JP2016526185A5 - - Google Patents
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- JP2016526185A5 JP2016526185A5 JP2016514083A JP2016514083A JP2016526185A5 JP 2016526185 A5 JP2016526185 A5 JP 2016526185A5 JP 2016514083 A JP2016514083 A JP 2016514083A JP 2016514083 A JP2016514083 A JP 2016514083A JP 2016526185 A5 JP2016526185 A5 JP 2016526185A5
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- Prior art keywords
- light
- tissue sample
- image
- sample
- spatial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims description 10
- 230000003287 optical effect Effects 0.000 claims description 2
- 238000003384 imaging method Methods 0.000 claims 5
- 238000005286 illumination Methods 0.000 claims 4
- 239000007850 fluorescent dye Substances 0.000 claims 3
- 230000010363 phase shift Effects 0.000 claims 3
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims 2
- 239000000975 dye Substances 0.000 claims 2
- 238000001000 micrograph Methods 0.000 claims 2
- 229910052710 silicon Inorganic materials 0.000 claims 2
- 239000010703 silicon Substances 0.000 claims 2
- KKAJSJJFBSOMGS-UHFFFAOYSA-N 3,6-diamino-10-methylacridinium chloride Chemical compound [Cl-].C1=C(N)C=C2[N+](C)=C(C=C(N)C=C3)C3=CC2=C1 KKAJSJJFBSOMGS-UHFFFAOYSA-N 0.000 claims 1
- -1 DRAQ5 TM Chemical compound 0.000 claims 1
- 239000004988 Nematic liquid crystal Substances 0.000 claims 1
- 239000004098 Tetracycline Substances 0.000 claims 1
- RZUBARUFLYGOGC-MTHOTQAESA-L acid fuchsin Chemical compound [Na+].[Na+].[O-]S(=O)(=O)C1=C(N)C(C)=CC(C(=C\2C=C(C(=[NH2+])C=C/2)S([O-])(=O)=O)\C=2C=C(C(N)=CC=2)S([O-])(=O)=O)=C1 RZUBARUFLYGOGC-MTHOTQAESA-L 0.000 claims 1
- DPKHZNPWBDQZCN-UHFFFAOYSA-N acridine orange free base Chemical compound C1=CC(N(C)C)=CC2=NC3=CC(N(C)C)=CC=C3C=C21 DPKHZNPWBDQZCN-UHFFFAOYSA-N 0.000 claims 1
- 229940023020 acriflavine Drugs 0.000 claims 1
- DZBUGLKDJFMEHC-UHFFFAOYSA-N benzoquinolinylidene Natural products C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 claims 1
- 238000007635 classification algorithm Methods 0.000 claims 1
- 238000007598 dipping method Methods 0.000 claims 1
- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 claims 1
- 239000005262 ferroelectric liquid crystals (FLCs) Substances 0.000 claims 1
- OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical compound OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
- 229960002180 tetracycline Drugs 0.000 claims 1
- 238000000799 fluorescence microscopy Methods 0.000 description 2
- 239000000090 biomarker Substances 0.000 description 1
- 238000001218 confocal laser scanning microscopy Methods 0.000 description 1
- 238000004624 confocal microscopy Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361823817P | 2013-05-15 | 2013-05-15 | |
| US61/823,817 | 2013-05-15 | ||
| US201361919434P | 2013-12-20 | 2013-12-20 | |
| US61/919,434 | 2013-12-20 | ||
| PCT/US2014/038141 WO2014186544A1 (en) | 2013-05-15 | 2014-05-15 | Microscopy of a tissue sample using structured illumination |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016526185A JP2016526185A (ja) | 2016-09-01 |
| JP2016526185A5 true JP2016526185A5 (enExample) | 2018-04-12 |
| JP6416887B2 JP6416887B2 (ja) | 2018-10-31 |
Family
ID=51898862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016514083A Active JP6416887B2 (ja) | 2013-05-15 | 2014-05-15 | 構造化照明を用いた組織試料の顕微鏡観察 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10042150B2 (enExample) |
