JP2017095404A - Citrus reticulata extract-containing inositol-trisphosphate receptor expression inducer - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an inositol-trisphosphate receptor expression inducer for an inositol-trisphosphate receptor associated with the keratinization of the skin or scalp or the hair restoration of the cells of the hair; and to provide various compositions having expression inductive action of inositol-trisphosphate receptors (cosmetic compositions, pharmaceutical compositions, and food and drink compositions).SOLUTION: The present invention provides an inositol-trisphosphate receptor expression inducer containing the extract of the peels or fruits of Citrus reticulata, and various compositions (cosmetic compositions, pharmaceutical compositions, and food and drink compositions) having expression inductive action of inositol-trisphosphate receptors of Citrus reticulata extract.SELECTED DRAWING: None

Description

  The present invention relates to an inositol trisphosphate receptor expression inducer containing a mandarin orange extract and various compositions characterized by having an inositol triphosphate receptor expression inducing action. is there.

  Skin and scalp, due to age-related aging, etc., decrease in skin barrier function, skin epidermis function, skin wrinkle formation, reduction in skin tension and gloss, rough skin, or scalp thinning or hair loss It is said to cause etc.

  Various components have been used for the purpose of improving the aging phenomenon of the skin and scalp as described above. As typical components, for example, hyaluronic acid, chondroitin tetrasulfate and soluble collagen are used as skin cosmetics (Patent Document 1). Pepper, licorice, dragonfly, peonies, peonies, buttonpis, yokuinin, peony, horseshoe flea, bowfish, chimpi, gentian pepper, dragonfly, tiso, tuna, euphorbia, Arnica, ginseng, peony, A moisturizing cosmetic composition (Patent Document 2) containing at least one kind of extract from Zhuzhou, Zhangzhou, and Shazenshi is already known.

JP 54-52733 A JP 60-258104 A

  Moreover, as thinning hair and hair loss of the scalp or hair nourishing / hair growth agent, for example, jaundice extract and its combination component (blood circulation promoter: assembly extract, carrot extract, ginkgo biloba extract, vitamin E and its derivatives, cephalanthin, Minoxidil, carpronium chloride and phthalides, antibacterial agents: octopirox, benzalkonium chloride, zinc pyrithione, salicylic acid and isopropylmethylphenol) are known for hair restoration (patent document 3), and mandarin orange extract It is used for hair nourishing and hair restoration (Patent Document 4).

JP-A-8-73325 JP-A-3-284614

  The inositol triphosphate receptor is a major factor involved in calcium transport and has been reported to play a very important role in keratinization of the epidermis (Non-patent Document 1). On the other hand, ultraviolet rays and inflammation have been reported to cause parakeratosis. Therefore, induction of inositol triphosphate receptor expression is expected to lead to improvement of skin condition.

Molecular Biology of the Cell (2005) 16, 3236-3246

  Inositol triphosphate is an intracellular second messenger, and is responsible for inositol triphosphate-induced calcium release that induces the release of calcium from intracellular calcium stores mainly composed of the endoplasmic reticulum (Non-patent Document 2). As the inositol triphosphate production pathway, a pathway for activating a G protein-coupled receptor and a pathway for activating a tyrosine kinase receptor are known. In both pathways, phospholipase C is activated, hydrolyzing the membrane component phosphatidylinositol-4,5-diphosphate, producing two second messengers, inositol triphosphate and diacylglycerol. Inositol triphosphate induces various physiological functions by acting on the inositol triphosphate receptor to cause calcium release. Calcium released into the cell acts as a second messenger, muscle contraction, neurotransmitter and hormone opening release, exocrine secretion, neurite outgrowth, plasma membrane excitability, synaptic plasticity, gene expression, cell shape change, division Involved in and proliferation. In other words, inositol triphosphate causes calcium release by binding as a ligand to the inositol triphosphate receptor necessary for inositol triphosphate-induced calcium release, thereby inducing various functions described above.

Calcium ions and signal transduction (1998) 1596-1602

  The inositol triphosphate receptor is an intracellular calcium release channel that exists on the membrane of a calcium storage organ mainly composed of the endoplasmic reticulum and is activated by binding to inositol triphosphate. The inositol triphosphate receptor has a primary agonist inositol triphosphate, and converts various signals into calcium signals using calcium as a co-agonist. Inositol triphosphate receptors have been found to be expressed in a wide range of tissues including cerebellum, heart, kidney, and stage of development from fertilized eggs.

  As a functional analysis of the inositol triphosphate receptor, evaluation using an inositol triphosphate receptor knockout mouse or a function-inhibiting antibody has been performed so far. As a result, the inhibition of inositol triphosphate receptor is determined by fertilization, dorsal and ventral axis determination, neuronal process extension, synaptic plasticity / memory learning, sweat secretion, cardiac function, salivary secretion / pancreatic juice secretion, tear secretion, taste It has been reported to affect hair formation, nasal mucosa function, and osteoclast formation (Non-Patent Documents 3 and 4). Moreover, since inhibition of inositol triphosphate receptor affects calcium release, it is considered to influence upstream G protein-coupled receptor signal and tyrosine kinase receptor signal transduction. Stimulation of the adrenergic receptor α1 and the muscarinic M3 receptor induces calcium release via the inositol triphosphate receptor, which has a major impact on transmitting upstream signals downstream. ing.

RIKEN NEWS 2014 July 9.06-09 Biochimica et Biophysica Acta (2009) 1793, 933-940

  Inositol triphosphate receptor is recently expressed in skin, scalp and hair cells, and has been found to play an important role in keratinization and hair growth of epidermis and scalp. However, on the other hand, it has been reported so far that the expression level of inositol triphosphate receptor is reduced not only in skin but also in many aging cells (Non-patent Document 5).

Journal of Aging Research (2011) 920178

  However, to date, various compositions (cosmetic compositions, pharmaceutical compositions, food and beverage compositions) have been developed to express inositol triphosphate receptors related to keratinization of skin and scalp cells and hair growth of hair cells. No current status has been found for what to guide.

  Accordingly, an object of the present invention is a novel and useful substance that induces the expression of inositol triphosphate receptor or a substance that induces the expression of inositol triphosphate receptor. Product, pharmaceutical composition, food / beverage product composition).

  Based on the above findings, the present inventor has made extensive studies on the theme of excellent natural substances that induce the expression of inositol triphosphate receptors.

  As a result, the present inventors have found that mandarin orange extract has an excellent effect of inducing the expression of inositol triphosphate receptor. And an inositol triphosphate receptor expression inducer containing mandarin orange extract, and various compositions having an inducing action of inositol triphosphate receptor in the mandarin orange extract (cosmetic composition, pharmaceutical composition) The present invention has been completed by providing food and drink composition.

Using normal human epidermal keratinocytes (manufactured by Kurashiki Boseki Co., Ltd.), the gene expression level of inositol triphosphate receptor when the mandarin orange extract of the present invention was added was determined by qRT-PCR using RNA. It is the figure which evaluated. As a control (comparison control), a 70% 1,3-butylene glycol aqueous solution as an extraction solvent was prepared under the same conditions and used in the test.

  The “mandarin orange” used in the present invention is a plant of Rutaceae, Citrus: Mandarin orange (Citrus reticulata) peel, fruit, fruit (including seeds). It should be noted that the skin and the fruit can be either immature or mature.

  In addition, the extract of mandarin orange of the present invention is a product obtained by pulverizing raw or dried fruit skin or fruit, or by pulverizing raw or dried raw material and then extracting it with a solvent. is there.

  Examples of the extraction solvent for obtaining the mandarin orange extract used in the present invention include water, lower alcohols such as methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol and isobutanol, or hydrous lower alcohols, propylene glycol, and 1,3-butylene. Glycol, 1,2-butylene glycol, 1,4-butylene glycol, 1,5-pentanediol, 1,2-pentanediol, 1,3-pentanediol, 1,4-pentanediol, 1,3,5- Polyhydric alcohol or hydrous polyhydric alcohol such as pentanetriol, glycerin, polyethylene glycol (molecular weight 100 to 100,000), acetone, ethyl acetate, diethyl ether, dimethyl ether, ethyl methyl ether, dioxane, acetonitrile, xylene, benzene, chloroform, four Carbon chloride, phenol In various organic solvents such as toluene, acids (hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, formic acid, acetic acid, etc.) and alkalis (sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonia, etc.) prepared as appropriate 1 type or 2 types or more of mixed liquids are mentioned, It is preferable to select 1 type, or 2 or more types especially chosen from water, ethanol, and 1, 3- butylene glycol. However, if it is not preferable to use a solvent depending on the application, use only water, or perform extraction with a highly volatile solvent that can be easily removed after extraction, and dissolve in water after removing the solvent. Such a method is also possible.

  Regarding the extraction method, the temperature of the solvent, the weight ratio of the solvent to the raw material, or the extraction time can be arbitrarily set for various raw materials and the solvent used. Although it can set arbitrarily as the temperature of a solvent in the range of -4 degreeC to 100 degreeC, 10-40 degreeC vicinity is preferable from the point of stability of the component contained in a raw material. Also, the weight ratio of the solvent to the raw material can be arbitrarily set, for example, in the range of the raw material: solvent 4: 1 to 1: 100, and the weight ratio of 1: 1 to 1:20 is particularly preferable.

