JP2016525563A5 - - Google Patents
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- Publication number
- JP2016525563A5 JP2016525563A5 JP2016530548A JP2016530548A JP2016525563A5 JP 2016525563 A5 JP2016525563 A5 JP 2016525563A5 JP 2016530548 A JP2016530548 A JP 2016530548A JP 2016530548 A JP2016530548 A JP 2016530548A JP 2016525563 A5 JP2016525563 A5 JP 2016525563A5
- Authority
- JP
- Japan
- Prior art keywords
- carbon atoms
- alkyl
- therapeutic agent
- halogen atom
- diazepin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004432 carbon atom Chemical group C* 0.000 claims 44
- 150000001875 compounds Chemical class 0.000 claims 33
- 125000000217 alkyl group Chemical group 0.000 claims 28
- 239000003814 drug Substances 0.000 claims 28
- 229940124597 therapeutic agent Drugs 0.000 claims 28
- 125000005843 halogen group Chemical group 0.000 claims 24
- -1 Methyl (S)-{4- (3′-cyanobiphenyl-4-yl) -2,3,9-trimethyl-6H-thieno [3,2-f] [1,2,4] tri- Azolo [4,3-a] [1,4] diazepin-6-yl} acetate Chemical compound 0.000 claims 16
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 16
- 125000003545 alkoxy group Chemical group 0.000 claims 12
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 12
- 239000007962 solid dispersion Substances 0.000 claims 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 8
- 229920000642 polymer Polymers 0.000 claims 8
- 125000004076 pyridyl group Chemical group 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 6
- GNMUEVRJHCWKTO-FQEVSTJZSA-N 6h-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-n-(4-hydroxyphenyl)-2,3,9-trimethyl-, (6s)- Chemical compound C([C@@H]1N=C(C2=C(N3C(C)=NN=C31)SC(=C2C)C)C=1C=CC(Cl)=CC=1)C(=O)NC1=CC=C(O)C=C1 GNMUEVRJHCWKTO-FQEVSTJZSA-N 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
- IYKJEILNJZQJPU-UHFFFAOYSA-N acetic acid;butanedioic acid Chemical compound CC(O)=O.OC(=O)CCC(O)=O IYKJEILNJZQJPU-UHFFFAOYSA-N 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 150000004683 dihydrates Chemical class 0.000 claims 4
- 230000009477 glass transition Effects 0.000 claims 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 4
- 229920000639 hydroxypropylmethylcellulose acetate succinate Polymers 0.000 claims 4
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 4
- 238000000634 powder X-ray diffraction Methods 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 2
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 2
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 2
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 2
- WEVYNIUIFUYDGI-UHFFFAOYSA-N 3-[6-[4-(trifluoromethoxy)anilino]-4-pyrimidinyl]benzamide Chemical compound NC(=O)C1=CC=CC(C=2N=CN=C(NC=3C=CC(OC(F)(F)F)=CC=3)C=2)=C1 WEVYNIUIFUYDGI-UHFFFAOYSA-N 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361861291P | 2013-08-01 | 2013-08-01 | |
| US61/861,291 | 2013-08-01 | ||
| US201361863118P | 2013-08-07 | 2013-08-07 | |
| US61/863,118 | 2013-08-07 | ||
| PCT/EP2014/066629 WO2015014998A1 (en) | 2013-08-01 | 2014-08-01 | Pharmaceutical formulation containing thienotriazolodiazepine compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016525563A JP2016525563A (ja) | 2016-08-25 |
| JP2016525563A5 true JP2016525563A5 (OSRAM) | 2017-09-14 |
| JP6453877B2 JP6453877B2 (ja) | 2019-01-16 |
Family
ID=51260882
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016530548A Expired - Fee Related JP6453877B2 (ja) | 2013-08-01 | 2014-08-01 | チエノトリアゾロジアゼピン化合物を含む医薬製剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9795612B2 (OSRAM) |
