JP2016522255A5 - - Google Patents
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- JP2016522255A5 JP2016522255A5 JP2016521484A JP2016521484A JP2016522255A5 JP 2016522255 A5 JP2016522255 A5 JP 2016522255A5 JP 2016521484 A JP2016521484 A JP 2016521484A JP 2016521484 A JP2016521484 A JP 2016521484A JP 2016522255 A5 JP2016522255 A5 JP 2016522255A5
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- plant
- group
- plant extract
- khk
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 claims 12
- 239000000419 plant extract Substances 0.000 claims 10
- 239000003795 chemical substances by application Substances 0.000 claims 7
- 241000196324 Embryophyta Species 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 3
- UZXMLGUMBQQVME-UHFFFAOYSA-N 4-methoxy-9-(3-methylbut-2-en-1-yl)-7H-furo[3,2-g]chromen-7-one Chemical compound O1C(=O)C=CC2=C1C(CC=C(C)C)=C1OC=CC1=C2OC UZXMLGUMBQQVME-UHFFFAOYSA-N 0.000 claims 2
- 241000219310 Beta vulgaris subsp. vulgaris Species 0.000 claims 2
- DQFBYFPFKXHELB-UHFFFAOYSA-N Chalcone Natural products C=1C=CC=CC=1C(=O)C=CC1=CC=CC=C1 DQFBYFPFKXHELB-UHFFFAOYSA-N 0.000 claims 2
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims 2
- 229930091371 Fructose Natural products 0.000 claims 2
- 239000005715 Fructose Substances 0.000 claims 2
- 240000006053 Garcinia mangostana Species 0.000 claims 2
- 235000017048 Garcinia mangostana Nutrition 0.000 claims 2
- 240000002045 Guettarda speciosa Species 0.000 claims 2
- 235000001287 Guettarda speciosa Nutrition 0.000 claims 2
- 241000237502 Ostreidae Species 0.000 claims 2
- 241000207929 Scutellaria Species 0.000 claims 2
- 235000021536 Sugar beet Nutrition 0.000 claims 2
- 235000005513 chalcones Nutrition 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- VEZXFTKZUMARDU-UHFFFAOYSA-N gamma-mangostin Chemical compound OC1=C(O)C(CC=C(C)C)=C2C(=O)C3=C(O)C(CC=C(C)C)=C(O)C=C3OC2=C1 VEZXFTKZUMARDU-UHFFFAOYSA-N 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- LKOJGSWUMISDOF-UHFFFAOYSA-N oroxylin A Chemical compound C=1C(=O)C2=C(O)C(OC)=C(O)C=C2OC=1C1=CC=CC=C1 LKOJGSWUMISDOF-UHFFFAOYSA-N 0.000 claims 2
- 235000020636 oyster Nutrition 0.000 claims 2
- VGEREEWJJVICBM-UHFFFAOYSA-N phloretin Chemical compound C1=CC(O)=CC=C1CCC(=O)C1=C(O)C=C(O)C=C1O VGEREEWJJVICBM-UHFFFAOYSA-N 0.000 claims 2
- DQFBYFPFKXHELB-VAWYXSNFSA-N trans-chalcone Chemical compound C=1C=CC=CC=1C(=O)\C=C\C1=CC=CC=C1 DQFBYFPFKXHELB-VAWYXSNFSA-N 0.000 claims 2
- ZWTDXYUDJYDHJR-UHFFFAOYSA-N (E)-1-(2,4-dihydroxyphenyl)-3-(2,4-dihydroxyphenyl)-2-propen-1-one Natural products OC1=CC(O)=CC=C1C=CC(=O)C1=CC=C(O)C=C1O ZWTDXYUDJYDHJR-UHFFFAOYSA-N 0.000 claims 1
- BTZSKUJZUQOZIL-UHFFFAOYSA-N 3-(3-methylbut-2-enyl)chromen-2-one Chemical compound C1=CC=C2OC(=O)C(CC=C(C)C)=CC2=C1 BTZSKUJZUQOZIL-UHFFFAOYSA-N 0.000 claims 1
- NTDLXWMIWOECHG-UHFFFAOYSA-N 7-labden-3beta,15-diol Natural products O1CC(O)(CO)C(O)C1OC1C(O)C(O)C(CO)OC1OC(C=1)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(O)C=C1 NTDLXWMIWOECHG-UHFFFAOYSA-N 0.000 claims 1
