JP2016516780A5 - - Google Patents
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- Publication number
- JP2016516780A5 JP2016516780A5 JP2016507662A JP2016507662A JP2016516780A5 JP 2016516780 A5 JP2016516780 A5 JP 2016516780A5 JP 2016507662 A JP2016507662 A JP 2016507662A JP 2016507662 A JP2016507662 A JP 2016507662A JP 2016516780 A5 JP2016516780 A5 JP 2016516780A5
- Authority
- JP
- Japan
- Prior art keywords
- chemotherapeutic agent
- paclitaxel
- therapeutically effective
- effective amount
- tissue site
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims 22
- 239000002246 antineoplastic agent Substances 0.000 claims 21
- 229940127089 cytotoxic agent Drugs 0.000 claims 20
- 229960001592 paclitaxel Drugs 0.000 claims 16
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 16
- 229930012538 Paclitaxel Natural products 0.000 claims 14
- 229940079593 drug Drugs 0.000 claims 11
- 229920006237 degradable polymer Polymers 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 5
- 230000015556 catabolic process Effects 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 238000006731 degradation reaction Methods 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 4
- 229920001577 copolymer Polymers 0.000 claims 3
- 238000001727 in vivo Methods 0.000 claims 3
- 108010058566 130-nm albumin-bound paclitaxel Proteins 0.000 claims 2
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 2
- 210000000013 bile duct Anatomy 0.000 claims 2
- 210000003445 biliary tract Anatomy 0.000 claims 2
- 210000001072 colon Anatomy 0.000 claims 2
- 229920000295 expanded polytetrafluoroethylene Polymers 0.000 claims 2
- 229960002949 fluorouracil Drugs 0.000 claims 2
- 210000000232 gallbladder Anatomy 0.000 claims 2
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 2
- 229960005277 gemcitabine Drugs 0.000 claims 2
- 229960004768 irinotecan Drugs 0.000 claims 2
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims 2
- 210000004185 liver Anatomy 0.000 claims 2
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims 2
- 229960001756 oxaliplatin Drugs 0.000 claims 2
- 210000000277 pancreatic duct Anatomy 0.000 claims 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 2
- 210000000813 small intestine Anatomy 0.000 claims 2
- 229910000684 Cobalt-chrome Inorganic materials 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- 229910001260 Pt alloy Inorganic materials 0.000 claims 1
- 229940123237 Taxane Drugs 0.000 claims 1
- 229910001069 Ti alloy Inorganic materials 0.000 claims 1
- 229910045601 alloy Inorganic materials 0.000 claims 1
- 239000000956 alloy Substances 0.000 claims 1
- 210000000941 bile Anatomy 0.000 claims 1
- 229910010293 ceramic material Inorganic materials 0.000 claims 1
- 229940044683 chemotherapy drug Drugs 0.000 claims 1
- 239000010952 cobalt-chrome Substances 0.000 claims 1
- 238000013270 controlled release Methods 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229910001000 nickel titanium Inorganic materials 0.000 claims 1
- HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical compound [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
- -1 polyethylene Polymers 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 229920001296 polysiloxane Polymers 0.000 claims 1
- 229910001256 stainless steel alloy Inorganic materials 0.000 claims 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361810543P | 2013-04-10 | 2013-04-10 | |
| US61/810,543 | 2013-04-10 | ||
| PCT/US2014/033671 WO2014169137A1 (en) | 2013-04-10 | 2014-04-10 | Local drug delivery devices and methods for treating cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018207608A Division JP2019034962A (ja) | 2013-04-10 | 2018-11-02 | 癌治療のための薬物局所送達装置及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016516780A JP2016516780A (ja) | 2016-06-09 |
| JP2016516780A5 true JP2016516780A5 (https=) | 2017-06-08 |
| JP6431528B2 JP6431528B2 (ja) | 2018-11-28 |
Family
ID=50841949
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016507662A Active JP6431528B2 (ja) | 2013-04-10 | 2014-04-10 | 癌治療のための薬物局所送達装置及び方法 |
| JP2018207608A Pending JP2019034962A (ja) | 2013-04-10 | 2018-11-02 | 癌治療のための薬物局所送達装置及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018207608A Pending JP2019034962A (ja) | 2013-04-10 | 2018-11-02 | 癌治療のための薬物局所送達装置及び方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US9301926B2 (https=) |
| EP (1) | EP2983730B1 (https=) |
