JP2017095675A - 親水性多孔質ポリテトラフルオロエチレン膜(i) - Google Patents
親水性多孔質ポリテトラフルオロエチレン膜(i) Download PDFInfo
- Publication number
- JP2017095675A JP2017095675A JP2016118954A JP2016118954A JP2017095675A JP 2017095675 A JP2017095675 A JP 2017095675A JP 2016118954 A JP2016118954 A JP 2016118954A JP 2016118954 A JP2016118954 A JP 2016118954A JP 2017095675 A JP2017095675 A JP 2017095675A
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- Prior art keywords
- copolymer
- hydrophilic porous
- porous membrane
- membrane
- ptfe
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- 229920001343 polytetrafluoroethylene Polymers 0.000 title claims abstract description 49
- 239000004810 polytetrafluoroethylene Substances 0.000 title claims abstract description 49
- -1 polytetrafluoroethylene Polymers 0.000 title claims description 9
- 229920001577 copolymer Polymers 0.000 claims abstract description 52
- 238000000034 method Methods 0.000 claims abstract description 39
- 239000000203 mixture Substances 0.000 claims abstract description 24
- 238000000137 annealing Methods 0.000 claims abstract description 7
- 239000000314 lubricant Substances 0.000 claims abstract description 7
- 239000000126 substance Substances 0.000 claims abstract description 6
- 239000003795 chemical substances by application Substances 0.000 claims abstract 2
- 239000012528 membrane Substances 0.000 claims description 80
- 239000012530 fluid Substances 0.000 claims description 23
- 229920001400 block copolymer Polymers 0.000 claims description 15
- 238000001914 filtration Methods 0.000 claims description 13
- 229920005604 random copolymer Polymers 0.000 claims description 12
- 239000003814 drug Substances 0.000 claims description 3
- 229940079593 drug Drugs 0.000 claims description 3
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 230000008569 process Effects 0.000 abstract description 8
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- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 32
- 239000003054 catalyst Substances 0.000 description 29
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 27
- 239000000178 monomer Substances 0.000 description 25
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- 238000007152 ring opening metathesis polymerisation reaction Methods 0.000 description 20
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 20
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 18
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 15
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 13
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 12
- 229910052786 argon Inorganic materials 0.000 description 12
- 238000006116 polymerization reaction Methods 0.000 description 12
- FJKIXWOMBXYWOQ-UHFFFAOYSA-N ethenoxyethane Chemical compound CCOC=C FJKIXWOMBXYWOQ-UHFFFAOYSA-N 0.000 description 10
- 229920001519 homopolymer Polymers 0.000 description 10