- 244000144730 Amygdalus persica Species 0.000 claims 1
- 241000746375 Andrographis Species 0.000 claims 1
- JBFOLLJCGUCDQP-ZFORQUDYSA-N Apigenin 7-glucuronide Chemical compound O1[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC1=CC(O)=C2C(=O)C=C(C=3C=CC(O)=CC=3)OC2=C1 JBFOLLJCGUCDQP-ZFORQUDYSA-N 0.000 claims 1
- 241000254173 Coleoptera Species 0.000 claims 1
- 206010012335 Dependence Diseases 0.000 claims 1
- 206010018429 Glucose tolerance impaired Diseases 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- 102100023418 Ketohexokinase Human genes 0.000 claims 1
- 108010062852 Ketohexokinase Proteins 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 240000000249 Morus alba Species 0.000 claims 1
- 235000008708 Morus alba Nutrition 0.000 claims 1
- 235000009134 Myrica cerifera Nutrition 0.000 claims 1
- YQHMWTPYORBCMF-UHFFFAOYSA-N Naringenin chalcone Natural products C1=CC(O)=CC=C1C=CC(=O)C1=C(O)C=C(O)C=C1O YQHMWTPYORBCMF-UHFFFAOYSA-N 0.000 claims 1
- 241000209490 Nymphaea Species 0.000 claims 1
- 235000016791 Nymphaea odorata subsp odorata Nutrition 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 240000009164 Petroselinum crispum Species 0.000 claims 1
- 235000006040 Prunus persica var persica Nutrition 0.000 claims 1
- 241000737257 Pteris <genus> Species 0.000 claims 1
- 244000061457 Solanum nigrum Species 0.000 claims 1
- 241000499883 Solaria <angiosperm> Species 0.000 claims 1
- BJBKXYIIWYIZCX-UHFFFAOYSA-N Trigraecum Natural products C1=C(O)C(OC)=CC(C(C=2)=O)=C1OC=2C1=CC=CC=C1 BJBKXYIIWYIZCX-UHFFFAOYSA-N 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- GTDSSCNJWWPJHR-UHFFFAOYSA-N apigenin 7-O-beta-D-glucuronide Natural products OC1C(Oc2ccc3C(=O)C=C(Oc3c2O)c4ccc(O)cc4)OC(C(O)C1O)C(=O)O GTDSSCNJWWPJHR-UHFFFAOYSA-N 0.000 claims 1
- JBFOLLJCGUCDQP-UNJWAJPSSA-N apigenin-7-O-alpha-D-glucuronide Natural products O[C@H]1[C@@H](Oc2cc(O)c3c(c2)oc(cc3=O)-c2ccc(O)cc2)O[C@@H]([C@@H](O)[C@@H]1O)C(O)=O JBFOLLJCGUCDQP-UNJWAJPSSA-N 0.000 claims 1
- NTDLXWMIWOECHG-YRCFQSNFSA-N apiin Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O)[C@H]1O[C@H]1[C@@H]([C@@](O)(CO)CO1)O)O)CO)C(C=1)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(O)C=C1 NTDLXWMIWOECHG-YRCFQSNFSA-N 0.000 claims 1
- NTDLXWMIWOECHG-WJAPLXOZSA-N apiin Natural products O([C@@H]1[C@@H](O)[C@H](O)[C@H](CO)O[C@H]1Oc1cc(O)c2C(=O)C=C(c3ccc(O)cc3)Oc2c1)[C@H]1[C@@H](O)[C@@](O)(CO)CO1 NTDLXWMIWOECHG-WJAPLXOZSA-N 0.000 claims 1
- 239000007894 caplet Substances 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 235000014633 carbohydrates Nutrition 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 239000008298 dragée Substances 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- ACRGTLGOYYTGNX-UHFFFAOYSA-N gamma-mangostin Natural products OC1=C(O)C=C2C(=O)C3=C(O)C(CC=C(C)C)=C(O)C=C3OC2=C1 ACRGTLGOYYTGNX-UHFFFAOYSA-N 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 235000015110 jellies Nutrition 0.000 claims 1
- 239000008274 jelly Substances 0.000 claims 1
