JP2016539183A5 - - Google Patents
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- JP2016539183A5 JP2016539183A5 JP2016553265A JP2016553265A JP2016539183A5 JP 2016539183 A5 JP2016539183 A5 JP 2016539183A5 JP 2016553265 A JP2016553265 A JP 2016553265A JP 2016553265 A JP2016553265 A JP 2016553265A JP 2016539183 A5 JP2016539183 A5 JP 2016539183A5
- Authority
- JP
- Japan
- Prior art keywords
- dosage form
- solid oral
- oral dosage
- composition
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 claims description 65
- 240000001717 Vaccinium macrocarpon Species 0.000 claims description 33
- 239000007787 solid Substances 0.000 claims description 31
- 235000012545 Vaccinium macrocarpon Nutrition 0.000 claims description 30
- 235000002118 Vaccinium oxycoccus Nutrition 0.000 claims description 30
- 235000004634 cranberry Nutrition 0.000 claims description 30
- 239000006186 oral dosage form Substances 0.000 claims description 30
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 12
- 230000001225 therapeutic effect Effects 0.000 claims description 12
- 239000000843 powder Substances 0.000 claims description 11
- YQUVCSBJEUQKSH-UHFFFAOYSA-N 3,4-dihydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C(O)=C1 YQUVCSBJEUQKSH-UHFFFAOYSA-N 0.000 claims description 10
- NGSWKAQJJWESNS-UHFFFAOYSA-N 4-coumaric acid Chemical compound OC(=O)C=CC1=CC=C(O)C=C1 NGSWKAQJJWESNS-UHFFFAOYSA-N 0.000 claims description 10
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 claims description 10
- ALRFYJWUVHBXLV-UHFFFAOYSA-N guaijaverin Natural products OC1COC(COC2=C(Oc3cc(O)cc(O)c3C2=O)c4ccc(O)c(O)c4)C(O)C1O ALRFYJWUVHBXLV-UHFFFAOYSA-N 0.000 claims description 10
- QAIPRVGONGVQAS-DUXPYHPUSA-N trans-caffeic acid Chemical compound OC(=O)\C=C\C1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-DUXPYHPUSA-N 0.000 claims description 10
- 235000012054 meals Nutrition 0.000 claims description 7
- RKWHWFONKJEUEF-WVXKDWSHSA-O cyanidin 3-O-beta-D-galactoside Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1OC1=CC2=C(O)C=C(O)C=C2[O+]=C1C1=CC=C(O)C(O)=C1 RKWHWFONKJEUEF-WVXKDWSHSA-O 0.000 claims description 6
- ACEAELOMUCBPJP-UHFFFAOYSA-N (E)-3,4,5-trihydroxycinnamic acid Natural products OC(=O)C=CC1=CC(O)=C(O)C(O)=C1 ACEAELOMUCBPJP-UHFFFAOYSA-N 0.000 claims description 5
- WQSDYZZEIBAPIN-VBQORRLJSA-N 1-caffeoyl-beta-D-glucose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 WQSDYZZEIBAPIN-VBQORRLJSA-N 0.000 claims description 5
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 claims description 5
- BDCDNTVZSILEOY-WNJKXWAASA-N 3-[(2s,3r,4r,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one Chemical compound O[C@@H]1[C@@H](O)[C@@H](CO)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O BDCDNTVZSILEOY-WNJKXWAASA-N 0.000 claims description 5
- NGSWKAQJJWESNS-ZZXKWVIFSA-M 4-Hydroxycinnamate Natural products OC1=CC=C(\C=C\C([O-])=O)C=C1 NGSWKAQJJWESNS-ZZXKWVIFSA-M 0.000 claims description 5
- DFYRUELUNQRZTB-UHFFFAOYSA-N Acetovanillone Natural products COC1=CC(C(C)=O)=CC=C1O DFYRUELUNQRZTB-UHFFFAOYSA-N 0.000 claims description 5
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 claims description 5
- ORTBMTXABUAMJS-VGEDXCMYSA-N Cyanidin 3-arabinoside Chemical compound [Cl-].O[C@H]1[C@H](O)[C@H](O)CO[C@H]1OC1=CC2=C(O)C=C(O)C=C2[O+]=C1C1=CC=C(O)C(O)=C1 ORTBMTXABUAMJS-VGEDXCMYSA-N 0.000 claims description 5
