JP2016523973A - 疾患の処置のためのキナーゼ阻害物質 - Google Patents
疾患の処置のためのキナーゼ阻害物質 Download PDFInfo
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- JP2016523973A JP2016523973A JP2016525463A JP2016525463A JP2016523973A JP 2016523973 A JP2016523973 A JP 2016523973A JP 2016525463 A JP2016525463 A JP 2016525463A JP 2016525463 A JP2016525463 A JP 2016525463A JP 2016523973 A JP2016523973 A JP 2016523973A
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| US61/901,808 | 2013-11-08 | ||
| PCT/US2014/046022 WO2015006492A1 (en) | 2013-07-09 | 2014-07-09 | Kinase inhibitors for the treatment of disease |
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| JP2016523973A true JP2016523973A (ja) | 2016-08-12 |
| JP2016523973A5 JP2016523973A5 (cg-RX-API-DMAC7.html) | 2017-07-27 |
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Cited By (3)
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|---|---|---|---|---|
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| JP2023508376A (ja) * | 2019-12-23 | 2023-03-02 | 北京賽特明強医薬科技有限公司 | シアノ置換ピリジンおよびシアノ置換ピリミジン系化合物、製造方法およびそれらの使用 |
| JP2024522832A (ja) * | 2021-08-02 | 2024-06-21 | 上海和誉生物医薬科技有限公司 | ピリミジン-4,6-ジアミン誘導体およびその製造方法と薬学上の応用 |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| US11241435B2 (en) | 2016-09-16 | 2022-02-08 | The General Hospital Corporation | Uses of salt-inducible kinase (SIK) inhibitors for treating osteoporosis |
| EP3589284A4 (en) | 2017-02-28 | 2020-12-16 | The General Hospital Corporation | USES OF PYRIMIDOPYRIMIDINONES AS SIK INHIBITORS |
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| DK3391907T3 (da) | 2017-04-20 | 2020-03-09 | Iomx Therapeutics Ag | Intracellulær kinase sik3, der er associeret med resistens over for antitumorimmunresponser, og anvendelser deraf |
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| US12162881B2 (en) | 2021-11-09 | 2024-12-10 | Ajax Therapeutics, Inc. | Forms and compositions of inhibitors of JAK2 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006000420A1 (en) * | 2004-06-24 | 2006-01-05 | Novartis Ag | Pyrimidine urea derivatives as kinase inhibitors |
| JP2009520768A (ja) * | 2005-12-21 | 2009-05-28 | ノバルティス アクチエンゲゼルシャフト | Fgf阻害剤であるピリミジニルアリールウレア誘導体 |
| JP2013512956A (ja) * | 2009-12-07 | 2013-04-18 | ノバルティス アーゲー | 3−(2,6−ジクロロ−3,5−ジメトキシ−フェニル)−1−{6−[4−(4−エチル−ピペラジン−1−イル)−フェニルアミノ]−ピリミジン−4−イル}−1−メチル−尿素の結晶形態およびその塩 |
| WO2014007951A2 (en) * | 2012-06-13 | 2014-01-09 | Incyte Corporation | Substituted tricyclic compounds as fgfr inhibitors |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002516327A (ja) * | 1998-05-26 | 2002-06-04 | ワーナー−ランバート・カンパニー | 細胞増殖の阻害剤としての二環式ピリミジンおよび二環式3,4−ジヒドロピリミジン |
| EP1801112A1 (en) | 1998-05-26 | 2007-06-27 | Warner-Lambert Company LLC | Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation |
| WO2001066099A2 (en) * | 2000-03-06 | 2001-09-13 | Astrazeneca Ab | Use of quinazoline derivatives as angiogenesis inhibitors |
| US20030158188A1 (en) | 2002-02-20 | 2003-08-21 | Chih-Hung Lee | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
| US7112676B2 (en) * | 2002-11-04 | 2006-09-26 | Hoffmann-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
| US7504396B2 (en) * | 2003-06-24 | 2009-03-17 | Amgen Inc. | Substituted heterocyclic compounds and methods of use |
| CA2533774A1 (en) * | 2003-07-29 | 2005-02-10 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| DK2439285T3 (da) | 2004-03-31 | 2019-07-29 | Massachusetts Gen Hospital | Fremgangsmåde til at bestemme reaktivitet af cancer på behandlinger målrettet mod epidermal vækstfaktor-receptor |
| US20090023723A1 (en) * | 2005-09-21 | 2009-01-22 | Pharmacopeia Drug Discovery, Inc. | Purinone derivatives for treating neurodegenerative diseases |