- 239000002904 solvent Substances 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 238000005160 1H NMR spectroscopy Methods 0.000 description 9
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 9
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- 238000006243 chemical reaction Methods 0.000 description 8
- OJURWUUOVGOHJZ-UHFFFAOYSA-N methyl 2-[(2-acetyloxyphenyl)methyl-[2-[(2-acetyloxyphenyl)methyl-(2-methoxy-2-oxoethyl)amino]ethyl]amino]acetate Chemical compound C=1C=CC=C(OC(C)=O)C=1CN(CC(=O)OC)CCN(CC(=O)OC)CC1=CC=CC=C1OC(C)=O OJURWUUOVGOHJZ-UHFFFAOYSA-N 0.000 description 8
- 238000009736 wetting Methods 0.000 description 8
- 150000001412 amines Chemical class 0.000 description 7
- JFNLZVQOOSMTJK-KNVOCYPGSA-N norbornene Chemical compound C1[C@@H]2CC[C@H]1C=C2 JFNLZVQOOSMTJK-KNVOCYPGSA-N 0.000 description 7
- 125000005005 perfluorohexyl group Chemical group FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)* 0.000 description 7
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- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 6
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
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- 208000034628 Celiac artery compression syndrome Diseases 0.000 description 5
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- NIDNOXCRFUCAKQ-RNGGSSJXSA-N (1r,2r,3s,4s)-bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid Chemical compound C1[C@@H]2C=C[C@H]1[C@H](C(=O)O)[C@@H]2C(O)=O NIDNOXCRFUCAKQ-RNGGSSJXSA-N 0.000 description 4
- HECLRDQVFMWTQS-RGOKHQFPSA-N 1755-01-7 Chemical compound C1[C@H]2[C@@H]3CC=C[C@@H]3[C@@H]1C=C2 HECLRDQVFMWTQS-RGOKHQFPSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 4
- 239000002585 base Substances 0.000 description 4
- FCDPQMAOJARMTG-UHFFFAOYSA-M benzylidene-[1,3-bis(2,4,6-trimethylphenyl)imidazolidin-2-ylidene]-dichlororuthenium;tricyclohexylphosphanium Chemical compound C1CCCCC1[PH+](C1CCCCC1)C1CCCCC1.CC1=CC(C)=CC(C)=C1N(CCN1C=2C(=CC(C)=CC=2C)C)C1=[Ru](Cl)(Cl)=CC1=CC=CC=C1 FCDPQMAOJARMTG-UHFFFAOYSA-M 0.000 description 4
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- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 230000005526 G1 to G0 transition Effects 0.000 description 3
- 238000005481 NMR spectroscopy Methods 0.000 description 3
- UDWMGVWNYMTWDM-UHFFFAOYSA-N [Ru+2].CC1=CC(C)=CC(C)=C1N(CCN1C=2C(=CC(C)=CC=2C)C)C1=C1C(Cl)=C(Cl)N=C(C(C=2C=CC=CC=2)C=2C(=CC=CN=2)Br)C1Br Chemical compound [Ru+2].CC1=CC(C)=CC(C)=C1N(CCN1C=2C(=CC(C)=CC=2C)C)C1=C1C(Cl)=C(Cl)N=C(C(C=2C=CC=CC=2)C=2C(=CC=CN=2)Br)C1Br UDWMGVWNYMTWDM-UHFFFAOYSA-N 0.000 description 3
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 3
- 150000008064 anhydrides Chemical group 0.000 description 3
- BBWBEZAMXFGUGK-UHFFFAOYSA-N bis(dodecylsulfanyl)-methylarsane Chemical compound CCCCCCCCCCCCS[As](C)SCCCCCCCCCCCC BBWBEZAMXFGUGK-UHFFFAOYSA-N 0.000 description 3
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- 229910021641 deionized water Inorganic materials 0.000 description 3
