JP2016531952A5 - - Google Patents
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- Publication number
- JP2016531952A5 JP2016531952A5 JP2016546894A JP2016546894A JP2016531952A5 JP 2016531952 A5 JP2016531952 A5 JP 2016531952A5 JP 2016546894 A JP2016546894 A JP 2016546894A JP 2016546894 A JP2016546894 A JP 2016546894A JP 2016531952 A5 JP2016531952 A5 JP 2016531952A5
- Authority
- JP
- Japan
- Prior art keywords
- aryl
- heterocyclyl
- cycloalkyl
- hetaryl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims description 98
- 125000001072 heteroaryl group Chemical group 0.000 claims description 95
- 125000000623 heterocyclic group Chemical group 0.000 claims description 90
- 125000003118 aryl group Chemical group 0.000 claims description 89
- 239000000651 prodrug Substances 0.000 claims description 58
- 229940002612 prodrug Drugs 0.000 claims description 58
- 150000003839 salts Chemical class 0.000 claims description 58
- 125000000217 alkyl group Chemical group 0.000 claims description 52
- 125000000304 alkynyl group Chemical group 0.000 claims description 47
- 125000004404 heteroalkyl group Chemical group 0.000 claims description 23
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 22
- 229910052739 hydrogen Inorganic materials 0.000 claims description 17
- 239000001257 hydrogen Substances 0.000 claims description 17
- 229910052736 halogen Inorganic materials 0.000 claims description 10
- 150000002367 halogens Chemical class 0.000 claims description 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 9
- 150000002431 hydrogen Chemical class 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- 125000003342 alkenyl group Chemical group 0.000 claims description 7
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 102000001253 Protein Kinase Human genes 0.000 claims description 4
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 4
- 108060006633 protein kinase Proteins 0.000 claims description 4
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims description 4
- 206010009944 Colon cancer Diseases 0.000 claims description 3
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 3
- 125000005842 heteroatom Chemical group 0.000 claims description 3
- 201000001441 melanoma Diseases 0.000 claims description 3
- 206010005003 Bladder cancer Diseases 0.000 claims description 2
- 206010006187 Breast cancer Diseases 0.000 claims description 2
- 208000026310 Breast neoplasm Diseases 0.000 claims description 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 2
- 206010038389 Renal cancer Diseases 0.000 claims description 2
- 201000010208 Seminoma Diseases 0.000 claims description 2
- 208000024770 Thyroid neoplasm Diseases 0.000 claims description 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 2
- 230000001154 acute effect Effects 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 201000010982 kidney cancer Diseases 0.000 claims description 2
- 208000032839 leukemia Diseases 0.000 claims description 2
- 201000007270 liver cancer Diseases 0.000 claims description 2
- 208000014018 liver neoplasm Diseases 0.000 claims description 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 2
- 201000002528 pancreatic cancer Diseases 0.000 claims description 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 125000003373 pyrazinyl group Chemical group 0.000 claims description 2
- 125000003226 pyrazolyl group Chemical group 0.000 claims description 2
- 125000002098 pyridazinyl group Chemical group 0.000 claims description 2
