JP2016523821A5 - - Google Patents
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- Publication number
- JP2016523821A5 JP2016523821A5 JP2016509477A JP2016509477A JP2016523821A5 JP 2016523821 A5 JP2016523821 A5 JP 2016523821A5 JP 2016509477 A JP2016509477 A JP 2016509477A JP 2016509477 A JP2016509477 A JP 2016509477A JP 2016523821 A5 JP2016523821 A5 JP 2016523821A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- recombinant fusion
- recombinant
- seq
- brassica
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims description 63
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims description 63
- 241000223960 Plasmodium falciparum Species 0.000 claims description 30
- 244000045947 parasite Species 0.000 claims description 25
- 241000224482 Apicomplexa Species 0.000 claims description 23
- 239000012634 fragment Substances 0.000 claims description 22
- 102000037865 fusion proteins Human genes 0.000 claims description 22
- 108020001507 fusion proteins Proteins 0.000 claims description 22
- 229960005486 vaccine Drugs 0.000 claims description 20
- 102000039446 nucleic acids Human genes 0.000 claims description 18
- 108020004707 nucleic acids Proteins 0.000 claims description 18
- 150000007523 nucleic acids Chemical class 0.000 claims description 18
- 108010052285 Membrane Proteins Proteins 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 13
- 102400000368 Surface protein Human genes 0.000 claims description 12
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims description 11
- 241000196324 Embryophyta Species 0.000 claims description 10
- 229920001184 polypeptide Polymers 0.000 claims description 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 10
- 241000219198 Brassica Species 0.000 claims description 9
- 235000011331 Brassica Nutrition 0.000 claims description 9
- 241000208125 Nicotiana Species 0.000 claims description 9
- 125000000539 amino acid group Chemical group 0.000 claims description 9
- 238000007792 addition Methods 0.000 claims description 8
- 239000008280 blood Substances 0.000 claims description 8
- 210000004369 blood Anatomy 0.000 claims description 8
- 238000012217 deletion Methods 0.000 claims description 8
- 230000037430 deletion Effects 0.000 claims description 8
- 238000003780 insertion Methods 0.000 claims description 8
- 230000037431 insertion Effects 0.000 claims description 8
- 238000010188 recombinant method Methods 0.000 claims description 8
- 238000006467 substitution reaction Methods 0.000 claims description 8
- 238000010189 synthetic method Methods 0.000 claims description 8
- 241000207746 Nicotiana benthamiana Species 0.000 claims description 6
- 244000061176 Nicotiana tabacum Species 0.000 claims description 5
- 241001505293 Plasmodium ovale Species 0.000 claims description 5
- 206010035502 Plasmodium ovale infection Diseases 0.000 claims description 5
- 230000001568 sexual effect Effects 0.000 claims description 5
- 241000227653 Lycopersicon Species 0.000 claims description 4
- 241001465754 Metazoa Species 0.000 claims description 4
- 240000009188 Phyllostachys vivax Species 0.000 claims description 4
- 241000223821 Plasmodium malariae Species 0.000 claims description 4
- 206010035501 Plasmodium malariae infection Diseases 0.000 claims description 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 101100024442 Anaplasma marginale msp4 gene Proteins 0.000 claims description 3
- 101710082261 Competence-stimulating peptide Proteins 0.000 claims description 3
- 101710138858 DnaJ homolog subfamily C member 5 Proteins 0.000 claims description 3
- 101150099000 EXPA1 gene Proteins 0.000 claims description 3
- 101100373498 Enterobacteria phage T4 y06L gene Proteins 0.000 claims description 3
- 101100373502 Enterobacteria phage T4 y06P gene Proteins 0.000 claims description 3
- 101100373503 Enterobacteria phage T4 y06Q gene Proteins 0.000 claims description 3
- 102100029095 Exportin-1 Human genes 0.000 claims description 3
- 102000018697 Membrane Proteins Human genes 0.000 claims description 3
- 108010057081 Merozoite Surface Protein 1 Proteins 0.000 claims description 3
- HCUVEUVIUAJXRB-UHFFFAOYSA-N OC1=C(C=C(CNC(CCCC=2SC=CC=2)=O)C=C1)OC Chemical compound OC1=C(C=C(CNC(CCCC=2SC=CC=2)=O)C=C1)OC HCUVEUVIUAJXRB-UHFFFAOYSA-N 0.000 claims description 3
