JP2016539164A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016539164A5 JP2016539164A5 JP2016536659A JP2016536659A JP2016539164A5 JP 2016539164 A5 JP2016539164 A5 JP 2016539164A5 JP 2016536659 A JP2016536659 A JP 2016536659A JP 2016536659 A JP2016536659 A JP 2016536659A JP 2016539164 A5 JP2016539164 A5 JP 2016539164A5
- Authority
- JP
- Japan
- Prior art keywords
- subject
- pharmaceutically acceptable
- acceptable salt
- composition
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 22
- 150000003839 salts Chemical class 0.000 claims 12
- 238000013268 sustained release Methods 0.000 claims 11
- 239000012730 sustained-release form Substances 0.000 claims 11
- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 claims 8
- 229960003086 naltrexone Drugs 0.000 claims 8
- SNPPWIUOZRMYNY-UHFFFAOYSA-N bupropion Chemical compound CC(C)(C)NC(C)C(=O)C1=CC=CC(Cl)=C1 SNPPWIUOZRMYNY-UHFFFAOYSA-N 0.000 claims 7
- 229960001058 bupropion Drugs 0.000 claims 7
- 208000024172 Cardiovascular disease Diseases 0.000 claims 6
- 208000006011 Stroke Diseases 0.000 claims 6
- 230000002526 effect on cardiovascular system Effects 0.000 claims 4
- 230000002411 adverse Effects 0.000 claims 3
- 230000007211 cardiovascular event Effects 0.000 claims 3
- 208000010125 myocardial infarction Diseases 0.000 claims 3
- 230000000250 revascularization Effects 0.000 claims 3
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 3
- 206010002388 Angina unstable Diseases 0.000 claims 2
- 206010003658 Atrial Fibrillation Diseases 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
- 208000007814 Unstable Angina Diseases 0.000 claims 2
- 206010003119 arrhythmia Diseases 0.000 claims 2
- 201000004332 intermediate coronary syndrome Diseases 0.000 claims 2
- 206010002329 Aneurysm Diseases 0.000 claims 1
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- 206010014486 Elevated triglycerides Diseases 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 208000004301 Sinus Arrhythmia Diseases 0.000 claims 1
- 206010065341 Ventricular tachyarrhythmia Diseases 0.000 claims 1
- 210000003423 ankle Anatomy 0.000 claims 1
- 210000001367 artery Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 230000036772 blood pressure Effects 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 230000001934 delay Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 230000000302 ischemic effect Effects 0.000 claims 1
- 210000003141 lower extremity Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 208000003663 ventricular fibrillation Diseases 0.000 claims 1
- 206010047302 ventricular tachycardia Diseases 0.000 claims 1
- 230000004580 weight loss Effects 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361913216P | 2013-12-06 | 2013-12-06 | |
| US61/913,216 | 2013-12-06 | ||
| US201361914938P | 2013-12-11 | 2013-12-11 | |
| US61/914,938 | 2013-12-11 | ||
| US201461984580P | 2014-04-25 | 2014-04-25 | |
| US61/984,580 | 2014-04-25 | ||
| US14/322,810 | 2014-07-02 | ||
| US14/322,810 US8969371B1 (en) | 2013-12-06 | 2014-07-02 | Compositions and methods for weight loss in at risk patient populations |
| PCT/US2014/068527 WO2015085044A1 (en) | 2013-12-06 | 2014-12-04 | Compositions and methods for reducing major adverse cardiovascular events |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019220444A Division JP7204634B2 (ja) | 2013-12-06 | 2019-12-05 | 主要有害心血管事象を低減するための組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016539164A JP2016539164A (ja) | 2016-12-15 |