  The mandarin orange extract used in the present invention can be further subjected to a purification operation after solvent extraction, and the purification operation can be performed using acid (hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, organic acid, etc.) or alkali (water). Decomposition by adding sodium oxide, calcium hydroxide, ammonia, etc., fermentation or metabolic conversion by microorganisms, component adsorption by ion exchange resin, activated carbon, diatomaceous earth, etc., various separation modes (ion exchange, hydrophilic adsorption, hydrophobic adsorption) Fractionation using chromatography with size exclusion, ligand exchange, affinity, etc.), filtration using filter paper, membrane filter, ultrafiltration membrane, etc., pressurization or decompression, heating or cooling, drying, pH Examples include adjustment, deodorization, decolorization, and long-term stationary storage, and it is possible to arbitrarily select and combine them.

  As the shape of the mandarin orange extract used in the present invention used in producing the inositol triphosphate receptor expression inducer and various compositions (cosmetic composition, pharmaceutical composition, food and beverage composition) of the present invention The liquid may be in any shape such as liquid, solid, powder, or paste, and an optimum shape can be arbitrarily selected for carrying out the present invention.

  The inositol triphosphate receptor expression inducer of the present invention and the content of the mandarin orange extract used in the present invention in various compositions (cosmetic compositions, pharmaceutical compositions, food and beverage compositions) include inositol triphosphate. Although it is not particularly limited as long as it has a receptor expression-inducing activity, it is generally set within a range of 0.01 mg / g to 200 mg / g (the denominator indicates the weight of the preparation). Preferably it is the range of 0.1 mg / g-20 mg / g, Most preferably, it is 200 microgram / g-10 mg / g.

  As a cosmetic composition, for example, it can be used in various external preparations (including preparations used for animals) in general, specifically, ampoules, capsules, pills, tablets, powders, granules, solids, liquids 1) Pharmaceuticals, 2) Quasi-drugs, 3) Topical or systemic skin cosmetics (eg lotion) , Basic cosmetics such as emulsion, cream, ointment, lotion, oil, pack, facial cleanser and skin cleanser, massage agent, cleansing agent, hair remover, hair remover, shaving treatment, after shave lotion, pre-shave Makeup cosmetics such as lotion, shaving cream, foundation, lipstick, blusher, eye shadow, eyeliner, mascara, perfume, beauty nail, beauty nail enamel, beauty nail Mel removers, poultices, plasters, tapes, sheets, patches, aerosols, etc.), 4) medicinal and / or cosmetic preparations applied to the scalp and hair (eg shampoos, rinses, Hair treatment agent, pre-hair treatment agent, permanent solution, hair dye, hair styling agent, hair styling agent, hair growth / hair nourishing agent, poultice agent, plaster agent, tape agent, sheet agent, patch, aerosol agent, etc.), 5) bath Bathing agents used in hot water, 6) Other anti-smell and deodorants, deodorants, antiperspirants, hygiene products, sanitary cotton, wet tissue, toothpaste, mouth freshener, gargle, dishwashing It can also be used for agents.

  As the pharmaceutical composition, either oral administration or parenteral administration can be employed. In administration, the active ingredient can be mixed with a solid or liquid nontoxic pharmaceutical carrier suitable for administration methods such as oral administration, rectal administration and injection, and administered in the form of a conventional pharmaceutical preparation. Examples of such preparations include solid preparations such as tablets, granules, powders and capsules, liquid preparations such as solutions, suspensions and emulsions, freeze-dried preparations, and the like. It can be prepared by conventional means. Examples of the non-toxic pharmaceutical carrier include glucose, lactose, sucrose, starch, mannitol, dextrin, fatty acid glyceride, polyethylene glycol, hydroxyethyl starch, ethylene glycol, polyoxyethylene sorbitan fatty acid ester, amino acid, gelatin, Examples include albumin, water, and physiological saline. If necessary, conventional additives such as a stabilizer, a wetting agent, an emulsifier, a binder, and a tonicity agent may be added as appropriate.

  As a food / beverage product composition, it is eaten as a health food or a health food, a supplement, or a food material as it is or by adding various nutritional components and adding it to the food / beverage product. For example, after adding the above-mentioned appropriate auxiliaries, it may be used for edible by using conventional means, and forming into an edible form, for example, granular, granular, tablet, capsule, paste, etc. In addition, various foods such as processed marine products such as kamaboko and chikuwa, livestock products such as sausage and ham, Western confectionery, Japanese confectionery, raw noodles, Chinese noodles, boiled noodles, buckwheat noodles, sauce, soy sauce, sauce, Seasonings such as sugar, honey, powdered candy, syrup, etc., spices such as curry powder, mustard powder, pepper powder, jam, marmalade, chocolate spread, pickles, red vegetables, sprinkles, canned and bottled vegetables and fruits Processed vegetables and fruits, dairy products such as cheese, butter, yogurt, miso soup, soup, fruit juice, vegetable juice, whey beverage, soft drink, alcoholic beverages, liquid food, etc. Addition to can be used, also, pet food, can also be used for animals and plants for feed and the like.

  In addition, the inositol triphosphate receptor expression inducer of the present invention and various compositions (pharmaceutical composition, food / beverage product composition, cosmetic composition) may include the present invention as needed in addition to the above essential components. In the range that does not impair the effect, various preparations can be produced by arbitrarily selecting and using the components and additives exemplified below, and the content in the preparation is not particularly limited, but is usually 0.0001 to 50 A concentration range of% is preferred.

  Examples of oily bases include cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, aralkyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, ceralkyl alcohol, batyl alcohol, hexyldecanol, isostearyl alcohol, Higher alcohols such as 2-octyldodecanol and dimer diol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, Palmitooleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexa Higher fatty acids such as canic acid, antiisohenicosanoic acid, long-chain branched fatty acid, dimer acid, hydrogenated dimer acid and metal soaps such as aluminum salts, calcium salts, magnesium salts, zinc salts, sodium salts and potassium salts And nitrogen-containing derivatives such as ethanolamine salts and amides; liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin, α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane , Olive-derived squalane, squalene, petroleum jelly, solid paraffin and other carbides; candelilla wax, carnauba wax, rice wax, waxy wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline Waxes such as wax, petrolatum, Fischer-Tropsch wax, polyethylene wax, ethylene propylene copolymer; palm oil, palm oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, Wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rosehip oil, meadow foam oil, persic oil, tea tree oil, mint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil Vegetable oils such as peanut oil, rice bran oil, cacao butter, shea butter, hydrogenated palm oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil; beef tallow, milk fat, horse fat, egg yolk oil, mink oil, turtle Animal fats and oils such as oil; movement of whale wax, lanolin, orange luffy oil, etc. Waxes: liquid lanolin, reduced lanolin, adsorption-purified lanolin, lanolin acetate, lanolin acetate, hydroxy lanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin alcohol acetate, acetic acid (cetyl lanolyl) ester Lanolins such as: lecithin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingophospholipids such as sphingomyelin, phospholipids such as phosphatidic acid, lysolecithin; hydrogenated soybean phospholipid, partially hydrogenated soybean Phospholipids such as phospholipids, hydrogenated egg yolk phospholipids, partially hydrogenated egg yolk phospholipids; cholesterol, dihydrocholesterol, lanosterol Sterols such as dihydrolanosterol, phytosterol and cholic acid; sapogenins; saponins; cholesteryl acetate, cholesteryl nonanoate, cholesteryl isostearate, cholesteryl isostearate, cholesteryl oleate, di-N-lauroyl-L-glutamate (cholesteryl / behenyl / Octyldodecyl), N-lauroyl-L-glutamate di (cholesteryl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / octyldodecyl) , Acyl sarcosine alkyl esters such as N-lauroyl sarcosine isopropyl, cholesteryl 12-hydroxystearate, macadamia nut oil fatty acid cholesterol Sterol esters such as ril, macadamia nut oil fatty acid phytosteryl, phytosteryl isostearate, soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long-chain branched fatty acid cholesteryl, long-chain α-hydroxy fatty acid cholesteryl; phospholipid / cholesterol complex, phospholipid / Lipid complexes such as phytosterol complex; octyldodecyl myristate, hexyldecyl myristate, octyldodecyl isostearate, cetyl paritate, octyldodecyl palmitate, cetyl octoate, hexyldecyl octoate, isotridecyl isononanoate, isononanoyl isononanoate, Octyl isononanoate, isotridecyl isononanoate, isodecyl neopentanoate, isotridecyl neopentanoate, neopenta Isostearyl acid, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, octyldodecyl lanolinate, hexyldecyl dimethyloctanoate, octyldodecyl erucate, isostearic acid hydrogenated castor oil, ethyl oleate, avocado Mono-alcohol carboxylates such as oil fatty acid ethyl, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, lanolin fatty acid isopropyl, triethyl citrate; cetyl lactate, diisostearyl malate, hydrogenated monoisostearate Oxyesters such as castor oil; glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, diiso Glyceryl stearate, tri (caprylic acid / capric acid) glyceryl, tri (caprylic acid / capric acid / myristic acid / stearic acid) glyceryl, hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), behenic acid Glyceryl eicosandioate, (tetradecanedioic acid / eicosandioic acid) glyceryl, (tetradecanedioic acid / eicosandioic acid) polyglyceryl-10, trimethylolpropane trioctanoate, trimethylolpropane triisostearate, neopentyl glycol dioctanoate, dicapric acid Neopentyl glycol, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, 3-methyl-1,5-pentanediol dineopentanoate, 2,4-diethyl dineopentanoate 1,5-pentanediol, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenated rosin pentaerythrityl, ditrimethylolpropane triethylhexanoate, (isostearic acid / sebacic acid) ditrimethylolpropane, pentaerythrityl triethylhexanoate , (Hydroxystearic acid / stearic acid / rosinic acid) dipentaerythrityl, diglyceryl diisostearate, polyglyceryl tetraisostearate, polyglyceryl nonaisostearate-10, deca (erucic acid / isostearic acid / ricinoleic acid) polyglyceryl-8, (hexyldecanoic acid / Multivalent alcohols such as sebacic acid) diglyceryl oligoester, glycol distearate (ethylene glycol distearate) Fatty acid esters: diisopropyl dimerlinoleate diisopropyl, dimer dilinoleate diisostearyl, dimer dilinoleate di (isostearyl / phytosteryl), dimer dilinoleate (phytosteryl / behenyl), dimer dilinoleate (phytosteryl / isostearyl / Cetyl / stearyl / behenyl), dimer dilinoleic acid dimer dilinoleyl, dimer dilinoleic acid dimer dilinoleyl bis (phytosteryl / behenyl / isostearyl), diisostearate dimer dilinoleyl, dimer dilinoleyl hydrogenated rosin condensate , Dimer linoleic acid hydrogenated castor oil, dimer acid or dimer diol derivative such as hydroxyalkyl dimer linoleyl ether; coconut oil fatty acid monoethanolamide (cocamide) MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamide MEA) ), Fatty acid alkanolamides such as palmitic acid diethanolamide (partamide DEA), coconut oil fatty acid methylethanolamide (cocamide methyl MEA); dimethicone (dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic) Dimethylsiloxane, decamethylcyclopentasiloxane), phenyltrimethicone, diphenyldimethicone, phenyldimethicone, stearoxypropyl Methylamine, (aminoethylaminopropyl methicone / dimethicone) copolymer, dimethiconol, dimethiconol crosspolymer, silicone resin, silicone rubber, amino-modified silicone such as aminopropyl dimethicone and amodimethicone, cation-modified silicone, polyether modification such as dimethicone copolyol Silicone, polyglycerin modified silicone, sugar modified silicone, carboxylic acid modified silicone, phosphoric acid modified silicone, sulfuric acid modified silicone, alkyl modified silicone, fatty acid modified silicone, alkyl ether modified silicone, amino acid modified silicone, peptide modified silicone, fluorine modified silicone, Cationic modified and polyether modified silicone, amino modified and polyether modified silicone, alkyl modified and Polyether-modified silicone, silicones such as polysiloxane polyoxyalkylene copolymer; perfluorodecane, perfluorooctane, fluorine-based oils such as perfluoropolyether may be mentioned as preferred.

