JP2017108748A5 - - Google Patents
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- JP2017108748A5 JP2017108748A5 JP2017018800A JP2017018800A JP2017108748A5 JP 2017108748 A5 JP2017108748 A5 JP 2017108748A5 JP 2017018800 A JP2017018800 A JP 2017018800A JP 2017018800 A JP2017018800 A JP 2017018800A JP 2017108748 A5 JP2017108748 A5 JP 2017108748A5
- Authority
- JP
- Japan
- Prior art keywords
- probe
- tag
- reverse
- labeled
- ligation product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000523 sample Substances 0.000 claims 39
- 238000000034 method Methods 0.000 claims 20
- 230000037452 priming Effects 0.000 claims 10
- 230000007614 genetic variation Effects 0.000 claims 6
- 230000003321 amplification Effects 0.000 claims 5
- 238000003199 nucleic acid amplification method Methods 0.000 claims 5
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 239000000758 substrate Substances 0.000 claims 3
- 108060002716 Exonuclease Proteins 0.000 claims 2
- 208000036878 aneuploidy Diseases 0.000 claims 2
- 231100001075 aneuploidy Toxicity 0.000 claims 2
- 102000013165 exonuclease Human genes 0.000 claims 2
- 230000002068 genetic effect Effects 0.000 claims 2
- 238000002372 labelling Methods 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 201000010374 Down Syndrome Diseases 0.000 claims 1
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 claims 1
- 201000006360 Edwards syndrome Diseases 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000009928 Patau syndrome Diseases 0.000 claims 1
- 206010070863 Toxicity to various agents Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 206010044686 Trisomy 13 Diseases 0.000 claims 1
- 208000006284 Trisomy 13 Syndrome Diseases 0.000 claims 1
- 208000007159 Trisomy 18 Syndrome Diseases 0.000 claims 1
- 206010044688 Trisomy 21 Diseases 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- 210000003754 fetus Anatomy 0.000 claims 1
- 230000003100 immobilizing effect Effects 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 206010053884 trisomy 18 Diseases 0.000 claims 1
- 208000026485 trisomy X Diseases 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361867559P | 2013-08-19 | 2013-08-19 | |
| US201361867554P | 2013-08-19 | 2013-08-19 | |
| US61/867,559 | 2013-08-19 | ||
| US61/867,554 | 2013-08-19 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016536393A Division JP6088710B2 (ja) | 2013-08-19 | 2014-08-19 | 単分子検出アッセイおよびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017108748A JP2017108748A (ja) | 2017-06-22 |
| JP2017108748A5 true JP2017108748A5 (https=) | 2018-02-08 |
| JP6397065B2 JP6397065B2 (ja) | 2018-09-26 |
Family
ID=52484110
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016536393A Active JP6088710B2 (ja) | 2013-08-19 | 2014-08-19 | 単分子検出アッセイおよびその使用 |
| JP2017018800A Active JP6397065B2 (ja) | 2013-08-19 | 2017-02-03 | 単分子検出アッセイおよびその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016536393A Active JP6088710B2 (ja) | 2013-08-19 | 2014-08-19 | 単分子検出アッセイおよびその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US9212394B2 (https=) |
| EP (3) | EP3036545B1 (https=) |
| JP (2) | JP6088710B2 (https=) |
