JP2016535054A5 - - Google Patents
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- Publication number
- JP2016535054A5 JP2016535054A5 JP2016527458A JP2016527458A JP2016535054A5 JP 2016535054 A5 JP2016535054 A5 JP 2016535054A5 JP 2016527458 A JP2016527458 A JP 2016527458A JP 2016527458 A JP2016527458 A JP 2016527458A JP 2016535054 A5 JP2016535054 A5 JP 2016535054A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- xrpd spectrum
- peaks
- compound
- crystalline compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 21
- 238000000634 powder X-ray diffraction Methods 0.000 claims 12
- 238000001228 spectrum Methods 0.000 claims 12
- 239000000203 mixture Substances 0.000 claims 9
- 238000002411 thermogravimetry Methods 0.000 claims 8
- 238000009472 formulation Methods 0.000 claims 7
- 238000000034 method Methods 0.000 claims 5
- 238000000113 differential scanning calorimetry Methods 0.000 claims 4
- 239000002904 solvent Substances 0.000 claims 4
- 239000011877 solvent mixture Substances 0.000 claims 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 3
- 239000002667 nucleating agent Substances 0.000 claims 3
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical group CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 2
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 claims 2
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 2
- RDOXTESZEPMUJZ-UHFFFAOYSA-N anisole Chemical compound COC1=CC=CC=C1 RDOXTESZEPMUJZ-UHFFFAOYSA-N 0.000 claims 2
- 239000012296 anti-solvent Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- JMMWKPVZQRWMSS-UHFFFAOYSA-N isopropanol acetate Natural products CC(C)OC(C)=O JMMWKPVZQRWMSS-UHFFFAOYSA-N 0.000 claims 1
- 229940011051 isopropyl acetate Drugs 0.000 claims 1
- GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- UZKWTJUDCOPSNM-UHFFFAOYSA-N methoxybenzene Substances CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- WMOVHXAZOJBABW-UHFFFAOYSA-N tert-butyl acetate Chemical compound CC(=O)OC(C)(C)C WMOVHXAZOJBABW-UHFFFAOYSA-N 0.000 claims 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021052653A JP7346485B2 (ja) | 2013-11-08 | 2021-03-26 | 結晶性β－ラクタマーゼ阻害剤 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1319776.9A GB201319776D0 (en) | 2013-11-08 | 2013-11-08 | Compound |
| GB1319776.9 | 2013-11-08 | ||
| GBGB1408643.3A GB201408643D0 (en) | 2013-11-08 | 2014-05-15 | Compound |
| GB1408643.3 | 2014-05-15 | ||
| PCT/EP2014/074108 WO2015067787A1 (en) | 2013-11-08 | 2014-11-07 | Crystalline beta-lactamase inhibitor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021052653A Division JP7346485B2 (ja) | 2013-11-08 | 2021-03-26 | 結晶性β－ラクタマーゼ阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016535054A JP2016535054A (ja) | 2016-11-10 |
| JP2016535054A5 true JP2016535054A5 (enExample) | 2017-12-14 |
| JP7045795B2 JP7045795B2 (ja) | 2022-04-01 |
Family
ID=49818360
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016527458A Active JP7045795B2 (ja) | 2013-11-08 | 2014-11-07 | 結晶性β－ラクタマーゼ阻害剤 |
| JP2021052653A Active JP7346485B2 (ja) | 2013-11-08 | 2021-03-26 | 結晶性β－ラクタマーゼ阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021052653A Active JP7346485B2 (ja) | 2013-11-08 | 2021-03-26 | 結晶性β－ラクタマーゼ阻害剤 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20160289245A1 (enExample) |
| EP (1) | EP3066103A1 (enExample) |
| JP (2) | JP7045795B2 (enExample) |