  As moisturizers / feel improvers, water (ordinary water, purified water, hard water, soft water, natural water, deep ocean water, electrolytic alkaline ionic water, electrolytic acidic ionic water, ionic water, cluster water) Glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, trimethylolpropane, pentaerythritol , Hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, polyols such as ethylene glycol / propylene glycol copolymer and polymers thereof; diethylene glycol monoethyl ether (ethoxydiglycol), Glycol alkyl ethers such as tylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether; sugar alcohols such as sorbitol, xylitol, erythritol, mannitol, maltitol; glucose, fructose, galactose, mannose, threose, xylose, arabinose , Fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid, β-glucan, chitin, chitosan, heparin and derivatives, pectin, arabinogalactan, dextrin, dextran, glycogen, ethyl glucoside, methacrylic Sugars such as glucosylethyl acid polymer or copolymer; and derivatives thereof; hyaluro Acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin sulfate, caroline sulfate, kerato sulfate, dermatan sulfate; white jellyfish extract, white jellyfish polysaccharide; fucoidan; polysaccharides such as tuberose polysaccharide; citric acid, tartaric acid, lactic acid Organic acids such as, and salts thereof; urea; salts such as 2-pyrrolidone-5-carboxylic acid and sodium; betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, amino acids such as β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine, and salts thereof; Lagen, fish-derived collagen, atelocollagen, gelatin, elastin, collagenolytic peptide, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastinolytic peptide, keratinolytic peptide, hydrolyzed keratin, conchiolinolytic peptide, hydrolyzed conchioline, silk protein Degraded peptide, hydrolyzed silk, lauroyl hydrolyzed sodium sodium, soybean proteolytic peptide, wheat proteolytic peptide, hydrolyzed wheat protein, casein degrading peptide, acylated peptide, and other peptide peptides; palmitoyl oligopeptide, palmitoyl penta Peptides, acylated peptides such as palmitoyl tetrapeptide; silylated peptides; lactic acid bacteria culture solution, yeast extract, eggshell membrane protein, bovine submandibular gland mucosa Chin, hypotaurine, sesame lignan glycoside, glutathione, albumin, whey; choline chloride, phosphorylcholine; placenta extract, aerustin, collagen, aloe extract, hamamelis water, loofah water, chamomile extract, licorice extract, comfrey extract, silk Extracts, Izayoi rose extract, Achillea millefolium extract, Eucalyptus extract, Merirot extract and other animal / plant extract components, natural ceramide (types 1, 2, 3, 4, 5, 6), hydroxyceramide, pseudoceramide, glycosphingolipid, Ceramides such as ceramide and sugar ceramide-containing extract are preferred.

