JP2016520075A5 - - Google Patents
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- Publication number
- JP2016520075A5 JP2016520075A5 JP2016513387A JP2016513387A JP2016520075A5 JP 2016520075 A5 JP2016520075 A5 JP 2016520075A5 JP 2016513387 A JP2016513387 A JP 2016513387A JP 2016513387 A JP2016513387 A JP 2016513387A JP 2016520075 A5 JP2016520075 A5 JP 2016520075A5
- Authority
- JP
- Japan
- Prior art keywords
- concentration
- formulation
- vwf
- binding agent
- tween
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018209611A JP6952019B2 (ja) | 2013-05-17 | 2018-11-07 | 免疫グロブリン単一可変ドメインの安定製剤及びその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361824523P | 2013-05-17 | 2013-05-17 | |
| US61/824,523 | 2013-05-17 | ||
| PCT/EP2014/060107 WO2014184352A1 (en) | 2013-05-17 | 2014-05-16 | Stable formulations of immunoglobulin single variable domains and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018209611A Division JP6952019B2 (ja) | 2013-05-17 | 2018-11-07 | 免疫グロブリン単一可変ドメインの安定製剤及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016520075A JP2016520075A (ja) | 2016-07-11 |
| JP2016520075A5 true JP2016520075A5 (https=) | 2017-06-15 |
| JP6433986B2 JP6433986B2 (ja) | 2018-12-05 |
Family
ID=49304267
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016513387A Active JP6433986B2 (ja) | 2013-05-17 | 2014-05-16 | 免疫グロブリン単一可変ドメインの安定製剤及びその使用 |
| JP2018209611A Active JP6952019B2 (ja) | 2013-05-17 | 2018-11-07 | 免疫グロブリン単一可変ドメインの安定製剤及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018209611A Active JP6952019B2 (ja) | 2013-05-17 | 2018-11-07 | 免疫グロブリン単一可変ドメインの安定製剤及びその使用 |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US10035862B2 (https=) |
| EP (2) | EP3511018B1 (https=) |
| JP (2) | JP6433986B2 (https=) |
| KR (1) | KR102166399B1 (https=) |
| CN (3) | CN105339003B (https=) |
| AU (3) | AU2014267222B2 (https=) |
| BR (1) | BR112015028411B1 (https=) |
| CA (1) | CA2912670A1 (https=) |
| CY (1) | CY1122090T1 (https=) |
| DK (1) | DK2996720T3 (https=) |
| ES (2) | ES2731922T3 (https=) |
| HR (1) | HRP20190954T1 (https=) |
| HU (1) | HUE044392T2 (https=) |
| LT (1) | LT2996720T (https=) |
| MX (2) | MX387527B (https=) |
| NL (1) | NL1040254C2 (https=) |
| PH (1) | PH12015502591B1 (https=) |
| PL (2) | PL3511018T3 (https=) |
| PT (2) | PT3511018T (https=) |
| RS (1) | RS58857B1 (https=) |
| RU (1) | RU2671977C2 (https=) |
| SI (1) | SI2996720T1 (https=) |
| SM (1) | SMT201900359T1 (https=) |
| TR (1) | TR201908663T4 (https=) |
| WO (1) | WO2014184352A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL1040254C2 (en) * | 2013-05-17 | 2014-11-24 | Ablynx Nv | Stable formulations of immunoglobulin single variable domains and uses thereof. |
| AU2015366284B2 (en) | 2014-12-19 | 2021-07-22 | Ablynx N.V. | Cysteine linked nanobody dimers |
| CN111035754A (zh) * | 2016-03-23 | 2020-04-21 | 兆科药业（合肥）有限公司 | 抗血小板溶栓素在制备治疗血栓性血小板减少性紫癜的药物中的应用 |
| GB201612043D0 (en) | 2016-07-11 | 2016-08-24 | Crescendo Biologics Ltd | Composition for treatment of disorders |