- 150000004985 diamines Chemical class 0.000 description 3
- 238000001125 extrusion Methods 0.000 description 3
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- 239000011988 third-generation catalyst Substances 0.000 description 3
- 238000005292 vacuum distillation Methods 0.000 description 3
- RRKODOZNUZCUBN-CCAGOZQPSA-N (1z,3z)-cycloocta-1,3-diene Chemical compound C1CC\C=C/C=C\C1 RRKODOZNUZCUBN-CCAGOZQPSA-N 0.000 description 2
- QPFMBZIOSGYJDE-UHFFFAOYSA-N 1,1,2,2-tetrachloroethane Chemical compound ClC(Cl)C(Cl)Cl QPFMBZIOSGYJDE-UHFFFAOYSA-N 0.000 description 2
- CNPVJWYWYZMPDS-UHFFFAOYSA-N 2-methyldecane Chemical compound CCCCCCCCC(C)C CNPVJWYWYZMPDS-UHFFFAOYSA-N 0.000 description 2
- NYPYPOZNGOXYSU-UHFFFAOYSA-N 3-bromopyridine Chemical compound BrC1=CC=CN=C1 NYPYPOZNGOXYSU-UHFFFAOYSA-N 0.000 description 2
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
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- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 2
- PNPBGYBHLCEVMK-UHFFFAOYSA-N benzylidene(dichloro)ruthenium;tricyclohexylphosphanium Chemical compound Cl[Ru](Cl)=CC1=CC=CC=C1.C1CCCCC1[PH+](C1CCCCC1)C1CCCCC1.C1CCCCC1[PH+](C1CCCCC1)C1CCCCC1 PNPBGYBHLCEVMK-UHFFFAOYSA-N 0.000 description 2
- WTEOIRVLGSZEPR-UHFFFAOYSA-N boron trifluoride Chemical compound FB(F)F WTEOIRVLGSZEPR-UHFFFAOYSA-N 0.000 description 2
- 238000003490 calendering Methods 0.000 description 2
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- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
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- VVWRJUBEIPHGQF-UHFFFAOYSA-N propan-2-yl n-propan-2-yloxycarbonyliminocarbamate Chemical compound CC(C)OC(=O)N=NC(=O)OC(C)C VVWRJUBEIPHGQF-UHFFFAOYSA-N 0.000 description 2
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- 230000008685 targeting Effects 0.000 description 2
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- 150000003624 transition metals Chemical class 0.000 description 2
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 2
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 description 1
- PGEVTVXEERFABN-UHFFFAOYSA-N 1,1-dichloropentane Chemical compound CCCCC(Cl)Cl PGEVTVXEERFABN-UHFFFAOYSA-N 0.000 description 1
- RELMFMZEBKVZJC-UHFFFAOYSA-N 1,2,3-trichlorobenzene Chemical compound ClC1=CC=CC(Cl)=C1Cl RELMFMZEBKVZJC-UHFFFAOYSA-N 0.000 description 1
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical group ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 1
- ZRPFJAPZDXQHSM-UHFFFAOYSA-L 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazole;dichloro-[(2-propan-2-yloxyphenyl)methylidene]ruthenium Chemical compound CC(C)OC1=CC=CC=C1C=[Ru](Cl)(Cl)=C1N(C=2C(=CC(C)=CC=2C)C)CCN1C1=C(C)C=C(C)C=C1C ZRPFJAPZDXQHSM-UHFFFAOYSA-L 0.000 description 1
- OCJBOOLMMGQPQU-UHFFFAOYSA-N 1,4-dichlorobenzene Chemical compound ClC1=CC=C(Cl)C=C1 OCJBOOLMMGQPQU-UHFFFAOYSA-N 0.000 description 1