| JP2016539164A5 true JP2016539164A5 (https=) | 2018-01-18 |
| JP6665094B2 JP6665094B2 (ja) | 2020-03-13 |
Family
ID=52575014
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016536659A Active JP6665094B2 (ja) | 2013-12-06 | 2014-12-04 | 主要有害心血管事象を低減するための組成物及び方法 |
| JP2019220444A Active JP7204634B2 (ja) | 2013-12-06 | 2019-12-05 | 主要有害心血管事象を低減するための組成物及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019220444A Active JP7204634B2 (ja) | 2013-12-06 | 2019-12-05 | 主要有害心血管事象を低減するための組成物及び方法 |
Country Status (34)
| Country | Link |
|---|---|
| US (9) | US8969371B1 (https=) |
| EP (2) | EP4005571A1 (https=) |
| JP (2) | JP6665094B2 (https=) |
| KR (3) | KR20220165791A (https=) |
| CN (3) | CN114404419A (https=) |
| AU (1) | AU2014360492A1 (https=) |
| BR (1) | BR112016012755A2 (https=) |
| CA (1) | CA2932127C (https=) |
| CL (1) | CL2016001362A1 (https=) |
| CR (1) | CR20160313A (https=) |
| CY (1) | CY1125114T1 (https=) |
| DK (1) | DK3076971T3 (https=) |
| EA (1) | EA201690964A1 (https=) |
| EC (1) | ECSP16057765A (https=) |
| ES (1) | ES2903391T3 (https=) |
| HR (1) | HRP20220058T1 (https=) |
| HU (1) | HUE057551T2 (https=) |
| IL (3) | IL300870A (https=) |
| JO (1) | JOP20140344B1 (https=) |
| LT (1) | LT3076971T (https=) |
| MX (2) | MX389742B (https=) |
| PE (1) | PE20161034A1 (https=) |
| PL (1) | PL3076971T3 (https=) |
| PT (1) | PT3076971T (https=) |
| PY (1) | PY1454647A (https=) |
| RS (1) | RS62846B1 (https=) |
| RU (1) | RU2711638C2 (https=) |
| SG (1) | SG10201808055QA (https=) |
| SI (1) | SI3076971T1 (https=) |
| TN (1) | TN2016000231A1 (https=) |
| TW (1) | TWI661826B (https=) |
| UY (1) | UY35864A (https=) |
| WO (1) | WO2015085044A1 (https=) |
| ZA (1) | ZA201603831B (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1617832B1 (en) | 2003-04-29 | 2008-03-12 | Orexigen Therapeutics, Inc. | Compositions for affecting weight loss |
| CN101370488B (zh) | 2005-11-22 | 2012-07-18 | 奥雷西根治疗公司 | 增加胰岛素敏感性的组合物 |
| WO2007089318A2 (en) * | 2005-11-23 | 2007-08-09 | Orexigen Therapeutics, Inc. | Compositions and methods for reducing food cravings |
| US8916195B2 (en) | 2006-06-05 | 2014-12-23 | Orexigen Therapeutics, Inc. | Sustained release formulation of naltrexone |
| KR20170077291A (ko) | 2006-11-09 | 2017-07-05 | 오렉시젠 세러퓨틱스 인크. | 단위 용량 팩키지 |
| WO2009158114A1 (en) | 2008-05-30 | 2009-12-30 | Orexigen Therapeutics, Inc. | Methods for treating visceral fat conditions |
| MX344303B (es) | 2010-01-11 | 2016-12-13 | Orexigen Therapeutics Inc | Metodos para proveer terapia de perdida de peso en pacientes con depresion mayor. |
| CN110893181A (zh) * | 2012-06-06 | 2020-03-20 | 纳丙药业有限责任公司 | 治疗超重和肥胖症的方法 |
| US8969371B1 (en) | 2013-12-06 | 2015-03-03 | Orexigen Therapeutics, Inc. | Compositions and methods for weight loss in at risk patient populations |
| US9968659B2 (en) | 2016-03-04 | 2018-05-15 | Novo Nordisk A/S | Liraglutide in cardiovascular conditions |
| JP7221694B2 (ja) | 2016-04-28 | 2023-02-14 | ノヴォ ノルディスク アー／エス | 心血管状態におけるセマグルチド |
| BR112019002781A2 (pt) * | 2016-08-11 | 2019-07-09 | Huawei Tech Co Ltd | método de comunicação sem fio, estação base e dispositivo terminal baseado em espectro não licenciado |
| WO2023107640A1 (en) * | 2021-12-09 | 2023-06-15 | Incarda Therapeutics, Inc. | Inhaled therapy for cardiac arrhythmia |
| US12303604B1 (en) | 2024-10-16 | 2025-05-20 | Currax Pharmaceuticals Llc | Pharmaceutical formulations comprising naltrexone and/or bupropion |