- KUCVMQMKRICXJC-FBVAEJEDSA-O Cyanidin 3-arabinoside Natural products O([C@H]1[C@@H](O)[C@@H](O)[C@H](O)CO1)c1c(-c2cc(O)c(O)cc2)[o+]c2c(c(O)cc(O)c2)c1 KUCVMQMKRICXJC-FBVAEJEDSA-O 0.000 claims description 5
- OVSQVDMCBVZWGM-IDRAQACASA-N Hirsutrin Natural products O([C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1)C1=C(c2cc(O)c(O)cc2)Oc2c(c(O)cc(O)c2)C1=O OVSQVDMCBVZWGM-IDRAQACASA-N 0.000 claims description 5
- FVQOMEDMFUMIMO-UHFFFAOYSA-N Hyperosid Natural products OC1C(O)C(O)C(CO)OC1OC1C(=O)C2=C(O)C=C(O)C=C2OC1C1=CC=C(O)C(O)=C1 FVQOMEDMFUMIMO-UHFFFAOYSA-N 0.000 claims description 5
- IKMDFBPHZNJCSN-UHFFFAOYSA-N Myricetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC(O)=C(O)C(O)=C1 IKMDFBPHZNJCSN-UHFFFAOYSA-N 0.000 claims description 5
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 claims description 5
- ZZWPMFROUHHAKY-SXFAUFNYSA-O Peonidin 3-O-beta-D-galactopyranoside Natural products O(C)c1c(O)ccc(-c2c(O[C@H]3[C@@H](O)[C@H](O)[C@@H](O)[C@H](CO)O3)cc3c(O)cc(O)cc3[o+]2)c1 ZZWPMFROUHHAKY-SXFAUFNYSA-O 0.000 claims description 5
- VDTNZDSOEFSAIZ-HVOKISQTSA-N Peonidin 3-O-galactoside Chemical compound [Cl-].C1=C(O)C(OC)=CC(C=2C(=CC=3C(O)=CC(O)=CC=3[O+]=2)O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)=C1 VDTNZDSOEFSAIZ-HVOKISQTSA-N 0.000 claims description 5
- ZTQGIZPDDMLVHP-KFTCICMSSA-N Peonidin 3-arabinoside Chemical compound [Cl-].C1=C(O)C(OC)=CC(C=2C(=CC=3C(O)=CC(O)=CC=3[O+]=2)O[C@H]2[C@@H]([C@@H](O)[C@@H](O)CO2)O)=C1 ZTQGIZPDDMLVHP-KFTCICMSSA-N 0.000 claims description 5
- KRUPPTWQKIEURV-WBHLOVLFSA-O Peonidin 3-arabinoside Natural products O(C)c1c(O)ccc(-c2c(O[C@H]3[C@H](O)[C@@H](O)[C@H](O)CO3)cc3c(O)cc(O)cc3[o+]2)c1 KRUPPTWQKIEURV-WBHLOVLFSA-O 0.000 claims description 5
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 claims description 5
- BDCDNTVZSILEOY-BQCJVYABSA-N Quercetin 3-arabinoside Chemical compound O[C@@H]1[C@@H](O)[C@H](CO)O[C@@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O BDCDNTVZSILEOY-BQCJVYABSA-N 0.000 claims description 5
- NSZQOXBBEWYGQH-UHFFFAOYSA-N Quercetin-3-rhamnosid Natural products CC1OC(O)C(O)C(OC2=C(Oc3cc(O)cc(O)c3C2=O)c4ccc(O)c(O)c4)C1O NSZQOXBBEWYGQH-UHFFFAOYSA-N 0.000 claims description 5
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 claims description 5
- 235000004883 caffeic acid Nutrition 0.000 claims description 5
- 229940074360 caffeic acid Drugs 0.000 claims description 5
- 235000001368 chlorogenic acid Nutrition 0.000 claims description 5
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 claims description 5
- 229940074393 chlorogenic acid Drugs 0.000 claims description 5
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 claims description 5
- YTMNONATNXDQJF-UBNZBFALSA-N chrysanthemin Chemical compound [Cl-].O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC2=C(O)C=C(O)C=C2[O+]=C1C1=CC=C(O)C(O)=C1 YTMNONATNXDQJF-UBNZBFALSA-N 0.000 claims description 5
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 claims description 5
- QAIPRVGONGVQAS-UHFFFAOYSA-N cis-caffeic acid Natural products OC(=O)C=CC1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-UHFFFAOYSA-N 0.000 claims description 5
- 229920002770 condensed tannin Polymers 0.000 claims description 5