- 240000007377 Petunia x hybrida Species 0.000 claims description 3
- 101000983333 Plasmodium falciparum (isolate NF54) 25 kDa ookinete surface antigen Proteins 0.000 claims description 3
- 235000019057 Raphanus caudatus Nutrition 0.000 claims description 3
- 244000088415 Raphanus sativus Species 0.000 claims description 3
- 235000011380 Raphanus sativus Nutrition 0.000 claims description 3
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 claims description 3
- 101100494770 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) CAT8 gene Proteins 0.000 claims description 3
- 101100119348 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) EXP1 gene Proteins 0.000 claims description 3
- 101100269618 Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) aliA gene Proteins 0.000 claims description 3
- 238000004113 cell culture Methods 0.000 claims description 3
- 108700002148 exportin 1 Proteins 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 241000208306 Apium Species 0.000 claims description 2
- 241000219194 Arabidopsis Species 0.000 claims description 2
- 244000257790 Brassica carinata Species 0.000 claims description 2
- 235000005156 Brassica carinata Nutrition 0.000 claims description 2
- 244000178993 Brassica juncea Species 0.000 claims description 2
- 235000011332 Brassica juncea Nutrition 0.000 claims description 2
- 235000014700 Brassica juncea var napiformis Nutrition 0.000 claims description 2
- 240000002791 Brassica napus Species 0.000 claims description 2
- 235000011293 Brassica napus Nutrition 0.000 claims description 2
- 244000180419 Brassica nigra Species 0.000 claims description 2
- 235000011291 Brassica nigra Nutrition 0.000 claims description 2
- 241000208175 Daucus Species 0.000 claims description 2
- 244000000626 Daucus carota Species 0.000 claims description 2
- 235000002767 Daucus carota Nutrition 0.000 claims description 2
- 108050002150 EGF-like domains Proteins 0.000 claims description 2
- 102000012545 EGF-like domains Human genes 0.000 claims description 2
- 241000208822 Lactuca Species 0.000 claims description 2
- 235000002262 Lycopersicon Nutrition 0.000 claims description 2
- 235000007688 Lycopersicon esculentum Nutrition 0.000 claims description 2
- 241000220261 Sinapis Species 0.000 claims description 2
- 239000012228 culture supernatant Substances 0.000 claims description 2
- 235000018417 cysteine Nutrition 0.000 claims description 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 2
- 241000894007 species Species 0.000 claims description 2
- 241000224016 Plasmodium Species 0.000 claims 2
- 235000002566 Capsicum Nutrition 0.000 claims 1
- 240000008574 Capsicum frutescens Species 0.000 claims 1
- 244000070406 Malus silvestris Species 0.000 claims 1
- 244000203593 Piper nigrum Species 0.000 claims 1
- 235000008184 Piper nigrum Nutrition 0.000 claims 1
- 241001040659 Plasmodium (Plasmodium) Species 0.000 claims 1
- 241000223801 Plasmodium knowlesi Species 0.000 claims 1
- 235000005733 Raphanus sativus var niger Nutrition 0.000 claims 1
- 240000001970 Raphanus sativus var. sativus Species 0.000 claims 1
- 241000207763 Solanum Species 0.000 claims 1
- 235000002634 Solanum Nutrition 0.000 claims 1
- 235000013614 black pepper Nutrition 0.000 claims 1
- 239000001390 capsicum minimum Substances 0.000 claims 1
- 201000004792 malaria Diseases 0.000 claims 1
- 239000001931 piper nigrum l. white Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 description 20
- 239000000725 suspension Substances 0.000 description 4
- 241000700605 Viruses Species 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 241000220259 Raphanus Species 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 108020001580 protein domains Proteins 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 102000014914 Carrier Proteins Human genes 0.000 description 1
- 108010078791 Carrier Proteins Proteins 0.000 description 1
- 241000235058 Komagataella pastoris Species 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 244000061458 Solanum melongena Species 0.000 description 1
- 235000002597 Solanum melongena Nutrition 0.000 description 1
- 238000010306 acid treatment Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361815486P | 2013-04-24 | 2013-04-24 | |