| CN (2) | CN105659091A (https=) |
| AU (2) | AU2014308980C1 (https=) |
| BR (1) | BR112016003480B1 (https=) |
| CA (1) | CA2921628A1 (https=) |
| ES (2) | ES2739430T3 (https=) |
| IL (3) | IL285521B2 (https=) |
| MX (2) | MX371428B (https=) |
| SG (1) | SG11201601201VA (https=) |
| WO (1) | WO2015026873A1 (https=) |
| ZA (1) | ZA201601029B (https=) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11111543B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
| US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12221653B2 (en) | 2010-05-18 | 2025-02-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12152275B2 (en) | 2010-05-18 | 2024-11-26 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| AU2011358564B9 (en) | 2011-02-09 | 2017-07-13 | Natera, Inc | Methods for non-invasive prenatal ploidy calling |
| WO2013106807A1 (en) | 2012-01-13 | 2013-07-18 | Curry John D | Scalable characterization of nucleic acids by parallel sequencing |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| US20140100126A1 (en) | 2012-08-17 | 2014-04-10 | Natera, Inc. | Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data |
| WO2015026873A1 (en) | 2013-08-19 | 2015-02-26 | Singular Bio, Inc. | Assays for single molecule detection and use thereof |
| EP3957749A1 (en) | 2014-04-21 | 2022-02-23 | Natera, Inc. | Detecting tumour specific mutations in biopsies with whole exome sequencing and in cell-free samples |
| US12492429B2 (en) | 2014-04-21 | 2025-12-09 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| US20180173845A1 (en) | 2014-06-05 | 2018-06-21 | Natera, Inc. | Systems and Methods for Detection of Aneuploidy |
| ES2741400T3 (es) | 2014-07-18 | 2020-02-10 | Univ Hong Kong Chinese | Análisis de patrones de metilación de tejidos en mezcla de ADN |
| US10364467B2 (en) | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
| CN107735497B (zh) | 2015-02-18 | 2021-08-20 | 卓异生物公司 | 用于单分子检测的测定及其应用 |
| AU2016229372B2 (en) | 2015-03-06 | 2020-01-30 | Pillar Biosciences Inc. | Selective amplification of overlapping amplicons |
| US10221448B2 (en) | 2015-03-06 | 2019-03-05 | Pillar Biosciences Inc. | Selective amplification of overlapping amplicons |
| WO2016183106A1 (en) | 2015-05-11 | 2016-11-17 | Natera, Inc. | Methods and compositions for determining ploidy |
| JP6310099B2 (ja) | 2015-07-07 | 2018-04-11 | ピラー バイオサイエンシズ インコーポレイティド | プライマーダイマーの増幅を低減する方法 |
| US11118216B2 (en) * | 2015-09-08 | 2021-09-14 | Affymetrix, Inc. | Nucleic acid analysis by joining barcoded polynucleotide probes |
| WO2017181202A2 (en) | 2016-04-15 | 2017-10-19 | Natera, Inc. | Methods for lung cancer detection |
| CN106053405B (zh) * | 2016-05-10 | 2018-10-02 | 东南大学 | 一种基于单分子定位法的超分辨光学成像方法 |
| US20190284552A1 (en) * | 2016-05-26 | 2019-09-19 | Singular Bio, Inc. | Arrays for Single Molecule Detection and Uses Thereof |
| US11254973B2 (en) | 2016-09-02 | 2022-02-22 | Invitae Corporation | Systems and methods for single molecule quantification |
| GB201618485D0 (en) | 2016-11-02 | 2016-12-14 | Ucl Business Plc | Method of detecting tumour recurrence |
| WO2018099418A1 (en) | 2016-11-30 | 2018-06-07 | The Chinese University Of Hong Kong | Analysis of cell-free dna in urine and other samples |