- GXMWXESSGGEWEM-UHFFFAOYSA-N isoquercitrin Natural products OCC(O)C1OC(OC2C(Oc3cc(O)cc(O)c3C2=O)c4ccc(O)c(O)c4)C(O)C1O GXMWXESSGGEWEM-UHFFFAOYSA-N 0.000 claims description 5
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 claims description 5
- PCOBUQBNVYZTBU-UHFFFAOYSA-N myricetin Natural products OC1=C(O)C(O)=CC(C=2OC3=CC(O)=C(O)C(O)=C3C(=O)C=2)=C1 PCOBUQBNVYZTBU-UHFFFAOYSA-N 0.000 claims description 5
- 235000007743 myricetin Nutrition 0.000 claims description 5
- 229940116852 myricetin Drugs 0.000 claims description 5
- ZZWPMFROUHHAKY-OUUKCGNVSA-O peonidin 3-O-beta-D-glucoside Chemical compound C1=C(O)C(OC)=CC(C=2C(=CC=3C(O)=CC(O)=CC=3[O+]=2)O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=C1 ZZWPMFROUHHAKY-OUUKCGNVSA-O 0.000 claims description 5
- 235000005875 quercetin Nutrition 0.000 claims description 5
- 229960001285 quercetin Drugs 0.000 claims description 5
- OVSQVDMCBVZWGM-QSOFNFLRSA-N quercetin 3-O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OVSQVDMCBVZWGM-QSOFNFLRSA-N 0.000 claims description 5
- HDDDNIUXSFCGMB-UHFFFAOYSA-N quercetin 3-galactoside Natural products OCC1OC(OC2=C(Oc3ccc(O)c(O)c3C2=O)c4ccc(O)c(O)c4)C(O)C(O)C1O HDDDNIUXSFCGMB-UHFFFAOYSA-N 0.000 claims description 5
- QDAMORAIRIHJCS-UHFFFAOYSA-N quercetin 3-rhamnoside Natural products CC1OC(OC2=C(Oc3ccc(O)c(O)c3C2=O)c4ccc(O)c(O)c4)C(O)C(O)C1O QDAMORAIRIHJCS-UHFFFAOYSA-N 0.000 claims description 5
- OXGUCUVFOIWWQJ-HQBVPOQASA-N quercitrin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OXGUCUVFOIWWQJ-HQBVPOQASA-N 0.000 claims description 5
- PUETUDUXMCLALY-HOTGVXAUSA-N (-)-secoisolariciresinol Chemical compound C1=C(O)C(OC)=CC(C[C@@H](CO)[C@H](CO)CC=2C=C(OC)C(O)=CC=2)=C1 PUETUDUXMCLALY-HOTGVXAUSA-N 0.000 claims description 4
- AAWZDTNXLSGCEK-LNVDRNJUSA-N (3r,5r)-1,3,4,5-tetrahydroxycyclohexane-1-carboxylic acid Chemical compound O[C@@H]1CC(O)(C(O)=O)C[C@@H](O)C1O AAWZDTNXLSGCEK-LNVDRNJUSA-N 0.000 claims description 4
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 4
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims description 4
- AAWZDTNXLSGCEK-UHFFFAOYSA-N Cordycepinsaeure Natural products OC1CC(O)(C(O)=O)CC(O)C1O AAWZDTNXLSGCEK-UHFFFAOYSA-N 0.000 claims description 4
- 206010020853 Hypertonic bladder Diseases 0.000 claims description 4
- 206010071289 Lower urinary tract symptoms Diseases 0.000 claims description 4
- 208000009722 Overactive Urinary Bladder Diseases 0.000 claims description 4
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims description 4
- AAWZDTNXLSGCEK-ZHQZDSKASA-N Quinic acid Natural products O[C@H]1CC(O)(C(O)=O)C[C@H](O)C1O AAWZDTNXLSGCEK-ZHQZDSKASA-N 0.000 claims description 4
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 4
- 239000001630 malic acid Substances 0.000 claims description 4
- 235000011090 malic acid Nutrition 0.000 claims description 4
- OGFXBIXJCWAUCH-UHFFFAOYSA-N meso-secoisolariciresinol Natural products C1=2C=C(O)C(OC)=CC=2CC(CO)C(CO)C1C1=CC=C(O)C(OC)=C1 OGFXBIXJCWAUCH-UHFFFAOYSA-N 0.000 claims description 4
- 150000007524 organic acids Chemical class 0.000 claims description 4
- 208000020629 overactive bladder Diseases 0.000 claims description 4
- 235000004239 secoisolariciresinol Nutrition 0.000 claims description 4
