JP2016537029A5 - - Google Patents
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- JP2016537029A5 JP2016537029A5 JP2016553748A JP2016553748A JP2016537029A5 JP 2016537029 A5 JP2016537029 A5 JP 2016537029A5 JP 2016553748 A JP2016553748 A JP 2016553748A JP 2016553748 A JP2016553748 A JP 2016553748A JP 2016537029 A5 JP2016537029 A5 JP 2016537029A5
- Authority
- JP
- Japan
- Prior art keywords
- dna
- interaction
- nucleotide sequence
- restriction enzyme
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 238000000034 method Methods 0.000 claims description 65
- 230000003993 interaction Effects 0.000 claims description 35
- 108091008146 restriction endonucleases Proteins 0.000 claims description 26
- 239000002773 nucleotide Substances 0.000 claims description 25
- 125000003729 nucleotide group Chemical group 0.000 claims description 25
- 108020004414 DNA Proteins 0.000 claims description 24
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 13
- 201000010099 disease Diseases 0.000 claims description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 12
- 239000000523 sample Substances 0.000 claims description 12
- 239000012634 fragment Substances 0.000 claims description 11
- 108020005187 Oligonucleotide Probes Proteins 0.000 claims description 10
- 230000002068 genetic effect Effects 0.000 claims description 10
- 239000002751 oligonucleotide probe Substances 0.000 claims description 10
- 238000011179 visual inspection Methods 0.000 claims description 9
- 108091034117 Oligonucleotide Proteins 0.000 claims description 8
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims description 8
- 108010077544 Chromatin Proteins 0.000 claims description 6
- 210000003483 chromatin Anatomy 0.000 claims description 6
- 230000029087 digestion Effects 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 6
- 208000011580 syndromic disease Diseases 0.000 claims description 6
- 230000002759 chromosomal effect Effects 0.000 claims description 5
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- 239000011324 bead Substances 0.000 claims description 4
- 210000004027 cell Anatomy 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 210000000349 chromosome Anatomy 0.000 claims description 4
- 238000004088 simulation Methods 0.000 claims description 4
- 108090000790 Enzymes Proteins 0.000 claims description 3
- 102000004190 Enzymes Human genes 0.000 claims description 3
- 238000003556 assay Methods 0.000 claims description 3
- 238000012163 sequencing technique Methods 0.000 claims description 3
- 208000034454 F12-related hereditary angioedema with normal C1Inh Diseases 0.000 claims description 2
- 101500006448 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) Endonuclease PI-MboI Proteins 0.000 claims description 2
- 101710163270 Nuclease Proteins 0.000 claims description 2
- 238000003766 bioinformatics method Methods 0.000 claims description 2
- 238000003776 cleavage reaction Methods 0.000 claims description 2
- 238000004132 cross linking Methods 0.000 claims description 2
- 238000003745 diagnosis Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 239000000835 fiber Substances 0.000 claims description 2
- 208000016861 hereditary angioedema type 3 Diseases 0.000 claims description 2
- 150000002500 ions Chemical class 0.000 claims description 2
- 238000002493 microarray Methods 0.000 claims description 2
- 238000004393 prognosis Methods 0.000 claims description 2
- 230000005855 radiation Effects 0.000 claims description 2
- 230000007017 scission Effects 0.000 claims description 2
- 238000012800 visualization Methods 0.000 claims description 2
- 108700026220 vif Genes Proteins 0.000 claims 1
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 208000026350 Inborn Genetic disease Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 108091023040 Transcription factor Proteins 0.000 description 1
- 102000040945 Transcription factor Human genes 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 208000016361 genetic disease Diseases 0.000 description 1
- 238000012165 high-throughput sequencing Methods 0.000 description 1
- 239000012212 insulator Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1320351.8 | 2013-11-18 | ||
| GBGB1320351.8A GB201320351D0 (en) | 2013-11-18 | 2013-11-18 | Method |
| PCT/IB2014/002485 WO2015071748A1 (en) | 2013-11-18 | 2014-11-18 | Method for analysing the interaction of nucleotide sequences in a three-dimensional dna structure |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016537029A JP2016537029A (ja) | 2016-12-01 |
| JP2016537029A5 true JP2016537029A5 (enExample) | 2017-10-19 |
Family