| EP (1) | EP2997353B1 (enExample) |
| JP (1) | JP6416887B2 (enExample) |
| AU (1) | AU2014265382B2 (enExample) |
| CA (1) | CA2912401C (enExample) |
| DK (1) | DK2997353T3 (enExample) |
| ES (1) | ES2935506T3 (enExample) |
| IL (2) | IL242474B (enExample) |
| WO (1) | WO2014186544A1 (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017075275A1 (en) * | 2015-10-29 | 2017-05-04 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and systems for imaging a biological sample |
| JP6961603B2 (ja) | 2016-02-12 | 2021-11-05 | マサチューセッツ インスティテュート オブ テクノロジー | 切断されていない組織検体を撮像するための方法及び装置 |
| US11269171B2 (en) * | 2016-05-19 | 2022-03-08 | Huron Technologies International Inc. | Spectrally-resolved scanning microscope |
| CN106291962B (zh) * | 2016-09-19 | 2018-07-17 | 浙江大学 | 基于偏振光相位调制的结构光生成装置与方法 |
| EP3538870B1 (en) * | 2016-11-14 | 2024-09-04 | Siemens Healthcare Diagnostics Inc. | Methods and apparatus for characterizing a specimen using pattern illumination |
| CN106706577B (zh) * | 2016-11-16 | 2019-08-16 | 深圳大学 | 一种光成像系统及方法 |
| JP6720402B2 (ja) | 2017-03-21 | 2020-07-08 | 株式会社Ｐｒｅｆｅｒｒｅｄ Ｎｅｔｗｏｒｋｓ | サーバ装置、学習済モデル提供プログラム、学習済モデル提供方法及び学習済モデル提供システム |
| US10401605B2 (en) * | 2017-05-02 | 2019-09-03 | SCREEN Holdings, Co., Ltd. | Structured illumination in inverted light sheet microscopy |
| EP3467563A1 (de) * | 2017-10-06 | 2019-04-10 | Siemens Healthcare GmbH | Mikroskopiervorrichtung |
| CN108120680B (zh) * | 2017-12-19 | 2019-11-22 | 清华大学 | 基于光电特性先验的显微成像的杂散光去除方法及装置 |
| TWI699816B (zh) * | 2017-12-26 | 2020-07-21 | 雲象科技股份有限公司 | 自動化顯微鏡系統之控制方法、顯微鏡系統及電腦可讀取記錄媒體 |
| JP6986452B2 (ja) * | 2018-01-04 | 2021-12-22 | 浜松ホトニクス株式会社 | 蛍光測定装置および蛍光測定方法 |
| WO2019148024A1 (en) | 2018-01-26 | 2019-08-01 | Park Jong Kang | Systems and methods to reduce scattering in temporal focusing multiphoton microscopy |
| US11988584B2 (en) | 2018-04-05 | 2024-05-21 | Instapath, Inc. | Disposable biopsy staining kit and related methods and systems |
| US11559298B2 (en) | 2018-07-16 | 2023-01-24 | Cilag Gmbh International | Surgical visualization of multiple targets |
| KR102130100B1 (ko) | 2018-09-07 | 2020-07-03 | 주식회사 더웨이브톡 | 광학 검출 시스템 |
| EP3995879A4 (en) * | 2018-09-28 | 2023-08-23 | Evident Corporation | MICROSCOPE SYSTEM, PROJECTION UNIT AND IMAGE PROJECTION METHOD |
| WO2020066041A1 (ja) | 2018-09-28 | 2020-04-02 | オリンパス株式会社 | 顕微鏡システム |
| CN112714886B (zh) | 2018-09-28 | 2023-03-21 | 仪景通株式会社 | 显微镜系统、投影单元以及图像投影方法 |
| JP7150868B2 (ja) | 2018-09-28 | 2022-10-11 | 株式会社エビデント | 顕微鏡システム、投影ユニット、及び、画像投影方法 |
| US20200284703A1 (en) * | 2019-03-08 | 2020-09-10 | Samantree Medical Sa | Staining agent solutions for use in fluorescence microscopy |
| US12257013B2 (en) | 2019-03-15 | 2025-03-25 | Cilag Gmbh International | Robotic surgical systems with mechanisms for scaling camera magnification according to proximity of surgical tool to tissue |
| US12618755B2 (en) | 2019-03-20 | 2026-05-05 | Dany Adams | Methods and systems for assessing bioelectric patterns |
| EP3953898A4 (en) | 2019-04-12 | 2023-01-11 | Invenio Imaging Inc. | IMAGING SYSTEM FOR DETECTING INTRAOPERATIVE CONTRAST AGENT IN TISSUE |
| CN117036248A (zh) * | 2019-10-01 | 2023-11-10 | 10X基因组学有限公司 | 用于识别组织样品中的形态学模式的系统和方法 |