Family Cites Families (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4217353A (en) | 1978-05-19 | 1980-08-12 | E. I. Du Pont De Nemours And Company | Method for inducing anorexia |
| IL58649A (en) | 1978-11-10 | 1982-04-30 | Beecham Group Ltd | Pharmaceutical dispensing container |
| EP0103636B1 (en) | 1982-03-16 | 1990-09-12 | Rockefeller University | Use of opium antagonists for the manufacture of medicaments for controlling gastrointestinal dysmotility |
| GB8613689D0 (en) | 1986-06-05 | 1986-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| DE3883606T2 (de) | 1987-05-04 | 1994-01-20 | Lilly Co Eli | Verwendung von Fluoxetin zur Behandlung des Diabetes. |
| US5486362A (en) | 1991-05-07 | 1996-01-23 | Dynagen, Inc. | Controlled, sustained release delivery system for treating drug dependency |
| US5403595A (en) | 1991-05-07 | 1995-04-04 | Dynagen, Inc. | Controlled, sustained release delivery system for smoking cessation |
| DE4136215A1 (de) | 1991-11-02 | 1993-05-06 | Ferring Arzneimittel Gmbh, 2300 Kiel, De | Verwendung von opiat-antagonisten zur behandlung von endogener hyperinsulinaemie |
| US5512593A (en) | 1993-03-02 | 1996-04-30 | John S. Nagle | Composition and method of treating depression using natoxone or naltrexone in combination with a serotonin reuptake inhibitor |
| EP0782445B1 (en) | 1994-09-19 | 2002-03-13 | Dupont Pharmaceuticals Company | Combination of an opioid antagonist and a selective serotonin reuptake inhibitor for treatment of alcoholism and alcohol dependence |
| US5627187A (en) | 1995-04-12 | 1997-05-06 | Katz; Bruce E. | 5-FU for treating actinic kerotoses |
| GB9517062D0 (en) | 1995-08-18 | 1995-10-25 | Scherer Ltd R P | Pharmaceutical compositions |
| EP0795327A1 (en) * | 1996-03-13 | 1997-09-17 | Pfizer Inc. | Use of Amlodipine for the treatment and prophylaxis of congestive cardiac failure of non-ischaemic origin |
| US5716976A (en) | 1996-03-13 | 1998-02-10 | Bernstein; Richard K. | Method of treatment for carbohydrate addiction |
| JPH11505547A (ja) | 1996-03-13 | 1999-05-21 | エール ユニバーシティ | ナルトレキソン及び関連化合物を用いる禁煙処置 |
| ATE344668T1 (de) | 1996-05-07 | 2006-11-15 | Pliva Istrazivanje I Razvoj D | Verfahren und zusammensetzung zur behandlung von stoerungen des fett- und glukosemetabolismus |
| AP1285A (en) | 1996-06-28 | 2004-06-24 | Ortho Mcneil Pharm Inc | Anticonvulsant sulfamate derivatives useful in treating obesity. |
| US5878750A (en) | 1996-11-14 | 1999-03-09 | Clemens; Anton H. | Method of treating the syndrome of coronary heart disease risk factors in humans |
| AU750808B2 (en) | 1997-10-03 | 2002-07-25 | Cary Medical Corporation | Compositon for the treatment of nicotine addiction containing a nicotine receptor antagonist and an anti-depressant or anti-anxiety drug |
| US6262049B1 (en) | 1997-10-28 | 2001-07-17 | Schering Corporation | Method of reducing nicotine and tobacco craving in mammals |
| US6110973A (en) | 1998-01-29 | 2000-08-29 | Sepracor | Methods for treating obesity and weight gain using optically pure (-)-bupropion |
| US6048322A (en) | 1998-04-15 | 2000-04-11 | Kushida; Clete | Morphometric measurement tool |
| US6589553B2 (en) | 2001-02-08 | 2003-07-08 | Andrx Pharmaceuticals, Inc. | Controlled release oral dosage form |
| US6210716B1 (en) | 1999-02-26 | 2001-04-03 | Andrx Pharmaceuticals, Inc. | Controlled release bupropion formulation |
| NZ514811A (en) | 1999-04-08 | 2005-01-28 | Ortho Mcneil Pharm Inc | Anticonvulsant derivatives useful in reducing blood glucose levels |