| US11093307B2 (en) * | 2016-12-08 | 2021-08-17 | Accenture Global Solutions Limited | Platform for supporting multiple virtual agent applications |
| WO2018170518A1 (en) * | 2017-03-17 | 2018-09-20 | Apton Biosystems, Inc. | Sequencing and high resolution imaging |
| AU2018288832B2 (en) | 2017-06-20 | 2025-03-06 | The Medical College Of Wisconsin, Inc. | Assessing transplant complication risk with total cell-free DNA |
| JP2021506342A (ja) | 2017-12-14 | 2021-02-22 | ティーエーアイ ダイアグノスティックス インコーポレイテッドＴａｉ Ｄｉａｇｎｏｓｔｉｃｓ，Ｉｎｃ． | 移植のための移植片適合性の評価 |
| US11639928B2 (en) | 2018-02-22 | 2023-05-02 | 10X Genomics, Inc. | Methods and systems for characterizing analytes from individual cells or cell populations |
| US10871485B2 (en) | 2018-04-13 | 2020-12-22 | Rarecyte, Inc. | Kits for labeling of biomarkers and methods of using the same |
| CA3090426A1 (en) | 2018-04-14 | 2019-10-17 | Natera, Inc. | Methods for cancer detection and monitoring by means of personalized detection of circulating tumor dna |
| US12234509B2 (en) | 2018-07-03 | 2025-02-25 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
| EP3591401A1 (de) * | 2018-07-06 | 2020-01-08 | Euroimmun Medizinische Labordiagnostika AG | Verfahren zum automatisierten detektieren von antikörpern in einer flüssigen biologischen probe unter verwendung eines antigen-chips und antigen-chip hierfür |
| US11931674B2 (en) | 2019-04-04 | 2024-03-19 | Natera, Inc. | Materials and methods for processing blood samples |
| JPWO2021117667A1 (https=) * | 2019-12-09 | 2021-06-17 | ||
| US11475981B2 (en) | 2020-02-18 | 2022-10-18 | Tempus Labs, Inc. | Methods and systems for dynamic variant thresholding in a liquid biopsy assay |
| US11211144B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Methods and systems for refining copy number variation in a liquid biopsy assay |
| US11211147B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing |
| CN112419235B (zh) * | 2020-10-22 | 2024-07-23 | 南京大学 | 一种精子活性检测系统及方法 |
| CN112345766B (zh) * | 2020-10-22 | 2024-02-02 | 中国工程物理研究院核物理与化学研究所 | 一种荧光-放射性联用的体外靶向筛选方法 |
| CN120158497A (zh) | 2021-02-23 | 2025-06-17 | 10X基因组学有限公司 | 基于探针的核酸和蛋白质分析 |
| EP4400599A3 (en) * | 2021-05-20 | 2024-08-28 | Sophia Genetics S.A. | Capture probes and uses thereof |
| AU2022400954A1 (en) * | 2021-12-01 | 2024-07-11 | Siscapa Assay Technologies, Inc. | Enriched peptide detection by single molecule sequencing |
| WO2024050553A1 (en) * | 2022-09-01 | 2024-03-07 | The Johns Hopkins University | Methods for measuring telomere length |
| WO2025199499A1 (en) * | 2024-03-22 | 2025-09-25 | Orbit Genomics, Inc. | Methods and systems for sample classification |
Family Cites Families (100)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8810400D0 (en) | 1988-05-03 | 1988-06-08 | Southern E | Analysing polynucleotide sequences |
| US5547839A (en) | 1989-06-07 | 1996-08-20 | Affymax Technologies N.V. | Sequencing of surface immobilized polymers utilizing microflourescence detection |
| US5256536A (en) | 1990-11-09 | 1993-10-26 | Syntex (U.S.A.) Inc. | Nucleotide probe for Neisseria gonrrhoeae |
