JP2016537027A5 - - Google Patents
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- JP2016537027A5 JP2016537027A5 JP2016553242A JP2016553242A JP2016537027A5 JP 2016537027 A5 JP2016537027 A5 JP 2016537027A5 JP 2016553242 A JP2016553242 A JP 2016553242A JP 2016553242 A JP2016553242 A JP 2016553242A JP 2016537027 A5 JP2016537027 A5 JP 2016537027A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- group
- alkylene
- alkyl
- heteroatoms selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229910052717 sulfur Inorganic materials 0.000 claims 56
- 125000005842 heteroatom Chemical group 0.000 claims 51
- 229910052760 oxygen Inorganic materials 0.000 claims 48
- 239000002157 polynucleotide Substances 0.000 claims 45
- 102000040430 polynucleotide Human genes 0.000 claims 45
- 108091033319 polynucleotide Proteins 0.000 claims 45
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 21
- 125000000217 alkyl group Chemical group 0.000 claims 21
- 229910052799 carbon Inorganic materials 0.000 claims 21
- 125000002993 cycloalkylene group Chemical group 0.000 claims 20
- 125000003118 aryl group Chemical group 0.000 claims 19
- 125000000732 arylene group Chemical group 0.000 claims 17
- 125000005724 cycloalkenylene group Chemical group 0.000 claims 17
- 125000005549 heteroarylene group Chemical group 0.000 claims 17
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 17
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 15
- 125000000623 heterocyclic group Chemical group 0.000 claims 13
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 12
- 125000001072 heteroaryl group Chemical group 0.000 claims 12
- 229920000642 polymer Polymers 0.000 claims 12
- 229920001184 polypeptide Polymers 0.000 claims 12
- 102000004196 processed proteins & peptides Human genes 0.000 claims 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims 12
- 235000014633 carbohydrates Nutrition 0.000 claims 11
- 150000001720 carbohydrates Chemical class 0.000 claims 11
- 239000003814 drug Substances 0.000 claims 11
- 230000007935 neutral effect Effects 0.000 claims 11
- 230000008685 targeting Effects 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 229920000620 organic polymer Polymers 0.000 claims 10
- 229940124597 therapeutic agent Drugs 0.000 claims 10
- 125000003545 alkoxy group Chemical group 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 9
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 9
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 8
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 8
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 7
- 125000004429 atom Chemical group 0.000 claims 7
- 210000001163 endosome Anatomy 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 125000006590 (C2-C6) alkenylene group Chemical group 0.000 claims 6
- 229960002685 biotin Drugs 0.000 claims 6
- 235000020958 biotin Nutrition 0.000 claims 6
- 239000011616 biotin Substances 0.000 claims 6
- 125000004432 carbon atom Chemical group C* 0.000 claims 6
- 239000001177 diphosphate Substances 0.000 claims 6
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims 6
- 235000011180 diphosphates Nutrition 0.000 claims 6
- 150000004712 monophosphates Chemical class 0.000 claims 6
- 125000003729 nucleotide group Chemical group 0.000 claims 6
- 125000004434 sulfur atom Chemical group 0.000 claims 6
- 239000001226 triphosphate Substances 0.000 claims 6
- 235000011178 triphosphate Nutrition 0.000 claims 6
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 claims 6