Preferred examples of the surfactant include an anionic surfactant, a nonionic surfactant, a cationic surfactant, an amphoteric surfactant, and a polymer surfactant. There is no restriction | limiting in particular in HLB of surfactant, It can use from about 1 low thing to about 20 high thing, It is also preferable to combine what has low and high HLB. Examples of preferable surfactants include fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfates such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate; laureth Polyoxyethylene alkyl sulfates such as sodium sulfate and laureth sulfate triethanolamine; cocoyl methyl taurine sodium, cocoyl methyl taurine potassium, lauroyl methyl taurine sodium, myristoyl methyl taurine sodium, lauroyl methyl alanine sodium, lauroyl sarcosine sodium, lauroyl sarcosine triethanol Acyl N-methyl amino acid salts such as amines and sodium methylalanine lauroylglutamate; Cocoyl Glue Acyl amino acid salts such as sodium minate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, ditriethanolamine palmitoyl aspartate, cocoylalanine triethanolamine; polyoxyethylene alkyl ethers such as sodium laureth acetate Acetic acid salt; Succinic acid ester salt such as sodium lauroyl monoethanolamide succinate; Fatty acid alkanolamide ether carboxylate; Acyl lactate; Polyoxyethylene fatty amine sulfate; Fatty acid alkanolamide sulfate; Hardened coconut oil fatty acid sodium glyceryl sulfate Fatty acid glyceride sulfate such as alkylbenzene polyoxyethylene sulfate; α-olefin Olefin sulfonates such as sodium sulfonate; alkylsulfosuccinates such as disodium lauryl sulfosuccinate and dioctyl sodium sulfosuccinate; disodium laureth sulfosuccinate, monolauroyl monoethanolamide polyoxyethylene sodium sulfosuccinate, lauryl polypropylene glycol sulfosuccinic acid Alkyl ether sulfosuccinates such as sodium; alkylbenzene sulfonates such as sodium tetradecylbenzenesulfonate and tetraethanolamine tetraethanol; alkylnaphthalenesulfonates; alkanesulfonates; α-sulfo fatty acid methyl ester salts; Acyl isethionate; alkyl glycidyl ether sulfonate; alkyl sulfoacetate; laurethrin Alkyl ether phosphates such as sodium, sodium dilaureth phosphate, sodium trilaureth phosphate, sodium monooles phosphate; alkyl phosphate salts such as potassium lauryl phosphate; sodium caseinate; alkyl aryl ether phosphate; fatty acid amide ether phosphorus Phospholipids such as phosphatidylglycerol, phosphatidylinositol, and phosphatidic acid; silicone anionic surfactants such as carboxylic acid-modified silicone, phosphate-modified silicone, and sulfate-modified silicone; and nonionic surfactants, laureth (Polyoxyethylene lauryl ether), ceteth (polyoxyethylene cetyl ether), steareth (polyoxyethylene stearyl ether), behenez (polyoxyethylene) Nbehenyl ethers), isosteares (polyoxyethylene isostearyl ethers), octyldecesses (polyoxyethylene octyldodecyl ethers) and other polyoxyethylene alkyl ethers with various polyoxyethylene addition numbers; polyoxyethylene alkylphenyl ethers; Polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearate diester, poly Castor oil such as oxyethylene hydrogenated castor oil maleic acid and hydrogenated castor oil derivatives; polyoxyethylene phytosterol; polyoxyethylene cholesterol; polyoxy Polyoxyethylene lanolin; polyoxyethylene reduced lanolin; polyoxyethylene polyoxypropylene cetyl ether, polyoxyethylene polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene polyoxypropylene monobutyl ether, polyoxyethylene lanolin; Oxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene / polyoxypropylene alkyl ethers such as polyoxyethylene / polyoxypropylene glycerin ether; polyoxyethylene / polyoxypropylene glycol; (poly) such as PPG-9 diglyceryl Glycerin polyoxypropylene glycol; glyceryl stearate, glyceryl isostearate, glyceryl palmitate, myristate group Glyceryl fatty acid partial esters such as ceryl, glyceryl oleate, glyceryl coconut fatty acid, mono-cotton oil fatty acid glycerin, glyceryl monoerucate, glyceryl sesquioleate, α, α'-oleic acid pyroglutamic acid glycerin, monostearic acid glycerin malic acid; Polyglyceryl stearate-2, 3, 4, 5, 6, 8, 10, polyglyceryl distearate-6, 10, polyglyceryl tristearate, polyglyceryl decastearate-10, polyglyceryl isostearate -2, 3, 4, 5, 6, 8, 10, diglycostyl diisostearate (diglyceryl diisostearate), 3, 10, polyglyceryl-2 triisostearate, polyglyceryl tetraisostearate Ril-2, polyglyceryl-10 decaisostearate, polyglyceryl-2 oleate, 3,4, 5,6, 8,8, dioleate polyglyceryl-6, trioleate polyglyceryl-2, dekaoleic acid Polyglyceryl fatty acid esters such as polyglyceryl-10; ethylene glycol monofatty acid esters such as ethylene glycol monostearate; propylene glycol monofatty acid esters such as propylene glycol monostearate; pentaerythritol partial fatty acid esters; sorbitol partial fatty acid esters; maltitol moieties Fatty acid ester; maltitol ether; sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monos Sorbitan fatty acid esters such as allate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate; sucrose fatty acid ester, methyl glucoside fatty acid ester, trehalose undecylenate, etc. Partial derivatives of sugar derivatives; alkyl glucosides such as caprylyl glucoside; alkyl polyglycosides; lanolin alcohols; reduced lanolin; polyoxyethylene distearate, polyethylene glycol diisostearate, polyoxyethylene monooleate, polyoxyethylene di- Polyoxyethylene fatty acid mono- and diesters such as oleate; polyoxyethylene propylene glycol fatty acid ester; polyoxyethylene Polyoxyethylene glycerin fatty acid esters such as polyoxyethylene monooleate such as polyglycerin monostearate, polyoxyethylene glycerin monoisostearate, polyoxyethylene glycerin triisostearate; polyoxyethylene sorbitan monooleate, polyoxy Polyoxyethylene sorbitan fatty acid esters such as ethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan tetraoleate; polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol penta Polyoxyethylene sorbitol fatty acid esters such as oleate and polyoxyethylene sorbitol monostearate Polyoxyethylene methyl glucoside fatty acid ester; Polyoxyethylene alkyl ether fatty acid ester; Polyoxyethylene animal and vegetable oils such as polyoxyethylene sorbitol beeswax; Alkyl such as isostearyl glyceryl ether, chimyl alcohol, ceralkyl alcohol, batyl alcohol Glyceryl ethers; polyhydric alcohol alkyl ethers; polyoxyethylene alkylamines; tetrapolyoxyethylene / tetrapolyoxypropylene-ethylenediamine condensates; natural surfactants such as saponins and sophorolipids; polyoxyethylene fatty acid amides; coconut oil Fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (laura) De MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide (partamide DEA), palm oil fatty acid methyl ethanolamide (cocamidomethyl) Fatty acid alkanolamides such as MEA); alkyldimethylamine oxides such as lauramine oxide, cocamamine oxide, stearamine oxide, and behenamine oxide; alkylethoxydimethylamine oxide; polyoxyethylene alkyl mercaptan; poly such as dimethicone copolyol Silicone such as ether-modified silicone, polysiloxane-oxyalkylene copolymer, polyglycerin-modified silicone, sugar-modified silicone Nonionic surfactants, etc .; for cationic surfactants, alkyltrimethylammonium chlorides such as behentrimonium chloride, steartrimonium chloride, cetrimonium chloride, lauryltrimonium chloride; alkyls such as stearyltrimonium bromide Trialkylammonium bromide; dialkyldimethylammonium chloride such as distearyldimonium chloride and dicocodimonium chloride; fatty acid amidoamines and salts thereof such as stearamidepropyldimethylamine and stearamideethyldiethylamine; alkyl ether amines such as stearoxypropyldimethylamine; Salt or quaternary salt thereof; ethyl sulfate long chain branched fatty acid (12-31) aminopropylethyldimethylammonium, ethyl lanolin sulfate Fatty acid amide-type quaternary ammonium salts such as aminopropylethyldimethylammonium fatty acid; polyoxyethylene alkylamine and its salts or quaternary salts; alkylamine salts; fatty acid amidoguanidinium salts; alkyl etheraminemonium salts; Benzalkonium salt; Pyridinium salt such as cetylpyridinium chloride; Imidazolinium salt; Alkylisoquinolinium salt; Dialkyl morpholinium salt; Polyamine fatty acid derivatives; Aminopropyl dimethicone and amodimethicone Silicone-based cationic surfactants such as amino-modified silicone, cation-modified silicone, cation-modified and polyether-modified silicone, amino-modified and polyether-modified silicone, etc .; amphoteric Surfactants include N-alkyl-N, N-dimethylamino acid betaines such as lauryl betaine (lauryldimethylaminoacetic acid betaine); fatty acid amide alkyl-N, N-dimethylamino acid betaines such as cocamidopropyl betaine and lauramidopropyl betaine. Imidazoline-type betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate; alkylsulfobetaines such as alkyldimethyltaurine; sulfate-type betaines such as alkyldimethylaminoethanol sulfate; phosphate-type betaines such as alkyldimethylaminoethanolphosphate; phosphatidylcholine , Phosphatidylethanolamine, phosphatidylserine, sphingomyelin, etc.

Phospholipids such as lipid, lysolecithin, hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid, and hydroxylated lecithin; silicone-based amphoteric surfactants, etc .; polymer Among surfactants, polyvinyl alcohol, sodium alginate, starch derivatives, tragacanth gum, acrylic acid / alkyl methacrylate copolymer, 2-methacryloyloxyethyl phosphorylcholine / stearyl methacrylate copolymer; various silicone surfactants are preferred. As mentioned.

  Polymers, thickeners and gelling agents include guar gum, locust bean gum, queens seed, carrageenan, galactan, arabic gum, tara gum, tamarind, far selelain, karaya gum, troarooi, cara gum, tragacanth gum, pectin, pectic acid and sodium Salt such as salt, salt such as alginic acid and sodium salt, mannan; starch such as rice, corn, potato, wheat; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salt, xanthan gum, pullulan, gellan gum, chitin , Chitosan, agar, gypsum extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropi Cellulose, carboxymethylcellulose and its salts such as sodium, methylhydroxypropylcellulose, sodium cellulose sulfate, cellulose dialkyldimethylammonium sulfate, crystalline cellulose, cellulose powder such as cellulose powder; soluble starch, carboxymethyl starch, methylhydroxypropyl starch, Starch-based polymers such as methyl starch, starch derivatives such as hydroxypropyltrimonium chloride, octenyl succinate corn starch and aluminum; alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyridone (PVP), polyvinyl alcohol (PVA), Vinyl pydridone-vinyl alcohol copolymer, polyvinyl methyl ether Polyethylene glycol, polypropylene glycol, polyoxyethylene / polyoxypropylene copolymer; amphoteric methacrylic acid such as (methacryloyloxyethylcarboxybetaine / alkyl methacrylate) copolymer, (acrylates / stearyl acrylate / ethylamine methacrylate oxide) copolymer, etc. Ester copolymer; (Dimethicone / vinyl dimethicone) crosspolymer, (alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP; Polyvinyl acetate partial saponification product, maleic acid copolymer; Vinylpyrrolidone / dialkylaminoalkyl methacrylate copolymer; acrylic resin alkanolamine; polyester, water-dispersible polyester; Kurylamide; Polyacrylic acid ester copolymer such as polyethyl acrylate, carboxyvinyl polymer, polyacrylic acid and its sodium salt, acrylic acid / methacrylic acid ester copolymer; acrylic acid / alkyl methacrylate Polymer: Cationized cellulose such as polyquaternium-10, diallyldimethylammonium chloride / acrylamide copolymer such as polyquaternium-7, acrylic acid / diallyldimethylammonium chloride copolymer such as polyquaternium-22, and acrylic acid such as polyquaternium-39・ Diallyldimethylammonium chloride / acrylamide copolymer, acrylic acid / cationized methacrylic acid ester copolymer, acrylic acid / cationized methacrylic acid amide copolymer, polyquaternium Acrylic acid / methyl acrylate / methacrylamidopropyltrimethylammonium chloride copolymer such as 47, methacrylic acid choline ester polymer; cationized polysaccharides such as cationized oligosaccharide, cationized dextran, guar hydroxypropyltrimonium chloride; Polyethyleneimine; Cationic polymer; Polymer of 2-methacryloyloxyethyl phosphorylcholine such as polyquaternium-51 and copolymer with butyl methacrylate copolymer; Acrylic resin emulsion, polyethyl acrylate emulsion, polyacrylalkyl ester emulsion, Polymer emulsions such as polyvinyl acetate resin emulsion, natural rubber latex, synthetic latex; nitrocellulose; polyurethanes and various copolymers; various silicones Various silicone-based copolymers such as acrylic-silicone graft copolymers; various fluoropolymers; 12-hydroxystearic acid and its salts; dextrin fatty acid esters such as dextrin palmitate and dextrin myristate; silicic anhydride, Smoke-like silica (ultrafine silicic anhydride), aluminum magnesium silicate, magnesium magnesium silicate, metal soap, dialkyl phosphate metal salt, bentonite, hectorite, organically modified clay mineral, sucrose fatty acid ester, fructooligosaccharide fatty acid ester It is mentioned as preferable.

  Solvents and propellants include ethanol, 2-propanol (isopropyl alcohol), butanol, isobutyl alcohol and other lower alcohols; propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, isopentyl diol and other glycols Diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether Glycol ethers such as ethylene glycol monoethyl ether Glycol ether esters such as acetate, diethylene glycol monoethyl ether acetate, propylene glycol monoethyl ether acetate; Glycol esters such as diethoxyethyl succinate, ethylene glycol disuccinate; benzyl alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate , Acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbon, next-generation flon; propellants such as LPG, dimethyl ether, carbon dioxide, and the like are preferable.