| DE69132531T2 (de) | 1990-12-06 | 2001-09-13 | Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) | Verbindungen und ihre Verwendung in einer binären Synthesestrategie |
| US6582908B2 (en) | 1990-12-06 | 2003-06-24 | Affymetrix, Inc. | Oligonucleotides |
| EP0566670A4 (en) | 1990-12-17 | 1993-12-08 | Idexx Laboratories, Inc. | Nucleic acid sequence detection by triple helix formation |
| WO1993017126A1 (en) | 1992-02-19 | 1993-09-02 | The Public Health Research Institute Of The City Of New York, Inc. | Novel oligonucleotide arrays and their use for sorting, isolating, sequencing, and manipulating nucleic acids |
| US5670330A (en) | 1992-09-29 | 1997-09-23 | Mcgill University | Anti-tumor agent assay using PKR |
| US5681943A (en) | 1993-04-12 | 1997-10-28 | Northwestern University | Method for covalently linking adjacent oligonucleotides |
| WO1996027025A1 (en) | 1995-02-27 | 1996-09-06 | Ely Michael Rabani | Device, compounds, algorithms, and methods of molecular characterization and manipulation with molecular parallelism |
| DE69638321D1 (de) | 1995-10-11 | 2011-03-03 | Luminex Corp | Gleichzeitige mehrfachanalyse klinischer proben |
| EP2332958B1 (en) * | 1996-02-09 | 2016-04-20 | Cornell Research Foundation, Inc. | Detection of nucleic and sequence differences using the ligase detection reaction with addressable arrays |
| EP1736554B1 (en) * | 1996-05-29 | 2013-10-09 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions |
| US6706473B1 (en) | 1996-12-06 | 2004-03-16 | Nanogen, Inc. | Systems and devices for photoelectrophoretic transport and hybridization of oligonucleotides |
| US6028189A (en) | 1997-03-20 | 2000-02-22 | University Of Washington | Solvent for oligonucleotide synthesis and methods of use |
| US20020055100A1 (en) | 1997-04-01 | 2002-05-09 | Kawashima Eric H. | Method of nucleic acid sequencing |
| CA2243985C (en) | 1997-09-11 | 2004-08-10 | F. Hoffmann-La Roche Ag | Thermostable dna polymerases incorporating nucleoside triphosphates labeled with fluorescein family dyes |
| US6465178B2 (en) | 1997-09-30 | 2002-10-15 | Surmodics, Inc. | Target molecule attachment to surfaces |
| US6238869B1 (en) | 1997-12-19 | 2001-05-29 | High Throughput Genomics, Inc. | High throughput assay system |
| US6268146B1 (en) | 1998-03-13 | 2001-07-31 | Promega Corporation | Analytical methods and materials for nucleic acid detection |
| US6284497B1 (en) | 1998-04-09 | 2001-09-04 | Trustees Of Boston University | Nucleic acid arrays and methods of synthesis |
| GB0002310D0 (en) | 2000-02-01 | 2000-03-22 | Solexa Ltd | Polynucleotide sequencing |
| WO2000006770A1 (en) | 1998-07-30 | 2000-02-10 | Solexa Ltd. | Arrayed biomolecules and their use in sequencing |
| WO2000036151A1 (en) | 1998-12-14 | 2000-06-22 | Li-Cor, Inc. | A heterogeneous assay for pyrophosphate detection |
| US6432642B1 (en) | 1999-01-15 | 2002-08-13 | Pe Corporation (Ny) | Binary probe and clamp composition and methods for a target hybridization detection |
| US6506594B1 (en) * | 1999-03-19 | 2003-01-14 | Cornell Res Foundation Inc | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
