JP2016527918A5 - - Google Patents
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- JP2016527918A5 JP2016527918A5 JP2016536393A JP2016536393A JP2016527918A5 JP 2016527918 A5 JP2016527918 A5 JP 2016527918A5 JP 2016536393 A JP2016536393 A JP 2016536393A JP 2016536393 A JP2016536393 A JP 2016536393A JP 2016527918 A5 JP2016527918 A5 JP 2016527918A5
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- 239000000523 sample Substances 0.000 claims 412
- 238000000034 method Methods 0.000 claims 122
- 108020004707 nucleic acids Proteins 0.000 claims 41
- 150000007523 nucleic acids Chemical group 0.000 claims 41
- 102000039446 nucleic acids Human genes 0.000 claims 41
- 239000000758 substrate Substances 0.000 claims 41
- 230000007614 genetic variation Effects 0.000 claims 38
- 108090000623 proteins and genes Proteins 0.000 claims 38
- 239000002773 nucleotide Substances 0.000 claims 35
- 125000003729 nucleotide group Chemical group 0.000 claims 35
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 34
- 230000008775 paternal effect Effects 0.000 claims 31
- 230000003287 optical effect Effects 0.000 claims 30
- 230000008774 maternal effect Effects 0.000 claims 29
- 230000003100 immobilizing effect Effects 0.000 claims 25
- 210000003754 fetus Anatomy 0.000 claims 16
- 230000037452 priming Effects 0.000 claims 14
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- 230000002068 genetic effect Effects 0.000 claims 12
- 230000003321 amplification Effects 0.000 claims 11
- 238000003199 nucleic acid amplification method Methods 0.000 claims 11
- 108700028369 Alleles Proteins 0.000 claims 8
- 210000000349 chromosome Anatomy 0.000 claims 8
- 208000036878 aneuploidy Diseases 0.000 claims 7
- 230000001268 conjugating effect Effects 0.000 claims 7
- 201000010374 Down Syndrome Diseases 0.000 claims 6
- 206010044688 Trisomy 21 Diseases 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 4
- 231100001075 aneuploidy Toxicity 0.000 claims 4
- 239000011230 binding agent Substances 0.000 claims 4
- 210000004369 blood Anatomy 0.000 claims 4
- 239000008280 blood Substances 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 230000001605 fetal effect Effects 0.000 claims 4
- 238000007834 ligase chain reaction Methods 0.000 claims 4
- 125000006850 spacer group Chemical group 0.000 claims 4
- 201000006360 Edwards syndrome Diseases 0.000 claims 3
- 108060002716 Exonuclease Proteins 0.000 claims 3
- 201000009928 Patau syndrome Diseases 0.000 claims 3
- 208000037280 Trisomy Diseases 0.000 claims 3
- 206010044686 Trisomy 13 Diseases 0.000 claims 3
- 208000006284 Trisomy 13 Syndrome Diseases 0.000 claims 3
- 208000007159 Trisomy 18 Syndrome Diseases 0.000 claims 3
- 210000002593 Y chromosome Anatomy 0.000 claims 3
- 230000003322 aneuploid effect Effects 0.000 claims 3
- 102000013165 exonuclease Human genes 0.000 claims 3
- 238000009396 hybridization Methods 0.000 claims 3
- 238000002372 labelling Methods 0.000 claims 3
- 239000000463 material Substances 0.000 claims 3
- 230000035772 mutation Effects 0.000 claims 3
- 210000002966 serum Anatomy 0.000 claims 3
- 206010053884 trisomy 18 Diseases 0.000 claims 3
- 108020004414 DNA Proteins 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 108091027568 Single-stranded nucleotide Proteins 0.000 claims 2
- 206010052779 Transplant rejections Diseases 0.000 claims 2
- 238000004458 analytical method Methods 0.000 claims 2
- 230000000692 anti-sense effect Effects 0.000 claims 2
- 229960002685 biotin Drugs 0.000 claims 2
- 235000020958 biotin Nutrition 0.000 claims 2
- 239000011616 biotin Substances 0.000 claims 2
- 230000015556 catabolic process Effects 0.000 claims 2
- 238000012790 confirmation Methods 0.000 claims 2
- 230000007423 decrease Effects 0.000 claims 2
- 238000006731 degradation reaction Methods 0.000 claims 2
- 230000000593 degrading effect Effects 0.000 claims 2
- 239000007790 solid phase Substances 0.000 claims 2
- PWZJEXGKUHVUFP-UHFFFAOYSA-N ATTO 590 meta-isomer Chemical compound [O-]Cl(=O)(=O)=O.C1=2C=C3C(C)=CC(C)(C)N(CC)C3=CC=2OC2=CC3=[N+](CC)C(C)(C)C=C(C)C3=CC2=C1C1=CC=C(C(O)=O)C=C1C(O)=O PWZJEXGKUHVUFP-UHFFFAOYSA-N 0.000 claims 1