  Antioxidants include α-lipoic acid, salts of α-lipoic acid, and derivatives of α-lipoic acid; tocopherol derivatives such as tocopherol (vitamin E), tocotrienol, tocopherol acetate; BHT, BHA; propyl gallate, etc. Gallic acid derivatives; vitamin C (ascorbic acid) and / or derivatives thereof; erythorbic acid and derivatives thereof; sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfite Salts: thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, cysteine hydrochloride are preferred. Preferred examples of the reducing agent include thioglycolic acid, cysteine, cysteamine and the like. Preferred examples of the oxidizing agent include aqueous hydrogen peroxide, ammonium persulfate, sodium bromate, and percarbonate.

  Preservatives and antibacterial agents include hydroxybenzoic acid such as methylparaben, ethylparaben, propylparaben, and butylparaben and salts or esters thereof; salicylic acid; sodium benzoate; phenoxyethanol; 1,2-pentanediol, 1,2-hexane 1,2-diols such as diols; isothiazolinone derivatives such as methylchloroisothiazolinone and methylisothiazolinone; imidazolinium urea; dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides , Quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, benzalkonium chloride, benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, Kichioru; phenol, isopropyl phenol, cresol, thymol, p-chlorophenol, phenylphenol, other phenols such as phenylphenol sodium; phenylethyl alcohol, photosensitive Motorui, be mentioned as antibacterial zeolite, silver ion.

  Examples of chelating agents include edetate (ethylenediaminetetraacetate) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetate such as HEDTA3Na; pentetate (diethylenetriaminepentaacetate); phytic acid; Phosphonic acid and its sodium salt; sodium oxalate; polyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine Gluconic acid, ascorbic acid, succinic acid, and tartaric acid are preferable.

  pH adjusters / acids / alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanol Amine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, hydroxylation Sodium, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate are preferable.

  Examples of powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, red mica, biotite, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, silica Barium acid, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluorine apatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, Metal soap (e.g. zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, bengara, yellow iron oxide, black iron oxide, ultramarine, bitumen, carbon black, titanium oxide, fine particles and ultrafine Titanium oxide, zinc oxide, fine and ultrafine zinc oxide, alumina, silica, fumed silica (ultrafine silica), titanium mica, fish scale foil, boron nitride, photochromic pigment, synthetic fluorophlogopite, fine particle composite powder Body, gold, aluminum, etc., various sizes and shapes of inorganic powders, and these are treated with various surface treatment agents such as hydrogen silicone, cyclic hydrogen silicone, or other silane or titanium coupling agents Inorganic powders such as hydrophobized or hydrophilized powders; starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, polyester powder, Benzoguanamine resin powder, polyethylene terephthalate, polymethyl Organic powders and surface-treated powders of various sizes and shapes, such as methacrylate powder, polyethylene terephthalate / aluminum / epoxy powder, urethane powder, silicone powder, Teflon (registered trademark) powder, organic-inorganic composite powder Is preferable. Inorganic salts include sodium chloride-containing salts such as salt, common salt, rock salt, sea salt, natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, Aluminum sulfate / potassium sulfate (alum), aluminum sulfate / ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na, 2Na and 3Na phosphates, phosphoric acid Potassium, calcium phosphates and magnesium phosphates are preferred.

  Examples of ultraviolet absorbers include paraaminobenzoic acid, paraaminobenzoic acid monoglycerin ester, N, N-dipropoxyparaaminobenzoic acid ethyl ester, N, N-diethoxyparaaminobenzoic acid ethyl ester, and N, N-dimethylparaaminobenzoic acid ethyl ester. Benzoic acid-based ultraviolet absorbers such as esters, N, N-dimethylparaaminobenzoic acid butyl ester, N, N-dimethylparaaminobenzoic acid ethyl ester; Anthranilic acid-based ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; Salicylic acid And salicylic acid-based purple such as sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate Line absorber: Octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p- Methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, 2-ethylhexyl p-methoxycinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (sinoxate), Cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamate (octocrine), glyceryl mono-2-ethylhexanoyl-diparamethoxy Cinnamic acid-based UV absorbers such as namate, ferulic acid and derivatives thereof; 2,4-dihydroxybenzophenone, 2,2′-dihydroxy-4-methoxybenzophenone, 2,2′-dihydroxy-4,4′-dimethoxybenzophenone, 2,2 ′, 4,4′-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4′-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone -5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone, etc. Benzophenone purple 3- (4'-methylbenzylidene) -d, l-camphor, 3-benzylidene-d, l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole; 2- (2′-hydroxy-5′-methylphenylbenzotriazole; dibenzalazine; dianisoylmethane; 5- (3 , 3-dimethyl-2-norbornylidene) -3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octyl triazone; urocanic acid derivatives such as urocanic acid and ethyl urocanate; 2- (2′-hydroxy-5′-methylphenyl) benzotriazole, 1- ( , 4-dimethoxyphenyl) -4,4-dimethyl-1,3-pentanedione, dimethoxybenzylidenedioxoimidazolidinepropionate 2-ethylhexyl, etc., hydantoin derivatives, phenylbenzimidazolazosulfonic acid, terephthalylidene dicamphsulfone Preference is given to acids, drometrizole trisiloxane, methyl anthranilate, rutin and its derivatives, oryzanol and its derivatives.

  As whitening agents, ascorbic acid, ascorbic acid phosphate sodium salt such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt, ascorbic acid fatty acid ester such as ascorbic acid tetraisopalmitate, ascorbic acid ethyl ether Ascorbic acid alkyl ethers such as ascorbic acid glucoside such as ascorbic acid-2-glucoside and fatty acid esters thereof, ascorbic acid sulfates, ascorbic acid derivatives such as tocopheryl phosphate ascorbyl; kojic acid, ellagic acid, tranexamic acid and the like Derivatives, ferulic acid and its derivatives, placenta extract, glutathione, oryzanol, butylresorcinol, oil-soluble chamomile extract, oil-soluble licorice extract, Nishikawayanagi extract Saxifrage extract, and the like plant extracts can be mentioned as preferred.

  Vitamins and their derivatives include vitamin A such as retinol, retinol acetate, retinol palmitate; thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, Flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid such as nicotinic acid amide / benzyl nicotinate, vitamin B group such as choline; vitamin C such as ascorbic acid and its sodium salt; vitamin D; α, Vitamin Es such as β, γ, δ-tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid phosphates such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt; Ascorbic acid fatty acid esters such as corobic acid tetraisopalmitic acid ester, ascorbyl stearate, ascorbyl palmitate and ascorbyl dipalmitate, ascorbic acid alkyl ether such as ascorbic acid ethyl ether, ascorbic acid glucoside such as ascorbic acid-2-glucoside and Ascorbic acid derivatives such as fatty acid esters and tocopheryl phosphate ascorbyl; vitamin derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol acetate, tocopherol linoleate, tocopherol phosphate, tocopherol phosphate etc., tocotrienol, and other various vitamin derivatives Is preferable.

  Anti-inflammatory and anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; peach leaf extract A plant extract such as a koji leaf extract is preferable.

  Plant growth and tinctures such as assembly extract, red pepper tincture, ginger tincture, ginger extract, cantalis tincture; capsaicin, nonyl acid valenylamide, gingeron, ictamol, tannic acid Borneol, cyclandelate, cinnarizine, trazoline, acetylcholine, verapamil, cephalanthin, γ-oryzanol, cephalanthin, vitamin E and nicotinic acid tocopherol / acetic acid tocopherol, derivatives, γ-oryzanol, nicotinic acid, nicotinic acid amide, nicotinic acid benzyl Derivatives such as ester, inositol hexanicotinate, nicotine alcohol, allantoin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, Preferable examples include flavonol derivatives, stigmasterol or stigmasteranol, its glycosides, and minoxidil.

  Preferred hormones include estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone and the like.

  Other remedies such as anti-wrinkle agents, anti-aging agents, squeeze agents, cooling sensations, warming sensation agents, wound healing promoters, irritation relievers, analgesics, cell activators include retinols, retinoic acids, retinoin Acid tocopheryl; derivatives such as lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and glycosides / esterified products thereof, α- or such as hydroxycapric acid, long chain α-hydroxy fatty acid, long chain α-hydroxy fatty acid cholesteryl β-hydroxy acids and derivatives thereof; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; carnosine; creatine; ceramides, sphingosines; caffeine, xanthine and the like; and coenzyme Q10, carotene, lycopene , Astaxanthin, lutein and other antioxidant and active oxygen scavengers; catechins; quercet Isoflavones; gallic acid and ester sugar derivatives; polyphenols such as tannin, sesamin, protoanthocyanidin, chlorogenic acid, apple polyphenol; derivatives such as rutin and glycosides; lignan glycosides; Licorice extract related substances such as liquiritin and isoliquiritin; lactoferrin; gingerol; fragrance substances such as menthol, camphor and cedrol and derivatives thereof; capsaicin, vanillin and other derivatives; insect repellents such as diethyltoluamide; physiologically active substances And a complex of cyclodextrins is preferred.