| EP (1) | EP3027194A1 (OSRAM) |
| JP (1) | JP6453877B2 (OSRAM) |
| KR (1) | KR20160036591A (OSRAM) |
| CN (1) | CN106029077A (OSRAM) |
| WO (1) | WO2015014998A1 (OSRAM) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015078929A1 (en) * | 2013-11-27 | 2015-06-04 | Oncoethix Sa | Method of treating leukemia using pharmaceutical formulation containing thienotriazolodiazepine compounds |
| JP2017514909A (ja) * | 2014-05-02 | 2017-06-08 | オンコエシックス ゲーエムベーハー | チエノトリアゾロジアゼピン化合物を用いる急性骨髄性白血病及び／又は急性リンパ芽球性白血病の治療方法 |
| KR20170044172A (ko) * | 2014-08-28 | 2017-04-24 | 온코에틱스 게엠베하 | 티에노트리아졸로디아제핀 화합물을 함유하는 약학적 조성물을 사용하여 급성 골수성 백혈병 또는 급성 림프구성 백혈병을 치료하는 방법 |
| US20180098997A1 (en) * | 2015-04-03 | 2018-04-12 | Oncoethix Gmbh | Pharmaceutical doses for a bromodomain and extraterminal protein (bet) inhibitor |
| US10683305B2 (en) | 2015-04-27 | 2020-06-16 | Concert Pharmaceuticals, Inc. | Deuterated OTX-015 |
| US10792249B2 (en) | 2017-07-24 | 2020-10-06 | Acryspharm Llc | High drug loading pharmaceutical compositions |
| AU2022289869A1 (en) | 2021-06-08 | 2023-12-21 | Poseidon Innovation, Llc | Anticancer compounds |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0989131B1 (en) * | 1996-09-13 | 2002-11-13 | Mitsubishi Pharma Corporation | Thienotriazolodiazepine compounds and medicinal uses thereof |
| CA2412776C (en) * | 2000-06-16 | 2011-03-15 | Mitsubishi Pharma Corporation | Compositions controlling release ph range and/or speed |
| EP1904654A2 (en) * | 2005-07-15 | 2008-04-02 | Brystol-Myers Squibb Company | Methods of identifying and treating individuals exhibiting mutant src kinase polypeptides |
| WO2008086342A2 (en) * | 2007-01-09 | 2008-07-17 | Bristol-Myers Squibb Company | Identification of polynucleotides for predicting activity of compounds that interact with and/or modulate protein tyrosine kinases and/or protein tyrosine kinase pathways in prostate cells |
| JP5478262B2 (ja) * | 2007-12-28 | 2014-04-23 | 田辺三菱製薬株式会社 | 抗癌剤 |
| WO2010077680A2 (en) * | 2008-12-08 | 2010-07-08 | Vm Discovery Inc. | Compositions of protein receptor tyrosine kinase inhibitors |
| JP5913292B2 (ja) * | 2010-05-14 | 2016-04-27 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | 代謝を調節する組成物および方法 |
| CA2799403C (en) * | 2010-05-14 | 2020-01-21 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating leukemia |
| AR084070A1 (es) * | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
| US9249161B2 (en) * | 2010-12-02 | 2016-02-02 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| BR112014032105A2 (pt) * | 2012-06-25 | 2017-08-01 | Oncoethix Sa | método para o tratamento de câncer |
| KR20150100613A (ko) | 2012-09-28 | 2015-09-02 | 온코에틱스 게엠베하 | 티에노트리아졸로디아제핀 화합물을 함유하는 약제학적 제제 |
| WO2015078929A1 (en) * | 2013-11-27 | 2015-06-04 | Oncoethix Sa | Method of treating leukemia using pharmaceutical formulation containing thienotriazolodiazepine compounds |
-
2014
- 2014-08-01 US US14/908,626 patent/US9795612B2/en not_active Expired - Fee Related
- 2014-08-01 CN CN201480052842.XA patent/CN106029077A/zh active Pending
- 2014-08-01 EP EP14745163.7A patent/EP3027194A1/en not_active Withdrawn
- 2014-08-01 WO PCT/EP2014/066629 patent/WO2015014998A1/en not_active Ceased
- 2014-08-01 JP JP2016530548A patent/JP6453877B2/ja not_active Expired - Fee Related
- 2014-08-01 KR KR1020167004843A patent/KR20160036591A/ko not_active Withdrawn
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