- 125000006591 (C2-C6) alkynylene group Chemical group 0.000 claims 5
- 125000002947 alkylene group Chemical group 0.000 claims 5
- 239000002773 nucleotide Substances 0.000 claims 5
- SHIBSTMRCDJXLN-UHFFFAOYSA-N Digoxigenin Natural products C1CC(C2C(C3(C)CCC(O)CC3CC2)CC2O)(O)C2(C)C1C1=CC(=O)OC1 SHIBSTMRCDJXLN-UHFFFAOYSA-N 0.000 claims 4
- RYYWUUFWQRZTIU-UHFFFAOYSA-N Thiophosphoric acid Chemical compound OP(O)(S)=O RYYWUUFWQRZTIU-UHFFFAOYSA-N 0.000 claims 4
- YDHWWBZFRZWVHO-UHFFFAOYSA-H [oxido-[oxido(phosphonatooxy)phosphoryl]oxyphosphoryl] phosphate Chemical compound [O-]P([O-])(=O)OP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O YDHWWBZFRZWVHO-UHFFFAOYSA-H 0.000 claims 4
- QTPILKSJIOLICA-UHFFFAOYSA-N bis[hydroxy(phosphonooxy)phosphoryl] hydrogen phosphate Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(O)=O QTPILKSJIOLICA-UHFFFAOYSA-N 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 235000012000 cholesterol Nutrition 0.000 claims 4
- 230000000295 complement effect Effects 0.000 claims 4
- QONQRTHLHBTMGP-UHFFFAOYSA-N digitoxigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C11OC1CC2C1=CC(=O)OC1 QONQRTHLHBTMGP-UHFFFAOYSA-N 0.000 claims 4
- SHIBSTMRCDJXLN-KCZCNTNESA-N digoxigenin Chemical compound C1([C@@H]2[C@@]3([C@@](CC2)(O)[C@H]2[C@@H]([C@@]4(C)CC[C@H](O)C[C@H]4CC2)C[C@H]3O)C)=CC(=O)OC1 SHIBSTMRCDJXLN-KCZCNTNESA-N 0.000 claims 4
- 125000002228 disulfide group Chemical group 0.000 claims 4
- 125000000524 functional group Chemical group 0.000 claims 4
- 125000005843 halogen group Chemical group 0.000 claims 4
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims 3
- 125000004450 alkenylene group Chemical group 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 150000003384 small molecules Chemical class 0.000 claims 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 2
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims 2
- 150000001408 amides Chemical class 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 125000001841 imino group Chemical group [H]N=* 0.000 claims 2
- 239000000178 monomer Substances 0.000 claims 2
- MWWATHDPGQKSAR-UHFFFAOYSA-N propyne Chemical group CC#C MWWATHDPGQKSAR-UHFFFAOYSA-N 0.000 claims 2
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 claims 2
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 claims 1
- -1 5 ′ Cap Chemical compound 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000004419 alkynylene group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 claims 1
- 235000021317 phosphate Nutrition 0.000 claims 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims 1
- 125000004437 phosphorous atom Chemical group 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 125000005309 thioalkoxy group Chemical group 0.000 claims 1
- 150000003573 thiols Chemical class 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361900685P | 2013-11-06 | 2013-11-06 | |
| US61/900,685 | 2013-11-06 | ||
| US201461975686P | 2014-04-04 | 2014-04-04 | |
| US61/975,686 | 2014-04-04 | ||
| US201462008906P | 2014-06-06 | 2014-06-06 | |
| US62/008,906 | 2014-06-06 | ||
| PCT/US2014/064401 WO2015069932A1 (en) | 2013-11-06 | 2014-11-06 | Polynucleotide constructs having disulfide groups |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016537027A JP2016537027A (ja) | 2016-12-01 |
| JP2016537027A5 true JP2016537027A5 (enExample) | 2017-12-14 |
Family
ID=53042090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016553242A Pending JP2016537027A (ja) | 2013-11-06 | 2014-11-06 | ジスルフィド基を有するポリヌクレオチド構築物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20160257961A1 (enExample) |