| TWI784982B (zh) * | 2016-11-02 | 2022-12-01 | 開曼群島商北極星藥業集團股份有限公司 | 聚乙二醇化精胺酸脫亞胺酶之調配物 |
| WO2019154867A1 (en) | 2018-02-06 | 2019-08-15 | Ablynx Nv | Methods of treating initial episode of ttp with immunoglobulin single variable domains |
| PL3817751T3 (pl) | 2018-07-03 | 2025-09-08 | Fennec Pharmaceuticals, Inc. | Postacie użytkowe bezwodnego tiosiarczanu sodu |
| EP3846840A4 (en) * | 2018-09-05 | 2022-06-15 | Ventria Bioscience Inc. | Formulations of immunoglobulin a |
| CA3115747A1 (en) * | 2018-10-10 | 2020-04-16 | Astellas Pharma Inc. | Pharmaceutical composition containing tagged site-antihuman antibody fab fragment complex |
| CN110564841A (zh) * | 2019-09-19 | 2019-12-13 | 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） | 脑缺血相关基因作为缺血性卒中行为学特征分析的生物标记的应用 |
| CN110624105B (zh) * | 2019-09-24 | 2021-06-11 | 苏州大学 | 血管性血友病因子的结构敏感多肽抗原的序列 |
| JP7502861B2 (ja) * | 2019-12-27 | 2024-06-19 | 旭化成株式会社 | 標的物質と両親媒性高分子との複合体の形成反応の反応温度の評価方法 |
| CN113908254B (zh) * | 2021-10-19 | 2024-05-28 | 山西锦波生物医药股份有限公司 | 一种干粉吸入剂及其制备方法和用途 |
| CN115850493B (zh) * | 2022-11-08 | 2024-03-12 | 江苏耀海生物制药有限公司 | 一种二价纳米抗体Cablivi的分离纯化方法 |
| WO2025240928A1 (en) * | 2024-05-16 | 2025-11-20 | Vega Therapeutics, Inc. | Treatment of von willebrand disease |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU701578B2 (en) | 1992-08-21 | 1999-02-04 | Vrije Universiteit Brussel | Immunoglobulins devoid of light chains |
| WO1994025591A1 (en) | 1993-04-29 | 1994-11-10 | Unilever N.V. | PRODUCTION OF ANTIBODIES OR (FUNCTIONALIZED) FRAGMENTS THEREOF DERIVED FROM HEAVY CHAIN IMMUNOGLOBULINS OF $i(CAMELIDAE) |
| FR2708622B1 (fr) | 1993-08-02 | 1997-04-18 | Raymond Hamers | Vecteur recombinant contenant une séquence d'un gène de lipoprotéine de structure pour l'expression de séquences de nucléotides. |
| ES2245780T3 (es) | 1994-05-18 | 2006-01-16 | Nektar Therapeutics | Metodos y composiciones para la formulacion de interferones como un polvo seco. |
| EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
| ES2294799T3 (es) | 1996-06-27 | 2008-04-01 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. | Moleculas de anticuerpos que interactuan especificamente con el sitio activo o hendidura de una molecula diana. |
| US6329516B1 (en) | 1997-04-28 | 2001-12-11 | Fmc Corporation | Lepidopteran GABA-gated chloride channels |
| BR9813276A (pt) | 1997-10-27 | 2000-08-22 | Unilever Nv | Proteìna multivalente de ligação de antìgeno, sequências de nucleotìdeos, vetor de expressão, célula hospedeira, processo para preparação de proteìna multivalente de ligação de antìgeno, e, uso da mesma |
| WO1999037681A2 (en) | 1998-01-26 | 1999-07-29 | Unilever Plc | Method for producing antibody fragments |
| EP0967284A1 (en) | 1998-05-28 | 1999-12-29 | Pfizer Limited | Phosphodiesterases |
| BR9916765A (pt) | 1999-01-05 | 2001-09-25 | Unilever Nv | Processo para produzir um material imunoadsorvente, uso de uma proteìna que é ligada por meio de uma ligação covalente a um fragmento de anticorpo, material imunadsorvente, uso de um material, e, kit de teste diagnóstico |
