JP2017000144A5 - - Google Patents

Info

Publication number

JP2017000144A5

JP2017000144A5 JP2016131637A JP2016131637A JP2017000144A5 JP 2017000144 A5 JP2017000144 A5 JP 2017000144A5 JP 2016131637 A JP2016131637 A JP 2016131637A JP 2016131637 A JP2016131637 A JP 2016131637A JP 2017000144 A5 JP2017000144 A5 JP 2017000144A5

Authority

JP

Japan

Prior art keywords

fusion protein

fvii

seq

linker

represented

Prior art date

2016-07-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 108020001507 fusion proteins Proteins 0.000 claims 14
• 102000037865 fusion proteins Human genes 0.000 claims 14
• 102100023804 Coagulation factor VII Human genes 0.000 claims 11
• 108010023321 Factor VII Proteins 0.000 claims 11
• 229940012413 factor vii Drugs 0.000 claims 11
• 102000004338 Transferrin Human genes 0.000 claims 5
• 108090000901 Transferrin Proteins 0.000 claims 5
• 125000003275 alpha amino acid group Chemical group 0.000 claims 5
• 210000004027 cell Anatomy 0.000 claims 5
• 108090000765 processed proteins & peptides Proteins 0.000 claims 5
• 239000012581 transferrin Substances 0.000 claims 5
• 150000001413 amino acids Chemical class 0.000 claims 4
• 108091005804 Peptidases Proteins 0.000 claims 3
• 239000004365 Protease Substances 0.000 claims 3
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 3
• 229920001184 polypeptide Polymers 0.000 claims 3
• 102000004196 processed proteins & peptides Human genes 0.000 claims 3
• 238000003776 cleavage reaction Methods 0.000 claims 2
• 108091008146 restriction endonucleases Proteins 0.000 claims 2
• 230000007017 scission Effects 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 108010048049 Factor IXa Proteins 0.000 claims 1
• 108010054265 Factor VIIa Proteins 0.000 claims 1
• 108010074860 Factor Xa Proteins 0.000 claims 1
• 108090000190 Thrombin Proteins 0.000 claims 1
• 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
• 230000035602 clotting Effects 0.000 claims 1
• 229940012414 factor viia Drugs 0.000 claims 1
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
• 229960004072 thrombin Drugs 0.000 claims 1