| US6238868B1 (en) | 1999-04-12 | 2001-05-29 | Nanogen/Becton Dickinson Partnership | Multiplex amplification and separation of nucleic acid sequences using ligation-dependant strand displacement amplification and bioelectronic chip technology |
| US20060275782A1 (en) | 1999-04-20 | 2006-12-07 | Illumina, Inc. | Detection of nucleic acid reactions on bead arrays |
| US20020086289A1 (en) | 1999-06-15 | 2002-07-04 | Don Straus | Genomic profiling: a rapid method for testing a complex biological sample for the presence of many types of organisms |
| US6818395B1 (en) | 1999-06-28 | 2004-11-16 | California Institute Of Technology | Methods and apparatus for analyzing polynucleotide sequences |
| US6495320B1 (en) | 1999-07-21 | 2002-12-17 | Affymetrix, Inc. | Even length proportional amplification of nucleic acids |
| WO2001023610A2 (en) | 1999-09-29 | 2001-04-05 | Solexa Ltd. | Polynucleotide sequencing |
| GB0002389D0 (en) | 2000-02-02 | 2000-03-22 | Solexa Ltd | Molecular arrays |
| US7582420B2 (en) | 2001-07-12 | 2009-09-01 | Illumina, Inc. | Multiplex nucleic acid reactions |
| US6913884B2 (en) | 2001-08-16 | 2005-07-05 | Illumina, Inc. | Compositions and methods for repetitive use of genomic DNA |
| EP1990428B1 (en) | 2000-02-07 | 2010-12-22 | Illumina, Inc. | Nucleic acid detection methods using universal priming |
| US7955794B2 (en) | 2000-09-21 | 2011-06-07 | Illumina, Inc. | Multiplex nucleic acid reactions |
| EP1303639A2 (en) | 2000-04-14 | 2003-04-23 | Cornell Research Foundation, Inc. | Method of designing addressable array for detection of nucleic acid sequence differences using ligase detection reaction |
| EP1313880A2 (en) * | 2000-05-30 | 2003-05-28 | PE Corporation (NY) | Methods for detecting target nucleic acids using coupled ligation and amplification |
| US6635425B2 (en) | 2001-01-05 | 2003-10-21 | Molecular Staging, Inc. | 5′-thio phosphate directed ligation of oligonucleotides and use in detection of single nucleotide polymorphisms |
| EP2801624B1 (en) | 2001-03-16 | 2019-03-06 | Singular Bio, Inc | Arrays and methods of use |
| EP1377686A4 (en) | 2001-04-12 | 2007-07-25 | Caliper Life Sciences Inc | SYSTEMS AND METHOD FOR GENETIC ANALYSIS WITH HIGH THROUGHPUT |
| CA2492048A1 (en) | 2002-07-18 | 2004-01-29 | The Board Of Trustees Of The Leland Stanford Junior University | Detection of chemical ligation using fluorescence quenching leaving groups |
| US7153658B2 (en) | 2002-09-19 | 2006-12-26 | Applera Corporation | Methods and compositions for detecting targets |
| AU2003267583A1 (en) * | 2002-09-19 | 2004-04-08 | The Chancellor, Master And Scholars Of The University Of Oxford | Molecular arrays and single molecule detection |
| EP2365095A1 (en) * | 2003-02-26 | 2011-09-14 | Callida Genomics, Inc. | Random array DNA analysis by hybridization |
| US7105024B2 (en) | 2003-05-06 | 2006-09-12 | Aesculap Ii, Inc. | Artificial intervertebral disc |
| EP1602733A1 (en) | 2004-06-02 | 2005-12-07 | Keygene N.V. | Detection of target nucleotide sequences using an asymmetric oligonucleotide ligation assay |
| WO2005026329A2 (en) * | 2003-09-12 | 2005-03-24 | Cornell Research Foundation, Inc. | Methods for identifying target nucleic acid molecules |