| DE60013767T3 (de) | 1999-01-19 | 2009-07-09 | Unilever N.V. | Verfahren zur herstellung von antikörperfragmenten |
| CA2361678A1 (en) | 1999-02-05 | 2000-08-10 | Rijksuniversiteit Leiden | Method of modulating metabolite biosynthesis in recombinant cells |
| US6617122B1 (en) | 1999-03-15 | 2003-09-09 | Xenon Genetics, Inc. | Process for identifying modulators of ABC1 activity |
| CN1252264C (zh) | 1999-04-22 | 2006-04-19 | 荷兰联合利华有限公司 | 利用单价抗原－结合蛋白抑制病毒感染 |
| SG121853A1 (en) | 1999-06-18 | 2006-05-26 | Cv Therapeutics Inc | Compositions and methods for increasing cholesterol efflux and raising hdl using atp binding cassette transporter protein abc1 |
| EP1198572A2 (en) | 1999-08-02 | 2002-04-24 | Keygene N.V. | Method for generating cgmmv resistant plants, genetic constructs, and obtained cgmmv-resistant plants |
| GB9922124D0 (en) | 1999-09-17 | 1999-11-17 | Pfizer Ltd | Phosphodiesterase enzymes |
| US6479280B1 (en) | 1999-09-24 | 2002-11-12 | Vlaams Interuniversitair Institutuut Voor Biotechnologie Vzw | Recombinant phages capable of entering host cells via specific interaction with an artificial receptor |
| DE19955408A1 (de) | 1999-11-18 | 2001-05-23 | Bayer Ag | GABA-B-Rezeptoren |
| DE60042789D1 (de) | 1999-11-29 | 2009-10-01 | Bac Ip B V | Immobilisierte antigenbindende moleküle aus einer domäne |
| AU1859201A (en) | 1999-11-29 | 2001-06-12 | Unilever Plc | Immobilisation of proteins |
| ES2324280T3 (es) | 2000-03-14 | 2009-08-04 | Unilever N.V. | Dominios variables de la cadena pesada de anticuerpos frente a lipasas dieteticas humanas y sus usos. |
| WO2001090190A2 (en) | 2000-05-26 | 2001-11-29 | National Research Council Of Canada | Single-domain antigen-binding antibody fragments derived from llama antibodies |
| ATE513854T1 (de) | 2000-12-13 | 2011-07-15 | Bac Ip B V | Proteinraster aus variablen domänen der schweren immunoglobulinkette von kamelen |
| CA2763913C (en) | 2001-08-10 | 2014-10-28 | Aberdeen University | Antigen binding domains |
| EP1433793A4 (en) | 2001-09-13 | 2006-01-25 | Inst Antibodies Co Ltd | METHOD FOR CREATING A CAMEL ANTIBODY LIBRARY |
| US6723359B2 (en) | 2001-10-18 | 2004-04-20 | Firmenich Sa | Spray-dried compositions and method for their preparation |
| JP2005289809A (ja) | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
| EP1456410A2 (en) | 2001-12-11 | 2004-09-15 | AlgoNomics N.V. | Method for displaying loops from immunoglobulin domains in different contexts |
| EP1456237A2 (en) | 2001-12-21 | 2004-09-15 | Vlaams Interuniversitair Instituut voor Biotechnologie vzw. | Method for cloning of variable domain sequences |
| WO2003055527A2 (en) | 2002-01-03 | 2003-07-10 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Immunoconjugates useful for treatment of tumours |
| GB0202633D0 (en) * | 2002-02-05 | 2002-03-20 | Delta Biotechnology Ltd | Stabilization of protein preparations |
| AU2003251238A1 (en) | 2002-08-07 | 2004-02-25 | Umc Utrecht Holding B.V. | Modulation of platelet adhesion based on the surface exposed beta-switch loop of platelet glycoprotein ib-alpha |