- 125000004076 pyridyl group Chemical group 0.000 claims description 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims description 2
- 201000002510 thyroid cancer Diseases 0.000 claims description 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 2
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 description 21
- 238000000034 method Methods 0.000 description 13
- 229910052757 nitrogen Inorganic materials 0.000 description 11
- 229910052760 oxygen Inorganic materials 0.000 description 8
- 102100024193 Mitogen-activated protein kinase 1 Human genes 0.000 description 6
- 108010007457 Extracellular Signal-Regulated MAP Kinases Proteins 0.000 description 5
- 229910052799 carbon Inorganic materials 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 208000035475 disorder Diseases 0.000 description 4
- 201000011510 cancer Diseases 0.000 description 3
- 208000020084 Bone disease Diseases 0.000 description 1
- 101000876610 Dictyostelium discoideum Extracellular signal-regulated kinase 2 Proteins 0.000 description 1
- 101001052493 Homo sapiens Mitogen-activated protein kinase 1 Proteins 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 238000010162 Tukey test Methods 0.000 description 1
- 238000000540 analysis of variance Methods 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
- 208000016097 disease of metabolism Diseases 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 208000026278 immune system disease Diseases 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361886552P | 2013-10-03 | 2013-10-03 | |
| US61/886,552 | 2013-10-03 | ||
| US201462032446P | 2014-08-01 | 2014-08-01 | |
| US62/032,446 | 2014-08-01 | ||
| PCT/US2014/059197 WO2015051341A1 (en) | 2013-10-03 | 2014-10-03 | Inhibitors of erk and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018201905A Division JP2019031549A (ja) | 2013-10-03 | 2018-10-26 | Ｅｒｋの阻害剤および使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016531952A JP2016531952A (ja) | 2016-10-13 |
| JP2016531952A5 true JP2016531952A5 (https=) | 2017-11-09 |
| JP6427197B2 JP6427197B2 (ja) | 2018-11-21 |
Family
ID=52779215
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016546894A Expired - Fee Related JP6427197B2 (ja) | 2013-10-03 | 2014-10-03 | Ｅｒｋの阻害剤および使用方法 |
| JP2018201905A Pending JP2019031549A (ja) | 2013-10-03 | 2018-10-26 | Ｅｒｋの阻害剤および使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018201905A Pending JP2019031549A (ja) | 2013-10-03 | 2018-10-26 | Ｅｒｋの阻害剤および使用方法 |
Country Status (28)
| Country | Link |
|---|---|
| US (4) | US9624228B2 (https=) |
| EP (2) | EP3052096B8 (https=) |
| JP (2) | JP6427197B2 (https=) |
| KR (1) | KR20160081908A (https=) |
| CN (2) | CN108864102A (https=) |
| AU (2) | AU2014331628B2 (https=) |
| BR (1) | BR112016006994A8 (https=) |
| CA (1) | CA2924584A1 (https=) |
| CY (1) | CY1120095T1 (https=) |
| DK (1) | DK3052096T3 (https=) |
| EA (1) | EA032196B1 (https=) |
| ES (1) | ES2664794T3 (https=) |
| HK (1) | HK1255851A1 (https=) |
| HR (1) | HRP20180538T1 (https=) |
| HU (1) | HUE036600T2 (https=) |
| IL (1) | IL244488A0 (https=) |
| LT (1) | LT3052096T (https=) |
| ME (1) | ME02991B (https=) |
| MX (1) | MX2016004163A (https=) |
| PH (1) | PH12016500432A1 (https=) |
| PL (1) | PL3052096T3 (https=) |
| PT (1) | PT3052096T (https=) |
| RS (1) | RS57058B1 (https=) |
| SG (1) | SG11201602572YA (https=) |
| SI (1) | SI3052096T1 (https=) |
| SM (1) | SMT201800205T1 (https=) |
| WO (1) | WO2015051341A1 (https=) |