- WTFAGPBUAGFMQX-UHFFFAOYSA-N 1-[2-[2-(2-aminopropoxy)propoxy]propoxy]propan-2-amine Chemical group CC(N)COCC(C)OCC(C)OCC(C)N WTFAGPBUAGFMQX-UHFFFAOYSA-N 0.000 description 1
- HIDBROSJWZYGSZ-UHFFFAOYSA-N 1-phenylpyrrole-2,5-dione Chemical compound O=C1C=CC(=O)N1C1=CC=CC=C1 HIDBROSJWZYGSZ-UHFFFAOYSA-N 0.000 description 1
- FYQFWFHDPNXORA-UHFFFAOYSA-N 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C=C FYQFWFHDPNXORA-UHFFFAOYSA-N 0.000 description 1
- UCHSAVGOZUCXHC-UHFFFAOYSA-N 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,12-henicosafluorododec-1-ene Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C=C UCHSAVGOZUCXHC-UHFFFAOYSA-N 0.000 description 1
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- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G61/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
- C08G61/12—Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
- C08G61/122—Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule derived from five- or six-membered heterocyclic compounds, other than imides
- C08G61/123—Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule derived from five- or six-membered heterocyclic compounds, other than imides derived from five-membered heterocyclic compounds
- C08G61/125—Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule derived from five- or six-membered heterocyclic compounds, other than imides derived from five-membered heterocyclic compounds with a five-membered ring containing one oxygen atom in the ring
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
- B01D71/06—Organic material
- B01D71/76—Macromolecular material not specifically provided for in a single one of groups B01D71/08 - B01D71/74
- B01D71/80—Block polymers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
- B01D67/0002—Organic membrane manufacture
- B01D67/0006—Organic membrane manufacture by chemical reactions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
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Abstract
Description
のうちの1つ又は複数から選択され、Bが、式:
のものであり、
両親媒性コポリマーが、ブロックコポリマー又はランダムコポリマーであり、
A及びBのそれぞれの反復単位の数がn及びmであり、1〜約1000の範囲であるが、但しn及びmの合計が10以上であることを条件とする、親水性多孔質膜を提供する。
(i)PTFE及び両親媒性コポリマーを、任意選択で滑剤と共に含むブレンドを調製するステップと、
(ii)ブレンドをテープへと押出するステップと、
(iii)テープを二軸延伸して、親水性多孔質膜を得るステップと、任意選択で、
(iv)親水性多孔質膜を薬剤と反応させて、コポリマーの化学構造を改変するステップと、任意選択で、
(v)親水性多孔質膜をアニーリングするステップと
を含み、両親媒性コポリマーが、反復単位A及びBを含み、Aが以下の構造:
のうちの1つ又は複数から選択され、Bが、式:
のものであり、
両親媒性コポリマーが、ブロックコポリマー又はランダムコポリマーであり、
A及びBのそれぞれの反復単位の数がn及びmであり、1〜約1000の範囲であるが、但しn及びmの合計が10以上であることを条件とする、方法をさらに提供する。
のうちの1つ又は複数から選択され、Bが、式:
のものであり、
両親媒性コポリマーが、ブロックコポリマー又はランダムコポリマーであり、
A及びBのそれぞれの反復単位の数がn及びmであり、1〜約1000の範囲であるが、但しn及びmの合計が10以上であることを条件とする、親水性多孔質膜を提供する。
のうちの1つを有し、式中、m1+m2=mである。
が挙げられる。
である。
から選択されるセグメントAを有するブロックコポリマーは、以下を含む方法で調製することができる。
[0022](ii)ROMP触媒で触媒された(i)5−(ペルフルオロヘキシル)ノルボルネンにおいて得られたホモポリマーの鎖端に連続的に重合するステップ。
を伴うセグメントAを有するコポリマーを得ることができる。
のコポリマーは、以下を含む方法で調製することができる。