| EP20130165161 EP2796147A1 (en) | 2013-04-24 | 2013-04-24 | Novel vaccines against apicomplexan pathoges |
| US61/815,486 | 2013-04-24 | ||
| EP13165161.4 | 2013-04-24 | ||
| PCT/EP2014/058409 WO2014174054A1 (en) | 2013-04-24 | 2014-04-24 | Novel vaccines against apicomplexan pathogens |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016523821A JP2016523821A (ja) | 2016-08-12 |
| JP2016523821A5 true JP2016523821A5 (enExample) | 2017-06-08 |
| JP6461100B2 JP6461100B2 (ja) | 2019-01-30 |
Family
ID=48143209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016509477A Expired - Fee Related JP6461100B2 (ja) | 2013-04-24 | 2014-04-24 | アピコンプレクサ病原体に対する新規ワクチン |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10131697B2 (enExample) |
| EP (2) | EP2796147A1 (enExample) |
| JP (1) | JP6461100B2 (enExample) |
| CA (1) | CA2910322A1 (enExample) |
| WO (1) | WO2014174054A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3081575A1 (en) | 2015-04-12 | 2016-10-19 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Anti-plasmodium parasite antibodies |
| JP2019502749A (ja) * | 2015-11-10 | 2019-01-31 | フラウンホーファーゲゼルシャフト ツール フォルデルング デル アンゲヴァンテン フォルシユング エー．フアー． | イムノアセンブリン（ｉａ）タンパク質複合体 |
| WO2017100598A1 (en) * | 2015-12-10 | 2017-06-15 | Immport Therapeutics, Inc. | Babesia biomarkers for diagnostic and screening in vitro diagnostic test |
| WO2018085444A1 (en) * | 2016-11-01 | 2018-05-11 | Washington University | COMPOSITIONS COMPRISING CelTOS IMMUNOGENS AND ANTIBODIES AND METHOD OF USE THEREOF |
| US11273212B2 (en) | 2016-11-11 | 2022-03-15 | Sumitomo Dainippon Pharma Co., Ltd. | Malaria vaccine |
| US20180348218A1 (en) * | 2017-06-05 | 2018-12-06 | Tokitae Llc | Serology assay for recent malaria infection |
| EP3946441A1 (en) | 2019-04-04 | 2022-02-09 | Statens Serum Institut | Multivalent malaria transmission-blocking vaccines |
| WO2022045173A1 (ja) | 2020-08-26 | 2022-03-03 | 国立大学法人愛媛大学 | 抗マラリア原虫抗体 |
| WO2024092112A2 (en) * | 2022-10-27 | 2024-05-02 | University Of Maryland, Baltimore | Method for identifying antigenic epitopes in plasmodium falciparum and uses thereof |
| GB202301244D0 (en) * | 2023-01-27 | 2023-03-15 | Univ Oxford Innovation Ltd | Vaccine |
| WO2025100417A1 (ja) * | 2023-11-06 | 2025-05-15 | 株式会社ダイセル | Ａａｖのフルカプシドに対するアフィニティポリペプチド |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2322552C2 (de) | 1972-11-06 | 1986-08-28 | Pharmacia AB, Uppsala | Verfahren zum Abtrennen von Protein A aus Staphylococcus aureus aus einer Flüssigkeit |
| US4599231A (en) | 1984-03-09 | 1986-07-08 | Scripps Clinic And Research Foundation | Synthetic hepatitis B virus vaccine including both T cell and B cell determinants |
| US4599230A (en) | 1984-03-09 | 1986-07-08 | Scripps Clinic And Research Foundation | Synthetic hepatitis B virus vaccine including both T cell and B cell determinants |
| US4608251A (en) | 1984-11-09 | 1986-08-26 | Pitman-Moore, Inc. | LHRH analogues useful in stimulating anti-LHRH antibodies and vaccines containing such analogues |
| US4601903A (en) | 1985-05-01 | 1986-07-22 | The United States Of America As Represented By The Department Of Health And Human Services | Vaccine against Neisseria meningitidis Group B serotype 2 invasive disease |
| WO2007027860A2 (en) * | 2005-08-31 | 2007-03-08 | Genvec, Inc. | Adenoviral vector-based malaria vaccines |
| US7931908B2 (en) * | 2007-02-23 | 2011-04-26 | Philadelphia Health Education Corporation | Chimeric MSP-based malaria vaccine |
| EP2352751A2 (en) | 2008-09-28 | 2011-08-10 | Fraunhofer USA, Inc. | Plasmodium vaccines, antigens, compositions and methods |
| MX355501B (es) * | 2010-09-27 | 2018-04-20 | Inovio Pharmaceuticals Inc Star | Estructuras de consenso de antigenos y vacunas elaboradas a partir de estas y metodos para utilizarlas en el tratamiento de la malaria. |
-
2013
- 2013-04-24 EP EP20130165161 patent/EP2796147A1/en not_active Withdrawn
-
2014
- 2014-04-24 CA CA2910322A patent/CA2910322A1/en not_active Abandoned
- 2014-04-24 US US14/786,509 patent/US10131697B2/en not_active Expired - Fee Related
- 2014-04-24 WO PCT/EP2014/058409 patent/WO2014174054A1/en not_active Ceased
- 2014-04-24 EP EP14719741.2A patent/EP2988776B1/en not_active Not-in-force
- 2014-04-24 JP JP2016509477A patent/JP6461100B2/ja not_active Expired - Fee Related
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