| ZA (1) | ZA201601701B (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201602572YA (en) | 2013-10-03 | 2016-04-28 | Kura Oncology Inc | Inhibitors of erk and methods of use |
| CN109661228A (zh) * | 2016-06-20 | 2019-04-19 | 库拉肿瘤学公司 | 用erk抑制剂治疗鳞状细胞癌 |
| WO2018177781A1 (en) | 2017-03-28 | 2018-10-04 | Basf Se | Pesticidal compounds |
| WO2018183762A1 (en) | 2017-03-29 | 2018-10-04 | United States Government As Represented By The Department Of Veterans Affairs | Methods and compositions for treating cancer |
| US20200247815A1 (en) * | 2017-10-19 | 2020-08-06 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | Pyrazolyl-containing tricyclic derivative, preparation method therefor and use thereof |
| CN109761986B (zh) * | 2017-11-10 | 2021-10-08 | 上海翰森生物医药科技有限公司 | 三并环类衍生物抑制剂、其制备方法和应用 |
| CN107879989B (zh) * | 2017-11-29 | 2020-01-03 | 重庆市中药研究院 | 具有生物活性的3,4,5-取代苯并二氮卓2-酮类药物分子及其制备方法 |
| EP3643705A1 (en) | 2018-10-24 | 2020-04-29 | Basf Se | Pesticidal compounds |
| BR112021009430A2 (pt) | 2018-11-16 | 2021-08-17 | California Institute Of Technology | inibidores de erk e usos dos mesmos |
| CN112020357B (zh) * | 2019-04-02 | 2023-08-29 | 上海翰森生物医药科技有限公司 | 含吲唑基的三并环类衍生物的盐及其晶型 |
| EP3766879A1 (en) | 2019-07-19 | 2021-01-20 | Basf Se | Pesticidal pyrazole derivatives |
| JPWO2022075445A1 (https=) * | 2020-10-08 | 2022-04-14 | ||
| EP4198023A1 (en) | 2021-12-16 | 2023-06-21 | Basf Se | Pesticidally active thiosemicarbazone compounds |
| US20250197358A1 (en) | 2022-02-17 | 2025-06-19 | Basf Se | Pesticidally active thiosemicarbazone compounds |
| TW202508595A (zh) | 2023-05-04 | 2025-03-01 | 美商銳新醫藥公司 | 用於ｒａｓ相關疾病或病症之組合療法 |
| EP4720053A1 (en) | 2023-05-25 | 2026-04-08 | Basf Se | Lactam pesticidal compounds |
| EP4467535A1 (en) | 2023-05-25 | 2024-11-27 | Basf Se | Lactam pesticidal compounds |
| US20250049810A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| TW202529768A (zh) | 2023-09-29 | 2025-08-01 | 大陸商德昇濟醫藥（無錫）有限公司 | 癌症治療的療法 |
| AU2024360465A1 (en) | 2023-10-12 | 2026-04-09 | Revolution Medicines, Inc. | Macrocyclic ras inhibitors |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| TW202547461A (zh) | 2024-05-17 | 2025-12-16 | 美商銳新醫藥公司 | Ｒａｓ抑制劑 |
| WO2025255438A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
| WO2026006747A1 (en) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026015796A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015790A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015801A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015825A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Use of ras inhibitor for treating pancreatic cancer |
| WO2026050446A1 (en) | 2024-08-29 | 2026-03-05 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026072904A2 (en) | 2024-09-26 | 2026-04-02 | Revolution Medicines, Inc. | Compositions and methods for treating lung cancer |
Family Cites Families (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3657744A (en) | 1970-05-08 | 1972-04-25 | Univ Minnesota | Method for fixing prosthetic implants in a living body |
| BE791816R (fr) * | 1971-11-24 | 1973-05-23 | Sandoz Sa | Derives de la quinazolinone, leur preparation et medicaments contenant ces |
| US3984556A (en) * | 1973-01-19 | 1976-10-05 | Sandoz, Inc. | Alkyl-substituted-tricyclic quinazolinones for lowering blood pressure |
| US4042704A (en) * | 1976-03-18 | 1977-08-16 | Sandoz, Inc. | Benzindazoles |
| US4352931A (en) | 1980-05-22 | 1982-10-05 | Siegfried Aktiengesellschaft | Lin-benzoaminopurinols |