| EP (1) | EP3066105A4 (enExample) |
| JP (1) | JP2016537027A (enExample) |
| CN (1) | CN106061981A (enExample) |
| AU (1) | AU2014346658A1 (enExample) |
| CA (1) | CA2929651A1 (enExample) |
| WO (1) | WO2015069932A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105764491A (zh) | 2013-12-09 | 2016-07-13 | 度瑞公司 | 药物活性剂复合物、聚合物复合物，以及包括其的组合物和方法 |
| EP3152308A4 (en) * | 2014-06-06 | 2017-12-27 | Solstice Biologics, Ltd. | Polynucleotide constructs having bioreversible and non-bioreversible groups |
| US20180133327A1 (en) * | 2015-03-16 | 2018-05-17 | Amal Therapeutics Sa | Cell Penetrating Peptides and Complexes Comprising the Same |
| CN105175546A (zh) * | 2015-05-27 | 2015-12-23 | 连祺周 | 人血管内皮生长因子与表皮生长因子样结构域7的融合蛋白 |
| JPWO2016208773A1 (ja) * | 2015-06-26 | 2018-04-12 | 協和発酵キリン株式会社 | オリゴヌクレオチド誘導体 |
| CN105037739B (zh) * | 2015-07-28 | 2017-10-27 | 四川大学 | 具有精氨酸穿膜作用的还原敏感型聚合物及其制备方法与应用 |
| AU2016349457B2 (en) * | 2015-11-06 | 2022-09-22 | Qiagen Sciences Llc | Nucleotide analogues |
| WO2017100461A1 (en) * | 2015-12-08 | 2017-06-15 | Solstice Biologics, Ltd. | Polynucleotide constructs having an auxiliary moiety non-bioreversibly linked to an internucleoside phosphate or phosphorothioate |
| RU2769314C1 (ru) | 2016-03-16 | 2022-03-30 | Амаль Терапьютикс Са | Комбинация модулятора иммунных контрольных точек и комплекса, содержащего проникающий в клетку пептид, карго-молекулу и пептидный агонист tlr, для применения в медицине |
| WO2018004004A1 (ja) * | 2016-06-30 | 2018-01-04 | 協和発酵キリン株式会社 | 核酸複合体 |
| CN109803973B (zh) | 2016-08-10 | 2022-05-24 | 癌靶技术有限责任公司 | 螯合psma抑制剂 |
| KR20190058477A (ko) | 2016-08-17 | 2019-05-29 | 솔스티스 바이올로직스, 리미티드 | 폴리뉴클레오티드 구축물 |
| WO2018039364A1 (en) | 2016-08-23 | 2018-03-01 | Dicerna Pharmaceuticals, Inc. | Compositions comprising reversibly modified oligonucleotides and uses thereof |
| HUE067838T2 (hu) | 2016-09-21 | 2024-11-28 | Amal Therapeutics Sa | Egy sejtpenetráló peptidet, egy multiepitópot és egy TLR peptidagonistát tartalmazó fúzió rák kezelésére |
| CA3043619A1 (en) * | 2016-11-23 | 2018-05-31 | Cancer Targeted Technology Llc | Albumin-binding psma inhibitors |
| AU2018252193B2 (en) * | 2017-04-14 | 2024-12-12 | Tallac Therapeutics, Inc. | Immunomodulating polynucleotides, antibody conjugates thereof, and methods of their use |
| WO2019006455A1 (en) | 2017-06-30 | 2019-01-03 | Solstice Biologics, Ltd. | AUXILIARIES OF CHIRAL PHOSPHORAMIDITIS AND METHODS OF USE THEREOF |
| AU2019222767A1 (en) | 2018-02-14 | 2020-08-27 | Deep Genomics Incorporated | Oligonucleotide therapy for Wilson disease |
| KR20210102204A (ko) * | 2018-10-17 | 2021-08-19 | 탈락 테라퓨틱스, 인크. | 면역 조절 폴리뉴클레오타이드 컨쥬게이트 및 사용 방법 |
| CN109384715B (zh) * | 2018-11-19 | 2021-09-03 | 复旦大学附属肿瘤医院 | 前列腺特异性膜抗原的小分子抑制剂的制备方法 |
| KR20220030204A (ko) * | 2018-12-28 | 2022-03-10 | 서나오믹스, 인크. | 치료 분자의 표적화된 전달 |
| CN115175685B (zh) | 2019-12-09 | 2024-12-13 | 艾姆皮瑞克公司 | 用于治疗血管生成素样4(angptl4)相关疾病的寡核苷酸 |
| US11920136B2 (en) | 2020-02-28 | 2024-03-05 | Tallac Therapeutics, Inc. | Transglutaminase-mediated conjugation |
| CN112402620A (zh) * | 2020-12-07 | 2021-02-26 | 南开大学 | 肿瘤微环境还原响应性的纳米药物及其制备方法 |
| CA3207125A1 (en) * | 2020-12-31 | 2022-07-07 | Alnylam Pharmaceuticals, Inc. | Cyclic-disulfide modified phosphate based oligonucleotide prodrugs |
| CN112679583B (zh) * | 2021-01-07 | 2022-02-22 | 杭州医学院 | 一种靶向癌蛋白boris的特异性多肽及其应用和基因 |
| KR20230137295A (ko) * | 2021-01-28 | 2023-10-04 | 난징 챔피언 바이오테크놀로지 컴퍼니 리미티드 | 접합체 및 이의 용도 |