  Plant / animal / microbe extracts include iris extract, ashitaba extract, asunalo extract, asparagus extract, avocado extract, achacha extract, almond extract, altea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo biloba extract , Incheon extract, Fennel extract, Turmeric extract, Oolong tea extract, Peony extract, Ages extract, Echinacea leaf extract, Enmeo extract, Ogon extract, Oat extract, Auren extract, Barley extract, Panax ginseng extract, Hypericum extract, Odori extract , Dutch mustard extract, dried sea water, seaweed extract, oyster leaf extract, oyster extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolyzed silk, cocoon Kiss, chamomile extract, oil-soluble chamomile extract, carrot extract, kawara mugwort extract, oat extract, calkade extract, licorice extract, oil-soluble licorice extract, kiwi extract, kiou extract, jellyfish extract, quina extract, cucumber extract, giraffe leaf extract, guanosine, guava Extract, Kujin Extract, Gardenia Extract, Kumazasa Extract, Clara Extract, Walnut Extract, Chestnut Extract, Grapefruit Extract, Clematis Extract, Black Rice Extract, Brown Sugar Extract, Black Vinegar, Chlorella Extract, Mulberry Extract, Gentianana Extract, Gennoshoco Extract, Black Tea Extract, Yeast Extract, kokuboku extract, coffee extract, burdock extract, rice extract, fermented rice extract, fermented rice bran extract, rice germ oil, comfrey extract, collagen, moss Moy extract, Saishin extract, Psycho extract, Saitai extract, Saffron extract, Salvia extract, Soybean extract, Sasa extract, Hawthorn extract, Sansha extract, Salamander extract, Shiitake extract, Giant extract, Shikon extract, Perilla extract, Linden extract, Shimotake extract, Jatoba extract , Peonies extract, Pepper extract, Pepper root extract, White birch extract, White jellyfish extract, Horsetail extract, Stevia extract, Stevia fermented product, Nishikawa willow extract, Horseshoe extract, Hawthorn extract, Horseshoe extract, Achillea millefolium extract Extract, sage extract, mallow extract, nematode extract, assembly extract, Sakuhakuhi extract, Diou extract, soybean extract, taiso Wu extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, chigaya extract, tea tree oil, strawberry tea extract, red pepper extract, touki extract, tomato extract, tonin extract, dokudami extract, tomato extract, natto extract, carrot extract, Garlic extract, Novara extract, Hibiscus extract, Bacmond extract, Lotus extract, Parsley extract, Birch extract, Honey, Hamamelis extract, Parietalia extract, Toad extract, Bisabolol, Hinoki extract, Bifidobacteria extract, Biwa extract, Japanese dandelion extract, Fukinoto extract Bukuryo extract, butcher bloom extract, grape extract, grape seed extract, propolis, loofah extract, safflower extract, peppermint extract, bodyfish Extract, button extract, hop extract, mai kaika extract, pine extract, maronier extract, mizuba sho extract, mukuroji extract, melissa extract, mozuku extract, peach extract, cornflower extract, eucalyptus extract, yukinoshita extract, yuzu extract, lily extract, yokoinin extract, mugwort extract, Lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract, litchi extract, lettuce extract, lemon extract, forsythia extract, forsythia extract, rose extract, rosemary extract, roman chamomile extract, royal jelly extract, bitumen extract, etc. An extract is mentioned as a preferable thing.

  Examples of the antipruritic agent include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitor, and the like. Examples of the exfoliating / dissolving agent include salicylic acid, sulfur, resorcin, selenium sulfide, pyridoxine and the like. Examples of the antiperspirant include chlorohydroxyaluminum, aluminum chloride, zinc oxide, and zinc paraphenol sulfonate. Examples of the refreshing agent include menthol and methyl salicylate. Examples of the astringent include citric acid, tartaric acid, lactic acid, aluminum sulfate / potassium sulfate, and tannic acid. Examples of enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease, and the like. Preferred nucleic acids include ribonucleic acid and salts thereof, deoxyribonucleic acid and salts thereof, and adenosine triphosphate disodium.

  As perfumes, acetyl cedrene, amylcinnamaldehyde, allyl amyl glycolate, β-ionone, iso-Esuper, isobutyl quinoline, Iris oil, Iron, indole, ylang ylang oil, undecanal, undecenal, γ-undecalactone, Estragole, eugenol, oak moss, opoponax resinoid, orange oil, eugenol, auranthiol, galac solid, carvacrol, L-carvone, camphor, cannon, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranyl nitrile , Isobornyl acetate, geranyl acetate, dimethylbenzyl carvinyl acetate, styrylyl acetate, cedolyl acetate, terpinel acetate, pt-butylcyclohexyl acetate, vetiberyl acetate, benzyl acetate, vinegar Linalyl, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, cyclamenaldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromilsenol, jasmine absolute, jasmine lactone, cis-jasmon, citral, citronenol, citronellal, Cinnamon bark oil, 1,8-cineole, cinnamaldehyde, stylus resinoid, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascon, damassenone, thymol, tuberose absolute, decanal, decalactone, terpineol, γ-terpinene, Tripral, Nellore, Nonanal, 2,6-Nonadienol, Nonalactone, Patchouli alcohol, Vanilla absolute, Vanillin Basil oil, patchouli oil, hydroxycitronellal, α-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, petitglen oil, hexylcinnamaldehyde, cis-3-hexenol, perubalsum, vetiver oil, vetiverol, peppermint oil, pepper oil, Heliotropin, bergamot oil, benzylbenzoate, borneol, milresinoid, musk ketone, methylnonylacetaldehyde, γ-methylyonone, menthol, L-menthol, L-menton, eucalyptus oil, β-yonone, lime oil, lavender oil, D-limonene Synthetic and natural fragrances such as linalool, rillar, rigliall, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, various essential oils, and various blended fragrances are preferred. It is cited as the.

  As pigments / colorants / dyes / pigments, brown 201, black 401, purple 201, purple 401, blue 1, blue 2, blue 201, blue 202, blue 203, blue 204 , Blue 205, Blue 403, Blue 404, Green 201, Green 202, Green 204, Green 205, Green 3, Green 401, Green 402, Red 102, Red 104-1 , Red 105-1, Red 106, Red 2, Red 201, Red 202, Red 203, Red 204, Red 205, Red 206, Red 207, Red 208, Red 213 Red 214, Red 215, Red 218, Red 219, Red 220, Red 221, Red 223, Red 225, Red 226, Red 227, Red 228, Red 230 No. 1, Red 230-2, Red 231, Red 232, Red 3, Red 401, Red 404, Red 405, Red 501, Red 502, Red 503, Red 504, Red 505, red 506, orange 201, orange 203, orange 204, orange 205, orange 206, orange 207, orange 401, orange 402, orange 403, yellow 201, yellow 202- No. 1, yellow 202-2, yellow 203, yellow 204, yellow 205, yellow 4, yellow 401, yellow 402, yellow 403-1, yellow 404, yellow 405, yellow 406 Legal dyes such as Yellow No. 407 and Yellow No. 5; Other acidic dyes such as Acid Red 14; Base dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, Arianor Straw Yellow; HC Yellow 2, HC Yellow 5, HC Red 3, 4- Nitro dyes such as hydoxypropylamino-3-nitrophenol, N, N'-bis (2-hydroxyethyl) -2-nitro-p-phenylenediamine, HC Blue 2 and Basic Blue 26; disperse dyes; inorganic white such as titanium dioxide and zinc oxide Pigments: Inorganic red pigments such as iron oxide (Bengara) and iron titanate; Inorganic brown pigments such as γ-iron oxide; Inorganic yellow pigments such as yellow iron oxide and loess; Black iron oxide, low-order titanium oxide, etc. Inorganic pigments such as mango violet and cobalt violet; inorganic green pigments such as chromium oxide, chromium hydroxide and cobalt titanate; inorganic blue pigments such as ultramarine and bitumen; titanium oxide coated mica; Titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, pearl pigments such as fish scale foil; gold such as aluminum powder, copper powder, gold Surface treated inorganic and metal powder pigments: Red 201, Red 202, Red 204, Red 205, Red 220, Red 226, Red 228, Red 405, Orange 203, Orange 204 , Yellow 205, Yellow 401, Blue 404, Red 3, Red 104, Red 106, Red 227, Red 230, Red 401, Red 505, Orange 205, Yellow 4, Yellow Organic pigments such as zirconium, barium or aluminum lakes such as No. 5, Yellow 202, Yellow 203, Green No. 3 and Blue No. 1; surface-treated organic pigments; anthraquinones such as astaxanthin and alizarin, anthocyanidins, β-carotene, Catenal, capsanthin, chalcone, calsamine, quercetin, crocin, chlorophyll, curcumin, cochineal Natural pigments and dyes such as naphthoquinones such as shikonin, bixin, flavones, betacyanidine, henna, hemoglobin, lycopene, riboflavin, rutin; p-phenylenediamine, toluene-2,5-diamine, o-, m-, Or intermediates and couplers of oxidation dyes such as p-aminophenol, m-phenylenediamine, 5-amino-2-methylphenol, resorcin, 1-naphthol, 2,6-diaminopyridine and their salts; autooxidation of indoline, etc. Type dyes; dihydroxyacetone is preferred.

  In addition to these, cosmetic raw material standards, blending ingredient standard by cosmetic varieties, Japan Cosmetic Industry Association ingredient display name list, INCI dictionary (The International Cosmetic Ingredient Dictionary and Handbook), quasi-drug raw material standards, Japanese pharmacopoeia, pharmaceutical additives Ingredients listed in standards, official food additives, etc., and Japanese and foreign patent publications and patent publications (including publications and republications) in which the international patent classification IPC belongs to the classification of A61K7 and A61K8 It is possible to contain known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., such as the ingredients described, in known combinations, blending ratios and blending amounts.

  Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited thereto.

(Production Example 1)
The dried mandarin orange peel is pulverized, 100 g is heated and extracted with purified water (about 30 ° C.) for about 5 hours, and filtered to obtain about 1.0 kg of the extract.