| EP2018167A4 (en) * | 2006-05-15 | 2010-07-14 | Irm Llc | COMPOSITIONS AND METHODS AS INHIBITORS OF FGF RECEPTOR KINASES |
| KR101705158B1 (ko) * | 2009-05-05 | 2017-02-09 | 다나-파버 캔서 인스티튜트 인크. | Egfr 억제제 및 질환 치료방법 |
| US20120258940A1 (en) * | 2009-12-18 | 2012-10-11 | Giordano Caponigro | Method for treating haematological cancers |
| KR101301533B1 (ko) * | 2010-02-09 | 2013-09-04 | 한미사이언스 주식회사 | 암세포 성장 억제 효과를 갖는 신규 피리미딘 유도체 |
| CN102816162B (zh) | 2011-06-10 | 2016-04-27 | 中国科学院广州生物医药与健康研究院 | 嘧啶并嘧啶酮类化合物及其药用组合物和应用 |
| WO2013088191A1 (en) * | 2011-12-12 | 2013-06-20 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Antagonist of the fibroblast growth factor receptor 3 (fgfr3) for use in the treatment or the prevention of skeletal disorders linked with abnormal activation of fgfr3 |
| GB201204384D0 (en) * | 2012-03-13 | 2012-04-25 | Univ Dundee | Anti-flammatory agents |
| BR112015000653A2 (pt) * | 2012-07-11 | 2019-11-05 | Blueprint Medicines Corp | compostos inibidores do receptor de fator de crescimento de fibroblasto, sua composição farmacêutica e seus usos |
| US9783504B2 (en) * | 2013-07-09 | 2017-10-10 | Dana-Farber Cancer Institute, Inc. | Kinase inhibitors for the treatment of disease |
-
2014
- 2014-07-09 US US14/903,650 patent/US9783504B2/en active Active
- 2014-07-09 AU AU2014287209A patent/AU2014287209B2/en not_active Ceased
- 2014-07-09 EP EP14822373.8A patent/EP3019491A4/en not_active Withdrawn
- 2014-07-09 CA CA2917667A patent/CA2917667A1/en not_active Abandoned
- 2014-07-09 WO PCT/US2014/046022 patent/WO2015006492A1/en not_active Ceased
- 2014-07-09 JP JP2016525463A patent/JP2016523973A/ja active Pending
-
2017
- 2017-09-06 US US15/696,309 patent/US10316002B2/en not_active Expired - Fee Related
-
2019
- 2019-05-06 US US16/403,793 patent/US10906878B2/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006000420A1 (en) * | 2004-06-24 | 2006-01-05 | Novartis Ag | Pyrimidine urea derivatives as kinase inhibitors |
| JP2009520768A (ja) * | 2005-12-21 | 2009-05-28 | ノバルティス アクチエンゲゼルシャフト | Fgf阻害剤であるピリミジニルアリールウレア誘導体 |
| JP2013512956A (ja) * | 2009-12-07 | 2013-04-18 | ノバルティス アーゲー | 3−(2,6−ジクロロ−3,5−ジメトキシ−フェニル)−1−{6−[4−(4−エチル−ピペラジン−1−イル)−フェニルアミノ]−ピリミジン−4−イル}−1−メチル−尿素の結晶形態およびその塩 |
| WO2014007951A2 (en) * | 2012-06-13 | 2014-01-09 | Incyte Corporation | Substituted tricyclic compounds as fgfr inhibitors |
Non-Patent Citations (1)
| Title |
|---|
| ZHOU, W. ET AL., CHEMISTRY & BIOLOGY, vol. 17, JPN7018001156, 2010, pages 285 - 295, ISSN: 0003908391 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020121994A (ja) * | 2015-02-20 | 2020-08-13 | インサイト・コーポレイションIncyte Corporation | Fgfr阻害剤としての二環式複素環 |
| JP2023508376A (ja) * | 2019-12-23 | 2023-03-02 | 北京賽特明強医薬科技有限公司 | シアノ置換ピリジンおよびシアノ置換ピリミジン系化合物、製造方法およびそれらの使用 |
| JP7491612B2 (ja) | 2019-12-23 | 2024-05-28 | 北京賽特明強医薬科技有限公司 | シアノ置換ピリジンおよびシアノ置換ピリミジン系化合物、製造方法およびそれらの使用 |
| JP2024522832A (ja) * | 2021-08-02 | 2024-06-21 | 上海和誉生物医薬科技有限公司 | ピリミジン-4,6-ジアミン誘導体およびその製造方法と薬学上の応用 |
| JP7765105B2 (ja) | 2021-08-02 | 2025-11-06 | 上海和誉生物医薬科技有限公司 | ピリミジン-4,6-ジアミン誘導体およびその製造方法と薬学上の応用 |
Also Published As
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| US20190256475A1 (en) | 2019-08-22 |
| US10906878B2 (en) | 2021-02-02 |
| WO2015006492A1 (en) | 2015-01-15 |
| US10316002B2 (en) | 2019-06-11 |
| EP3019491A1 (en) | 2016-05-18 |
| US20160176825A1 (en) | 2016-06-23 |
| US9783504B2 (en) | 2017-10-10 |
| AU2014287209B2 (en) | 2019-01-24 |
| AU2014287209A1 (en) | 2016-01-28 |
| US20170369449A1 (en) | 2017-12-28 |
| CA2917667A1 (en) | 2015-01-15 |
| EP3019491A4 (en) | 2016-12-21 |
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