JP2016523849A5 - - Google Patents
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- Publication number
- JP2016523849A5 JP2016523849A5 JP2016518420A JP2016518420A JP2016523849A5 JP 2016523849 A5 JP2016523849 A5 JP 2016523849A5 JP 2016518420 A JP2016518420 A JP 2016518420A JP 2016518420 A JP2016518420 A JP 2016518420A JP 2016523849 A5 JP2016523849 A5 JP 2016523849A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical formulation
- prostate cancer
- composition
- effective amount
- preparation according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 12
- 206010060862 Prostate cancer Diseases 0.000 claims 8
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 8
- 241000196324 Embryophyta Species 0.000 claims 7
- 239000000825 pharmaceutical preparation Substances 0.000 claims 7
- 239000000284 extract Substances 0.000 claims 6
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 5
- 229960003668 docetaxel Drugs 0.000 claims 5
- 235000014113 dietary fatty acids Nutrition 0.000 claims 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 4
- 229930195729 fatty acid Natural products 0.000 claims 4
- 239000000194 fatty acid Substances 0.000 claims 4
- -1 polyoxyethylene glycerin Polymers 0.000 claims 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- 240000008397 Ganoderma lucidum Species 0.000 claims 3
- 235000001637 Ganoderma lucidum Nutrition 0.000 claims 3
- 150000004665 fatty acids Chemical group 0.000 claims 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- 102000007066 Prostate-Specific Antigen Human genes 0.000 claims 2
- 108010072866 Prostate-Specific Antigen Proteins 0.000 claims 2
- 241001072909 Salvia Species 0.000 claims 2
- 235000017276 Salvia Nutrition 0.000 claims 2
- 241000304195 Salvia miltiorrhiza Species 0.000 claims 2
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 claims 2
- 241000915604 Scutellaria barbata Species 0.000 claims 2
- 239000003098 androgen Substances 0.000 claims 2
- 239000003963 antioxidant agent Substances 0.000 claims 2
- 230000003078 antioxidant effect Effects 0.000 claims 2
- 235000006708 antioxidants Nutrition 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003995 emulsifying agent Substances 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 2
- 239000008389 polyethoxylated castor oil Substances 0.000 claims 2
- 208000023958 prostate neoplasm Diseases 0.000 claims 2
- GHBFNMLVSPCDGN-UHFFFAOYSA-N rac-1-monooctanoylglycerol Chemical compound CCCCCCCC(=O)OCC(O)CO GHBFNMLVSPCDGN-UHFFFAOYSA-N 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 1
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 1
- 239000005642 Oleic acid Substances 0.000 claims 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229920002685 Polyoxyl 35CastorOil Polymers 0.000 claims 1
- 239000008565 Scutellaria barbata extract Substances 0.000 claims 1
- 208000009956 adenocarcinoma Diseases 0.000 claims 1
- 230000001476 alcoholic effect Effects 0.000 claims 1
- 229940087168 alpha tocopherol Drugs 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 229920001400 block copolymer Polymers 0.000 claims 1
- LDVVMCZRFWMZSG-UHFFFAOYSA-N captan Chemical compound C1C=CCC2C(=O)N(SC(Cl)(Cl)Cl)C(=O)C21 LDVVMCZRFWMZSG-UHFFFAOYSA-N 0.000 claims 1
- 239000004359 castor oil Substances 0.000 claims 1
- 235000019438 castor oil Nutrition 0.000 claims 1
- 238000011260 co-administration Methods 0.000 claims 1
- GHVNFZFCNZKVNT-UHFFFAOYSA-M decanoate Chemical compound CCCCCCCCCC([O-])=O GHVNFZFCNZKVNT-UHFFFAOYSA-M 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 1
- 229940087068 glyceryl caprylate Drugs 0.000 claims 1
- 239000001087 glyceryl triacetate Substances 0.000 claims 1
- 235000013773 glyceryl triacetate Nutrition 0.000 claims 1
- 150000002334 glycols Chemical class 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 1
- QUANRIQJNFHVEU-UHFFFAOYSA-N oxirane;propane-1,2,3-triol Chemical compound C1CO1.OCC(O)CO QUANRIQJNFHVEU-UHFFFAOYSA-N 0.000 claims 1
