JP2016521275A5 - - Google Patents
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- JP2016521275A5 JP2016521275A5 JP2016509500A JP2016509500A JP2016521275A5 JP 2016521275 A5 JP2016521275 A5 JP 2016521275A5 JP 2016509500 A JP2016509500 A JP 2016509500A JP 2016509500 A JP2016509500 A JP 2016509500A JP 2016521275 A5 JP2016521275 A5 JP 2016521275A5
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- JP
- Japan
- Prior art keywords
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- 239000000203 mixture Substances 0.000 claims description 37
- 238000000034 method Methods 0.000 claims description 13
- 230000005298 paramagnetic effect Effects 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 7
- 229910052751 metal Inorganic materials 0.000 claims description 7
- 239000002184 metal Substances 0.000 claims description 7
- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
- 239000000243 solution Substances 0.000 claims description 6
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 claims description 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 4
- 239000011575 calcium Substances 0.000 claims description 4
- 238000002059 diagnostic imaging Methods 0.000 claims description 4
- WDLRUFUQRNWCPK-UHFFFAOYSA-N Tetraxetan Chemical compound OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 WDLRUFUQRNWCPK-UHFFFAOYSA-N 0.000 claims description 3
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 3
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 3
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 claims description 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
- 239000007995 HEPES buffer Substances 0.000 claims description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 2
- 239000007987 MES buffer Substances 0.000 claims description 2
- 239000007983 Tris buffer Substances 0.000 claims description 2
- 229940072107 ascorbate Drugs 0.000 claims description 2
- 235000010323 ascorbic acid Nutrition 0.000 claims description 2
- 239000011668 ascorbic acid Substances 0.000 claims description 2
- 239000000872 buffer Substances 0.000 claims description 2
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 claims description 2
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims description 2
- 239000000292 calcium oxide Substances 0.000 claims description 2
- 159000000007 calcium salts Chemical class 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
- 238000003384 imaging method Methods 0.000 claims description 2
- 150000002500 ions Chemical class 0.000 claims description 2
- 229910021644 lanthanide ion Inorganic materials 0.000 claims description 2
- 239000003446 ligand Substances 0.000 claims description 2
- 229910021645 metal ion Inorganic materials 0.000 claims description 2
- 150000002739 metals Chemical class 0.000 claims description 2
- 230000001954 sterilising effect Effects 0.000 claims description 2
- 238000004659 sterilization and disinfection Methods 0.000 claims description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims description 2
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 2
- QBSWRLMNLFROKO-UHFFFAOYSA-N [Ca].OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 Chemical compound [Ca].OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 QBSWRLMNLFROKO-UHFFFAOYSA-N 0.000 claims 1
- 150000004697 chelate complex Chemical class 0.000 claims 1
- 229940001447 lactate Drugs 0.000 claims 1
- 229940049920 malate Drugs 0.000 claims 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229940095064 tartrate Drugs 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 3
- 229910052791 calcium Inorganic materials 0.000 description 2