(i)シス−5−オキサノルボルネン−エキソ−2,3−ジカルボン酸無水物を、開環メタセシス重合(ROMP)触媒で触媒することで重合させて、ホモポリマーを得るステップ、並びに
(ii)下に図示されるように、ROMP触媒で触媒された(i)5−(ペルフルオロヘキシル)ノルボルネンにおいて得られたホモポリマーの鎖端に重合するステップ。
(i)シス−5−ノルボルネン−エキソ−2,3−ジカルボン酸のジメチルエステルを、開環メタセシス重合(ROMP)触媒で触媒することで重合させて、ホモポリマーを得るステップ、並びに
(ii)下に図示されるように、ROMP触媒で触媒された(i)5−(ペルフルオロヘキシル)ノルボルネンにおいて得られたホモポリマーの鎖端に重合するステップ。
(i)シス−5−オキサノルボルネン−エキソ−2,3−ジカルボン酸のジメチルエステルを、ROMP触媒で触媒することで重合させて、ホモポリマーを得るステップ、並びに
(ii)ROMP触媒で触媒された(i)5−(ペルフルオロヘキシル)ノルボルネンにおいて得られたホモポリマーの鎖端に重合するステップ。
(i)PTFE及び両親媒性コポリマーを、任意選択で滑剤と共に含むブレンドを調製するステップと、
(ii)ブレンドをテープへと押出するステップと、
(iii)テープを二軸延伸して、親水性多孔質膜を得るステップと、任意選択で、
(iv)親水性多孔質膜を薬剤と反応させて、コポリマーの化学構造を改変するステップと、任意選択で、
(v)親水性多孔質膜をアニーリングするステップとを含み、
両親媒性コポリマーが、反復単位A及びBを含み、Aが以下の構造:
のうちの1つ又は複数から選択され、Bが、式:
のものであり、
両親媒性コポリマーが、ブロックコポリマー又はランダムコポリマーであり、
A及びBのそれぞれの反復単位の数がn及びmであり、1〜約1000の範囲であるが、但しn及びmの合計が10以上であることを条件とする、方法をさらに提供する。
[0059]材料:以下の材料を購入し、受け取ったままで使用した。
[0062]この実施例は、ジクロロ[1,3−ビス(2,4,6−トリメチルフェニル)−2−イミダゾリジニリデン](ベンジリデン)ビス(3−ブロモピリジン)ルテニウム(II)(G3)触媒の調製を例証する。
[0064]この実施例は、本発明の実施形態によるホモポリマー及びコポリマーのゲル浸透クロマトグラフ特性を例証する。
[0066]移動相:ジクロロメタン(DCM)。
[0067]移動相温度:30℃。
[0068]UV波長:245nm。
[0069]使用したカラム:3つのPSS SVD Lux分析カラム(スチレン−ジビニルベンゼンコポリマーネットワーク)、直径5μm及び1000A、100,000A、及び1,000,000Aの孔径のビーズを固定相として有するカラム、並びにガードカラム。
[0070]流量:1mL/分。
[0071]GPCシステム:UV及びRI検出器を有するwaters HPLC alliance e2695システム
[0072]MALSシステム:664.5nmのレーザーを操作する8つの検出器を有するThe DAWN HELEOS 8システム。
[0073]この実施例は、本発明の実施形態によるNPF6モノマーを調製するための手順について例証する。
[0076]この実施例は、本発明の実施形態によるNPF10モノマーを調製するための手順について例証する。
[0079]この実施例は、本発明の実施形態によるC2モノマーを調製するための手順について例証する。
[0081]この実施例は、C2モノマーのジメチルエステルである、本発明の実施形態によるC4モノマーを調製するための手順について例証する。
[0083]この実施例は、本発明の実施形態によるコポリマー、ポリ(C2−b−NPF6)の合成及び特性を例証する。
[0087]この実施例は、本発明の実施形態による別のコポリマー、ポリ(C3−b−NPF6)の合成及び特性を実証する。
[0091]この実施例は、本発明の実施形態によるさらなる別のコポリマーの合成及び特性を実証する。
[0095]この実施例は、本発明の実施形態によるさらなるコポリマーの合成及び特性を実証する。
[0099]この実施例は、本発明の実施形態による別のさらなるコポリマー、ポリ(C3−r−NPF6)の合成及び特性を実証する。
[0102]この実施例は、本発明の実施形態による親水性多孔質PTFE膜を調製する方法について例証する。
[0106]この実施例は、本発明の実施形態による親水性多孔質PTFE膜を化学的に改変する方法について例証する。
Claims (7)
- ポリテトラフルオロエチレン(PTFE)及び両親媒性コポリマーのブレンドを含む親水性多孔質膜であって、前記両親媒性コポリマーが、反復単位A及びBを含み、Aが以下の構造:
のうちの1つ又は複数から選択され、Bが、式:
のものであり、
前記両親媒性コポリマーが、ブロックコポリマー又はランダムコポリマーであり、
A及びBのそれぞれの反復単位の数がn及びmであり、1〜約1000の範囲であるが、但しn及びmの合計が10以上であることを条件とする、親水性多孔質膜。 - 前記両親媒性コポリマーが、アリール基及びアルコキシ基から選択される鎖末端基を有する、請求項1に記載の親水性多孔質膜。
- 前記両親媒性コポリマーが、以下の式:
のうちの1つのものであり、式中、m1+m2=mである、請求項1又は2に記載の親水性多孔質膜。 - 親水性多孔質膜を調製する方法であって、
(i)PTFE及び両親媒性コポリマーを、任意選択で滑剤と共に含むブレンドを調製するステップと、
(ii)前記ブレンドをテープへと押出するステップと、
(iii)前記テープを二軸延伸して、前記親水性多孔質膜を得るステップと、任意選択で、
(iv)前記親水性多孔質膜を薬剤と反応させて、前記コポリマーの化学構造を改変するステップと、任意選択で、
(v)前記親水性多孔質膜をアニーリングするステップと
を含み、前記両親媒性コポリマーが、反復単位A及びBを含み、Aが以下の構造:
のうちの1つ又は複数から選択され、Bが、式:
のものであり、
前記両親媒性コポリマーが、ブロックコポリマー又はランダムコポリマーであり、
A及びBのそれぞれの反復単位の数がn及びmであり、1〜約1000の範囲であるが、但しn及びmの合計が10以上であることを条件とする、方法。 - (iv)の前記薬剤が塩基である、請求項4に記載の方法。
- 請求項4又は5に記載の方法によって調製される、親水性多孔質膜。
- 流体を濾過する方法であって、前記流体を請求項1〜3又は6のいずれか一項に記載の親水性多孔質膜を通して通過させるステップを含む、方法。
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