| US6071918A (en) | 1999-07-21 | 2000-06-06 | Dupont Pharmaceuticals Company | Combination of an opioid antagonist and a selective serotonin reuptake inhibitor for treatment of alcoholism and alcohol dependence |
| WO2001019321A2 (en) | 1999-09-15 | 2001-03-22 | Elan Pharmaceuticals, Inc. | Methods for treating neuropathic pain using hetreoarylmethanesulfonamides |
| US6403657B1 (en) | 1999-10-04 | 2002-06-11 | Martin C. Hinz | Comprehensive pharmacologic therapy for treatment of obesity |
| AR031682A1 (es) | 1999-11-19 | 2003-10-01 | Reckitt Benckiser Helthcare Uk | Composiciones farmaceuticas |
| US20020055512A1 (en) | 2000-01-21 | 2002-05-09 | Cortendo Ab. | Compositions for delivery of a cortisol antagonist |
| GB0001449D0 (en) | 2000-01-21 | 2000-03-08 | Cortendo Ab | Compositions |
| WO2001052851A1 (en) | 2000-01-22 | 2001-07-26 | Albert Shulman | Methods for the treatment of substance abuse |
| CN1406129A (zh) | 2000-01-22 | 2003-03-26 | 艾伯特·舒尔曼 | 用于治疗物质滥用的方法 |
| EP2092936B1 (en) | 2000-02-08 | 2013-03-20 | Euro-Celtique S.A. | Tamper-resistant oral opioid agonist formulations |
| US6306436B1 (en) | 2000-04-28 | 2001-10-23 | Teva Pharmaceuticals Usa, Inc. | Stabilized, acid-free formulation for sustained release of bupropion hydrochloride |
| US6528520B2 (en) | 2000-08-15 | 2003-03-04 | Cpd, Llc | Method of treating the syndrome of coronary heart disease risk factors in humans |
| ES2310192T3 (es) | 2000-09-18 | 2009-01-01 | Sanos Bioscience A/S | Uso de peptidos glp-2. |
| AU2002314968B2 (en) | 2001-06-08 | 2006-12-07 | Endo Pharmaceuticals, Inc. | Controlled release dosage forms using acrylic polymer, and process for making the same |
| BR0212019A (pt) | 2001-08-06 | 2005-08-09 | Euro Celtique Sa | Formas de dosagem, métodos para o tratamento da dor, métodos de preparação de uma forma de dosagem e métodos para impedir o abuso de uma forma de dosagem |
| US20030068375A1 (en) | 2001-08-06 | 2003-04-10 | Curtis Wright | Pharmaceutical formulation containing gelling agent |
| IL160222A0 (en) | 2001-08-06 | 2004-07-25 | Euro Celtique Sa | Opioid agonist formulations with releasable and sequestered antagonist |
| US7842307B2 (en) | 2001-08-06 | 2010-11-30 | Purdue Pharma L.P. | Pharmaceutical formulation containing opioid agonist, opioid antagonist and gelling agent |
| US20030087896A1 (en) | 2001-08-09 | 2003-05-08 | Hillel Glover | Treatment of refractory depression with an opiate antagonist and an antidepressant |
| US20040102440A1 (en) | 2002-07-01 | 2004-05-27 | Wong Erik Ho Fong | Method of promoting smoking cessation |
| US20040029941A1 (en) | 2002-05-06 | 2004-02-12 | Jennings Julianne E. | Zonisamide use in obesity and eating disorders |
| US20050176746A1 (en) | 2002-05-17 | 2005-08-11 | Frank Weber | Use of compounds that are effective as selective opiate receptor modulators |
| EP3173082A1 (en) | 2002-05-17 | 2017-05-31 | Duke University | Method for treating obesity |
| US20040005368A1 (en) | 2002-07-01 | 2004-01-08 | Morris Mann | Novel approach to weight loss comprising a modified protein composition that regulates blood sugar in conjunction with compositions that increase oxygen uptake and suppress appetite |
| US6972291B2 (en) | 2002-07-02 | 2005-12-06 | Bernstein Richard K | Method for reducing food intake |
| US7086532B2 (en) | 2003-07-16 | 2006-08-08 | Allergan, Inc. | Titration/compliance pack with increasing doses |
| WO2004024096A2 (en) | 2002-09-13 | 2004-03-25 | Eisai Co., Ltd. | Method of treating tremors |
| WO2004071423A2 (en) | 2003-02-05 | 2004-08-26 | Euro-Celtique S.A. | Methods of administering opioid antagonists and compositions thereof |