- HGXBRUKMWQGOIE-AFHBHXEDSA-N (+)-pinoresinol Chemical compound C1=C(O)C(OC)=CC([C@@H]2[C@@H]3[C@@H]([C@H](OC3)C=3C=C(OC)C(O)=CC=3)CO2)=C1 HGXBRUKMWQGOIE-AFHBHXEDSA-N 0.000 claims description 3
- WCGUUGGRBIKTOS-GPOJBZKASA-N (3beta)-3-hydroxyurs-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C WCGUUGGRBIKTOS-GPOJBZKASA-N 0.000 claims description 3
- 208000010228 Erectile Dysfunction Diseases 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims description 3
- 235000021019 cranberries Nutrition 0.000 claims description 3
- 201000001881 impotence Diseases 0.000 claims description 3
- 235000007221 pinoresinol Nutrition 0.000 claims description 3
- OHOPKHNWLCMLSW-UHFFFAOYSA-N pinoresinol Natural products C1=C(O)C(OC)=CC(C2C3C(C(OC3)C=3C=C(CO)C(O)=CC=3)CO2)=C1 OHOPKHNWLCMLSW-UHFFFAOYSA-N 0.000 claims description 3
- 210000002307 prostate Anatomy 0.000 claims description 3
- 229940096998 ursolic acid Drugs 0.000 claims description 3
- PLSAJKYPRJGMHO-UHFFFAOYSA-N ursolic acid Natural products CC1CCC2(CCC3(C)C(C=CC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1C)C(=O)O PLSAJKYPRJGMHO-UHFFFAOYSA-N 0.000 claims description 3
- BURBOJZOZGMMQF-UHFFFAOYSA-N xanthoxylol Natural products C1=C(O)C(OC)=CC=C1C1C(COC2C=3C=C4OCOC4=CC=3)C2CO1 BURBOJZOZGMMQF-UHFFFAOYSA-N 0.000 claims description 3
- 206010005060 Bladder obstruction Diseases 0.000 claims description 2
- 206010061218 Inflammation Diseases 0.000 claims description 2
- 208000005615 Interstitial Cystitis Diseases 0.000 claims description 2
- 208000000450 Pelvic Pain Diseases 0.000 claims description 2
- 241000736767 Vaccinium Species 0.000 claims description 2
- 235000012511 Vaccinium Nutrition 0.000 claims description 2
- 244000291414 Vaccinium oxycoccus Species 0.000 claims description 2
- 230000004054 inflammatory process Effects 0.000 claims description 2
- 201000007094 prostatitis Diseases 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- 206010058914 Hypotonic urinary bladder Diseases 0.000 claims 1
- 206010072903 Prostatic fibrosis Diseases 0.000 claims 1
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- VEVZSMAEJFVWIL-UHFFFAOYSA-O cyanidin cation Chemical compound [O+]=1C2=CC(O)=CC(O)=C2C=C(O)C=1C1=CC=C(O)C(O)=C1 VEVZSMAEJFVWIL-UHFFFAOYSA-O 0.000 description 2
- 239000000902 placebo Substances 0.000 description 2
- 229940068196 placebo Drugs 0.000 description 2
- 206010016654 Fibrosis Diseases 0.000 description 1
- 208000004168 Underactive Urinary Bladder Diseases 0.000 description 1
- 206010046543 Urinary incontinence Diseases 0.000 description 1
- 235000007336 cyanidin Nutrition 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361902376P | 2013-11-11 | 2013-11-11 | |
| US61/902,376 | 2013-11-11 | ||
| PCT/US2014/064961 WO2015070203A1 (en) | 2013-11-11 | 2014-11-11 | Compositions and methods useful in treatment of lower urinary tract sysptoms, benign prostatic hyperplasia, erectile dysfunction |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019211391A Division JP7083330B2 (ja) | 2013-11-11 | 2019-11-22 | 下部尿路症状、良性前立腺過形成、勃起障害の治療に有用な組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016539183A JP2016539183A (ja) | 2016-12-15 |
| JP2016539183A5 true JP2016539183A5 (https=) | 2017-12-14 |
| JP6966196B2 JP6966196B2 (ja) | 2021-11-10 |
Family
ID=53042226
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016553265A Active JP6966196B2 (ja) | 2013-11-11 | 2014-11-11 | 下部尿路症状、良性前立腺過形成、勃起障害の治療に有用な組成物及び方法 |
