CN105992825A - 用于分析三维dna结构中的核苷酸序列相互作用的方法 - Google Patents

用于分析三维dna结构中的核苷酸序列相互作用的方法 Download PDF

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Publication number
CN105992825A
CN105992825A CN201480062775.XA CN201480062775A CN105992825A CN 105992825 A CN105992825 A CN 105992825A CN 201480062775 A CN201480062775 A CN 201480062775A CN 105992825 A CN105992825 A CN 105992825A
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dna
interaction
interactions
restriction enzyme
sequence
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F·格罗斯瓦尔德
T·诺奇
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Erasmus University Medical Center
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Erasmus University Medical Center
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/682—Signal amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/30—Phosphoric diester hydrolysing, i.e. nuclease
    • C12Q2521/301—Endonuclease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/50—Other enzymatic activities
    • C12Q2521/501—Ligase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00—Reactions characterised by treatment of reaction samples
    • C12Q2523/10—Characterised by chemical treatment
    • C12Q2523/101—Crosslinking agents, e.g. psoralen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/10—Detection mode being characterised by the assay principle
    • C12Q2565/133—Detection mode being characterised by the assay principle conformational analysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/50—Detection characterised by immobilisation to a surface
    • C12Q2565/501—Detection characterised by immobilisation to a surface being an array of oligonucleotides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN201480062775.XA 2013-11-18 2014-11-18 用于分析三维dna结构中的核苷酸序列相互作用的方法 Pending CN105992825A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1320351.8 2013-11-18
GBGB1320351.8A GB201320351D0 (en) 2013-11-18 2013-11-18 Method
PCT/IB2014/002485 WO2015071748A1 (en) 2013-11-18 2014-11-18 Method for analysing the interaction of nucleotide sequences in a three-dimensional dna structure

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CN105992825A true CN105992825A (zh) 2016-10-05

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US (1) US10934575B2 (enExample)
EP (1) EP3071710B1 (enExample)
JP (1) JP2016537029A (enExample)
KR (1) KR102332522B1 (enExample)
CN (1) CN105992825A (enExample)
AU (1) AU2014349817B2 (enExample)
CA (1) CA2928012C (enExample)
GB (1) GB201320351D0 (enExample)
WO (1) WO2015071748A1 (enExample)

Cited By (4)

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CN108197431A (zh) * 2018-01-24 2018-06-22 清华大学 染色质相互作用差异的分析方法和系统
CN108300767A (zh) * 2017-10-27 2018-07-20 清华大学 一种核酸复合体中核酸区段相互作用的分析方法
CN113215141A (zh) * 2021-02-23 2021-08-06 华南农业大学 细菌hi-c基因组及质粒构象捕获方法
CN113853440A (zh) * 2019-05-22 2021-12-28 牛津纳米孔科技公开有限公司 用于检测细胞内一个或多个dna分子内相互作用的方案

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GB2554572B (en) * 2015-03-26 2021-06-23 Dovetail Genomics Llc Physical linkage preservation in DNA storage
JP2018518203A (ja) * 2015-06-24 2018-07-12 オックスフォード バイオダイナミックス リミテッド エピジェネティックな染色体相互作用
WO2017066908A1 (zh) * 2015-10-19 2017-04-27 安诺优达基因科技(北京)有限公司 构建高分辨率、大信息量单细胞Hi-C文库的方法
CN115369161A (zh) * 2015-12-04 2022-11-22 10X 基因组学有限公司 用于核酸分析的方法和组合物
GB201608000D0 (en) * 2016-05-06 2016-06-22 Oxford Biodynamics Ltd Chromosome detection
EP3455356B1 (en) 2016-05-13 2021-08-04 Dovetail Genomics LLC Recovering long-range linkage information from preserved samples
CA3045070A1 (en) * 2016-12-01 2018-06-07 Oxford Biodynamics Limited Application of epigenetic chromsomal interactions in cancer diagnostics
WO2019005763A1 (en) * 2017-06-26 2019-01-03 Phase Genomics Inc. METHOD FOR REGROUPING DNA SEQUENCES
US12378592B2 (en) * 2018-01-31 2025-08-05 Dovetail Genomics, Llc. Sample prep for DNA linkage recovery
EP3847261A1 (en) * 2018-09-05 2021-07-14 Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft A method for engineering synthetic cis-regulatory dna
GB2607514B (en) 2020-07-20 2023-06-21 Enanta Pharm Inc Functionalized peptides as antiviral agents
US11384090B2 (en) 2020-11-23 2022-07-12 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
CN116829571A (zh) 2020-11-23 2023-09-29 英安塔制药有限公司 新型螺旋吡咯烷衍生的抗病毒药物
US11352363B1 (en) 2020-11-23 2022-06-07 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
US11319325B1 (en) 2021-05-11 2022-05-03 Enanta Pharmaceuticals, Inc. Macrocyclic spiropyrrolidine derived antiviral agents
US11325916B1 (en) 2021-07-29 2022-05-10 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
US11339170B1 (en) 2021-07-23 2022-05-24 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
GB202111195D0 (en) * 2021-08-03 2021-09-15 Cergentis B V Method for targeted sequencing
CN113946730B (zh) * 2021-10-19 2023-03-17 四川大学 一种基于基因数据的染色质层次结构分析的可视化方法
US20240095226A1 (en) * 2022-09-15 2024-03-21 Rodney Kuhn Haffnerson King Methods and related devices for storing and accessing data using multi-level fractal grids

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108300767A (zh) * 2017-10-27 2018-07-20 清华大学 一种核酸复合体中核酸区段相互作用的分析方法
CN108300767B (zh) * 2017-10-27 2021-08-20 清华大学 一种核酸复合体中核酸区段相互作用的分析方法
CN108197431A (zh) * 2018-01-24 2018-06-22 清华大学 染色质相互作用差异的分析方法和系统
CN113853440A (zh) * 2019-05-22 2021-12-28 牛津纳米孔科技公开有限公司 用于检测细胞内一个或多个dna分子内相互作用的方案
CN113215141A (zh) * 2021-02-23 2021-08-06 华南农业大学 细菌hi-c基因组及质粒构象捕获方法

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EP3071710A1 (en) 2016-09-28
AU2014349817B2 (en) 2020-11-12
WO2015071748A1 (en) 2015-05-21
CA2928012A1 (en) 2015-05-21
KR102332522B1 (ko) 2021-11-29
GB201320351D0 (en) 2014-01-01
US10934575B2 (en) 2021-03-02
CA2928012C (en) 2023-05-16
AU2014349817A1 (en) 2016-05-19
US20160289738A1 (en) 2016-10-06
KR20160079120A (ko) 2016-07-05
EP3071710B1 (en) 2019-05-15
JP2016537029A (ja) 2016-12-01

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Application publication date: 20161005