- BBGMLJQAPLPLPI-UHFFFAOYSA-N 2-[4,7,10-tris(carboxymethyl)cyclododecyl]acetic acid Chemical compound OC(=O)CC1CCC(CC(O)=O)CCC(CC(O)=O)CCC(CC(O)=O)CC1 BBGMLJQAPLPLPI-UHFFFAOYSA-N 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1353883 | 2013-04-26 | ||
| FR1353883 | 2013-04-26 | ||
| PCT/EP2014/058617 WO2014174120A1 (fr) | 2013-04-26 | 2014-04-28 | Formulation de produit de contraste et son procede de preparation associe |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016521275A JP2016521275A (ja) | 2016-07-21 |
| JP2016521275A5 true JP2016521275A5 (enExample) | 2017-06-01 |
| JP6608805B2 JP6608805B2 (ja) | 2019-11-20 |
Family
ID=48856855
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016509500A Active JP6608805B2 (ja) | 2013-04-26 | 2014-04-28 | 造影製剤および関連する調製方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10918743B2 (enExample) |
| EP (1) | EP2988756B2 (enExample) |
| JP (1) | JP6608805B2 (enExample) |
| KR (1) | KR102231121B1 (enExample) |
| CN (2) | CN105142649A (enExample) |
| BR (1) | BR112015026473B1 (enExample) |
| CA (1) | CA2909919C (enExample) |
| DK (1) | DK2988756T4 (enExample) |
| ES (1) | ES2626582T5 (enExample) |
| HR (1) | HRP20170874T4 (enExample) |
| HU (1) | HUE033219T2 (enExample) |
| PL (1) | PL2988756T5 (enExample) |
| PT (1) | PT2988756T (enExample) |
| WO (1) | WO2014174120A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3101012A1 (en) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
| FR3039767B1 (fr) | 2015-08-04 | 2017-09-08 | Guerbet Sa | Composition destinee a vectoriser un agent anticancereux |
| GB201610738D0 (en) | 2016-06-20 | 2016-08-03 | Ge Healthcare As | Chelate compounds |
| EP3544964B1 (en) | 2016-11-28 | 2020-06-17 | Bayer Pharma Aktiengesellschaft | High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging |
| CN110290815A (zh) | 2016-12-21 | 2019-09-27 | 通用电气医疗集团股份有限公司 | 适合作为mri显像剂的基于四氮杂双环-大环的锰螯合化合物 |
| US11110186B2 (en) | 2017-12-20 | 2021-09-07 | General Electric Company | Anionic chelate compounds |
| US10973934B2 (en) * | 2018-08-06 | 2021-04-13 | Bracco Imaging S.P.A. | Gadolinium bearing PCTA-based contrast agents |
| IL321215B2 (en) | 2018-11-23 | 2026-05-01 | Bayer Ag | Contrast media formulation and process for its preparation |
| FR3091872B1 (fr) * | 2019-01-17 | 2020-12-25 | Guerbet Sa | Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de synthese |
| FR3091873B1 (fr) * | 2019-01-17 | 2020-12-25 | Guerbet Sa | Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification |
| US11426470B2 (en) | 2019-01-17 | 2022-08-30 | Guerbet | Complex of gadolinium and a chelating ligand derived of a diastereoisomerically enriched PCTA and synthesis method |
| US11370804B2 (en) | 2019-01-17 | 2022-06-28 | Guerbet | Complex of gadolinium and a chelating ligand derived from a diastereoisomerically enriched PCTA and preparation and purification process |
| US20230339945A1 (en) | 2020-07-17 | 2023-10-26 | Guerbet | Method for preparing a chelating ligand derived from pcta |
| US12409239B2 (en) | 2021-06-25 | 2025-09-09 | Beacon Mri Ltd | Particles for use in hyperpolarization |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4647447A (en) | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
| US4957939A (en) | 1981-07-24 | 1990-09-18 | Schering Aktiengesellschaft | Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging |
| AU608759B2 (en) | 1986-08-04 | 1991-04-18 | Amersham Health Salutar Inc | NMR imaging with paramagnetic polyvalents metal salts of poly-(acid-alkylene-amido)-alkanes |
| DE3640708C2 (de) | 1986-11-28 | 1995-05-18 | Schering Ag | Verbesserte metallhaltige Pharmazeutika |
| AU629171B2 (en) * | 1987-06-30 | 1992-10-01 | Mallinckrodt, Inc. | Method for enhancing the safety of metal-ligand chelates as magnetic resonants imaging agents and x-ray contrast agents |
