JP2017529332A5 - - Google Patents
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- Publication number
- JP2017529332A5 JP2017529332A5 JP2017511200A JP2017511200A JP2017529332A5 JP 2017529332 A5 JP2017529332 A5 JP 2017529332A5 JP 2017511200 A JP2017511200 A JP 2017511200A JP 2017511200 A JP2017511200 A JP 2017511200A JP 2017529332 A5 JP2017529332 A5 JP 2017529332A5
- Authority
- JP
- Japan
- Prior art keywords
- therapeutic agent
- agent according
- thieno
- triazolo
- chlorophenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000003814 drug Substances 0.000 claims 26
- 229940124597 therapeutic agent Drugs 0.000 claims 26
- 150000001875 compounds Chemical class 0.000 claims 15
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 14
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 9
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 8
- 239000007962 solid dispersion Substances 0.000 claims 8
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 6
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 5
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 5
- GNMUEVRJHCWKTO-FQEVSTJZSA-N 6h-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-n-(4-hydroxyphenyl)-2,3,9-trimethyl-, (6s)- Chemical compound C([C@@H]1N=C(C2=C(N3C(C)=NN=C31)SC(=C2C)C)C=1C=CC(Cl)=CC=1)C(=O)NC1=CC=C(O)C=C1 GNMUEVRJHCWKTO-FQEVSTJZSA-N 0.000 claims 4
- 102100022103 Histone-lysine N-methyltransferase 2A Human genes 0.000 claims 4
- 230000004927 fusion Effects 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 101001021281 Homo sapiens Protein HEXIM1 Proteins 0.000 claims 3
- 102100036307 Protein HEXIM1 Human genes 0.000 claims 3
- 229920000639 hydroxypropylmethylcellulose acetate succinate Polymers 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 230000001105 regulatory effect Effects 0.000 claims 3
- WEVYNIUIFUYDGI-UHFFFAOYSA-N 3-[6-[4-(trifluoromethoxy)anilino]-4-pyrimidinyl]benzamide Chemical compound NC(=O)C1=CC=CC(C=2N=CN=C(NC=3C=CC(OC(F)(F)F)=CC=3)C=2)=C1 WEVYNIUIFUYDGI-UHFFFAOYSA-N 0.000 claims 2
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims 2
- 230000003796 beauty Effects 0.000 claims 2
- 239000013078 crystal Substances 0.000 claims 2
- 108020004999 messenger RNA Proteins 0.000 claims 2
- 238000000634 powder X-ray diffraction Methods 0.000 claims 2
- 230000008707 rearrangement Effects 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 125000004203 4-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 108091005625 BRD4 Proteins 0.000 claims 1
- 102100033641 Bromodomain-containing protein 2 Human genes 0.000 claims 1
- 102100029895 Bromodomain-containing protein 4 Human genes 0.000 claims 1
- 102100039788 GTPase NRas Human genes 0.000 claims 1
- 101000871850 Homo sapiens Bromodomain-containing protein 2 Proteins 0.000 claims 1
- 101000744505 Homo sapiens GTPase NRas Proteins 0.000 claims 1
- 101001109719 Homo sapiens Nucleophosmin Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 102100022678 Nucleophosmin Human genes 0.000 claims 1
- HMKHWYHCDUFAJR-UHFFFAOYSA-N acetamide;dihydrate Chemical compound O.O.CC(N)=O HMKHWYHCDUFAJR-UHFFFAOYSA-N 0.000 claims 1
- ZUAAPNNKRHMPKG-UHFFFAOYSA-N acetic acid;butanedioic acid;methanol;propane-1,2-diol Chemical compound OC.CC(O)=O.CC(O)CO.OC(=O)CCC(O)=O ZUAAPNNKRHMPKG-UHFFFAOYSA-N 0.000 claims 1
- -1 compounds acetamide dihydrate Chemical class 0.000 claims 1
- 230000009477 glass transition Effects 0.000 claims 1
- 108010006693 promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462043063P | 2014-08-28 | 2014-08-28 | |
| US62/043,063 | 2014-08-28 | ||
| PCT/EP2015/069754 WO2016030509A1 (en) | 2014-08-28 | 2015-08-28 | Methods of treating acute myeloid leukemia or acute lymphoid leukemia using pharmaceutical compositions containing thienotriazolodiazepine compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017529332A JP2017529332A (ja) | 2017-10-05 |
| JP2017529332A5 true JP2017529332A5 (OSRAM) | 2018-10-11 |
Family