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 206010070863 Toxicity to various agents Diseases 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 230000021615 conjugation Effects 0.000 claims 1
- 239000013068 control sample Substances 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 239000000975 dye Substances 0.000 claims 1
- 238000005562 fading Methods 0.000 claims 1
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- 239000007850 fluorescent dye Substances 0.000 claims 1
- 239000011521 glass Substances 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- VYNDHICBIRRPFP-UHFFFAOYSA-N pacific blue Chemical compound FC1=C(O)C(F)=C2OC(=O)C(C(=O)O)=CC2=C1 VYNDHICBIRRPFP-UHFFFAOYSA-N 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
- 238000011002 quantification Methods 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 238000012163 sequencing technique Methods 0.000 claims 1
- 210000004243 sweat Anatomy 0.000 claims 1
- ABZLKHKQJHEPAX-UHFFFAOYSA-N tetramethylrhodamine Chemical compound C=12C=CC(N(C)C)=CC2=[O+]C2=CC(N(C)C)=CC=C2C=1C1=CC=CC=C1C([O-])=O ABZLKHKQJHEPAX-UHFFFAOYSA-N 0.000 claims 1
- 208000026485 trisomy X Diseases 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361867559P | 2013-08-19 | 2013-08-19 | |
| US201361867554P | 2013-08-19 | 2013-08-19 | |
| US61/867,554 | 2013-08-19 | ||
| US61/867,559 | 2013-08-19 | ||
| PCT/US2014/051763 WO2015026873A1 (en) | 2013-08-19 | 2014-08-19 | Assays for single molecule detection and use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017018800A Division JP6397065B2 (ja) | 2013-08-19 | 2017-02-03 | 単分子検出アッセイおよびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016527918A JP2016527918A (ja) | 2016-09-15 |
| JP2016527918A5 true JP2016527918A5 (OSRAM) | 2016-10-27 |
| JP6088710B2 JP6088710B2 (ja) | 2017-03-01 |
Family
ID=52484110
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016536393A Active JP6088710B2 (ja) | 2013-08-19 | 2014-08-19 | 単分子検出アッセイおよびその使用 |
| JP2017018800A Active JP6397065B2 (ja) | 2013-08-19 | 2017-02-03 | 単分子検出アッセイおよびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017018800A Active JP6397065B2 (ja) | 2013-08-19 | 2017-02-03 | 単分子検出アッセイおよびその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US9212394B2 (OSRAM) |
| EP (3) | EP3036545B1 (OSRAM) |
| JP (2) | JP6088710B2 (OSRAM) |
| CN (2) | CN110283888B (OSRAM) |
| AU (2) | AU2014308980C1 (OSRAM) |
| BR (1) | BR112016003480B1 (OSRAM) |
| CA (1) | CA2921628A1 (OSRAM) |
| ES (1) | ES2739430T3 (OSRAM) |
| IL (3) | IL285521B2 (OSRAM) |
| MX (2) | MX371428B (OSRAM) |
| SG (1) | SG11201601201VA (OSRAM) |
| WO (1) | WO2015026873A1 (OSRAM) |
| ZA (1) | ZA201601029B (OSRAM) |
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| US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
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| US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| CA2824387C (en) | 2011-02-09 | 2019-09-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
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| US12492429B2 (en) | 2014-04-21 | 2025-12-09 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| EP3957749A1 (en) | 2014-04-21 | 2022-02-23 | Natera, Inc. | Detecting tumour specific mutations in biopsies with whole exome sequencing and in cell-free samples |
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| US10364467B2 (en) | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
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| US11479812B2 (en) | 2015-05-11 | 2022-10-25 | Natera, Inc. | Methods and compositions for determining ploidy |
| EP3134554B1 (en) | 2015-07-07 | 2018-08-29 | Pillar Biosciences Inc. | Method for reducing primer-dimer amplification |
| US11118216B2 (en) * | 2015-09-08 | 2021-09-14 | Affymetrix, Inc. | Nucleic acid analysis by joining barcoded polynucleotide probes |
| JP7280044B2 (ja) | 2016-04-15 | 2023-05-23 | ナテラ， インコーポレイテッド | 肺癌の検出方法 |
| CN106053405B (zh) * | 2016-05-10 | 2018-10-02 | 东南大学 | 一种基于单分子定位法的超分辨光学成像方法 |
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| CN109863503B (zh) * | 2016-09-02 | 2023-05-23 | 英维特公司 | 用于单分子定量的系统和方法 |
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