ID=49883800
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016553748A Pending JP2016537029A (ja) | 2013-11-18 | 2014-11-18 | 三次元ｄｎａ構造におけるヌクレオチド配列の相互作用を分析する方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10934575B2 (enExample) |
| EP (1) | EP3071710B1 (enExample) |
| JP (1) | JP2016537029A (enExample) |
| KR (1) | KR102332522B1 (enExample) |
| CN (1) | CN105992825A (enExample) |
| AU (1) | AU2014349817B2 (enExample) |
| CA (1) | CA2928012C (enExample) |
| GB (1) | GB201320351D0 (enExample) |
| WO (1) | WO2015071748A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2554572B (en) * | 2015-03-26 | 2021-06-23 | Dovetail Genomics Llc | Physical linkage preservation in DNA storage |
| JP2018518203A (ja) * | 2015-06-24 | 2018-07-12 | オックスフォード バイオダイナミックス リミテッド | エピジェネティックな染色体相互作用 |
| WO2017066908A1 (zh) * | 2015-10-19 | 2017-04-27 | 安诺优达基因科技(北京)有限公司 | 构建高分辨率、大信息量单细胞Hi-C文库的方法 |
| CN115369161A (zh) * | 2015-12-04 | 2022-11-22 | 10X 基因组学有限公司 | 用于核酸分析的方法和组合物 |
| GB201608000D0 (en) * | 2016-05-06 | 2016-06-22 | Oxford Biodynamics Ltd | Chromosome detection |
| EP3455356B1 (en) | 2016-05-13 | 2021-08-04 | Dovetail Genomics LLC | Recovering long-range linkage information from preserved samples |
| CA3045070A1 (en) * | 2016-12-01 | 2018-06-07 | Oxford Biodynamics Limited | Application of epigenetic chromsomal interactions in cancer diagnostics |
| WO2019005763A1 (en) * | 2017-06-26 | 2019-01-03 | Phase Genomics Inc. | METHOD FOR REGROUPING DNA SEQUENCES |
| CN108300767B (zh) * | 2017-10-27 | 2021-08-20 | 清华大学 | 一种核酸复合体中核酸区段相互作用的分析方法 |
| CN108197431B (zh) * | 2018-01-24 | 2022-04-05 | 清华大学 | 染色质相互作用差异的分析方法和系统 |
| US12378592B2 (en) * | 2018-01-31 | 2025-08-05 | Dovetail Genomics, Llc. | Sample prep for DNA linkage recovery |
| EP3847261A1 (en) * | 2018-09-05 | 2021-07-14 | Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft | A method for engineering synthetic cis-regulatory dna |
| WO2020234608A1 (en) * | 2019-05-22 | 2020-11-26 | Oxford Nanopore Technologies Limited | Protocol for detecting interactions within one or more dna molecules within a cell |
| GB2607514B (en) | 2020-07-20 | 2023-06-21 | Enanta Pharm Inc | Functionalized peptides as antiviral agents |
| US11384090B2 (en) | 2020-11-23 | 2022-07-12 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| CN116829571A (zh) | 2020-11-23 | 2023-09-29 | 英安塔制药有限公司 | 新型螺旋吡咯烷衍生的抗病毒药物 |
| US11352363B1 (en) | 2020-11-23 | 2022-06-07 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| CN113215141A (zh) * | 2021-02-23 | 2021-08-06 | 华南农业大学 | 细菌hi-c基因组及质粒构象捕获方法 |
| US11319325B1 (en) | 2021-05-11 | 2022-05-03 | Enanta Pharmaceuticals, Inc. | Macrocyclic spiropyrrolidine derived antiviral agents |
| US11325916B1 (en) | 2021-07-29 | 2022-05-10 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| US11339170B1 (en) | 2021-07-23 | 2022-05-24 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| GB202111195D0 (en) * | 2021-08-03 | 2021-09-15 | Cergentis B V | Method for targeted sequencing |
| CN113946730B (zh) * | 2021-10-19 | 2023-03-17 | 四川大学 | 一种基于基因数据的染色质层次结构分析的可视化方法 |
| US20240095226A1 (en) * | 2022-09-15 | 2024-03-21 | Rodney Kuhn Haffnerson King | Methods and related devices for storing and accessing data using multi-level fractal grids |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7348178B1 (en) * | 1994-03-14 | 2008-03-25 | New York University Medical Center | Recombinant adenoviral vector system |
| NZ564262A (en) * | 2005-07-04 | 2010-02-26 | Univ Erasmus Medical Ct | Chromosome conformation capture-on-chip (4C) assay |
| AU2008204338B2 (en) * | 2007-01-11 | 2014-03-06 | Erasmus University Medical Center | Circular chromosome conformation capture (4C) |
| CA2804450C (en) | 2010-07-09 | 2022-10-11 | Max Jan van Min | 3-d genomic region of interest sequencing strategies |
| US10287621B2 (en) * | 2013-04-11 | 2019-05-14 | Pelin Sahlén | Targeted chromosome conformation capture |
-
2013
- 2013-11-18 GB GBGB1320351.8A patent/GB201320351D0/en not_active Ceased
-
2014
- 2014-11-18 CA CA2928012A patent/CA2928012C/en active Active
- 2014-11-18 EP EP14815428.9A patent/EP3071710B1/en active Active
- 2014-11-18 CN CN201480062775.XA patent/CN105992825A/zh active Pending
- 2014-11-18 WO PCT/IB2014/002485 patent/WO2015071748A1/en not_active Ceased
- 2014-11-18 JP JP2016553748A patent/JP2016537029A/ja active Pending
- 2014-11-18 KR KR1020167015969A patent/KR102332522B1/ko active Active
- 2014-11-18 US US15/037,210 patent/US10934575B2/en active Active
- 2014-11-18 AU AU2014349817A patent/AU2014349817B2/en active Active
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