- -1 kratoxyarborenone E Chemical compound 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- MBRLOUHOWLUMFF-UHFFFAOYSA-N osthole Chemical compound C1=CC(=O)OC2=C(CC=C(C)C)C(OC)=CC=C21 MBRLOUHOWLUMFF-UHFFFAOYSA-N 0.000 claims 1
- 235000011197 perejil Nutrition 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- 229930001119 polyketide Natural products 0.000 claims 1
- 150000003881 polyketide derivatives Chemical class 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 125000001844 prenyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- JBFOLLJCGUCDQP-UHFFFAOYSA-N scutellarin A Natural products O1C(C(O)=O)C(O)C(O)C(O)C1OC1=CC(O)=C2C(=O)C=C(C=3C=CC(O)=CC=3)OC2=C1 JBFOLLJCGUCDQP-UHFFFAOYSA-N 0.000 claims 1
- 239000002002 slurry Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 239000006188 syrup Substances 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361836843P | 2013-06-19 | 2013-06-19 | |
| US61/836,843 | 2013-06-19 | ||
| PCT/US2014/042534 WO2014204853A1 (en) | 2013-06-19 | 2014-06-16 | Plant-based inhibitors of ketohexokinase for the support of weight management |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016522255A JP2016522255A (ja) | 2016-07-28 |
| JP2016522255A5 true JP2016522255A5 (https=) | 2017-07-27 |
Family
ID=51136839
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016521484A Pending JP2016522255A (ja) | 2013-06-19 | 2014-06-16 | 体重管理を支援するための植物をベースとしたケトヘキソキナーゼ阻害剤 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20140377386A1 (https=) |
| EP (1) | EP3010520A1 (https=) |
| JP (1) | JP2016522255A (https=) |
| KR (1) | KR20160020472A (https=) |
| CN (1) | CN105555287A (https=) |
| AU (1) | AU2014281768A1 (https=) |
| HK (1) | HK1224201A1 (https=) |
| RU (1) | RU2015152566A (https=) |
| TW (1) | TW201534315A (https=) |
| WO (1) | WO2014204853A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107375256A (zh) * | 2017-09-13 | 2017-11-24 | 上海壹志医药科技有限公司 | 根皮素的药物用途 |
| WO2020166494A1 (ja) * | 2019-02-15 | 2020-08-20 | 国立大学法人信州大学 | 血圧低下作用を有するナス由来組成物 |
| CN110025603A (zh) * | 2019-05-15 | 2019-07-19 | 大连天星本草生物科技有限公司 | 补骨脂查尔酮类化合物在制备治疗肥胖症的药物中的应用 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5282710A (en) * | 1975-12-29 | 1977-07-11 | Nippon Shinyaku Co Ltd | Extraction of effective drug component from mulberry |
| JP2001513571A (ja) * | 1997-08-29 | 2001-09-04 | ザ リセックス カンパニー インコーポレイテッド | 糖尿病、高血糖症及び低血糖症の治療法 |
| ATE369868T1 (de) * | 2000-06-27 | 2007-09-15 | Qualilife Pharmaceuticals Inc | Zusammensetzungen und verfahren zur behandlung der weiblichen sexuellen reaktion |
| JP2002138045A (ja) * | 2000-10-30 | 2002-05-14 | Ichimaru Pharcos Co Ltd | 前駆脂肪細胞分化誘導剤 |
| WO2005009351A2 (en) * | 2003-07-17 | 2005-02-03 | Santé International, Inc. | Dietary supplement for promoting control of blood-sugar levels and associated pathology in type 2 diabetics |
| CN1921872A (zh) * | 2004-02-03 | 2007-02-28 | 智利南方大学 | 用于激活PPR－γ受体而治疗自身免疫性疾病和阿尔茨海默病的提取自穿心莲的半日花烷型二萜类组合物 |