| US20040204472A1 (en) | 2003-03-04 | 2004-10-14 | Pharmacia Corporation | Treatment and prevention of obesity with COX-2 inhibitors alone or in combination with weight-loss agents |
| AU2004229551A1 (en) | 2003-04-14 | 2004-10-28 | Pain Therapeutics, Inc. | Methods for the treatment of pain comprising opioid antagonists |
| EP1617832B1 (en) | 2003-04-29 | 2008-03-12 | Orexigen Therapeutics, Inc. | Compositions for affecting weight loss |
| WO2004100992A2 (en) | 2003-05-16 | 2004-11-25 | Pfizer Products Inc. | Therapeutic combinations of atypical antipsychotics with gaba modulators, anticonvulsants or benzodiazapines |
| EP1635832A2 (en) | 2003-06-06 | 2006-03-22 | Merck & Co., Inc. | Combination therapy for the treatment of diabetes |
| DE602004026604D1 (de) | 2003-09-25 | 2010-05-27 | Euro Celtique Sa | Pharmazeutische kombinationen von hydrocodon und naltrexon |
| US20050096311A1 (en) | 2003-10-30 | 2005-05-05 | Cns Response | Compositions and methods for treatment of nervous system disorders |
| US20070149451A1 (en) | 2003-11-17 | 2007-06-28 | Holmes David G | Combination of a dpp IV inhibitor and an antiobesity or appetite regulating agent |
| KR20060128995A (ko) | 2004-01-13 | 2006-12-14 | 듀크 유니버시티 | 체중감량에 영향을 미치는 항경련제와 항정신병 약물의조성물 |
| US20050245541A1 (en) | 2004-03-19 | 2005-11-03 | Elliot Ehrich | Methods for treating alcoholism |
| CA2565154A1 (en) | 2004-05-03 | 2005-11-24 | Duke University | Compositions for affecting weight loss |
| US20050250838A1 (en) | 2004-05-04 | 2005-11-10 | Challapalli Prasad V | Formulation for sustained delivery |
| JP2008509142A (ja) | 2004-08-03 | 2008-03-27 | オレキシジェン・セラピューティクス・インコーポレーテッド | 体重減少に影響を及ぼすためのブプロピオンと第２の化合物との組合せ |
| WO2007047351A2 (en) | 2005-10-13 | 2007-04-26 | Orexigen Therapeutics, Inc. | Methods for treating hypertension in overweight and obese individuals |
| US20070099947A1 (en) | 2005-11-03 | 2007-05-03 | Alkermes, Inc. | Methods and compositions for the treatment of brain reward system disorders by combination therapy |
| CN101370488B (zh) | 2005-11-22 | 2012-07-18 | 奥雷西根治疗公司 | 增加胰岛素敏感性的组合物 |
| WO2007089318A2 (en) | 2005-11-23 | 2007-08-09 | Orexigen Therapeutics, Inc. | Compositions and methods for reducing food cravings |
| EP1954316A1 (en) | 2005-11-28 | 2008-08-13 | Orexigen Therapeutics, Inc. | Methods of treating anxiety disorders |
| EP1813276A1 (en) | 2006-01-27 | 2007-08-01 | Euro-Celtique S.A. | Tamper resistant dosage forms |
| ES2749800T3 (es) | 2006-06-05 | 2020-03-23 | Nalpropion Pharmaceuticals Llc | Formulación de liberación sostenida de naltrexona |
| US8916195B2 (en) | 2006-06-05 | 2014-12-23 | Orexigen Therapeutics, Inc. | Sustained release formulation of naltrexone |
| SI2719378T1 (sl) | 2006-06-19 | 2016-11-30 | Alpharma Pharmaceuticals Llc | Farmacevtski sestavki |
| WO2008011150A1 (en) | 2006-07-20 | 2008-01-24 | Somaxon Pharmaceuticals, Inc. | Methods of improving the pharmacokinetics of doxepin |
| US8682445B2 (en) | 2006-07-28 | 2014-03-25 | Cyberonics, Inc. | Patient management system for treating depression using an implantable medical device |
| KR20170077291A (ko) | 2006-11-09 | 2017-07-05 | 오렉시젠 세러퓨틱스 인크. | 단위 용량 팩키지 |
| DK2089005T3 (da) | 2006-11-09 | 2010-07-19 | Orexigen Therapeutics Inc | Lagdelte farmaceutiske formuleringer omfattende et hurtigt opløsende mellemlag |
| GB2447949B (en) | 2007-03-29 | 2010-03-31 | Renasci Consultancy Ltd | A method for identifying a compound for treating a disorder or condition associated with dysfunction of monoamine neurotransmission |