| JP2019211391A Active JP7083330B2 (ja) | 2013-11-11 | 2019-11-22 | 下部尿路症状、良性前立腺過形成、勃起障害の治療に有用な組成物及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019211391A Active JP7083330B2 (ja) | 2013-11-11 | 2019-11-22 | 下部尿路症状、良性前立腺過形成、勃起障害の治療に有用な組成物及び方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (5) | US20160324911A1 (https=) |
| EP (2) | EP3782634B1 (https=) |
| JP (2) | JP6966196B2 (https=) |
| KR (2) | KR102745710B1 (https=) |
| CN (2) | CN105848663A (https=) |
| AU (1) | AU2014346415B2 (https=) |
| BR (1) | BR112016010509B1 (https=) |
| CA (2) | CA2928631C (https=) |
| CL (1) | CL2016001109A1 (https=) |
| CR (1) | CR20160254A (https=) |
| ES (2) | ES2980381T3 (https=) |
| IL (1) | IL245552B (https=) |
| MX (1) | MX373448B (https=) |
| MY (1) | MY184225A (https=) |
| NZ (1) | NZ719268A (https=) |
| PH (1) | PH12016500780A1 (https=) |
| PL (1) | PL3068414T3 (https=) |
| RU (1) | RU2696584C1 (https=) |
| SG (2) | SG10201910781SA (https=) |
| WO (1) | WO2015070203A1 (https=) |
| ZA (1) | ZA201602941B (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102745710B1 (ko) * | 2013-11-11 | 2024-12-20 | 나투렉스 인코포레이티드 | 하부 요로 증상, 양성 전립선 비대증, 발기부전 치료에 유용한 조성물 및 방법 |
| WO2018134962A1 (ja) * | 2017-01-20 | 2018-07-26 | マルカイコーポレーション株式会社 | 頻尿の改善剤 |
| CN107647387A (zh) * | 2017-08-15 | 2018-02-02 | 孟广千 | 用于补膀胱的保健食品 |
| IT201800007473A1 (it) | 2018-07-24 | 2020-01-24 | Sistema di aggancio ad evidenza di manomissione, procedimento per la realizzazione di detto sistema di aggancio, contenitore comprendente detto sistema di aggancio ed uso di quest'ultimo | |
| JP7219907B2 (ja) * | 2018-07-25 | 2023-02-09 | 株式会社 沖縄リサーチセンター | 下部尿路症状改善用組成物 |
| JP6738388B2 (ja) * | 2018-09-27 | 2020-08-12 | マルカイコーポレーション株式会社 | 頻尿の改善剤 |
| US20200360466A1 (en) * | 2019-05-13 | 2020-11-19 | Nymox Corporation | Method of improving lower urinary tract symptoms |
| US20220400727A1 (en) * | 2019-11-08 | 2022-12-22 | Cj Cheiljedang Corporation | Composition containing polyphenol |
| EP4205756A4 (en) * | 2020-08-31 | 2024-10-23 | K-Biotech Co., Ltd. | PHARMACEUTICAL COMPOSITION COMPRISING AN EXTRACT OF ABELIOPHYLLUM DISTICHUM AS ACTIVE INGREDIENT FOR TREATING AN ANDROGEN RECEPTOR-RELATED DISEASE |
| WO2022189010A1 (en) * | 2021-03-07 | 2022-09-15 | Givaudan Sa | Methods and compositions for treating and preventing urinary tract infections |
| KR102388984B1 (ko) * | 2021-11-16 | 2022-04-20 | 재단법인 전남바이오산업진흥원 | 모새나무 열매 추출물을 유효성분으로 포함하는 전립선 비대증 예방 또는 치료용 약학조성물 |
| WO2025038998A1 (en) * | 2023-08-17 | 2025-02-20 | University Of Wyoming | Materials and methods for inhibiting, preventing, and dispersing biofilms |
| WO2025078239A1 (en) | 2023-10-09 | 2025-04-17 | Givaudan Sa | Compositions |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| US5073543A (en) | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
| IT1229203B (it) | 1989-03-22 | 1991-07-25 | Bioresearch Spa | Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative. |
| US5120548A (en) | 1989-11-07 | 1992-06-09 | Merck & Co., Inc. | Swelling modulated polymeric drug delivery device |
| US5698155A (en) | 1991-05-31 | 1997-12-16 | Gs Technologies, Inc. | Method for the manufacture of pharmaceutical cellulose capsules |