| US7521543B2 (en) | 2002-10-23 | 2009-04-21 | Ludwig Institute For Cancer Research | A34 and A33-like 3 DNA, proteins, antibodies thereto and methods of treatment using same |
| WO2004041867A2 (en) | 2002-11-08 | 2004-05-21 | Ablynx N.V. | Camelidae antibodies against imminoglobulin e and use thereof for the treatment of allergic disorders |
| CA2505316C (en) | 2002-11-08 | 2014-08-05 | Ablynx N.V. | Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor |
| WO2005044858A1 (en) | 2003-11-07 | 2005-05-19 | Ablynx N.V. | Camelidae single domain antibodies vhh directed against epidermal growth factor receptor and uses therefor |
| EP1587838B1 (en) | 2003-01-10 | 2015-04-15 | Ablynx N.V. | Therapeutic polypeptides, homologues thereof, fragments thereof and their use in modulating platelet-mediated aggregation |
| WO2006040153A2 (en) | 2004-10-13 | 2006-04-20 | Ablynx N.V. | Single domain camelide anti -amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as alzheimer's disease |
| DK1836500T3 (da) | 2005-01-14 | 2010-11-01 | Ablynx Nv | Fremgangsmåde og assays til at skelne mellem forskellige former af sygdomme og lidelser, der er kendetegnet ved thrombocytopeni og/eller ved spantan interaktion mellem von Willbrandfaktor 8vWF) og blodplader |
| AU2005325801A1 (en) | 2005-01-31 | 2006-08-03 | Ablynx N.V. | Method for generating variable domain sequences of heavy chain antibodies |
| WO2006122787A1 (en) | 2005-05-18 | 2006-11-23 | Ablynx Nv | Serum albumin binding proteins |
| ES2852423T3 (es) | 2005-05-20 | 2021-09-13 | Ablynx Nv | NanobodiesTM mejorados para el tratamiento de trastornos mediados por agregación |
| KR101360671B1 (ko) * | 2005-06-10 | 2014-02-07 | 추가이 세이야쿠 가부시키가이샤 | ｓｃ（Ｆｖ）２를 함유하는 의약조성물 |
| WO2007104529A2 (en) | 2006-03-13 | 2007-09-20 | Ablynx N.V. | Amino acid sequences directed against il-6 and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling |
| CA2671581A1 (en) | 2006-12-05 | 2008-06-12 | Ablynx N.V. | Peptides capable of binding to serum proteins |
| AU2008228823A1 (en) * | 2007-03-22 | 2008-09-25 | Imclone Llc | Stable antibody formulations |
| CN105816858B (zh) * | 2007-12-28 | 2024-10-18 | 武田药品工业株式会社 | 重组vwf配方 |
| WO2009090189A1 (en) * | 2008-01-15 | 2009-07-23 | Abbott Gmbh & Co.Kg | Powdered protein compositions and methods of making same |
| EP2252303A2 (en) * | 2008-03-21 | 2010-11-24 | Ablynx NV | Von willebrand factor specific binders and methods of use therefor |
| EP2268668A1 (en) | 2008-04-17 | 2011-01-05 | Ablynx N.V. | Peptides capable of binding to serum proteins and compounds, constructs and polypeptides comprising the same |
| EP2349314B1 (en) * | 2008-10-21 | 2013-02-27 | Baxter International Inc. | Lyophilized recombinant vwf formulations |
| EP2362767B1 (en) * | 2008-10-29 | 2017-12-06 | Ablynx N.V. | Formulations of single domain antigen binding molecules |
| EP2196476A1 (en) * | 2008-12-10 | 2010-06-16 | Novartis Ag | Antibody formulation |
