JP2016539164A5 - - Google Patents
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- JP2016539164A5 JP2016539164A5 JP2016536659A JP2016536659A JP2016539164A5 JP 2016539164 A5 JP2016539164 A5 JP 2016539164A5 JP 2016536659 A JP2016536659 A JP 2016536659A JP 2016536659 A JP2016536659 A JP 2016536659A JP 2016539164 A5 JP2016539164 A5 JP 2016539164A5
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- JP
- Japan
- Prior art keywords
- subject
- pharmaceutically acceptable
- acceptable salt
- composition
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims 22
- 150000003839 salts Chemical class 0.000 claims 12
- 238000013268 sustained release Methods 0.000 claims 11
- 239000012730 sustained-release form Substances 0.000 claims 11
- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 claims 8
- 229960003086 naltrexone Drugs 0.000 claims 8
- SNPPWIUOZRMYNY-UHFFFAOYSA-N bupropion Chemical compound CC(C)(C)NC(C)C(=O)C1=CC=CC(Cl)=C1 SNPPWIUOZRMYNY-UHFFFAOYSA-N 0.000 claims 7
- 229960001058 bupropion Drugs 0.000 claims 7
- 208000024172 Cardiovascular disease Diseases 0.000 claims 6
- 208000006011 Stroke Diseases 0.000 claims 6
- 230000002526 effect on cardiovascular system Effects 0.000 claims 4
- 230000002411 adverse Effects 0.000 claims 3
- 230000007211 cardiovascular event Effects 0.000 claims 3
- 208000010125 myocardial infarction Diseases 0.000 claims 3
- 230000000250 revascularization Effects 0.000 claims 3
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 3
- 206010002388 Angina unstable Diseases 0.000 claims 2
- 206010003658 Atrial Fibrillation Diseases 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
- 208000007814 Unstable Angina Diseases 0.000 claims 2
- 206010003119 arrhythmia Diseases 0.000 claims 2
- 201000004332 intermediate coronary syndrome Diseases 0.000 claims 2
- 206010002329 Aneurysm Diseases 0.000 claims 1
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- 206010014486 Elevated triglycerides Diseases 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 208000004301 Sinus Arrhythmia Diseases 0.000 claims 1
- 206010065341 Ventricular tachyarrhythmia Diseases 0.000 claims 1
- 210000003423 ankle Anatomy 0.000 claims 1
- 210000001367 artery Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 230000036772 blood pressure Effects 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 230000001934 delay Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 230000000302 ischemic effect Effects 0.000 claims 1
- 210000003141 lower extremity Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 208000003663 ventricular fibrillation Diseases 0.000 claims 1
- 206010047302 ventricular tachycardia Diseases 0.000 claims 1
- 230000004580 weight loss Effects 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361913216P | 2013-12-06 | 2013-12-06 | |
| US61/913,216 | 2013-12-06 | ||
| US201361914938P | 2013-12-11 | 2013-12-11 | |
| US61/914,938 | 2013-12-11 | ||
| US201461984580P | 2014-04-25 | 2014-04-25 | |
| US61/984,580 | 2014-04-25 | ||
| US14/322,810 US8969371B1 (en) | 2013-12-06 | 2014-07-02 | Compositions and methods for weight loss in at risk patient populations |
| US14/322,810 | 2014-07-02 | ||
| PCT/US2014/068527 WO2015085044A1 (en) | 2013-12-06 | 2014-12-04 | Compositions and methods for reducing major adverse cardiovascular events |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019220444A Division JP7204634B2 (ja) | 2013-12-06 | 2019-12-05 | 主要有害心血管事象を低減するための組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016539164A JP2016539164A (ja) | 2016-12-15 |
| JP2016539164A5 true JP2016539164A5 (https=) | 2018-01-18 |
| JP6665094B2 JP6665094B2 (ja) | 2020-03-13 |
Family
ID=52575014
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016536659A Active JP6665094B2 (ja) | 2013-12-06 | 2014-12-04 | 主要有害心血管事象を低減するための組成物及び方法 |
| JP2019220444A Active JP7204634B2 (ja) | 2013-12-06 | 2019-12-05 | 主要有害心血管事象を低減するための組成物及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019220444A Active JP7204634B2 (ja) | 2013-12-06 | 2019-12-05 | 主要有害心血管事象を低減するための組成物及び方法 |
Country Status (34)
| Country | Link |
|---|---|
| US (9) | US8969371B1 (https=) |
| EP (2) | EP4005571A1 (https=) |
| JP (2) | JP6665094B2 (https=) |
| KR (3) | KR102472432B1 (https=) |
| CN (3) | CN105899210A (https=) |
| AU (1) | AU2014360492A1 (https=) |
| BR (1) | BR112016012755A2 (https=) |
| CA (1) | CA2932127C (https=) |