| DE102019129932B4 (de) * | 2019-11-06 | 2023-12-21 | Technische Universität Braunschweig | Optische Detektionseinrichtung und Verfahren zum Betreiben einer optischen Detektionseinrichtung |
| KR102304036B1 (ko) * | 2019-11-27 | 2021-09-17 | 울산과학기술원 | 연속 블록면 광간섭 현미경 장치 |
| TWI868262B (zh) * | 2019-12-06 | 2025-01-01 | 美商伊路米納有限公司 | 提供參數估計的裝置和方法以及相關的處理器可讀取媒體 |
| US11284963B2 (en) | 2019-12-30 | 2022-03-29 | Cilag Gmbh International | Method of using imaging devices in surgery |
| US11776144B2 (en) * | 2019-12-30 | 2023-10-03 | Cilag Gmbh International | System and method for determining, adjusting, and managing resection margin about a subject tissue |
| US12453592B2 (en) | 2019-12-30 | 2025-10-28 | Cilag Gmbh International | Adaptive surgical system control according to surgical smoke cloud characteristics |
| US11759283B2 (en) | 2019-12-30 | 2023-09-19 | Cilag Gmbh International | Surgical systems for generating three dimensional constructs of anatomical organs and coupling identified anatomical structures thereto |
| US12207881B2 (en) | 2019-12-30 | 2025-01-28 | Cilag Gmbh International | Surgical systems correlating visualization data and powered surgical instrument data |
| US11832996B2 (en) | 2019-12-30 | 2023-12-05 | Cilag Gmbh International | Analyzing surgical trends by a surgical system |
| US12002571B2 (en) | 2019-12-30 | 2024-06-04 | Cilag Gmbh International | Dynamic surgical visualization systems |
| US12053223B2 (en) | 2019-12-30 | 2024-08-06 | Cilag Gmbh International | Adaptive surgical system control according to surgical smoke particulate characteristics |
| US11744667B2 (en) | 2019-12-30 | 2023-09-05 | Cilag Gmbh International | Adaptive visualization by a surgical system |
| US11896442B2 (en) | 2019-12-30 | 2024-02-13 | Cilag Gmbh International | Surgical systems for proposing and corroborating organ portion removals |
| US12019250B2 (en) * | 2020-06-08 | 2024-06-25 | The Regents Of The University Of California | White dwarf: cross-polarized white light slide-free imaging |
| WO2022081370A1 (en) | 2020-10-15 | 2022-04-21 | Applied Materials, Inc. | In-line metrology systems, apparatus, and methods for optical devices |
| DE102020131047B4 (de) | 2020-11-24 | 2024-08-22 | Abberior Instruments Gmbh | Verfahren und Vorrichtung zur Aufnahme nanoskopischer Bilder mehrfach gefärbter Proben |
| EP4274465A4 (en) * | 2021-01-05 | 2024-10-23 | Cytoveris Inc. | MULTIMODAL MULTISPECTRAL IMAGING SYSTEM AND METHOD FOR CHARACTERIZING TISSUE TYPES IN BLADDER SAMPLES |
| CN113568294B (zh) * | 2021-07-16 | 2022-07-12 | 西安交通大学 | 一种全息光镊融合结构光照明显微系统和方法 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6671540B1 (en) * | 1990-08-10 | 2003-12-30 | Daryl W. Hochman | Methods and systems for detecting abnormal tissue using spectroscopic techniques |
| JP2000095758A (ja) | 1998-09-18 | 2000-04-04 | Schering Ag | 近赤外蛍光造影剤および蛍光造影方法 |
| US7139598B2 (en) | 2002-04-04 | 2006-11-21 | Veralight, Inc. | Determination of a measure of a glycation end-product or disease state using tissue fluorescence |
| JP4700001B2 (ja) * | 2003-09-19 | 2011-06-15 | ザ ジェネラル ホスピタル コーポレイション | 蛍光偏極撮像方法 |
| US20070016078A1 (en) * | 2004-12-06 | 2007-01-18 | Hoyt Clifford C | Systems and methods for in-vivo optical imaging and measurement |
| US8504140B2 (en) | 2008-04-08 | 2013-08-06 | Bruker Biospin Corporation | Apparatus and method for fluorescence imaging and tomography using spatially structured illumination |
