JP2016537028A - Ｃｒｉｓｐｒ−ｃａｓシステムの材料及び方法 - Google Patents

Ｃｒｉｓｐｒ−ｃａｓシステムの材料及び方法 Download PDF

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JP2016537028A
JP2016537028A JP2016553732A JP2016553732A JP2016537028A JP 2016537028 A JP2016537028 A JP 2016537028A JP 2016553732 A JP2016553732 A JP 2016553732A JP 2016553732 A JP2016553732 A JP 2016553732A JP 2016537028 A JP2016537028 A JP 2016537028A
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sequence
rna
dna
guide rna
tracrrna
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JP2016537028A5 (enExample
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エマヌエレ ヒャルペンティア，
エマヌエレ ヒャルペンティア，
クルズィストフ ヒリンスキ，
クルズィストフ ヒリンスキ，
イネス フォンファーラ，
イネス フォンファーラ，
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クリスパー セラピューティクス アーゲー
クリスパー セラピューティクス アーゲー
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    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin

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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
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JP2016553732A 2013-11-18 2014-11-17 Ｃｒｉｓｐｒ−ｃａｓシステムの材料及び方法 Withdrawn JP2016537028A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361905835P 2013-11-18 2013-11-18
US61/905,835 2013-11-18
PCT/EP2014/074813 WO2015071474A2 (en) 2013-11-18 2014-11-17 Crispr-cas system materials and methods

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JP2018004036A Division JP2018057407A (ja) 2013-11-18 2018-01-15 Ｃｒｉｓｐｒ−ｃａｓシステムの材料及び方法
JP2019217897A Division JP2020043870A (ja) 2013-11-18 2019-12-02 Ｃｒｉｓｐｒ−ｃａｓシステムの材料及び方法

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JP2016537028A true JP2016537028A (ja) 2016-12-01
JP2016537028A5 JP2016537028A5 (enExample) 2017-12-28

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JP2016553732A Withdrawn JP2016537028A (ja) 2013-11-18 2014-11-17 Ｃｒｉｓｐｒ−ｃａｓシステムの材料及び方法
JP2018004036A Pending JP2018057407A (ja) 2013-11-18 2018-01-15 Ｃｒｉｓｐｒ−ｃａｓシステムの材料及び方法
JP2019217897A Withdrawn JP2020043870A (ja) 2013-11-18 2019-12-02 Ｃｒｉｓｐｒ−ｃａｓシステムの材料及び方法
JP2021092836A Pending JP2021176298A (ja) 2013-11-18 2021-06-02 Ｃｒｉｓｐｒ−ｃａｓシステムの材料及び方法

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JP2018004036A Pending JP2018057407A (ja) 2013-11-18 2018-01-15 Ｃｒｉｓｐｒ−ｃａｓシステムの材料及び方法
JP2019217897A Withdrawn JP2020043870A (ja) 2013-11-18 2019-12-02 Ｃｒｉｓｐｒ−ｃａｓシステムの材料及び方法
JP2021092836A Pending JP2021176298A (ja) 2013-11-18 2021-06-02 Ｃｒｉｓｐｒ−ｃａｓシステムの材料及び方法

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US (1) US20160298096A1 (enExample)
EP (3) EP3071695A2 (enExample)
JP (4) JP2016537028A (enExample)
AU (3) AU2014350051A1 (enExample)
CA (1) CA2930877A1 (enExample)
WO (1) WO2015071474A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021506251A (ja) * 2017-12-14 2021-02-22 クリスパー セラピューティクス アーゲー 新規ｒｎａプログラム可能エンドヌクレアーゼ系、ならびにゲノム編集および他の適用におけるその使用
JP2022513642A (ja) * 2018-11-26 2022-02-09 ジョイント・ストック・カンパニー “バイオキャド” バイオテクノロジー的に重要な細菌、クロストリジウム・セルロリティクム（Ｃｌｏｓｔｒｉｄｉｕｍ ｃｅｌｌｕｌｏｌｙｔｉｃｕｍ）由来のＣａｓ９タンパク質に基づく、ＤＮＡカット手段

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