| US4733665C2 (en) | 1985-11-07 | 2002-01-29 | Expandable Grafts Partnership | Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft |
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US5040548A (en) | 1989-06-01 | 1991-08-20 | Yock Paul G | Angioplasty mehtod |
| US5350395A (en) | 1986-04-15 | 1994-09-27 | Yock Paul G | Angioplasty apparatus facilitating rapid exchanges |
| US5061273A (en) | 1989-06-01 | 1991-10-29 | Yock Paul G | Angioplasty apparatus facilitating rapid exchanges |
| US4748982A (en) | 1987-01-06 | 1988-06-07 | Advanced Cardiovascular Systems, Inc. | Reinforced balloon dilatation catheter with slitted exchange sleeve and method |
| DE3701277A1 (de) * | 1987-01-17 | 1988-07-28 | Boehringer Mannheim Gmbh | Neue tricyclische benzimidazole, verfahren zu ihrer herstellung und verwendung als arzneimittel |
| US4992445A (en) | 1987-06-12 | 1991-02-12 | American Cyanamid Co. | Transdermal delivery of pharmaceuticals |
| US5001139A (en) | 1987-06-12 | 1991-03-19 | American Cyanamid Company | Enchancers for the transdermal flux of nivadipine |
| CA1322628C (en) | 1988-10-04 | 1993-10-05 | Richard A. Schatz | Expandable intraluminal graft |
| GB8827305D0 (en) | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
| US5674278A (en) | 1989-08-24 | 1997-10-07 | Arterial Vascular Engineering, Inc. | Endovascular support device |
| US6344053B1 (en) | 1993-12-22 | 2002-02-05 | Medtronic Ave, Inc. | Endovascular support device and method |
| US5292331A (en) | 1989-08-24 | 1994-03-08 | Applied Vascular Engineering, Inc. | Endovascular support device |
| US5455258A (en) | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
| IL112248A0 (en) * | 1994-01-25 | 1995-03-30 | Warner Lambert Co | Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them |
| US5863949A (en) | 1995-03-08 | 1999-01-26 | Pfizer Inc | Arylsulfonylamino hydroxamic acid derivatives |
| ES2153031T4 (es) | 1995-04-20 | 2001-05-16 | Pfizer | Derivados del acido arilsulfonil hidroxamico como inhibidores de mmp y tnf. |
| ATE225343T1 (de) | 1995-12-20 | 2002-10-15 | Hoffmann La Roche | Matrix-metalloprotease inhibitoren |
| KR20000067904A (ko) | 1996-07-18 | 2000-11-25 | 디. 제이. 우드, 스피겔 알렌 제이 | 매트릭스 메탈로프로테아제의 포스피네이트계 억제제 |
| KR20000068248A (ko) | 1996-08-23 | 2000-11-25 | 디. 제이. 우드, 스피겔 알렌 제이 | 아릴설포닐아미노 하이드록삼산 유도체 |
| JP3338064B2 (ja) | 1997-01-06 | 2002-10-28 | ファイザー・インク | 環状スルホン誘導体 |
| NZ336840A (en) | 1997-02-03 | 2001-01-26 | Pfizer Prod Inc | Arylsulfonylamino hydroxamic acid derivatives useful in the treatment of tumor necrosis factor and matrix metalloproteinase mediated diseases |
| JP2000507975A (ja) | 1997-02-07 | 2000-06-27 | ファイザー・インク | Ｎ−ヒドロキシ−β−スルホニルプロピオンアミド誘導体類及びそれらのマトリックスメタロプロテイナーゼ阻害薬としての使用 |
| EP0960098A1 (en) | 1997-02-11 | 1999-12-01 | Pfizer Inc. | Arylsulfonyl hydroxamic acid derivatives |
| GB9725782D0 (en) | 1997-12-05 | 1998-02-04 | Pfizer Ltd | Therapeutic agents |
| GB9801690D0 (en) | 1998-01-27 | 1998-03-25 | Pfizer Ltd | Therapeutic agents |
| PA8469401A1 (es) | 1998-04-10 | 2000-05-24 | Pfizer Prod Inc | Derivados biciclicos del acido hidroxamico |
| PA8469501A1 (es) | 1998-04-10 | 2000-09-29 | Pfizer Prod Inc | Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico |
| US6087368A (en) | 1998-06-08 | 2000-07-11 | Bristol-Myers Squibb Company | Quinazolinone inhibitors of cGMP phosphodiesterase |
| US6562836B1 (en) * | 1999-05-24 | 2003-05-13 | Queen's University Of Kingston | Methods and compounds for inhibiting amyloid deposits |