| US5334371A (en) | 1988-07-20 | 1994-08-02 | Schering Aktiengesellschaft | Marcocyclic polyaza bicyclo compounds containing 5 or 6 membered rings, and method for MRI |
| DE4001655A1 (de) | 1990-01-18 | 1991-07-25 | Schering Ag | 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| US5364613A (en) | 1989-04-07 | 1994-11-15 | Sieving Paul F | Polychelants containing macrocyclic chelant moieties |
| GB9001245D0 (en) * | 1990-01-19 | 1990-03-21 | Salutar Inc | Compounds |
| US7385041B2 (en) | 1990-04-25 | 2008-06-10 | Bracco International B.V. | Dual functioning excipient for metal chelate contrast agents |
| CA2039399C (en) * | 1990-04-25 | 2000-09-05 | C. Allen Chang | Dual functioning excipient for metal chelate contrast agents |
| DE4115789A1 (de) | 1991-05-10 | 1992-11-12 | Schering Ag | Makrocyclische polymer-komplexbildner, deren komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| DE69230970T2 (de) | 1991-12-10 | 2001-01-04 | The Dow Chemical Co., Midland | Bicylclische, polyazamakrocyclocarbonsäure-komplexe, konjugate, herstellung und verwendung als kontraststoffe |
| US5582814A (en) | 1994-04-15 | 1996-12-10 | Metasyn, Inc. | 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging |
| DE19719033C1 (de) | 1997-04-29 | 1999-01-28 | Schering Ag | Ionenpaare, Verfahren zu ihrer Herstellung und ihre Verwendung als Kontrastmittel |
| FR2794744B1 (fr) | 1999-06-09 | 2001-09-21 | Guerbet Sa | Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale |
| US6559330B1 (en) | 1999-09-09 | 2003-05-06 | Schering Aktiengesellschaft | Calcium complex of [[(4r)-4-[bis{carboxy-.kappa.o)methyl]amino-.kappa.n]-6,9-bis[(carboxy.kappa.o)methyl]-1-[(4,4-diphenylcyclohexyl)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-ylic-acid-.kappa.n6,.kappa.n9,.kappa.011]1-oxidato(6-)]-, hexahydrogen, its salts, pharmaceutical agents that contain these complexes, their use in treatment and as additives in diagnosis, as well as processes for the production of the complexes and agents |
| FR2891830B1 (fr) | 2005-10-07 | 2011-06-24 | Guerbet Sa | Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale |
| FR2927539B1 (fr) | 2008-02-19 | 2010-07-30 | Guerbet Sa | Procede de preparation d'une formulation pharmaceutique d'agents de contraste. |
| US20090208421A1 (en) † | 2008-02-19 | 2009-08-20 | Dominique Meyer | Process for preparing a pharmaceutical formulation of contrast agents |
| NO331773B1 (no) | 2009-12-18 | 2012-03-26 | Ge Healthcare As | Mangankelater, sammensetninger omfattende slike og anvendelse av disse som kontrastmidler for magnettomografi (MR) |
| EP2554167A1 (en) | 2011-08-02 | 2013-02-06 | Bracco Imaging S.p.A | New use of l-histidine and derivatives thereof |
-
2014
- 2014-04-28 CA CA2909919A patent/CA2909919C/fr active Active
- 2014-04-28 CN CN201480022899.5A patent/CN105142649A/zh active Pending
- 2014-04-28 HU HUE14723750A patent/HUE033219T2/en unknown
- 2014-04-28 PT PT147237507T patent/PT2988756T/pt unknown
- 2014-04-28 JP JP2016509500A patent/JP6608805B2/ja active Active
- 2014-04-28 US US14/786,926 patent/US10918743B2/en active Active
- 2014-04-28 DK DK14723750.7T patent/DK2988756T4/da active
- 2014-04-28 KR KR1020157030592A patent/KR102231121B1/ko active Active
- 2014-04-28 CN CN202211543013.4A patent/CN116173247A/zh active Pending
- 2014-04-28 PL PL14723750.7T patent/PL2988756T5/pl unknown
- 2014-04-28 WO PCT/EP2014/058617 patent/WO2014174120A1/fr not_active Ceased
- 2014-04-28 HR HRP20170874TT patent/HRP20170874T4/hr unknown
- 2014-04-28 ES ES14723750T patent/ES2626582T5/es active Active
- 2014-04-28 BR BR112015026473-5A patent/BR112015026473B1/pt active IP Right Grant
- 2014-04-28 EP EP14723750.7A patent/EP2988756B2/fr active Active
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