| US8318813B2 (en) | 2007-09-13 | 2012-11-27 | Lcs Group, Llc | Method of treating binge eating disorder |
| WO2009158114A1 (en) | 2008-05-30 | 2009-12-30 | Orexigen Therapeutics, Inc. | Methods for treating visceral fat conditions |
| MX344303B (es) * | 2010-01-11 | 2016-12-13 | Orexigen Therapeutics Inc | Metodos para proveer terapia de perdida de peso en pacientes con depresion mayor. |
| TWI536986B (zh) | 2010-12-03 | 2016-06-11 | 歐瑞根治療有限公司 | 降低暴食或強迫進食之方法 |
| CN110893181A (zh) * | 2012-06-06 | 2020-03-20 | 纳丙药业有限责任公司 | 治疗超重和肥胖症的方法 |
| US8969371B1 (en) | 2013-12-06 | 2015-03-03 | Orexigen Therapeutics, Inc. | Compositions and methods for weight loss in at risk patient populations |
-
2014
- 2014-07-02 US US14/322,810 patent/US8969371B1/en active Active
- 2014-12-03 JO JOP/2014/0344A patent/JOP20140344B1/ar active
- 2014-12-04 UY UY0001035864A patent/UY35864A/es not_active Application Discontinuation
- 2014-12-04 WO PCT/US2014/068527 patent/WO2015085044A1/en not_active Ceased
- 2014-12-04 CN CN202111066895.5A patent/CN114404419A/zh active Pending
- 2014-12-04 EP EP21202875.7A patent/EP4005571A1/en active Pending
- 2014-12-04 HU HUE14867191A patent/HUE057551T2/hu unknown
- 2014-12-04 PE PE2016000724A patent/PE20161034A1/es unknown
- 2014-12-04 IL IL300870A patent/IL300870A/en unknown
- 2014-12-04 CR CR20160313A patent/CR20160313A/es unknown
- 2014-12-04 JP JP2016536659A patent/JP6665094B2/ja active Active
- 2014-12-04 SG SG10201808055QA patent/SG10201808055QA/en unknown
- 2014-12-04 KR KR1020227041333A patent/KR20220165791A/ko not_active Ceased
- 2014-12-04 KR KR1020237036479A patent/KR20230152800A/ko active Pending
- 2014-12-04 PL PL14867191T patent/PL3076971T3/pl unknown
- 2014-12-04 ES ES14867191T patent/ES2903391T3/es active Active
- 2014-12-04 CA CA2932127A patent/CA2932127C/en active Active
- 2014-12-04 RU RU2016122483A patent/RU2711638C2/ru active
- 2014-12-04 RS RS20220039A patent/RS62846B1/sr unknown
- 2014-12-04 BR BR112016012755A patent/BR112016012755A2/pt not_active Application Discontinuation
- 2014-12-04 MX MX2016007231A patent/MX389742B/es unknown
- 2014-12-04 TN TN2016000231A patent/TN2016000231A1/en unknown
- 2014-12-04 CN CN202310405573.1A patent/CN117159547A/zh active Pending
- 2014-12-04 PT PT148671910T patent/PT3076971T/pt unknown
- 2014-12-04 KR KR1020167017977A patent/KR102472432B1/ko active Active
- 2014-12-04 HR HRP20220058TT patent/HRP20220058T1/hr unknown
- 2014-12-04 AU AU2014360492A patent/AU2014360492A1/en not_active Abandoned
- 2014-12-04 EP EP14867191.0A patent/EP3076971B1/en active Active
- 2014-12-04 SI SI201431935T patent/SI3076971T1/sl unknown
- 2014-12-04 CN CN201480072729.8A patent/CN105899210A/zh active Pending
- 2014-12-04 DK DK14867191.0T patent/DK3076971T3/da active
- 2014-12-04 US US15/101,878 patent/US10231962B2/en active Active
- 2014-12-04 EA EA201690964A patent/EA201690964A1/ru unknown
- 2014-12-04 LT LTEPPCT/US2014/068527T patent/LT3076971T/lt unknown
- 2014-12-05 PY PY201401454647A patent/PY1454647A/es unknown
- 2014-12-05 TW TW103142498A patent/TWI661826B/zh active
-
2015
- 2015-03-02 US US14/635,518 patent/US9119850B2/en active Active
- 2015-08-28 US US14/839,792 patent/US9801875B2/en active Active
-
2016
- 2016-05-30 IL IL245919A patent/IL245919A0/en unknown
- 2016-06-02 MX MX2022001251A patent/MX2022001251A/es unknown
- 2016-06-03 CL CL2016001362A patent/CL2016001362A1/es unknown
