JP2016517960A5 - - Google Patents
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- JP2016517960A5 JP2016517960A5 JP2016506682A JP2016506682A JP2016517960A5 JP 2016517960 A5 JP2016517960 A5 JP 2016517960A5 JP 2016506682 A JP2016506682 A JP 2016506682A JP 2016506682 A JP2016506682 A JP 2016506682A JP 2016517960 A5 JP2016517960 A5 JP 2016517960A5
- Authority
- JP
- Japan
- Prior art keywords
- her3
- amount
- her2
- total
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102100029986 Receptor tyrosine-protein kinase erbB-3 Human genes 0.000 claims description 235
- 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 claims description 235
- 206010028980 Neoplasm Diseases 0.000 claims description 109
- 239000000523 sample Substances 0.000 claims description 98
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims description 79
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims description 79
- 238000000034 method Methods 0.000 claims description 60
- 102000010400 1-phosphatidylinositol-3-kinase activity proteins Human genes 0.000 claims description 36
- 108091007960 PI3Ks Proteins 0.000 claims description 36
- 201000011510 cancer Diseases 0.000 claims description 35
- 230000008685 targeting Effects 0.000 claims description 30
- 239000000833 heterodimer Substances 0.000 claims description 28
- 238000003776 cleavage reaction Methods 0.000 claims description 24
- 230000007017 scission Effects 0.000 claims description 24
- 238000002560 therapeutic procedure Methods 0.000 claims description 17
- 239000003795 chemical substances by application Substances 0.000 claims description 16
- 230000026731 phosphorylation Effects 0.000 claims description 10
- 238000006366 phosphorylation reaction Methods 0.000 claims description 10
- 229950008835 neratinib Drugs 0.000 claims description 8
- ZNHPZUKZSNBOSQ-BQYQJAHWSA-N neratinib Chemical compound C=12C=C(NC\C=C\CN(C)C)C(OCC)=CC2=NC=C(C#N)C=1NC(C=C1Cl)=CC=C1OCC1=CC=CC=N1 ZNHPZUKZSNBOSQ-BQYQJAHWSA-N 0.000 claims description 8
- 239000012472 biological sample Substances 0.000 claims description 6
- 238000011278 co-treatment Methods 0.000 claims description 6
- 229960002087 pertuzumab Drugs 0.000 claims description 6
- 238000005259 measurement Methods 0.000 claims description 5
- QSUPQMGDXOHVLK-FFXKMJQXSA-N 4-n-[3-chloro-4-(1,3-thiazol-2-ylmethoxy)phenyl]-6-n-[(4r)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]quinazoline-4,6-diamine;4-methylbenzenesulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1.CC1=CC=C(S(O)(=O)=O)C=C1.C[C@@H]1COC(NC=2C=C3C(NC=4C=C(Cl)C(OCC=5SC=CN=5)=CC=4)=NC=NC3=CC=2)=N1 QSUPQMGDXOHVLK-FFXKMJQXSA-N 0.000 claims description 4
- SDEAXTCZPQIFQM-UHFFFAOYSA-N 6-n-(4,4-dimethyl-5h-1,3-oxazol-2-yl)-4-n-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]quinazoline-4,6-diamine Chemical compound C=1C=C(OC2=CC3=NC=NN3C=C2)C(C)=CC=1NC(C1=C2)=NC=NC1=CC=C2NC1=NC(C)(C)CO1 SDEAXTCZPQIFQM-UHFFFAOYSA-N 0.000 claims description 4
- OONFNUWBHFSNBT-HXUWFJFHSA-N AEE788 Chemical compound C1CN(CC)CCN1CC1=CC=C(C=2NC3=NC=NC(N[C@H](C)C=4C=CC=CC=4)=C3C=2)C=C1 OONFNUWBHFSNBT-HXUWFJFHSA-N 0.000 claims description 4
- 206010006187 Breast cancer Diseases 0.000 claims description 4
- 208000026310 Breast neoplasm Diseases 0.000 claims description 4
- 239000002136 L01XE07 - Lapatinib Substances 0.000 claims description 4
- 229960001686 afatinib Drugs 0.000 claims description 4
- ULXXDDBFHOBEHA-CWDCEQMOSA-N afatinib Chemical compound N1=CN=C2C=C(O[C@@H]3COCC3)C(NC(=O)/C=C/CN(C)C)=CC2=C1NC1=CC=C(F)C(Cl)=C1 ULXXDDBFHOBEHA-CWDCEQMOSA-N 0.000 claims description 4
- 229960004891 lapatinib Drugs 0.000 claims description 4