(Production Example 2)
The dried mandarin orange peel is pulverized, 100 g is heated and extracted with purified water (about 80 ° C.) for about 5 hours, and filtered to obtain about 1.0 kg of the extract.

(Production Example 3)
The dried mandarin orange peel is pulverized, 100 g is immersed in a 70% 1,3-butylene glycol solution, extracted at room temperature for 5 days and nights, and then filtered to obtain about 1.0 kg of the extract.

(Production Example 4)
The dried mandarin orange fruit is pulverized, 100 g is immersed in a 50% ethanol solution, extracted at room temperature for 5 days, and then filtered to obtain about 1.0 kg of the extract.

(Production Example 5)
The dried mandarin orange fruit is pulverized, 100 g is immersed in a 30% propylene glycol solution, extracted at room temperature for 5 days and nights, and then filtered to obtain about 1.0 kg of the extract.

(Test 1) Inositol triphosphate receptor expression inducing action The present inventor evaluated the inositol triphosphate receptor expression inducing action using a qRT-PCR method using RNA.
"Test method and evaluation method"
Normal human epidermal keratinocytes (manufactured by Kurashiki Boseki Co., Ltd.) were cultured to sub-confluence, and further cultured for 48 hours, and then the sample “product of the present invention or control (comparative control)” was added and cultured for 6 hours. Extraction was performed from cells 6 hours after the addition using an RNA extraction kit (QIAGEN), and cDNA was synthesized using the obtained RNA as a template and PrimeScript RT reagent Kit (Takara Bio). Using this cDNA, the expression level of the inositol triphosphate receptor gene was measured by quantitative PCR. As a control (comparison control), a 70% 1,3-butylene glycol aqueous solution as an extraction solvent was prepared under the same conditions and used in the test.
In addition, SYBR Premix Ex Taq (Takara Bio Inc.) and Thermal Cycler Dice Real Time System (Takara Bio Inc.) were used for the quantitative PCR method. As an internal standard, the expression level of the β-Actin gene, which is a housekeeping gene, was quantified, and the relative expression level with respect to β-Actin was calculated and used as the inositol triphosphate receptor gene expression level. Qiagen's ITPR and β-Actin were used as PCR primers.
"sample"
For the sample, 0.3% of the mandarin orange extract obtained in Production Example 3 of the product of the present invention was added for the test. As a control (comparison control), a 70% 1,3-butylene glycol solution, which is an extraction solvent for the mandarin orange extract obtained in Production Example 3 of the present invention, was prepared under the same conditions and used in the test. .

(Test results)
As shown in FIG. 1, the expression level of inositol triphosphate receptor in the 70% 1,3-butylene glycol aqueous solution of the control (comparative control) is 1.0, and the mandarin orange extract is 3.07. It was confirmed that the expression level was increased and the effect of inducing the expression of inositol triphosphate receptor was confirmed.
Therefore, the mandarin orange extract induces the expression of inositol triphosphate receptor and is useful as an inositol triphosphate receptor expression inducer.
In addition, the same result was obtained also about the mandarin orange extract obtained by the manufacture examples 1-2 of this invention, and manufacture examples 4-5.

(Prescription Example) Inositol Triphosphate Receptor Expression Inducing Agent, Production of Various Compositions According to the above evaluation results, the prescription examples are shown below, but each prescription example is produced by a conventional method in the production of each product. Only the blending amount was shown. The present invention is not limited to these.

(Formulation Example 1) Inositol triphosphate receptor expression inducer Impregnate a gauze or liniment cloth with a prescription solution containing a suitable amount of mandarin orange fruit hot water extract, antibiotics, anti-inflammatory agent, etc. and attach it to the wound . Alternatively, the hot water extract of mandarin orange fruit may be directly applied locally and covered with gauze or the like.

(Formulation Example 2) Milk Mass%
1.Squalane 5.0
2.Olive oil 5.0
3. Jojoba oil 5.0
4.Cetyl alcohol 1.5
5. Glycerin monostearate 2.0
6.Polyoxyethylene (20) cetyl ether 3.0
7. Polyoxyethylene (20) soorbitan monooleate 2.0
8.1,3-Butylene glycol 1.0
9.Glycerin 2.0
10. Mandarin orange extract from Production Example 3 5.0
11. Tochu Nakaba Hot Water Extract 3.0
12. Preservative (paraoxybenzoic acid ester) appropriate amount
13. Perfume (rose water) appropriate amount
14. Residue with 100 purified water

(Formulation example 3) Flexible lotion mass%
1.Glycerin 5.0
2.1,3-Butylene glycol 5.0
3. Monolauric acid polyoxyethylene sorbitan (20E.O) 1.0
4.Ethanol 15.0
5. Mandarin orange peel 30% ethanol extract 5.0
6. Bodaiju flower or fruit 50% 1,3-butylene glycol extract 5.0
7. Kiwi fruit 50% ethanol extract 1.0
8. Amino acids (Arginine, Glycine, Glutamine, etc.) 0.5
9. Antibacterial (Lactoferrin solution) appropriate amount
10. Preservative (Ethylparaben) appropriate amount
11. Fragrance (Western light water) appropriate amount
12.Residue with 100 purified water

(Formulation example 4) Essence liquid mass%
1.Polyvinyl alcohol 15.0
2.Xanthan gum 0.4
3.Hydroxyethyl cellulose 0.2
4.1,3-Butylene glycol 5.0
5. Mandarin orange peel extract from Production Example 3 5.0
6.Dipotassium glycyrrhizinate 0.2
7. Preservative (salicylic acid) appropriate amount
8. Perfume (flooded water) appropriate amount
9. Residue with 100 purified water

(Formulation Example 5) Facial cleansing cream mass%
1.Myristic acid 25.0
2.Stearic acid 5.0
3. Tallow fatty acid 5.0
4.Propylene glycol 10.0
5.Potassium hydroxide 6.0
6. Palm oil fatty acid diethanolamide 6.0
7. Mandarin orange peel 50% diglycerin extract 2.0
8. Apple fruit 20% 1,3-butylene glycol extract 2.0
9. Kawara mugwort leaf 20% 1,3-butylene glycol extract 2.0
10. Rosehip fruit 30% ethanol extract 1.0
11.Apricot kernel 0.1
12. Preservative (Ethylparaben) 0.1
13. Perfume (today water) appropriate amount
14. Residue with 100 purified water

(Formulation example 6) Body soap mass%
1.Potassium laurate 15.0
2.Potassium myristate 5.0
3.Propylene glycol 5.0
4. Mandarin orange fruit 90% 1,3-butylene glycol extract 1.0
5.Oolong tea leaves 70% 1,3-butylene glycol extract 1.0
6. Toki rhizome 70% 2,3-butylene glycol extract 0.5
7. Wakame 70% 1,3-butylene glycol extract 0.5
8. Melilot flower or leaf 70% 1,3-butylene glycol extract 0.5
9. Aloe pulp 70% ethanol extract 2.0
10 Monoammonium glycyrrhizinate 0.1
11. Preservative (Triclocarban, undecylenic acid, phenol)
12. Fragrance (lavender water) appropriate amount
13. Residue with 100 purified water

(Formulation example 7) Sunscreen cosmetics (O / W type)
1.Oxybenzone 2.0
2.Octyl paramethoxycinnamate 5.0
3.Dihydroxymethoxybenzophenone 0.2
4.Squalane 10.0
5.Vaseline 5.0
6. Stearyl alcohol 3.0
7.Stearic acid 3.0
8. Glyceryl monostearate 2.0
9.Ethyl polyacrylate 1.0
10.1,3-Butylene glycol 6.0
11. Edetate disodium 0.1
12.Triethanolamine 1.0
13.Titanium dioxide 5.0
14. Mandarin orange fruit 50% dipropylene glycol extract 0.5
15. Birch bark 70% dipropylene glycol extract 0.5
16. Kakkon 50% propylene glycol extract 0.5
17. Palm fruit 50% dipropylene glycol extract 0.5
18. Preservative (benzyl paraoxybenzoate) appropriate amount
19. Fragrance (jasmine water) appropriate amount
20.Residue with 100 purified water

(Formulation example 8) Sunscreen cosmetics (oil type)
1.liquid paraffin 70.0
2.Tetrahydroxybenzophenone 1.0
3.Cetyl octanoate 23.8
4. Mandarin orange peel 30% 1,3-butylene glycol extract 1.0
5. Roman chamomile flower 10% 1,3-butylene glycol extract 1.0
6. Burdock root hot water extract 0.5
7. Horse chestnut whole plant 30% 1,3-butylene glycol extract 0.5
8. Mallow flower or leaf 50% propyl alcohol extract 0.5
9. Whole barley 50% 1,3-butylene glycol extract 0.5
10. Antioxidant (butylhydroxytoluene) appropriate amount
11. Fragrance (cornflower water) appropriate amount

(Formulation example 9) Cream foundation (O / W type)
1. Stearic acid 4.0
2.Glycerol monostearate3.0
3.Cetanol 1.5
4.Isopropyl myristate 7.0
5. Liquid paraffin 10.0
6. Sarah Beeswax 3.0
7.Triethanolamine 1.5
8.Glycerin 3.0
9. Bentonite 1.0
10.Titanium oxide 8.0
11.2,4-Dihydroxybenzophenone 8.0
12.Kaolin 3.0
13. Talc 3.0
14. Colored pigment (yellow iron oxide) 1.0
15. Mandarin orange peel hot water extract dry powder 0.2
16.Dokudami leaf hot water extract dry powder 0.2
17. Wenzhou citrus peel or fruit hot water extract dry powder 0.2
18.Yukinoshita Whole Grass Hot Water Extract Dry Powder 0.2
19. Preservative (phenoxyethanol) 0.1
20. Fragrance (rose water) appropriate amount
21. The balance of 100 purified water

