JP2016528178A5 - - Google Patents

Info

Publication number

JP2016528178A5

JP2016528178A5 JP2016518421A JP2016518421A JP2016528178A5 JP 2016528178 A5 JP2016528178 A5 JP 2016528178A5 JP 2016518421 A JP2016518421 A JP 2016518421A JP 2016518421 A JP2016518421 A JP 2016518421A JP 2016528178 A5 JP2016528178 A5 JP 2016528178A5

Authority

JP

Japan

Prior art keywords

formulation

extract

formulation according

emulsifier

ethyl acetate

Prior art date

2014-06-03

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 238000009472 formulation Methods 0.000 claims 16
• 239000000203 mixture Substances 0.000 claims 16
• 239000000284 extract Substances 0.000 claims 7
• 238000002360 preparation method Methods 0.000 claims 5
• CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 4
• GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 4
• WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 3
• LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 3
• QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 3
• XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical group CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
• ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 3
• 239000005642 Oleic acid Substances 0.000 claims 3
• 239000002246 antineoplastic agent Substances 0.000 claims 3
• 239000003963 antioxidant agent Substances 0.000 claims 3
• 230000003078 antioxidant effect Effects 0.000 claims 3
• 235000006708 antioxidants Nutrition 0.000 claims 3
• 229940127089 cytotoxic agent Drugs 0.000 claims 3
• 239000003085 diluting agent Substances 0.000 claims 3
• 239000002024 ethyl acetate extract Substances 0.000 claims 3
• QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 3
• ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 3
• -1 Avastin® Chemical compound 0.000 claims 2
• GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 claims 2
• 240000008397 Ganoderma lucidum Species 0.000 claims 2
• 235000001637 Ganoderma lucidum Nutrition 0.000 claims 2
• 229920002685 Polyoxyl 35CastorOil Polymers 0.000 claims 2
• 241000304195 Salvia miltiorrhiza Species 0.000 claims 2
• 235000011135 Salvia miltiorrhiza Nutrition 0.000 claims 2
• 241000915604 Scutellaria barbata Species 0.000 claims 2
• 230000001476 alcoholic effect Effects 0.000 claims 2
• 229940087168 alpha tocopherol Drugs 0.000 claims 2
• 235000010323 ascorbic acid Nutrition 0.000 claims 2
• 229960005070 ascorbic acid Drugs 0.000 claims 2
• 239000011668 ascorbic acid Substances 0.000 claims 2
• 239000003995 emulsifying agent Substances 0.000 claims 2
• 150000002148 esters Chemical group 0.000 claims 2
• SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 2
• 231100000682 maximum tolerated dose Toxicity 0.000 claims 2
• 239000003960 organic solvent Substances 0.000 claims 2
• QUANRIQJNFHVEU-UHFFFAOYSA-N oxirane;propane-1,2,3-triol Chemical compound C1CO1.OCC(O)CO QUANRIQJNFHVEU-UHFFFAOYSA-N 0.000 claims 2
• BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 2
• 239000008389 polyethoxylated castor oil Substances 0.000 claims 2
• 235000012424 soybean oil Nutrition 0.000 claims 2
• 239000003549 soybean oil Substances 0.000 claims 2
• 229960000984 tocofersolan Drugs 0.000 claims 2
• 235000004835 α-tocopherol Nutrition 0.000 claims 2
• 239000002076 α-tocopherol Substances 0.000 claims 2
• AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 claims 1
• GAGWJHPBXLXJQN-UHFFFAOYSA-N Capecitabine Natural products C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1C1C(O)C(O)C(C)O1 GAGWJHPBXLXJQN-UHFFFAOYSA-N 0.000 claims 1
• CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 1
• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 1
• HTIJFSOGRVMCQR-UHFFFAOYSA-N Epirubicin Natural products COc1cccc2C(=O)c3c(O)c4CC(O)(CC(OC5CC(N)C(=O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)CO HTIJFSOGRVMCQR-UHFFFAOYSA-N 0.000 claims 1
• GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 1
• 239000002136 L01XE07 - Lapatinib Substances 0.000 claims 1
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
• 229930012538 Paclitaxel Natural products 0.000 claims 1
• 229940079156 Proteasome inhibitor Drugs 0.000 claims 1
• 240000004534 Scutellaria baicalensis Species 0.000 claims 1
• 235000017089 Scutellaria baicalensis Nutrition 0.000 claims 1
• 229940122803 Vinca alkaloid Drugs 0.000 claims 1
• 229940110282 alimta Drugs 0.000 claims 1
• 239000002168 alkylating agent Substances 0.000 claims 1
• 229940100198 alkylating agent Drugs 0.000 claims 1
• 239000003817 anthracycline antibiotic agent Substances 0.000 claims 1
• 229940045799 anthracyclines and related substance Drugs 0.000 claims 1
• 230000000340 anti-metabolite Effects 0.000 claims 1
• 229940100197 antimetabolite Drugs 0.000 claims 1
• 239000002256 antimetabolite Substances 0.000 claims 1
• 229940120638 avastin Drugs 0.000 claims 1
• GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 claims 1
• 229960004117 capecitabine Drugs 0.000 claims 1
• 229960004562 carboplatin Drugs 0.000 claims 1
• 190000008236 carboplatin Chemical compound 0.000 claims 1
• DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 1
• 229960004316 cisplatin Drugs 0.000 claims 1
• 229960004397 cyclophosphamide Drugs 0.000 claims 1
• 239000003534 dna topoisomerase inhibitor Substances 0.000 claims 1
• 229960003668 docetaxel Drugs 0.000 claims 1
• 229940115080 doxil Drugs 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 230000001804 emulsifying effect Effects 0.000 claims 1
• 229960001904 epirubicin Drugs 0.000 claims 1
• 229960002949 fluorouracil Drugs 0.000 claims 1
• 229960005277 gemcitabine Drugs 0.000 claims 1
• 229940020967 gemzar Drugs 0.000 claims 1
• 229940022353 herceptin Drugs 0.000 claims 1
• BCFGMOOMADDAQU-UHFFFAOYSA-N lapatinib Chemical compound O1C(CNCCS(=O)(=O)C)=CC=C1C1=CC=C(N=CN=C2NC=3C=C(Cl)C(OCC=4C=C(F)C=CC=4)=CC=3)C2=C1 BCFGMOOMADDAQU-UHFFFAOYSA-N 0.000 claims 1
• 229960004891 lapatinib Drugs 0.000 claims 1
• 239000003120 macrolide antibiotic agent Substances 0.000 claims 1
• 229940041033 macrolides Drugs 0.000 claims 1
• 229940086322 navelbine Drugs 0.000 claims 1
• 239000002777 nucleoside Substances 0.000 claims 1
• 150000003833 nucleoside derivatives Chemical class 0.000 claims 1
• 229960001592 paclitaxel Drugs 0.000 claims 1
• WBXPDJSOTKVWSJ-ZDUSSCGKSA-L pemetrexed(2-) Chemical compound C=1NC=2NC(N)=NC(=O)C=2C=1CCC1=CC=C(C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)C=C1 WBXPDJSOTKVWSJ-ZDUSSCGKSA-L 0.000 claims 1
• 229910052697 platinum Inorganic materials 0.000 claims 1
• 239000003207 proteasome inhibitor Substances 0.000 claims 1
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
• 229940044693 topoisomerase inhibitor Drugs 0.000 claims 1
• 239000005483 tyrosine kinase inhibitor Substances 0.000 claims 1
• 229940121358 tyrosine kinase inhibitor Drugs 0.000 claims 1
• 229940099039 velcade Drugs 0.000 claims 1
• GBABOYUKABKIAF-IELIFDKJSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-IELIFDKJSA-N 0.000 claims 1
• 229960002066 vinorelbine Drugs 0.000 claims 1
• CILBMBUYJCWATM-PYGJLNRPSA-N vinorelbine ditartrate Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC CILBMBUYJCWATM-PYGJLNRPSA-N 0.000 claims 1
• 229940053867 xeloda Drugs 0.000 claims 1