- BCFGMOOMADDAQU-UHFFFAOYSA-N lapatinib Chemical compound O1C(CNCCS(=O)(=O)C)=CC=C1C1=CC=C(N=CN=C2NC=3C=C(Cl)C(OCC=4C=C(F)C=CC=4)=CC=3)C2=C1 BCFGMOOMADDAQU-UHFFFAOYSA-N 0.000 claims description 4
- JXLVPHOTGHZUCE-ZSIUJALASA-N methyl n-[4-[5-chloro-2-[(1s)-1-[[(e)-3-[5-chloro-2-(tetrazol-1-yl)phenyl]prop-2-enoyl]amino]-3-morpholin-4-yl-3-oxopropyl]-1h-imidazol-4-yl]phenyl]carbamate Chemical compound C1=CC(NC(=O)OC)=CC=C1C1=C(Cl)NC([C@H](CC(=O)N2CCOCC2)NC(=O)\C=C\C=2C(=CC=C(Cl)C=2)N2N=NN=C2)=N1 JXLVPHOTGHZUCE-ZSIUJALASA-N 0.000 claims description 4
- 229960000575 trastuzumab Drugs 0.000 claims description 4
- 229960001612 trastuzumab emtansine Drugs 0.000 claims description 4
- 208000003174 Brain Neoplasms Diseases 0.000 claims description 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 2
- 206010009944 Colon cancer Diseases 0.000 claims description 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 2
- 206010014733 Endometrial cancer Diseases 0.000 claims description 2
- 206010014759 Endometrial neoplasm Diseases 0.000 claims description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 2
- 206010033128 Ovarian cancer Diseases 0.000 claims description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 2
- 206010060862 Prostate cancer Diseases 0.000 claims description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 2
- 201000010881 cervical cancer Diseases 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 206010017758 gastric cancer Diseases 0.000 claims description 2
- 201000010536 head and neck cancer Diseases 0.000 claims description 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims description 2
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims description 2
- 201000005202 lung cancer Diseases 0.000 claims description 2
- 208000020816 lung neoplasm Diseases 0.000 claims description 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 2
- 201000001441 melanoma Diseases 0.000 claims description 2
- 206010061289 metastatic neoplasm Diseases 0.000 claims description 2
- 201000002528 pancreatic cancer Diseases 0.000 claims description 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 2
- 230000004850 protein–protein interaction Effects 0.000 claims description 2
- DFJSJLGUIXFDJP-UHFFFAOYSA-N sapitinib Chemical compound C1CN(CC(=O)NC)CCC1OC(C(=CC1=NC=N2)OC)=CC1=C2NC1=CC=CC(Cl)=C1F DFJSJLGUIXFDJP-UHFFFAOYSA-N 0.000 claims description 2
- 201000011549 stomach cancer Diseases 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- 238000001356 surgical procedure Methods 0.000 claims description 2
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims description 2
- 238000011262 co‐therapy Methods 0.000 claims 2
- 239000000539 dimer Substances 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 230000009257 reactivity Effects 0.000 claims 1
- 239000000710 homodimer Substances 0.000 description 4
- 101100067974 Arabidopsis thaliana POP2 gene Proteins 0.000 description 2
- 102000001301 EGF receptor Human genes 0.000 description 2
- 101100118549 Homo sapiens EGFR gene Proteins 0.000 description 2
- 101100123851 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) HER1 gene Proteins 0.000 description 2
- 230000004043 responsiveness Effects 0.000 description 2
- 239000000556 agonist Substances 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361809083P | 2013-04-05 | 2013-04-05 | |
| US61/809,083 | 2013-04-05 | ||
| PCT/US2014/033208 WO2014165855A1 (en) | 2013-04-05 | 2014-04-07 | Systems and methods for facilitating diagnosis, prognosis and treatment of cancer based on detection of her3 activation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016517960A JP2016517960A (ja) | 2016-06-20 |