| KR (1) | KR20160081964A (enExample) |
| CN (1) | CN105873935B (enExample) |
| AU (1) | AU2014345507B2 (enExample) |
| CA (1) | CA2929199C (enExample) |
| CL (1) | CL2016001097A1 (enExample) |
| EA (1) | EA031348B1 (enExample) |
| GB (2) | GB201319776D0 (enExample) |
| IL (1) | IL245386A0 (enExample) |
| MX (1) | MX2016005869A (enExample) |
| PE (1) | PE20160890A1 (enExample) |
| WO (1) | WO2015067787A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201319776D0 (en) * | 2013-11-08 | 2013-12-25 | Allecra Therapeutics Sas | Compound |
| WO2026086730A1 (zh) * | 2024-10-21 | 2026-04-30 | 齐鲁制药有限公司 | 恩美他唑巴坦的晶型及其制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4562073A (en) * | 1982-12-24 | 1985-12-31 | Taiho Pharmaceutical Company Limited | Penicillin derivatives |
| US6156745A (en) * | 1997-12-29 | 2000-12-05 | Research Corporation Technologies, Inc. | 2β-substituted-6-alkylidene penicillanic acid derivatives as β-lactamase inhibitors |
| US7273935B2 (en) * | 2003-08-21 | 2007-09-25 | Orchid Chemicals & Pharmaceuticals, Ltd. | Process for the preparation of 3-methylcepham derivatives |
| US7417143B2 (en) * | 2004-04-07 | 2008-08-26 | Orchid Chemicals & Pharmaceuticals Limited | Process for the preparation of Tazobactam in pure form |
| US7687488B2 (en) * | 2006-07-12 | 2010-03-30 | Orchid Chemicals & Pharmaceuticals Ltd. | 2-substituted methyl penam derivatives |
| NZ610247A (en) * | 2010-11-25 | 2014-09-26 | Allecra Therapeutics Gmbh | Β-lactamase inhibitors and their use |
| EP2847205A4 (en) * | 2012-05-07 | 2016-01-20 | Univ California | NOVEL OXYSTEROL ANALOGUE OXY149 FOR THE INDUCTION OF OSTEOGENESIS AND HEDGEHOG SIGNAL PATH AND THE INHIBITION OF ADIPOGENESIS |
| US9683009B2 (en) * | 2013-05-02 | 2017-06-20 | The Regents Of The University Of California | Bone-selective osteogenic oxysterol-bone targeting agents |
| GB201319776D0 (en) | 2013-11-08 | 2013-12-25 | Allecra Therapeutics Sas | Compound |
| GB201408649D0 (en) * | 2014-05-15 | 2014-07-02 | Allecra Therapeutics Sas | Method |
| KR20170101940A (ko) * | 2014-12-09 | 2017-09-06 | 워쏘우 오르쏘페딕 인코포레이티드 | 스테롤 관련 화합물 및 방법 |
-
2013
- 2013-11-08 GB GBGB1319776.9A patent/GB201319776D0/en not_active Ceased
-
2014
- 2014-05-15 GB GBGB1408643.3A patent/GB201408643D0/en not_active Ceased
- 2014-11-07 US US15/035,176 patent/US20160289245A1/en not_active Abandoned
- 2014-11-07 KR KR1020167014701A patent/KR20160081964A/ko not_active Withdrawn
- 2014-11-07 EA EA201690963A patent/EA031348B1/ru not_active IP Right Cessation
- 2014-11-07 JP JP2016527458A patent/JP7045795B2/ja active Active
- 2014-11-07 CA CA2929199A patent/CA2929199C/en active Active
- 2014-11-07 AU AU2014345507A patent/AU2014345507B2/en active Active
- 2014-11-07 WO PCT/EP2014/074108 patent/WO2015067787A1/en not_active Ceased
- 2014-11-07 EP EP14799382.8A patent/EP3066103A1/en not_active Withdrawn
- 2014-11-07 MX MX2016005869A patent/MX2016005869A/es unknown
- 2014-11-07 PE PE2016000598A patent/PE20160890A1/es not_active Application Discontinuation
- 2014-11-07 CN CN201480071497.4A patent/CN105873935B/zh active Active
-
2016
- 2016-05-02 IL IL245386A patent/IL245386A0/en unknown
- 2016-05-06 CL CL2016001097A patent/CL2016001097A1/es unknown
-
2018
- 2018-10-31 US US16/177,406 patent/US11124526B2/en active Active
-
2021
- 2021-03-26 JP JP2021052653A patent/JP7346485B2/ja active Active
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