| US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| US5525341A (en) * | 1992-10-09 | 1996-06-11 | Jlb, Inc. | Partially purified cranberry anti-adhesion activity |
| IT1270594B (it) | 1994-07-07 | 1997-05-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida |
| US6231866B1 (en) * | 1998-04-30 | 2001-05-15 | Douglas G. Mann | Infused vegetable, fruit, herb, and/or seed fiber product and dietary supplements containing same |
| US20010025059A1 (en) | 2000-01-10 | 2001-09-27 | Kastke Floyd A. | Composition and method for treating non-bacterial prostatitis |
| US6391345B1 (en) | 2000-05-12 | 2002-05-21 | Tim Heeg | Cranberry seed oil, cranberry seed flour and a method for making |
| JP2001342142A (ja) * | 2000-06-01 | 2001-12-11 | Nissui Pharm Co Ltd | 泌尿器系疾患予防治療用組成物 |
| US7270837B2 (en) * | 2003-11-10 | 2007-09-18 | Rutgers, The State University Of New Jersey | Anti-inflammatory cranberry flavonol extract preparations |
| EP1727522A2 (en) * | 2004-02-04 | 2006-12-06 | Foamix Ltd. | Cosmetic and pharmaceutical foam with solid matter |
| CA2580628C (en) * | 2004-05-03 | 2014-08-19 | Northern Lights Food Processing, Llc | Berry oils and products |
| US8153166B2 (en) * | 2006-06-08 | 2012-04-10 | Chih-Hsiung Lin | Composition for prophylaxis or treatment of urinary system infection and method thereof |
| CN101784279A (zh) * | 2007-06-27 | 2010-07-21 | 科洛普拉斯特公司 | 使用皂角苷和抗生素的混合物治疗泌尿道感染 |
| CN101095764B (zh) * | 2007-07-13 | 2010-05-19 | 天津天狮生物发展有限公司 | 具有辅助治疗女性泌尿道感染的保健食品 |
| US8173178B1 (en) | 2007-08-03 | 2012-05-08 | Decas Botanical Synergies, Llc | Compositions and methods for controlling metabolic syndrome using whole fruit-derived cranberry ingredient profile enriched in stress adapted bioactives (SABs) |
| US20090175843A1 (en) * | 2008-01-08 | 2009-07-09 | Medical Nutrition Usa, Inc. | Composition for prevention or treatment of urinary tract infection |
| US20090180999A1 (en) * | 2008-01-11 | 2009-07-16 | U.S. Nutraceuticals, Llc D/B/A Valensa International | Method of preventing, controlling and ameliorating urinary tract infections using cranberry derivative and d-mannose composition |
| US20110064706A1 (en) | 2008-01-11 | 2011-03-17 | U.S. Nutraceuticals, Llc D/B/A Valensa International | Method of preventing, controlling and ameliorating urinary tract infections and supporting digestive health by using a synergistic cranberry derivative, a d-mannose composition and a proprietary probiotic blend |
| EP2156835A1 (en) * | 2008-08-19 | 2010-02-24 | Sanofi-Aventis | New therapeutic use of drotaverine |
| WO2011088420A1 (en) | 2010-01-15 | 2011-07-21 | Ocean Spray Cranberries, Inc. | Process for extracting compound from cranberry leaves and related products |
| CN101999648B (zh) * | 2010-10-11 | 2012-10-31 | 宝鸡市虹源生物科技有限公司 | 蔓越橘果实中花色苷及原花青素类成分的提取方法 |
| JP2012171899A (ja) * | 2011-02-21 | 2012-09-10 | Unitika Ltd | 尿路感染症予防改善剤 |
| FR2972328A1 (fr) * | 2011-03-07 | 2012-09-14 | Walmark A S | Complement alimentaire augmentant la protection de l'epithelium des voies urinaires basses contre les infections a repetition |
| US20130122146A1 (en) * | 2011-11-16 | 2013-05-16 | Decas Botanical Synergies, Llc | Process for Spray Drying Botanical Food |
| KR102745710B1 (ko) * | 2013-11-11 | 2024-12-20 | 나투렉스 인코포레이티드 | 하부 요로 증상, 양성 전립선 비대증, 발기부전 치료에 유용한 조성물 및 방법 |
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