| CN112898206A (zh) * | 2021-02-05 | 2021-06-04 | 河北凡博医药科技有限公司 | 一种5,6-二甲基苯并咪唑的制备方法 |
| CN113024854B (zh) * | 2021-03-24 | 2022-06-03 | 西南石油大学 | 一种结构可控且规整的凝胶材料的制备方法 |
| WO2023178144A2 (en) | 2022-03-16 | 2023-09-21 | Empirico Inc. | Galnac compositions for improving sirna bioavailability |
| CN120112641A (zh) * | 2022-10-31 | 2025-06-06 | 大睿生物医药科技(上海)有限公司 | 向细胞内递送siRNA的前药 |
| CN115925586A (zh) * | 2022-11-01 | 2023-04-07 | 青岛蓝谷多肽生物医药科技有限公司 | 一种靶向psma的母体及其衍生物的制备方法 |
| CN116715624B (zh) * | 2023-06-14 | 2025-11-28 | 信阳师范学院 | 一种n-烷基化吡啶硫酮类化合物的合成方法 |
| WO2025160446A1 (en) * | 2024-01-25 | 2025-07-31 | Ai Proteins, Inc. | Methods and systems for characterizing structural features of a protein |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991014696A1 (en) * | 1990-03-29 | 1991-10-03 | Gilead Sciences, Inc. | Oligonucleotide-transport agent disulfide conjugates |
| US6610841B1 (en) * | 1997-12-18 | 2003-08-26 | Gilead Sciences, Inc. | Nucleotide-based prodrugs |
| US20070142267A1 (en) * | 1998-11-23 | 2007-06-21 | Novelos Therapeutics, Inc. | Methods for production of the oxidized glutathione composite with CIS-diamminedichloroplatinum and pharmaceutical compositions based thereof regulating metabolism, proliferation, differentiation and apoptotic mechanisms for normal and transformed cells |
| US6906182B2 (en) * | 2000-12-01 | 2005-06-14 | Cell Works Therapeutics, Inc. | Conjugates of glycosylated/galactosylated peptide, bifunctional linker, and nucleotidic monomers/polymers, and related compositions and method of use |
| US20030073618A1 (en) * | 2001-02-08 | 2003-04-17 | Kozhemyakin Leonid A. | Compounds comprising disulfide-containing peptides and nitrogenous bases, and medical uses thereof |
| US7785610B2 (en) * | 2001-06-21 | 2010-08-31 | Dynavax Technologies Corporation | Chimeric immunomodulatory compounds and methods of using the same—III |
| AU2002345847B2 (en) * | 2001-06-21 | 2008-05-29 | Dynavax Technologies Corporation | Chimeric immunomodulatory compounds and methods of using the same |
| WO2007011722A2 (en) * | 2005-07-15 | 2007-01-25 | President And Fellows Of Harvard College | Reaction discovery system |
| EP2644199B1 (en) * | 2007-03-05 | 2017-10-11 | NewSouth Innovations Pty Limited | Methods for detecting and modulating the sensitivity of tumour cells to anti-mitotic agents |
| EP2438079A4 (en) * | 2009-06-01 | 2013-05-22 | Univ California | NUCLEIC ACID DELIVERY COMPOSITIONS AND METHOD OF USE THEREOF |
| EP3248982A1 (en) * | 2011-07-19 | 2017-11-29 | Wave Life Sciences Ltd. | Thiosulfonate reagents for the synthesis of functionalized nucleic acids |
| US20150018579A1 (en) * | 2012-02-22 | 2015-01-15 | Suresh C. Srivastava | Synthesis of high purity dmt-c3-disulfide phosphoramidite |
| CA2880869A1 (en) * | 2012-08-20 | 2014-02-27 | The Regents Of The University Of California | Polynucleotides having bioreversible groups |
-
2014
- 2014-11-06 CN CN201480072173.2A patent/CN106061981A/zh active Pending
- 2014-11-06 EP EP14860025.7A patent/EP3066105A4/en not_active Withdrawn
- 2014-11-06 CA CA2929651A patent/CA2929651A1/en not_active Abandoned
- 2014-11-06 JP JP2016553242A patent/JP2016537027A/ja active Pending
- 2014-11-06 AU AU2014346658A patent/AU2014346658A1/en not_active Abandoned
- 2014-11-06 US US15/034,973 patent/US20160257961A1/en not_active Abandoned
- 2014-11-06 WO PCT/US2014/064401 patent/WO2015069932A1/en not_active Ceased
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