| DE60328193D1 (de) | 2003-10-16 | 2009-08-13 | Sequenom Inc | Nicht invasiver Nachweis fötaler genetischer Merkmale |
| US8192937B2 (en) | 2004-04-07 | 2012-06-05 | Exiqon A/S | Methods for quantification of microRNAs and small interfering RNAs |
| WO2006014869A1 (en) * | 2004-07-26 | 2006-02-09 | Parallele Bioscience, Inc. | Simultaneous analysis of multiple genomes |
| CA2601735C (en) * | 2005-03-18 | 2015-10-06 | The Chinese University Of Hong Kong | Markers for prenatal diagnosis and monitoring of trisomy 21 |
| CN1824786A (zh) * | 2005-12-23 | 2006-08-30 | 上海生物芯片有限公司 | 基于连接的选择性扩增方法 |
| US20080038733A1 (en) | 2006-03-28 | 2008-02-14 | Baylor College Of Medicine | Screening for down syndrome |
| WO2007147074A2 (en) * | 2006-06-14 | 2007-12-21 | Living Microsystems, Inc. | Use of highly parallel snp genotyping for fetal diagnosis |
| US8137912B2 (en) * | 2006-06-14 | 2012-03-20 | The General Hospital Corporation | Methods for the diagnosis of fetal abnormalities |
| JP5165933B2 (ja) * | 2007-06-12 | 2013-03-21 | 日本碍子株式会社 | 標的核酸中の特定部分配列の検出方法及びアレイ |
| EP2176281A4 (en) | 2007-07-11 | 2010-09-15 | Univ Laval | NUCLEIC ACID SEQUENCES AND COMBINATION THEREOF FOR SENSITIVE AMPLIFICATION AND SENSITIVE DETECTION OF BACTERIAL AND MIRACLE SEPSISPATHOGENESE |
| US20100297585A1 (en) | 2008-01-29 | 2010-11-25 | Uriel Yarovesky | Process for making a dental restoration and resultant apparatus |
| JP5319148B2 (ja) * | 2008-03-27 | 2013-10-16 | 日本碍子株式会社 | 標的核酸中の変異の検出方法及びアレイ |
| US20120252015A1 (en) | 2011-02-18 | 2012-10-04 | Bio-Rad Laboratories | Methods and compositions for detecting genetic material |
| CA2742726A1 (en) | 2008-11-05 | 2010-05-14 | Stichting Sanquin Bloedvoorziening | Means and methods for investigating nucleic acid sequences |
| US20100273164A1 (en) | 2009-03-24 | 2010-10-28 | President And Fellows Of Harvard College | Targeted and Whole-Genome Technologies to Profile DNA Cytosine Methylation |
| EP2443457A4 (en) | 2009-06-18 | 2012-10-31 | Penn State Res Found | METHODS, SYSTEMS AND KITS FOR DETECTING PROTEIN NUCLEIC ACID INTERACTIONS |
| JP5613160B2 (ja) * | 2009-07-09 | 2014-10-22 | 日本碍子株式会社 | ゲノムｄｎａ中の標的配列の検出又は解析方法 |
| CN101864482A (zh) * | 2010-02-10 | 2010-10-20 | 深圳出入境检验检疫局动植物检验检疫技术中心 | Mlcr探针、二步反应模式和悬浮芯片检测用捕获探针 |
| US20140186827A1 (en) * | 2010-05-14 | 2014-07-03 | Fluidigm, Inc. | Assays for the detection of genotype, mutations, and/or aneuploidy |
| CA2801039A1 (en) | 2010-06-07 | 2011-12-15 | Esoterix Genetic Laboratories, Llc | Enumeration of nucleic acids |
| CN103069006A (zh) * | 2010-07-23 | 2013-04-24 | 艾索特里克斯遗传实验室有限责任公司 | 区别表达的胚胎或母源基因组区的鉴定及其用途 |
| US20130261003A1 (en) | 2010-08-06 | 2013-10-03 | Ariosa Diagnostics, In. | Ligation-based detection of genetic variants |
| US20120034603A1 (en) | 2010-08-06 | 2012-02-09 | Tandem Diagnostics, Inc. | Ligation-based detection of genetic variants |
| US10167508B2 (en) | 2010-08-06 | 2019-01-01 | Ariosa Diagnostics, Inc. | Detection of genetic abnormalities |
| US20120190557A1 (en) | 2011-01-25 | 2012-07-26 | Aria Diagnostics, Inc. | Risk calculation for evaluation of fetal aneuploidy |