| JP2006273788A (ja) * | 2005-03-30 | 2006-10-12 | Kaneka Corp | Ｐｐａｒリガンド活性を有する植物由来の組成物 |
| KR101802415B1 (ko) * | 2005-05-09 | 2017-11-28 | 유니젠, 인크. | 바쿠치올의 조성물 및 그것의 제조방법 |
| JP2008133192A (ja) * | 2005-09-29 | 2008-06-12 | Kureha Corp | 抗糖尿病剤 |
| CN101835480B (zh) * | 2007-10-24 | 2013-06-12 | 三得利控股株式会社 | 单子山楂乙醇提取物在制备预防及/或改善肥胖的组合物中的用途 |
| JP5450952B2 (ja) * | 2007-11-27 | 2014-03-26 | 安幸 城田 | 健康飲食物及び薬剤 |
| US20090252758A1 (en) * | 2008-04-07 | 2009-10-08 | Mazed Mohammad A | Nutritional supplement for the prevention of cardiovascular disease, alzheimer's disease, diabetes, and regulation and reduction of blood sugar and insulin resistance |
| JP2009298742A (ja) * | 2008-06-16 | 2009-12-24 | Toyobo Co Ltd | 生活習慣病改善剤 |
| US20100055247A1 (en) * | 2008-08-29 | 2010-03-04 | Tirrito Salvatore J | Nutritional Compositions for Athletes |
| JP2010083838A (ja) * | 2008-10-02 | 2010-04-15 | Ichimaru Pharcos Co Ltd | アディポネクチン産生促進剤 |
| US20100215782A1 (en) * | 2008-10-22 | 2010-08-26 | Metaproteomics, Llc | Novel mitochondrial uncoupling methods and compositions for enhancing adipocyte thermogenesis |
| KR101746867B1 (ko) * | 2009-01-26 | 2017-06-14 | 타이페이 메디컬 유니이버시티 | 당뇨 및 비만을 치료하기 위한 프테로신 화합물의 용도 |
| CA2751227C (en) * | 2009-02-02 | 2021-10-26 | Laila Nutraceuticals | Composition from sphaeranthus indicus and garcinia mangostana for the control of metabolic syndrome |
| CN101642477A (zh) * | 2009-08-28 | 2010-02-10 | 李来杰 | 中药凤尾草的用途 |
| JP2011079752A (ja) * | 2009-10-05 | 2011-04-21 | Kracie Home Products Ltd | 膵リパーゼ阻害剤並びにそれを含有する飲食品組成物及び医薬品組成物 |
| JP2011168547A (ja) * | 2010-02-19 | 2011-09-01 | Sun Foods Co Ltd | α−グルコシダ−ゼ活性阻害剤、及びこれを含有する果実飲料 |
| JP2013525370A (ja) * | 2010-04-22 | 2013-06-20 | ヤンセン ファーマシューティカ エヌ．ベー． | ケトヘキソキナーゼ阻害剤として有用なインダゾール化合物 |
| CN101856351B (zh) * | 2010-05-28 | 2012-05-30 | 暨南大学 | 一种组合物及其在制备rxr受体转录抑制剂中的应用 |
| KR20120031800A (ko) * | 2010-09-27 | 2012-04-04 | 농업회사법인 주식회사 상로 | 뽕나무 열매 씨앗 추출물을 함유하는 항산화, 항당뇨 및 항노화 활성 조성물 |
| WO2013085338A2 (ko) * | 2011-12-07 | 2013-06-13 | 한국생명공학연구원 | 수련뿌리 추출물, 이의 분획물 또는 이로부터 분리된 폴리페놀계 화합물을 유효성분으로 함유하는 대사성 질환 예방 및 치료용 약학적 조성물 |
| EP3549587A1 (de) * | 2012-06-30 | 2019-10-09 | BioActive Food GmbH | Zusammensetzung zur behandlung von hyperglykämischen erkrankungen |
-
2014
- 2014-06-16 US US14/305,876 patent/US20140377386A1/en not_active Abandoned
- 2014-06-16 RU RU2015152566A patent/RU2015152566A/ru unknown
- 2014-06-16 HK HK16112540.2A patent/HK1224201A1/zh unknown
- 2014-06-16 WO PCT/US2014/042534 patent/WO2014204853A1/en not_active Ceased
- 2014-06-16 EP EP14736568.8A patent/EP3010520A1/en not_active Withdrawn
- 2014-06-16 KR KR1020167000195A patent/KR20160020472A/ko not_active Withdrawn
- 2014-06-16 CN CN201480034872.8A patent/CN105555287A/zh active Pending
- 2014-06-16 JP JP2016521484A patent/JP2016522255A/ja active Pending
- 2014-06-16 AU AU2014281768A patent/AU2014281768A1/en not_active Abandoned
- 2014-06-18 TW TW103121028A patent/TW201534315A/zh unknown
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