- 230000000737 periodic effect Effects 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 239000003549 soybean oil Substances 0.000 claims 1
- 235000012424 soybean oil Nutrition 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 238000011287 therapeutic dose Methods 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 229960000984 tocofersolan Drugs 0.000 claims 1
- 230000001988 toxicity Effects 0.000 claims 1
- 231100000419 toxicity Toxicity 0.000 claims 1
- 229960002622 triacetin Drugs 0.000 claims 1
- 239000002076 α-tocopherol Substances 0.000 claims 1
- 235000004835 α-tocopherol Nutrition 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361830626P | 2013-06-03 | 2013-06-03 | |
| US61/830,626 | 2013-06-03 | ||
| PCT/US2014/040769 WO2014197519A1 (en) | 2013-06-03 | 2014-06-03 | Combination therapy for prostate cancer using botanical compositions and docetaxel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016523849A JP2016523849A (ja) | 2016-08-12 |
| JP2016523849A5 true JP2016523849A5 (enExample) | 2017-07-13 |
Family
ID=52008544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016518420A Pending JP2016523849A (ja) | 2013-06-03 | 2014-06-03 | 植物組成物とドセタキセルを使用する前立腺癌用併用療法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20160143971A1 (enExample) |
| EP (1) | EP3003490B1 (enExample) |
| JP (1) | JP2016523849A (enExample) |
| CN (1) | CN105636647A (enExample) |
| CA (1) | CA2951110A1 (enExample) |
| SG (1) | SG11201510802QA (enExample) |
| WO (1) | WO2014197519A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3630090A4 (en) * | 2017-05-26 | 2021-04-07 | Genyous Biomed International | CANCER POLYTHERAPY USING PLANT COMPOSITIONS AND ENZALUTAMIDE |
| US10835538B2 (en) * | 2018-03-28 | 2020-11-17 | Nymox Corporation | Method of treating benign prostatic hyperlasia with antibiotics |
| CN108836994B (zh) * | 2018-07-25 | 2021-06-18 | 南京林业大学 | 一种人工林树皮皂苷类活性成分的提取方法 |
| AR133093A1 (es) * | 2023-06-30 | 2025-08-27 | Future Biome Corp | Mezclas de polisacáridos de ganoderma sessile, composiciones y métodos relacionados |
| CN117064899B (zh) * | 2023-10-13 | 2024-01-23 | 暨南大学附属第一医院（广州华侨医院） | 灵芝酸a在制备治疗去势抵抗性前列腺癌的药物中的应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6395770B1 (en) * | 1995-10-26 | 2002-05-28 | Baker Norton Pharmaceuticals, Inc. | Method and compositions for administering taxanes orally to human patients |
| US5910308A (en) | 1997-03-19 | 1999-06-08 | Sante International Inc. | Herbal extract composition containing gynostemma pentaphyllum, crataegus pinnatifida and camellia sinensis |
| US6168795B1 (en) | 1998-06-09 | 2001-01-02 | Sant{acute over (e)} International Inc. | Method for anticancer therapy using an herbal extract composition |
| PL1663103T3 (pl) * | 2003-09-08 | 2012-05-31 | Genyous Biomed Int Inc | Kompozycje roślinnych ekstraktów do leczenia nowotworu |
| SG149053A1 (en) * | 2003-09-22 | 2009-01-29 | Genyous Biomed Internat Inc | Hippophae rhamnoides compositions for cancer therapy |
| US20050196409A1 (en) | 2003-09-24 | 2005-09-08 | James Dao | Compositions of botanical extracts for treating malignancy-associated changes |
| US20110117121A1 (en) * | 2006-10-27 | 2011-05-19 | James Dao | Compositions for treatment and inhibition of pain |
| EP2635127B1 (en) * | 2010-11-04 | 2018-10-17 | Genyous Biomed International | Combination therapy for prostate cancer using botanical compositions and bicalutamide |
-
2014
- 2014-06-03 CA CA2951110A patent/CA2951110A1/en not_active Abandoned
- 2014-06-03 SG SG11201510802QA patent/SG11201510802QA/en unknown
- 2014-06-03 WO PCT/US2014/040769 patent/WO2014197519A1/en not_active Ceased
- 2014-06-03 US US14/392,117 patent/US20160143971A1/en not_active Abandoned
- 2014-06-03 EP EP14807920.5A patent/EP3003490B1/en active Active
- 2014-06-03 JP JP2016518420A patent/JP2016523849A/ja active Pending
- 2014-06-03 CN CN201480042054.2A patent/CN105636647A/zh active Pending
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