| US8700338B2 (en) | 2011-01-25 | 2014-04-15 | Ariosa Diagnosis, Inc. | Risk calculation for evaluation of fetal aneuploidy |
| US20140342940A1 (en) | 2011-01-25 | 2014-11-20 | Ariosa Diagnostics, Inc. | Detection of Target Nucleic Acids using Hybridization |
| US20130040375A1 (en) | 2011-08-08 | 2013-02-14 | Tandem Diagnotics, Inc. | Assay systems for genetic analysis |
| US20120077185A1 (en) | 2010-08-06 | 2012-03-29 | Tandem Diagnostics, Inc. | Detection of genetic abnormalities and infectious disease |
| WO2012021749A1 (en) * | 2010-08-11 | 2012-02-16 | Celula, Inc. | Genotyping dna |
| WO2012103031A2 (en) | 2011-01-25 | 2012-08-02 | Ariosa Diagnostics, Inc. | Detection of genetic abnormalities |
| US9994897B2 (en) | 2013-03-08 | 2018-06-12 | Ariosa Diagnostics, Inc. | Non-invasive fetal sex determination |
| US10131947B2 (en) | 2011-01-25 | 2018-11-20 | Ariosa Diagnostics, Inc. | Noninvasive detection of fetal aneuploidy in egg donor pregnancies |
| US11270781B2 (en) | 2011-01-25 | 2022-03-08 | Ariosa Diagnostics, Inc. | Statistical analysis for non-invasive sex chromosome aneuploidy determination |
| WO2012118745A1 (en) | 2011-02-28 | 2012-09-07 | Arnold Oliphant | Assay systems for detection of aneuploidy and sex determination |
| US8759036B2 (en) * | 2011-03-21 | 2014-06-24 | Affymetrix, Inc. | Methods for synthesizing pools of probes |
| WO2012135658A2 (en) | 2011-03-30 | 2012-10-04 | Noblegen Biosciences, Inc. | Sequence preserved dna conversion for optical nanopore sequencing |
| ES2556580T3 (es) | 2011-07-08 | 2016-01-19 | Keygene N.V. | Genotipado a base de secuencias en base a ensayos de ligación a oligonucleótidos |
| CA2850785C (en) | 2011-10-06 | 2022-12-13 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| CN104204228A (zh) | 2012-02-14 | 2014-12-10 | 康奈尔大学 | 使用组合的核酸酶、连接和聚合酶反应用于核酸序列的相对定量、表达或拷贝变化的方法 |
| US20130310262A1 (en) | 2012-05-21 | 2013-11-21 | Ariosa Diagnostics, Inc. | Noninvasive detection of robertsonian translocations |
| JP2015522293A (ja) | 2012-07-19 | 2015-08-06 | アリオサ ダイアグノスティックス インコーポレイテッドＡｒｉｏｓａ Ｄｉａｇｎｏｓｔｉｃｓ，Ｉｎｃ． | 多重化連続ライゲーションに基づく遺伝子変異体の検出 |
| CN102936755B (zh) * | 2012-10-19 | 2015-01-21 | 上海交通大学 | 一种单分子核酸芯片的制作方法 |
| WO2014089536A1 (en) | 2012-12-07 | 2014-06-12 | Invitae Corporation | Multiplex nucleic acid detection methods |
| US20140242582A1 (en) | 2013-02-28 | 2014-08-28 | Ariosa Diagnostics, Inc. | Detection of genetic abnormalities using ligation-based detection and digital pcr |
| JP6441893B2 (ja) | 2013-03-19 | 2018-12-19 | ディレクティド・ジェノミクス・エル・エル・シー | 標的配列の濃縮 |
| TWI707038B (zh) | 2013-08-05 | 2020-10-11 | 美商扭轉生物科技有限公司 | 重新合成之基因庫 |
| WO2015026873A1 (en) * | 2013-08-19 | 2015-02-26 | Singular Bio, Inc. | Assays for single molecule detection and use thereof |
| EP3175236B1 (en) | 2014-08-01 | 2019-08-21 | Ariosa Diagnostics, Inc. | Detection of target nucleic acids using hybridization |
| WO2016070164A1 (en) | 2014-11-01 | 2016-05-06 | Singular Bio, Inc. | Assays for single molecule detection and use thereof |
| CN107735497B (zh) | 2015-02-18 | 2021-08-20 | 卓异生物公司 | 用于单分子检测的测定及其应用 |
-
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