ID=54012215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017511200A Withdrawn JP2017529332A (ja) | 2014-08-28 | 2015-08-28 | チエノトリアゾロジアゼピン化合物を含む医薬組成物を用いる急性骨髄性白血病又は急性リンパ性白血病の治療方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20170281642A1 (OSRAM) |
| EP (1) | EP3185871A1 (OSRAM) |
| JP (1) | JP2017529332A (OSRAM) |
| KR (1) | KR20170044172A (OSRAM) |
| CN (1) | CN107427524A (OSRAM) |
| WO (1) | WO2016030509A1 (OSRAM) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017514909A (ja) * | 2014-05-02 | 2017-06-08 | オンコエシックス ゲーエムベーハー | チエノトリアゾロジアゼピン化合物を用いる急性骨髄性白血病及び／又は急性リンパ芽球性白血病の治療方法 |
| CA3002560A1 (en) | 2015-10-23 | 2017-04-27 | Array Biopharma, Inc. | 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2h)-one compounds as inhibitors of fgfr tyrosine kinases |
| CN114569606B (zh) * | 2016-07-29 | 2024-04-19 | 英克特诺治疗公司 | 吲哚啉酮化合物的用途 |
| EP3898626A1 (en) | 2018-12-19 | 2021-10-27 | Array Biopharma, Inc. | Substituted pyrazolo[1,5-a]pyridine compounds as inhibitors of fgfr tyrosine kinases |
| WO2020131674A1 (en) | 2018-12-19 | 2020-06-25 | Array Biopharma Inc. | 7-((3,5-dimethoxyphenyl)amino)quinoxaline derivatives as fgfr inhibitors for treating cancer |
| CN114364681A (zh) * | 2019-05-17 | 2022-04-15 | 西建卡尔有限责任公司 | 治疗mk2介导的病症的方法 |
| US12441707B2 (en) | 2019-12-30 | 2025-10-14 | Tyra Biosciences, Inc. | Indazole compounds |
| US20230115945A1 (en) | 2019-12-30 | 2023-04-13 | Tyra Biosciences, Inc. | Aminopyrimidine compounds |
| KR102325607B1 (ko) * | 2020-02-20 | 2021-11-12 | 한국과학기술원 | Ash1l 히스톤 메틸화 효소 활성을 억제하는 벤조퓨란-피라졸 유도체 화합물을 포함하는 백혈병의 예방 또는 치료용 조성물 |
| AU2021239956A1 (en) * | 2020-03-18 | 2022-10-13 | Eli Lilly And Company | Formulations of a farnesoid X receptor agonist |
| US12264149B2 (en) | 2020-12-30 | 2025-04-01 | Tyra Biosciences, Inc. | Indazole compounds as kinase inhibitors |
| MX2023009954A (es) | 2021-02-26 | 2023-11-09 | Tyra Biosciences Inc | Compuestos de aminopirimidina y métodos de uso de estos. |
| EP4547670A1 (en) | 2022-06-29 | 2025-05-07 | Tyra Biosciences, Inc. | Polymorphic compounds and uses thereof |
| AU2023300362A1 (en) | 2022-06-29 | 2025-01-09 | Tyra Biosciences, Inc. | Indazole compounds |
| WO2024138112A1 (en) | 2022-12-22 | 2024-06-27 | Tyra Biosciences, Inc. | Indazole compounds |
| TW202535368A (zh) | 2023-12-15 | 2025-09-16 | 美商泰拉生物科學公司 | 吲唑化合物 |
| WO2025222097A1 (en) | 2024-04-19 | 2025-10-23 | Tyra Biosciences, Inc. | Indazole-based protac degraders and their anticancer activity |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2412776C (en) * | 2000-06-16 | 2011-03-15 | Mitsubishi Pharma Corporation | Compositions controlling release ph range and/or speed |
| JP5478262B2 (ja) * | 2007-12-28 | 2014-04-23 | 田辺三菱製薬株式会社 | 抗癌剤 |
| DK2571503T3 (en) * | 2010-05-14 | 2015-04-20 | Dana Farber Cancer Inst Inc | COMPOSITIONS AND THEIR USE IN THE TREATMENT OF NEOPLASIA, INFLAMMATORY DISEASE AND OTHER DISORDERS |
| CA2799403C (en) * | 2010-05-14 | 2020-01-21 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating leukemia |
| DE102011082013A1 (de) * | 2011-09-01 | 2013-03-07 | Bayer Pharma AG | 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine |
| KR20150100613A (ko) * | 2012-09-28 | 2015-09-02 | 온코에틱스 게엠베하 | 티에노트리아졸로디아제핀 화합물을 함유하는 약제학적 제제 |
| US9795612B2 (en) * | 2013-08-01 | 2017-10-24 | Merck Sharp & Dohme Corp. | Pharmaceutical formulation containing thienotriazolodiazepine compounds |
| WO2015078929A1 (en) * | 2013-11-27 | 2015-06-04 | Oncoethix Sa | Method of treating leukemia using pharmaceutical formulation containing thienotriazolodiazepine compounds |
-
2015
- 2015-08-28 KR KR1020177007647A patent/KR20170044172A/ko not_active Withdrawn
- 2015-08-28 EP EP15756648.0A patent/EP3185871A1/en not_active Withdrawn
- 2015-08-28 US US15/507,496 patent/US20170281642A1/en not_active Abandoned
- 2015-08-28 JP JP2017511200A patent/JP2017529332A/ja not_active Withdrawn
- 2015-08-28 CN CN201580046616.5A patent/CN107427524A/zh active Pending
- 2015-08-28 WO PCT/EP2015/069754 patent/WO2016030509A1/en not_active Ceased
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