| JP2016517960A5 true JP2016517960A5 (enExample) | 2017-03-30 |
| JP6402173B2 JP6402173B2 (ja) | 2018-10-10 |
Family
ID=50686216
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016506682A Expired - Fee Related JP6402173B2 (ja) | 2013-04-05 | 2014-04-07 | Ｈｅｒ３の検出に基づく癌の診断、予後予測、および処置を容易にするためのシステムおよび方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20160041171A1 (enExample) |
| EP (1) | EP2981828A1 (enExample) |
| JP (1) | JP6402173B2 (enExample) |
| CN (1) | CN105264382A (enExample) |
| CA (1) | CA2908515A1 (enExample) |
| WO (1) | WO2014165855A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3110849T1 (sl) | 2014-02-28 | 2021-01-29 | Merus N.V. | Protitelo, ki veže ERBB-2 in ERBB-3 |
| SG11201607109QA (en) | 2014-02-28 | 2016-09-29 | Merus Nv | Antibodies that bind egfr and erbb3 |
| US20190041389A1 (en) * | 2015-02-13 | 2019-02-07 | The University Of Queensland | Methods for classifying tumors and uses therefor |
| BR112018008068A2 (en) | 2015-10-23 | 2018-11-13 | Merus N.V. | binding molecules that inhibit cancer growth |
| CA3016914C (en) | 2016-03-15 | 2019-08-27 | Laboratory Corporation Of America Holdings | Methods of assessing protein interactions between cells |
| CN109789204A (zh) * | 2016-05-31 | 2019-05-21 | 雀巢产品技术援助有限公司 | 基于her2和her3通路亚型选择乳癌患者药物疗法的方法 |
| CA3058343A1 (en) | 2017-03-31 | 2018-10-04 | Merus N.V. | Erbb-2 and erbb-3 binding bispecific antibodies for use in the treatment of cells that have an nrg1 fusion gene |
| KR20180117529A (ko) * | 2017-04-19 | 2018-10-29 | 주식회사 프로티나 | 단백질-단백질 상호작용 분석에 의한 약물 반응성 예측 방법 |
| US12195551B2 (en) | 2017-05-17 | 2025-01-14 | Merus N.V. | Combination of an ErbB-2/ErbB-3 bispecific antibody with endocrine therapy for breast cancer |
| HUE071182T2 (hu) | 2017-08-09 | 2025-08-28 | Merus Nv | EGFR és CMET kötõ antitestek |
| US20210239702A1 (en) * | 2018-06-14 | 2021-08-05 | Memorial Sloan Kettering Cancer Center | Methods for predicting responsiveness of lung cancer patients to her2-targeting therapies |
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|---|---|---|---|---|
| US4318846A (en) | 1979-09-07 | 1982-03-09 | Syva Company | Novel ether substituted fluorescein polyamino acid compounds as fluorescers and quenchers |
| US4709016A (en) | 1982-02-01 | 1987-11-24 | Northeastern University | Molecular analytical release tags and their use in chemical analysis |
| US5516931A (en) | 1982-02-01 | 1996-05-14 | Northeastern University | Release tag compounds producing ketone signal groups |
| US4650750A (en) | 1982-02-01 | 1987-03-17 | Giese Roger W | Method of chemical analysis employing molecular release tag compounds |
| JP3040121B2 (ja) | 1988-01-12 | 2000-05-08 | ジェネンテク，インコーポレイテッド | 増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法 |
| JP2681061B2 (ja) | 1988-06-08 | 1997-11-19 | ロンドン・ダイアグノスティック・インコーポレーテッド | 検出可能なシグナルのセンシタイザー誘導発生を利用したアッセイ |
| US4997928A (en) | 1988-09-15 | 1991-03-05 | E. I. Du Pont De Nemours And Company | Fluorescent reagents for the preparation of 5'-tagged oligonucleotides |
| US5654442A (en) | 1989-11-14 | 1997-08-05 | The Perkin-Elmer Corporation | 4,7-dichlorofluorescein dyes as molecular probes |
| US5183884A (en) | 1989-12-01 | 1993-02-02 | United States Of America | Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor |
| EP0484027B1 (en) | 1990-11-02 | 1996-12-18 | Zeneca Limited | Polysubstituted phthalocyanines |
| JP2758730B2 (ja) | 1991-04-25 | 1998-05-28 | 三菱電機株式会社 | 放電励起パルスレーザ発振装置 |
| US5578498A (en) | 1991-05-22 | 1996-11-26 | Behringwerke Ag | Metal chelate containing compositions for use in chemiluminescent assays |
