JP2016522792A5 - - Google Patents

Info

Publication number

JP2016522792A5

JP2016522792A5 JP2016502413A JP2016502413A JP2016522792A5 JP 2016522792 A5 JP2016522792 A5 JP 2016522792A5 JP 2016502413 A JP2016502413 A JP 2016502413A JP 2016502413 A JP2016502413 A JP 2016502413A JP 2016522792 A5 JP2016522792 A5 JP 2016522792A5

Authority

JP

Japan

Prior art keywords

delivery system

drug delivery

transdermal drug

group

sucrose

Prior art date

2014-03-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 238000013271 transdermal drug delivery Methods 0.000 claims 16
• -1 polyoxyethylene Polymers 0.000 claims 11
• 239000010410 layer Substances 0.000 claims 6
• 239000004215 Carbon black (E152) Substances 0.000 claims 5
• 229940079593 drug Drugs 0.000 claims 5
• 239000003814 drug Substances 0.000 claims 5
• 239000011159 matrix material Substances 0.000 claims 4
• 229920000642 polymer Polymers 0.000 claims 4
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
• 239000002202 Polyethylene glycol Substances 0.000 claims 3
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 3
• 229930006000 Sucrose Natural products 0.000 claims 3
• 238000010521 absorption reaction Methods 0.000 claims 3
• 239000003623 enhancer Substances 0.000 claims 3
• 229940049964 oleate Drugs 0.000 claims 3
• 229920001223 polyethylene glycol Polymers 0.000 claims 3
• 239000005720 sucrose Substances 0.000 claims 3
• ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 claims 2
• 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 2
• XSVMFMHYUFZWBK-NSHDSACASA-N Rivastigmine Chemical compound CCN(C)C(=O)OC1=CC=CC([C@H](C)N(C)C)=C1 XSVMFMHYUFZWBK-NSHDSACASA-N 0.000 claims 2
• 150000005215 alkyl ethers Chemical class 0.000 claims 2
• LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 claims 2
• 150000002148 esters Chemical class 0.000 claims 2
• 229930195733 hydrocarbon Natural products 0.000 claims 2
• XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 claims 2
• 229960003511 macrogol Drugs 0.000 claims 2
• ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 2
• 229940055577 oleyl alcohol Drugs 0.000 claims 2
• XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 claims 2
• 229940017686 palm kernel glycerides Drugs 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 229920000259 polyoxyethylene lauryl ether Polymers 0.000 claims 2
• 229960004136 rivastigmine Drugs 0.000 claims 2
• 150000003839 salts Chemical class 0.000 claims 2
• 239000004094 surface-active agent Substances 0.000 claims 2
• 150000003505 terpenes Chemical group 0.000 claims 2
• 235000007586 terpenes Nutrition 0.000 claims 2
• ZFFMLCVRJBZUDZ-UHFFFAOYSA-N 2,3-dimethylbutane Chemical group CC(C)C(C)C ZFFMLCVRJBZUDZ-UHFFFAOYSA-N 0.000 claims 1
• GLCFQKXOQDQJFZ-UHFFFAOYSA-N 2-ethylhexyl 12-hydroxyoctadecanoate Chemical compound CCCCCCC(O)CCCCCCCCCCC(=O)OCC(CC)CCCC GLCFQKXOQDQJFZ-UHFFFAOYSA-N 0.000 claims 1
• HBJWAZIHHPYWAJ-UHFFFAOYSA-N 4-(2,2-diethoxyethoxy)-4-oxobutanoic acid Chemical class CCOC(OCC)COC(=O)CCC(O)=O HBJWAZIHHPYWAJ-UHFFFAOYSA-N 0.000 claims 1
• HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 claims 1
• HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical group O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims 1
• 235000011437 Amygdalus communis Nutrition 0.000 claims 1
• CMBYOWLFQAFZCP-UHFFFAOYSA-N Hexyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCCCCC CMBYOWLFQAFZCP-UHFFFAOYSA-N 0.000 claims 1
• 241000220304 Prunus dulcis Species 0.000 claims 1
• NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 claims 1
• GCSPRLPXTPMSTL-IBDNADADSA-N [(2s,3r,4s,5s,6r)-2-[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)O[C@@]1([C@]2(CO)[C@H]([C@H](O)[C@@H](CO)O2)O)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O GCSPRLPXTPMSTL-IBDNADADSA-N 0.000 claims 1
• ZPVGIKNDGJGLCO-VGAMQAOUSA-N [(2s,3r,4s,5s,6r)-2-[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)O[C@@]1([C@]2(CO)[C@H]([C@H](O)[C@@H](CO)O2)O)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O ZPVGIKNDGJGLCO-VGAMQAOUSA-N 0.000 claims 1
• SZYSLWCAWVWFLT-UTGHZIEOSA-N [(2s,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)-2-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-2-yl]methyl octadecanoate Chemical group O([C@@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@]1(COC(=O)CCCCCCCCCCCCCCCCC)O[C@H](CO)[C@@H](O)[C@@H]1O SZYSLWCAWVWFLT-UTGHZIEOSA-N 0.000 claims 1
• 230000002745 absorbent Effects 0.000 claims 1
• 239000002250 absorbent Substances 0.000 claims 1
• NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
• 239000000853 adhesive Substances 0.000 claims 1
• 230000001070 adhesive effect Effects 0.000 claims 1
• 239000012790 adhesive layer Substances 0.000 claims 1
• 125000005250 alkyl acrylate group Chemical group 0.000 claims 1
• 235000020224 almond Nutrition 0.000 claims 1
• 229940116224 behenate Drugs 0.000 claims 1
• UKMSUNONTOPOIO-UHFFFAOYSA-M behenate Chemical compound CCCCCCCCCCCCCCCCCCCCCC([O-])=O UKMSUNONTOPOIO-UHFFFAOYSA-M 0.000 claims 1
• XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 claims 1
• 229940031578 diisopropyl adipate Drugs 0.000 claims 1
• 238000012377 drug delivery Methods 0.000 claims 1
• 150000002191 fatty alcohols Chemical class 0.000 claims 1
• 230000009477 glass transition Effects 0.000 claims 1
• 125000005456 glyceride group Chemical group 0.000 claims 1
• 229940100463 hexyl laurate Drugs 0.000 claims 1
• 150000002430 hydrocarbons Chemical class 0.000 claims 1
• XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 claims 1
• 235000001510 limonene Nutrition 0.000 claims 1
• 229940087305 limonene Drugs 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 239000000178 monomer Substances 0.000 claims 1
• BARWIPMJPCRCTP-UHFFFAOYSA-N oleic acid oleyl ester Natural products CCCCCCCCC=CCCCCCCCCOC(=O)CCCCCCCC=CCCCCCCCC BARWIPMJPCRCTP-UHFFFAOYSA-N 0.000 claims 1
• BARWIPMJPCRCTP-CLFAGFIQSA-N oleyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC BARWIPMJPCRCTP-CLFAGFIQSA-N 0.000 claims 1
• 229920000058 polyacrylate Polymers 0.000 claims 1
• 229950008882 polysorbate Drugs 0.000 claims 1
• 229920000136 polysorbate Polymers 0.000 claims 1
• 229950004959 sorbitan oleate Drugs 0.000 claims 1
• 239000012745 toughening agent Substances 0.000 claims 1