| WO2002022605A1 (en) | 2000-09-15 | 2002-03-21 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| JP3896309B2 (ja) * | 2001-07-09 | 2007-03-22 | ファイザー株式会社 | プロテインキナーゼｃ阻害物質としてのピラゾロキノリノン誘導体 |
| US7119111B2 (en) | 2002-05-29 | 2006-10-10 | Amgen, Inc. | 2-oxo-1,3,4-trihydroquinazolinyl derivatives and methods of use |
| TWI339206B (en) | 2003-09-04 | 2011-03-21 | Vertex Pharma | Compositions useful as inhibitors of protein kinases |
| WO2005025515A2 (en) * | 2003-09-12 | 2005-03-24 | California Institute Of Technology | Proteasome pathway inhibitors and related methods |
| US7244757B2 (en) | 2004-04-01 | 2007-07-17 | Pfizer Inc | Pyrazole-amine compounds for the treatment of neurodegenerative disorders |
| US7384930B2 (en) | 2004-11-03 | 2008-06-10 | Bristol-Myers Squibb Company | Constrained compounds as CGRP-receptor antagonists |
| JP2009528280A (ja) | 2006-02-16 | 2009-08-06 | シェーリング コーポレイション | Ｅｒｋインヒビターとしてのピロリジン誘導体 |
| MY148609A (en) | 2007-06-05 | 2013-05-15 | Merck Sharp & Dohme | Polycyclic indazole derivatives and their use as erk inhibitors for the treatment of cancer |
| CA2691417A1 (en) * | 2007-06-18 | 2008-12-24 | Schering Corporation | Heterocyclic compounds and use thereof as erk inhibitors |
| WO2009046025A1 (en) | 2007-10-01 | 2009-04-09 | Comentis, Inc. | Quinuclidin-4-ylmethyl 1h-indole-3-carboxylate derivatives as alpha 7 nicotinic acetylcholine receptor ligands for the treatment of alzheimer's disease |
| US8716483B2 (en) | 2008-02-21 | 2014-05-06 | Merck Sharp & Dohme Corp. | Compounds that are ERK inhibitors |
| US8022227B2 (en) * | 2008-08-27 | 2011-09-20 | The Ohio State University | Method of synthesizing 1H-indazole compounds |
| EP2408448A4 (en) | 2009-03-18 | 2012-09-19 | Univ Leland Stanford Junior | METHODS AND COMPOSITIONS FOR TREATING INFECTION WITH A FLAVIVIRIDAE FAMILY VIRUS |
| EP3594213A1 (en) * | 2009-07-17 | 2020-01-15 | Japan Tobacco Inc. | Triazolopyridine compounds and action thereof as prolyl hydroxylase inhibitors and erythropoietin production inducers |
| JP2013506669A (ja) | 2009-09-30 | 2013-02-28 | メルク・シャープ・アンド・ドーム・コーポレーション | Ｅｒｋ阻害剤である新規化合物 |
| EP2613782B1 (en) | 2010-09-01 | 2016-11-02 | Merck Sharp & Dohme Corp. | Indazole derivatives useful as erk inhibitors |
| US9242981B2 (en) | 2010-09-16 | 2016-01-26 | Merck Sharp & Dohme Corp. | Fused pyrazole derivatives as novel ERK inhibitors |
| EP3536319A1 (en) | 2010-10-29 | 2019-09-11 | Merck Sharp & Dohme Corp. | Novel compounds that are erk inhibitors |
| WO2012087772A1 (en) | 2010-12-21 | 2012-06-28 | Schering Corporation | Indazole derivatives useful as erk inhibitors |
| US9260452B2 (en) | 2011-06-08 | 2016-02-16 | Sunovion Pharmaceuticals Inc. | Metabotrophic glutamate receptor 5 modulators and methods of use thereof |
| EP2770987B1 (en) | 2011-10-27 | 2018-04-04 | Merck Sharp & Dohme Corp. | Novel compounds that are erk inhibitors |
| RU2660429C2 (ru) | 2012-09-28 | 2018-07-06 | Мерк Шарп И Доум Корп. | Новые соединения, которые являются ингибиторами erk |
| WO2014052566A1 (en) | 2012-09-28 | 2014-04-03 | Merck Sharp & Dohme Corp. | Novel compounds that are erk inhibitors |
| WO2014134772A1 (en) | 2013-03-04 | 2014-09-12 | Merck Sharp & Dohme Corp. | Compounds inhibiting leucine-rich repeat kinase enzyme activity |
| WO2014179154A2 (en) | 2013-04-30 | 2014-11-06 | Merck Sharp & Dohme Corp. | Novel compounds that are erk inhibitors |
| SG11201602572YA (en) | 2013-10-03 | 2016-04-28 | Kura Oncology Inc | Inhibitors of erk and methods of use |