(Prescription Example 10) Shampoo Mass%
1.Lauryl sulfate triethanolamine 5.0
2. Sodium polyoxyethylene lauryl ether sulfate 12.0
3.1,3-Butylene glycol 4.0
4.Lauric acid diethanolamide 2.0
5. Edetate disodium 0.1
6. Mandarin orange fruit 20% 2,3-butylene glycol extract 2.0
7. Clam bark hot water extract 2.0
8. Toki 30% 1,4-butylene glycol extract 1.0
9.Hydroxypropyl chitosan solution 1.0
10. Mucopolysaccharide solution 1.0
11.Dipotassium glycyrrhizinate 0.1
12.Zinc pyrithione 0.1
13. Antibacterial and antiseptic (photosensitive element 101) appropriate amount
14.Adjustable pH adjuster
15. Perfume (white sand water) appropriate amount
16.Residue with 100 purified water

(Prescription Example 11) Rinse mass%
1. Stearyl trimethyl ammonium chloride 3.0
2.Cetostearyl alcohol 3.0
3.Polyoxyethylene lanolin ether 3.0
4.Propylene glycol 5.0
5.1,2-Pentanediol 2.0
6. Mandarin orange peel 30% 2,3-butylene glycol extract 5.0
7. Forsythia 50% 2,3-butylene glycol extract 2.0
8. Perfumed fruit 30% 1,2-butylene glycol extract 2.0
9. Comfrey leaf or stem 50% 1,3-butylene glycol extract 1.0
10.Hydroxyethyl chitosan solution 0.5
11. Trehalose solution 0.5
12. Antibacterial and antiseptic (benzalkonium chloride) appropriate amount
13. Perfume (flooded water) appropriate amount
14. Residue with 100 purified water

(Prescription Example 12) Hair Liquid Mass%
1.Ethanol 29.0
2.Polyoxypropylene butyl ether phosphate 10.0
3.Polyoxypropylene monobutyl ether 5.0
4.Triethanolamine 1.0
5. Mandarin orange peel 50% 1,3-butylene glycol extract 1.0
6. Tormentilla root or rhizome 50% 1,3-butylene glycol extract 1.0
7. Hop female flower ear 50% ethanol extract 1.0
8. Usbasaicin rhizome 30% ethanol extract 1.0
9. Birch sap 1.0
10.Carpronium chloride 0.3
11.Keratin degradation solution 0.5
12. Antibacterial and antiseptic (paraben, benzalkonium chloride) appropriate amount
13. Fragrance (Rosehip water)
14. Residue with 100 purified water

(Formulation example 13) Hair artnic mass%
1.Ethanol 40.0
2.Ethyl oleate 1.0
3.Polyoxyethylene (40) hydrogenated castor oil 2.0
4. Mandarin orange extract of Production Example 2 5.0
5. Ogon Rhizome or Rhizome 50% Ethanol Extract 1.0
6. Persimmon rhizome or root bark 50% ethanol extract 1.0
7. Preservative (paraben) appropriate amount
8. Fragrance (sage water) appropriate amount
9. Residue with 100 purified water

(Prescription Example 14) Hair growth / hair growth agent
1.Ethanol 60.0
2. Mandarin orange extract of Production Example 5 5.0
3. Allergen 50% propylene glycol extract 2.0
4. Vitamin E derivative 0.5
5.Pepper tincture 0.5
6.Resorcin 0.5
7.Dipotassium glycyrrhizinate 0.5
8.Carboxymethylchitin solution 0.5
9. Collagen protein enzyme solution 2.0
10. Amino acids (Arginine, Glycine, Glutamine, etc.) 0.5
11. Antibacterial and antiseptic (propylparaben) 0.1
12. Fragrance (rosemary water)
13. Residue with 100 purified water

(Prescription Example 15) Hair loss inhibitor% by weight
1.Ethanol 40.0
2.Ethyl oleate 1.0
3.Polyoxyethylene (40) hydrogenated castor oil 2.0
4. Mandarin orange extract from Production Example 4 5.0
5. Sakura leaf 50% ethanol extract 1.0
6. Comfrey 60% ethanol extract 1.0
7.Glycyrrhizic acid 0.5
8. Preservative (Ethylparaben) appropriate amount
9. Perfume (green tea extract) appropriate amount
10. Residue with 100 purified water

(Formulation Example 16) Granule bath agent
1.Sodium bicarbonate 58.0
2.Anhydrous sodium sulfate 30.0
3. Borax 6.0
4. Mandarin orange extract dry powder 2.0 of Production Example 5
5. Eucalyptus hot water extract dry powder 2.0
6. Peach leaf 70% ethanol extract dry powder 1.0
7. Silk Protein Enzyme Decomposition Dry Powder 1.0
8. Pigment (Gunjo Pink) appropriate amount

(Prescription Example 17) Granule bath agent
1.Sodium bicarbonate 58.0
2.Anhydrous sodium sulfate 30.0
3. Borax 3.0
4. Mandarin orange extract dry powder of Production Example 5 3.0
5. Elderflower or berries hot water extract dry powder 1.0
6. Kawara mugwort leaf or stem hot water extract dry powder 1.0
7. Wenzhou citrus peel or fruit 50% ethanol extract dry powder 1.0
8. Peach leaf 70% ethanol extract dry powder 1.0
9. Persimmon leaves or roots 70% ethanol extract dry powder 1.0
10. Apple juice powder 1.0
11. Dye (Gunjou, chromium hydroxide) appropriate amount
12. Perfume (boiled water) appropriate amount

(Prescription Example 18) Freshener in mouth Mass%
1.Ethanol 20.0
2.Glycerin 15.0
3. Polyoxyethylene hydrogenated castor oil 1.0
4.Saccharin 0.2
5.Chlorohexidine 0.01
6. Mandarin orange extract dry powder of Production Example 2 0.1
7. Almond seed hot water extract dry powder 0.1
8.Green tea leaf hot water extract dry powder 0.1
9. Pigment (Gunjo green) appropriate amount
10. Residue with 100 purified water

(Prescription Example 19) Toothpaste%
1.Heavy calcium carbonate 5.0
2.Light calcium carbonate 5.0
3. Silicic acid 8.0
4.70% sorbite solution 45.0
5.Sodium fluoride 0.1
6.Saccharin sodium 0.2
7. Sodium lauryl sulfate 2.0
8.Sodium alginate 0.4
9. Mandarin orange extract dried powder of Production Example 2 0.1
10.Green tea leaf hot water extract dry powder 0.1
11. Fragrance (Mint) Appropriate amount
12.Residue with 100 purified water

(Prescription Example 20) Inositol triphosphate receptor expression inducer (drinking)
1. Mandarin orange extract dry powder of Production Example 2 3.0
2.Reduced maltose syrup 38.0
3.Microcrystalline cellulose 59.0
4. Fragrance proper amount
5. Residue with 100 purified water

(Prescription Example 21) Oral granules (pharmaceuticals)
1. Mandarin orange fruit hot water extract dry powder 1.0
2.Lactose 30.0
3.Corn starch 58.0
4.crystalline cellulose 7.0
5. Polyvinylpyrrolidone 4.0
6.Perfume appropriate amount

(Prescription Example 22) Capsule (drinking)
1. Mandarin orange fruit hot water extract dry powder 3.0
2.Cellulose 97.0
3.Perfume appropriate amount

(Prescription Example 23) Pasta Mass%
1. Flour 75.0
2.Bacon 10.0
3.Zushi 13.0
4. Mandarin orange peel hot water extract dry powder 2.0
5.Salt / Pepper appropriate amount
6.Butter proper amount
7.Green seaweed
8.Olive oil

(Prescription Example 24) Beverage Mass%
1.Glucose liquid sugar 30.0
2. Grapefruit juice 55.0
3.Luteolin-7-O-glucoside 5.0
4. Mandarin orange extract dry powder of Production Example 1 3.0
5. Mucopolysaccharide solution 3.0
6. Iyokan Juice 2.0
7.Perfume appropriate amount
8. Suitable amount of acidulant

(Prescription example 25) Candy mass%
1. Mandarin orange fruit hot water extract dry powder 0.5
2.Sugar 50.0
3. Minamata 34.0
4.Water 15.5
5.Perfume appropriate amount

  The present invention has found an excellent inositol triphosphate receptor expression-inducing action for mandarin orange extract, and an inositol triphosphate receptor expression inducer containing mandarin orange extract, Various compositions (cosmetic composition, pharmaceutical composition, food and beverage composition) having an inositol triphosphate receptor expression-inducing action can be provided.

Claims (8)

  An inositol triphosphate receptor expression inducer comprising a mandarin orange extract.   An inositol triphosphate receptor expression inducer characterized by containing a mandarin orange peel or fruit extract.   A cosmetic composition characterized by having an inducing action of inositol triphosphate receptor of mandarin orange extract.   A cosmetic composition characterized by having an action of inducing inositol triphosphate receptor expression of mandarin orange peel or fruit extract.   A pharmaceutical composition having an inducing action of inositol triphosphate receptor of mandarin orange extract.   A pharmaceutical composition comprising an inositol triphosphate receptor expression-inducing action of mandarin orange peel or fruit extract.   A food and drink composition characterized by having an inducing action of inositol triphosphate receptor of mandarin orange extract.   A food or beverage composition characterized by having an action of inducing inositol triphosphate receptor expression of mandarin orange peel or fruit extract.