| US20120321640A1 (en) | 2009-12-01 | 2012-12-20 | Ablynx N.V. | Von willebrand factor specific binding agents and uses thereof |
| CN102781959A (zh) | 2010-02-05 | 2012-11-14 | 埃博灵克斯股份有限公司 | 能够结合血清白蛋白的肽和包含所述肽的化合物、构建体和多肽 |
| PT3501499T (pt) * | 2010-02-11 | 2022-11-22 | Ablynx Nv | Métodos e composições para a preparação de aerossóis |
| US20120225072A1 (en) * | 2011-03-02 | 2012-09-06 | Ablynx N.V. | Stable formulations of immunoglobulin single variable domains and uses thereof |
| NL1040254C2 (en) * | 2013-05-17 | 2014-11-24 | Ablynx Nv | Stable formulations of immunoglobulin single variable domains and uses thereof. |
-
2013
- 2013-06-14 NL NL1040254A patent/NL1040254C2/en active
-
2014
- 2014-05-16 BR BR112015028411-6A patent/BR112015028411B1/pt active IP Right Grant
- 2014-05-16 CN CN201480034630.9A patent/CN105339003B/zh active Active
- 2014-05-16 DK DK14727433.6T patent/DK2996720T3/da active
- 2014-05-16 ES ES14727433T patent/ES2731922T3/es active Active
- 2014-05-16 AU AU2014267222A patent/AU2014267222B2/en active Active
- 2014-05-16 MX MX2019005269A patent/MX387527B/es unknown
- 2014-05-16 KR KR1020157035523A patent/KR102166399B1/ko active Active
- 2014-05-16 PL PL19157147T patent/PL3511018T3/pl unknown
- 2014-05-16 CN CN201811423557.0A patent/CN110063935B/zh active Active
- 2014-05-16 SM SM20190359T patent/SMT201900359T1/it unknown
- 2014-05-16 JP JP2016513387A patent/JP6433986B2/ja active Active
- 2014-05-16 LT LTEP14727433.6T patent/LT2996720T/lt unknown
- 2014-05-16 TR TR2019/08663T patent/TR201908663T4/tr unknown
- 2014-05-16 SI SI201431229T patent/SI2996720T1/sl unknown
- 2014-05-16 CA CA2912670A patent/CA2912670A1/en not_active Abandoned
- 2014-05-16 WO PCT/EP2014/060107 patent/WO2014184352A1/en not_active Ceased
- 2014-05-16 PT PT191571470T patent/PT3511018T/pt unknown
- 2014-05-16 ES ES19157147T patent/ES2895150T3/es active Active
- 2014-05-16 PT PT14727433T patent/PT2996720T/pt unknown
- 2014-05-16 HU HUE14727433 patent/HUE044392T2/hu unknown
- 2014-05-16 US US14/891,441 patent/US10035862B2/en active Active
- 2014-05-16 MX MX2015015722A patent/MX364664B/es active IP Right Grant
- 2014-05-16 EP EP19157147.0A patent/EP3511018B1/en active Active
- 2014-05-16 PL PL14727433T patent/PL2996720T3/pl unknown
- 2014-05-16 RU RU2015154214A patent/RU2671977C2/ru active
- 2014-05-16 RS RS20190694A patent/RS58857B1/sr unknown
- 2014-05-16 EP EP14727433.6A patent/EP2996720B1/en active Active
- 2014-05-16 HR HRP20190954TT patent/HRP20190954T1/hr unknown
- 2014-05-16 CN CN201811422890.XA patent/CN110037983A/zh active Pending
-
2015
- 2015-11-16 PH PH12015502591A patent/PH12015502591B1/en unknown
-
2018
- 2018-06-14 US US16/008,103 patent/US20190010249A1/en active Pending
- 2018-11-07 JP JP2018209611A patent/JP6952019B2/ja active Active
-
2019
- 2019-02-25 AU AU2019201307A patent/AU2019201307B2/en active Active
- 2019-06-26 CY CY20191100669T patent/CY1122090T1/el unknown
-
2021
- 2021-01-05 AU AU2021200035A patent/AU2021200035A1/en not_active Abandoned
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