| US5340716A (en) | 1991-06-20 | 1994-08-23 | Snytex (U.S.A.) Inc. | Assay method utilizing photoactivated chemiluminescent label |
| US6251581B1 (en) | 1991-05-22 | 2001-06-26 | Dade Behring Marburg Gmbh | Assay method utilizing induced luminescence |
| US5565552A (en) | 1992-01-21 | 1996-10-15 | Pharmacyclics, Inc. | Method of expanded porphyrin-oligonucleotide conjugate synthesis |
| US5622929A (en) | 1992-01-23 | 1997-04-22 | Bristol-Myers Squibb Company | Thioether conjugates |
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| JP3464798B2 (ja) | 1992-07-31 | 2003-11-10 | デイド・ベーリング・マルブルク・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング | 光活性化化学発光基質 |
| US5565324A (en) | 1992-10-01 | 1996-10-15 | The Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
| US5811098A (en) | 1992-11-24 | 1998-09-22 | Bristol-Myers Squibb Company | Antibodies to HER4, human receptor tyrosine kinase |
| US5986076A (en) | 1994-05-11 | 1999-11-16 | Trustees Of Boston University | Photocleavable agents and conjugates for the detection and isolation of biomolecules |
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| JP2005505749A (ja) | 2001-05-21 | 2005-02-24 | アクララ バイオサイエンシーズ， インコーポレイテッド | タンパク質を分析するための方法および組成物 |
| EP1283053A1 (en) * | 2001-08-09 | 2003-02-12 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Inhibitors of HER3 activity |
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| KR20040108655A (ko) | 2002-03-05 | 2004-12-24 | 아클라라 바이오사이언시스 인코퍼레이티드 | 막-결합된 민감제를 사용하는 복합 분석법 |
| US20040229294A1 (en) * | 2002-05-21 | 2004-11-18 | Po-Ying Chan-Hui | ErbB surface receptor complexes as biomarkers |
| US20040229380A1 (en) * | 2002-05-21 | 2004-11-18 | Po-Ying Chan-Hui | ErbB heterodimers as biomarkers |
| EP2263691B1 (en) * | 2002-07-15 | 2012-08-29 | F.Hoffmann-La Roche Ag | Treatment of cancer with the recombinant humanized monoclonal anti-erbb2 antibody 2C4 (rhuMAb 2C4) |
| EP1540347B1 (en) | 2002-07-25 | 2009-09-09 | Aclara BioSciences, Inc. | Detecting receptor oligomerization |
| WO2004087887A2 (en) * | 2003-04-01 | 2004-10-14 | Monogram Biosciences, Inc. | Intracellular complexes as biomarkers |
| WO2009068423A2 (en) * | 2007-11-30 | 2009-06-04 | Siemens Healthcare Diagnostics Gmbh | Method for predicting therapy responsiveness in basal like tumors |
| US10416162B2 (en) | 2007-12-20 | 2019-09-17 | Monogram Biosciences, Inc. | Her2 diagnostic methods |
| WO2010065568A2 (en) | 2008-12-01 | 2010-06-10 | Laboratory Corporation Of America Holdings | METHODS AND ASSAYS FOR MEASURING p95 AND/OR p95 IN A SAMPLE AND ANTIBODIES SPECIFIC FOR p95 |
| SG172983A1 (en) | 2009-01-15 | 2011-08-29 | Lab Corp America Holdings | Methods of determining patient response by measurement of her-3 |
| EP2387717B1 (en) * | 2009-01-15 | 2014-12-10 | Laboratory Corporation of America Holdings | Methods of determining patient response by measurement of her-2 expression |
| WO2013033623A1 (en) * | 2011-09-02 | 2013-03-07 | Nestec S.A. | Profiling of signal pathway proteins to determine therapeutic efficacy |
| CN102492039B (zh) * | 2011-11-21 | 2015-03-11 | 无锡天演生物技术有限公司 | 全人源抗人her2单抗 |
-
2014
- 2014-04-07 EP EP14722931.4A patent/EP2981828A1/en not_active Withdrawn
- 2014-04-07 CA CA2908515A patent/CA2908515A1/en not_active Abandoned
- 2014-04-07 CN CN201480030240.4A patent/CN105264382A/zh active Pending
- 2014-04-07 JP JP2016506682A patent/JP6402173B2/ja not_active Expired - Fee Related
- 2014-04-07 WO PCT/US2014/033208 patent/WO2014165855A1/en not_active Ceased
- 2014-04-07 US US14/781,468 patent/US20160041171A1/en not_active Abandoned
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