| WO2016095089A1 (en) | 2014-12-15 | 2016-06-23 | Merck Sharp & Dohme Corp. | Erk inhibitors |
| WO2016095088A1 (en) | 2014-12-15 | 2016-06-23 | Merck Sharp & Dohme Corp. | Erk inhibitors |
| CA2970717A1 (en) | 2014-12-18 | 2016-06-23 | Merck Sharp & Dohme Corp. | (s)-n-(3-(6-isopropoxypyridin-3-yl)-1h-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2h)-yl)-2-oxoethyl)-3- (methylthio)pyrrolidine-3-carboxamide compositions for pharmaceutical preparations |
| BR112017012558A2 (pt) | 2014-12-19 | 2018-01-02 | Merck Sharp & Dohme | Composições de (s)-n-(3-(6-isopropoxipiridin-3-il)-1h- indazol-5-il)-1-(2-(4-(4-(1-metil-1h-1,2,4-triazol-3-il) fenil)-3,6-diidropiridin-1(2h)-il)-2-oxoetil)-3-(metiltio) pirrolidina-3-carboxamida para preparações farmacêuticas |
| TWI704151B (zh) | 2014-12-22 | 2020-09-11 | 美商美國禮來大藥廠 | Ｅｒｋ抑制劑 |
-
2014
- 2014-10-03 SG SG11201602572YA patent/SG11201602572YA/en unknown
- 2014-10-03 SI SI201430659T patent/SI3052096T1/en unknown
- 2014-10-03 SM SM20180205T patent/SMT201800205T1/it unknown
- 2014-10-03 CN CN201810401122.XA patent/CN108864102A/zh active Pending
- 2014-10-03 LT LTEP14850964.9T patent/LT3052096T/lt unknown
- 2014-10-03 WO PCT/US2014/059197 patent/WO2015051341A1/en not_active Ceased
- 2014-10-03 CA CA2924584A patent/CA2924584A1/en not_active Abandoned
- 2014-10-03 HU HUE14850964A patent/HUE036600T2/hu unknown
- 2014-10-03 EP EP14850964.9A patent/EP3052096B8/en active Active
- 2014-10-03 RS RS20180373A patent/RS57058B1/sr unknown
- 2014-10-03 US US15/026,581 patent/US9624228B2/en not_active Expired - Fee Related
- 2014-10-03 ES ES14850964.9T patent/ES2664794T3/es active Active
- 2014-10-03 DK DK14850964.9T patent/DK3052096T3/en active
- 2014-10-03 ME MEP-2018-90A patent/ME02991B/me unknown
- 2014-10-03 AU AU2014331628A patent/AU2014331628B2/en not_active Ceased
- 2014-10-03 MX MX2016004163A patent/MX2016004163A/es unknown
- 2014-10-03 KR KR1020167011270A patent/KR20160081908A/ko not_active Ceased
- 2014-10-03 EA EA201690708A patent/EA032196B1/ru not_active IP Right Cessation
- 2014-10-03 HR HRP20180538TT patent/HRP20180538T1/hr unknown
- 2014-10-03 PL PL14850964T patent/PL3052096T3/pl unknown
- 2014-10-03 CN CN201480054909.3A patent/CN105636586B/zh not_active Expired - Fee Related
- 2014-10-03 JP JP2016546894A patent/JP6427197B2/ja not_active Expired - Fee Related
- 2014-10-03 PT PT148509649T patent/PT3052096T/pt unknown
- 2014-10-03 BR BR112016006994A patent/BR112016006994A8/pt not_active Application Discontinuation
- 2014-10-03 EP EP17204999.1A patent/EP3363800A1/en not_active Withdrawn
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2016
- 2016-03-07 PH PH12016500432A patent/PH12016500432A1/en unknown
- 2016-03-08 IL IL244488A patent/IL244488A0/en unknown
- 2016-03-11 ZA ZA2016/01701A patent/ZA201601701B/en unknown
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2017
- 2017-02-22 US US15/439,719 patent/US9951078B2/en not_active Expired - Fee Related
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2018
- 2018-02-14 US US15/896,929 patent/US10301317B2/en not_active Expired - Fee Related
- 2018-03-27 CY CY20181100340T patent/CY1120095T1/el unknown
- 2018-10-18 AU AU2018250439A patent/AU2018250439A1/en not_active Abandoned
- 2018-10-26 JP JP2018201905A patent/JP2019031549A/ja active Pending
- 2018-11-22 HK HK18114927.9A patent/HK1255851A1/en unknown
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2019
- 2019-03-29 US US16/370,718 patent/US20190292194A1/en not_active Abandoned
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