23 | 烧津水产化学工业株式会社 | Taste improving agent for food and beverage containing potassium chloride, process for producing food and beverage containing potassium chloride and food and beverage containing potassium chloride pro |
JP2011042588A (en) * | 2009-08-19 | 2011-03-03 | Kenzo Ito | Moisturizing cosmetic |
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JP2001115197A (en) * | 1999-10-14 | 2001-04-24 | Take:Kk | Soap |
JP2002020277A (en) * | 2000-06-30 | 2002-01-23 | Lion Corp | External preparation composition |
JP4077282B2 (en) * | 2001-09-21 | 2008-04-16 | 花王株式会社 | Vanillyl ether derivative |
JP2004161709A (en) * | 2002-11-15 | 2004-06-10 | Pola Chem Ind Inc | Cosmetic kit for ameliorating edema |
JP4138679B2 (en) * | 2004-02-25 | 2008-08-27 | 株式会社資生堂 | Irritation relief agent |
JP4809161B2 (en) * | 2006-08-29 | 2011-11-09 | 富士フイルム株式会社 | Topical skin preparation |
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- 2015-12-14 JP JP2015242786A patent/JP5966231B1/en active Active
-
2016
- 2016-12-08 WO PCT/JP2016/086566 patent/WO2017104537A1/en active Application Filing
- 2016-12-08 KR KR1020177036995A patent/KR20180010255A/en not_active Application Discontinuation
- 2016-12-08 CN CN201680038189.0A patent/CN107708659B/en not_active Expired - Fee Related
- 2016-12-12 TW TW105141102A patent/TWI641391B/en not_active IP Right Cessation
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CN101166427A (en) * | 2005-04-22 | 2008-04-23 | 烧津水产化学工业株式会社 | Taste improving agent for food and beverage containing potassium chloride, process for producing food and beverage containing potassium chloride and food and beverage containing potassium chloride pro |
JP2008069134A (en) * | 2006-09-15 | 2008-03-27 | Noevir Co Ltd | Composition for slimming body |
JP2011042588A (en) * | 2009-08-19 | 2011-03-03 | Kenzo Ito | Moisturizing cosmetic |
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HK1246172A1 (en) | 2018-09-07 |
TWI641391B (en) | 2018-11-21 |
CN107708659B (en) | 2020-07-03 |
KR20180010255A (en) | 2018-01-30 |
WO2017104537A1 (en) | 2017-06-22 |
TW201720418A (en) | 2017-06-16 |
JP5966231B1 (en) | 2016-08-10 |
JP2017109927A (en) | 2017-06-22 |
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