- 2016-06-06 ZA ZA2016/03831A patent/ZA201603831B/en unknown
- 2016-07-04 EC ECIEPI201657765A patent/ECSP16057765A/es unknown
-
2017
- 2017-10-05 US US15/725,830 patent/US10231964B2/en active Active
-
2019
- 2019-03-18 US US16/356,663 patent/US10835527B2/en active Active
- 2019-03-18 US US16/356,657 patent/US10828294B2/en active Active
- 2019-12-05 JP JP2019220444A patent/JP7204634B2/ja active Active
-
2020
- 2020-11-16 US US17/099,316 patent/US11998542B2/en active Active
-
2021
- 2021-04-07 IL IL282117A patent/IL282117A/en unknown
-
2022
- 2022-01-19 CY CY20221100048T patent/CY1125114T1/el unknown
-
2024
- 2024-06-03 US US18/731,965 patent/US20250144089A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016539164A5 (https=) | ||
| HRP20220058T1 (hr) | Sastavi i metode za smanjenje velikih neželjenih kardiovaskularnih događaja | |
| JP2022062151A5 (https=) | ||
| Stiell et al. | A multicenter, open-label study of vernakalant for the conversion of atrial fibrillation to sinus rhythm | |
| JCS Joint Working Group | Guidelines for Pharmacotherapy of Atrial Fibrillation (JCS 2008)–Digest Version– | |
| FI3750536T3 (fi) | Menetelmiä sydän- ja verisuonitapahtumien riskin pienentämiseksi henkilöllä | |
| US20110166220A1 (en) | Dronedarone for the prevention of permanent atrial fibrillation | |
| Iguchi et al. | Beneficial effects of cilostazol in a patient with recurrent ventricular fibrillation associated with early repolarization syndrome | |
| JP2015518897A5 (https=) | ||
| JP2019206562A5 (https=) | ||
| HRP20250931T1 (hr) | Pripravak za upotrebu u postupku liječenja prekomjerne težine i pretilosti kod pacijenata s visokim kardiovaskularnim rizikom | |
| Onk et al. | Is the preoperative administration of amiodarone or metoprolol more effective in reducing atrial fibrillation: after coronary bypass surgery? | |
| Quah et al. | The management of the older adult patient with anomalous left coronary artery from the pulmonary artery syndrome: a presentation of two cases and review of the literature | |
| Schweizer et al. | Successful acute and long-term management of electrical storm in Brugada syndrome using orciprenaline and quinine/quinidine | |
| Boriani et al. | The effects of gender on electrical therapies for the heart: physiology, epidemiology, and access to therapies | |
| Wybraniec et al. | Efficacy and safety of antazoline for cardioversion of atrial fibrillation: propensity score matching analysis of a multicenter registry (CANT II Study) | |
| Camm et al. | Medical treatment of atrial fibrillation | |
| Vora et al. | Control of heart rate versus rhythm in rheumatic atrial fibrillation: a randomized study | |
| Dan Kiselnik et al. | Acute myocarditis and myopathy as presenting manifestations of human immunodeficiency virus infection | |
| Brazão et al. | Effects of Chloroquine and Hydroxychloroquine on the Cardiovascular System-Limitations for Use in the Treatment of COVID-19 | |
| Demangone | ECG manifestations: noncoronary heart disease | |
| Duggan et al. | Intravenous vernakalant: a review of its use in the management of recent-onset atrial fibrillation | |
| Breithardt et al. | Acute effects of resynchronisation treatment on functional mitral regurgitation in dilated cardiomyopathy | |
| Yavuz et al. | Role of endogenous adenosine in atrial fibrillation after coronary artery bypass graft | |
| Nagra et al. | Marked QT prolongation and torsades de pointes secondary to acute ischemia in an elderly man taking dofetilide for atrial fibrillation: a cautionary tale |