| CL (1) | CL2016001362A1 (https=) |
| CR (1) | CR20160313A (https=) |
| CY (1) | CY1125114T1 (https=) |
| DK (1) | DK3076971T3 (https=) |
| EA (1) | EA201690964A1 (https=) |
| EC (1) | ECSP16057765A (https=) |
| ES (1) | ES2903391T3 (https=) |
| HR (1) | HRP20220058T1 (https=) |
| HU (1) | HUE057551T2 (https=) |
| IL (3) | IL300870A (https=) |
| JO (1) | JOP20140344B1 (https=) |
| LT (1) | LT3076971T (https=) |
| MX (2) | MX389742B (https=) |
| PE (1) | PE20161034A1 (https=) |
| PL (1) | PL3076971T3 (https=) |
| PT (1) | PT3076971T (https=) |
| PY (1) | PY1454647A (https=) |
| RS (1) | RS62846B1 (https=) |
| RU (1) | RU2711638C2 (https=) |
| SG (1) | SG10201808055QA (https=) |
| SI (1) | SI3076971T1 (https=) |
| TN (1) | TN2016000231A1 (https=) |
| TW (1) | TWI661826B (https=) |
| UY (1) | UY35864A (https=) |
| WO (1) | WO2015085044A1 (https=) |
| ZA (1) | ZA201603831B (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE034290T2 (en) | 2003-04-29 | 2018-02-28 | Orexigen Therapeutics Inc | Preparations containing opioid antagonist and bupropion to affect weight loss |
| CA2630624C (en) | 2005-11-22 | 2013-08-06 | Orexigen Therapeutics, Inc. | Compositions and methods for increasing insulin sensitivity |
| WO2007089318A2 (en) * | 2005-11-23 | 2007-08-09 | Orexigen Therapeutics, Inc. | Compositions and methods for reducing food cravings |
| US8916195B2 (en) | 2006-06-05 | 2014-12-23 | Orexigen Therapeutics, Inc. | Sustained release formulation of naltrexone |
| KR20170077291A (ko) | 2006-11-09 | 2017-07-05 | 오렉시젠 세러퓨틱스 인크. | 단위 용량 팩키지 |
| JP2011521973A (ja) | 2008-05-30 | 2011-07-28 | オレキシジェン・セラピューティクス・インコーポレーテッド | 内臓脂肪の状態を処置するための方法 |
| ES2762113T3 (es) | 2010-01-11 | 2020-05-22 | Nalpropion Pharmaceuticals Inc | Métodos de proporcionar terapia de pérdida de peso en pacientes con depresión mayor |
| LT3730132T (lt) * | 2012-06-06 | 2022-08-25 | Nalpropion Pharmaceuticals Llc | Kompozicija, skirta panaudoti pacientų su didele širdies ir kraujagyslių ligų rizika antsvorio ir nutukimo gydymo būde |
| US8969371B1 (en) | 2013-12-06 | 2015-03-03 | Orexigen Therapeutics, Inc. | Compositions and methods for weight loss in at risk patient populations |
| US9968659B2 (en) | 2016-03-04 | 2018-05-15 | Novo Nordisk A/S | Liraglutide in cardiovascular conditions |
| CA3022535A1 (en) | 2016-04-28 | 2017-11-02 | Novo Nordisk A/S | Semaglutide in cardiovascular conditions |
| EP3493574B1 (en) * | 2016-08-11 | 2023-04-12 | Huawei Technologies Co., Ltd. | Wireless communication method based on unlicensed frequency spectrum, and base station and terminal device |
| WO2023107640A1 (en) * | 2021-12-09 | 2023-06-15 | Incarda Therapeutics, Inc. | Inhaled therapy for cardiac arrhythmia |
| US12303604B1 (en) | 2024-10-16 | 2025-05-20 | Currax Pharmaceuticals Llc | Pharmaceutical formulations comprising naltrexone and/or bupropion |
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| US8969371B1 (en) | 2013-12-06 | 2015-03-03 | Orexigen Therapeutics, Inc. | Compositions and methods for weight loss in at risk patient populations |
-
2014
- 2014-07-02 US US14/322,810 patent/US8969371B1/en active Active
- 2014-12-03 JO JOP/2014/0344A patent/JOP20140344B1/ar active
- 2014-12-04 CN CN201480072729.8A patent/CN105899210A/zh active Pending
- 2014-12-04 HU HUE14867191A patent/HUE057551T2/hu unknown
- 2014-12-04 ES ES14867191T patent/ES2903391T3/es active Active
- 2014-12-04 EP EP21202875.7A patent/EP4005571A1/en active Pending
- 2014-12-04 PL PL14867191T patent/PL3076971T3/pl unknown
- 2014-12-04 LT LTEPPCT/US2014/068527T patent/LT3076971T/lt unknown
- 2014-12-04 RS RS20220039A patent/RS62846B1/sr unknown
- 2014-12-04 WO PCT/US2014/068527 patent/WO2015085044A1/en not_active Ceased
- 2014-12-04 RU RU2016122483A patent/RU2711638C2/ru active
- 2014-12-04 KR KR1020167017977A patent/KR102472432B1/ko active Active
- 2014-12-04 UY UY0001035864A patent/UY35864A/es not_active Application Discontinuation
- 2014-12-04 TN TN2016000231A patent/TN2016000231A1/en unknown
- 2014-12-04 HR HRP20220058TT patent/HRP20220058T1/hr unknown
- 2014-12-04 DK DK14867191.0T patent/DK3076971T3/da active
- 2014-12-04 MX MX2016007231A patent/MX389742B/es unknown
- 2014-12-04 CN CN202310405573.1A patent/CN117159547A/zh active Pending
- 2014-12-04 IL IL300870A patent/IL300870A/en unknown
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