| JP2007199572A (ja) * | 2006-01-30 | 2007-08-09 | Nikon Corp | 顕微鏡装置 |
| US9080977B2 (en) * | 2006-10-23 | 2015-07-14 | Xenogen Corporation | Apparatus and methods for fluorescence guided surgery |
| EP2110697B1 (en) | 2008-04-17 | 2016-02-10 | Ruprecht-Karls-Universität Heidelberg | Wave field microscope with sub-wavelength resolution and methods for processing microscopic images to detect objects with sub-wavelength dimensions |
| US8406859B2 (en) * | 2008-08-10 | 2013-03-26 | Board Of Regents, The University Of Texas System | Digital light processing hyperspectral imaging apparatus |
| DE102008049878A1 (de) | 2008-09-30 | 2010-04-01 | Carl Zeiss Microlmaging Gmbh | Verbesserte Verfahren und Vorrichtungen für die Mikroskopie mit strukturierter Beleuchtung |
| US20110224574A1 (en) * | 2008-11-13 | 2011-09-15 | Sadler John W | Methods and systems for tissue processing and imaging |
| JP2010151566A (ja) | 2008-12-25 | 2010-07-08 | Hitachi High-Technologies Corp | 粒子画像解析方法及び装置 |
| CA2762886A1 (en) * | 2009-05-22 | 2010-11-25 | British Columbia Cancer Agency Branch | Selective excitation light fluorescence imaging methods and apparatus |
| WO2011072175A2 (en) * | 2009-12-09 | 2011-06-16 | Applied Precision, Inc. | Method and system for fast three-dimensional structured-illumination-microscopy imaging |
| EP2629133A4 (en) * | 2010-10-14 | 2017-12-13 | Nikon Corporation | Structured illumination device, structured illumination microscope device, and surface shape measurement device |
| JP5655608B2 (ja) | 2011-02-08 | 2015-01-21 | 株式会社ニコン | 観察装置及び画像補正プログラム |
| WO2012135823A1 (en) * | 2011-04-01 | 2012-10-04 | Massachusetts Institute Of Technology | High sensitivity temporal focusing widefield multiphoton endoscope capable of deep imaging |
| US20120307247A1 (en) | 2011-05-31 | 2012-12-06 | Nanyang Technological University | Fluorescence Microscopy Method And System |
| JP5834584B2 (ja) | 2011-07-25 | 2015-12-24 | ソニー株式会社 | 情報処理装置、情報処理方法、プログラム及び蛍光スペクトルの強度補正方法 |
| WO2013021615A1 (ja) | 2011-08-11 | 2013-02-14 | 株式会社ニコン | 構造化照明装置及び構造化照明方法、並びに構造化照明顕微鏡装置 |
| US9254103B2 (en) * | 2011-08-15 | 2016-02-09 | The Trustees Of Dartmouth College | Operative microscope having diffuse optical imaging system with tomographic image reconstruction and superposition in field of view |
| US9599805B2 (en) | 2011-10-19 | 2017-03-21 | National Synchrotron Radiation Research Center | Optical imaging system using structured illumination |
-
2014
- 2014-05-15 DK DK14797836.5T patent/DK2997353T3/da active
- 2014-05-15 CA CA2912401A patent/CA2912401C/en active Active
- 2014-05-15 JP JP2016514083A patent/JP6416887B2/ja active Active
- 2014-05-15 EP EP14797836.5A patent/EP2997353B1/en active Active
- 2014-05-15 WO PCT/US2014/038141 patent/WO2014186544A1/en not_active Ceased
- 2014-05-15 US US14/888,257 patent/US10042150B2/en active Active
- 2014-05-15 AU AU2014265382A patent/AU2014265382B2/en active Active
- 2014-05-15 ES ES14797836T patent/ES2935506T3/es active Active
-
2015
- 2015-11-05 IL IL242474A patent/IL242474B/en active IP Right Grant
-
2018
- 2018-08-03 US US16/054,235 patent/US10768402B2/en active Active
-
2020
- 2020-02-26 IL IL272907A patent/IL272907B/en active IP Right Grant
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