| JP (2) | JP6431528B2 (https=) |
| CA (1) | CA2944480C (https=) |
| ES (1) | ES2762555T3 (https=) |
| WO (1) | WO2014169137A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX367070B (es) | 2012-08-31 | 2019-08-05 | Taris Biomedical Llc | Sistemas de administracion de farmaco y metodos para el tratamiento de la prostata. |
| CA2944480C (en) * | 2013-04-10 | 2021-05-18 | Massachusetts Institute Of Technology | Local drug delivery devices and methods for treating cancer |
| LT4124339T (lt) | 2014-03-06 | 2025-11-10 | Vaisto įvedimo sistemos ir būdai šlapimo pūslės vėžiui gydyti gemcitabinu | |
| EP3797768A1 (en) | 2014-06-23 | 2021-03-31 | Placon Therapeutics, Inc. | Maleimide-functionalised platinum for use in the treatment of cancer |
| EP3302423B1 (en) | 2015-06-04 | 2022-05-25 | Crititech, Inc. | Particle production system and particle collection device |
| HRP20240082T1 (hr) | 2015-07-07 | 2024-03-29 | H. Lundbeck A/S | Inhibitor pde9 s okosnicom imidazopirazinona za liječenje perifernih bolesti |
| BR112018069628A2 (pt) | 2016-04-04 | 2019-02-12 | Crititech, Inc. | métodos para tratamento de tumor sólido |
| TN2018000383A1 (en) | 2016-07-06 | 2020-06-15 | H Lundbeck As | Pde9 inhibitors for treatment of peripheral diseases. |
| WO2018213579A1 (en) | 2017-05-17 | 2018-11-22 | Massachusetts Institute Of Technology | Self-actuating articles |
| DK3630772T3 (da) | 2017-05-26 | 2024-02-05 | Cardurion Pharmaceuticals Inc | Fremgangsmåder til fremstilling og anvendelse af pde9-hæmmere |
| EP3615145B1 (en) | 2017-06-09 | 2024-05-15 | Crititech, Inc. | Compositions for use in the treatment of epithelial cysts by intracystic injection of antineoplastic particles |
| WO2018231908A1 (en) | 2017-06-14 | 2018-12-20 | Crititech, Inc. | Methods for treating lung disorders |
| BR112020000832A2 (pt) | 2017-07-25 | 2020-07-21 | Taris Biomedical Llc | métodos para tratar metástase tumoral |
| KR20250057947A (ko) | 2017-10-03 | 2025-04-29 | 크리티테크, 인크. | 암의 치료를 위한 면역치료제의 전신 전달과 조합된 항신생물성 입자의 국소 전달 |
| JOP20200124A1 (ar) | 2017-11-08 | 2020-05-20 | Taris Biomedical Llc | طُرق لعلاج سرطان المثانة باستخدام جيمسيتابين وعلاج مدوامة لذلك |
| JP7105505B2 (ja) * | 2017-11-30 | 2022-07-25 | ディー． ドスタ、アナトリ | 生体組織への局所曝露方法、組織置換アプリケーターおよび多孔質ポリテトラフルオロエチレンの使用 |
| AU2019269636A1 (en) | 2018-05-17 | 2020-11-19 | Massachusetts Institute Of Technology | Systems for electrical stimulation |
| KR20260007295A (ko) | 2018-05-24 | 2026-01-13 | 셀라니즈 이브이에이 퍼포먼스 폴리머스 엘엘씨 | 거대 분자 약물 화합물의 지속적인 방출을 위한 이식가능 장치 |
| US11690806B2 (en) | 2018-05-24 | 2023-07-04 | Celanese Eva Performance Polymers Llc | Implantable device for sustained release of a macromolecular drug compound |
| US11689849B2 (en) | 2018-05-24 | 2023-06-27 | Nureva, Inc. | Method, apparatus and computer-readable media to manage semi-constant (persistent) sound sources in microphone pickup/focus zones |
| FI3801526T3 (fi) | 2018-05-25 | 2024-03-20 | Cardurion Pharmaceuticals Inc | 6-[(3s,4s)-4-metyyli-1-(pyrimidin-2-yylimetyyli)pyrrolidin-3-yyli]-3-tetrahydropyran-4-yyli-7h-imidatso[1,5-a]pyratsin-8-onin monohydraattimuotoja ja kiteisiä muotoja |
| EP3843737A4 (en) | 2018-08-31 | 2022-06-01 | Imara Inc. | PDE9 INHIBITORS FOR THE TREATMENT OF SICKLE CELL DISEASE |
| BR112023022439A2 (pt) | 2021-04-26 | 2023-12-26 | Celanese Eva Performance Polymers Llc | Dispositivo implantável para liberação sustentada de um composto de fármaco macromolecular |
| IL312842A (en) | 2021-11-17 | 2024-07-01 | Panther Therapeutics Inc | Implantable and biodegradable drug delivery devices and methods of using them |
| CN119855585A (zh) * | 2022-07-22 | 2025-04-18 | 潘瑟治疗股份有限公司 | 组织穿透和可生物降解的药物递送装置及其使用方法 |
| JP2025538459A (ja) | 2022-11-17 | 2025-11-28 | パンサー セラピューティクス，インコーポレイティド | 膵臓がんを治療する方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5886026A (en) * | 1993-07-19 | 1999-03-23 | Angiotech Pharmaceuticals Inc. | Anti-angiogenic compositions and methods of use |
| US20050271701A1 (en) * | 2000-03-15 | 2005-12-08 | Orbus Medical Technologies, Inc. | Progenitor endothelial cell capturing with a drug eluting implantable medical device |
| US9216239B2 (en) | 2001-06-08 | 2015-12-22 | Leo Rubin | Medical device for intra-lumenal delivery of pharmaceutical agents |
| JP2005160600A (ja) * | 2003-12-01 | 2005-06-23 | Ir:Kk | 液含浸性ステント及び薬液含浸ステント |
| JP5028605B2 (ja) * | 2004-11-22 | 2012-09-19 | 国立大学法人九州大学 | バイオフィルム形成阻害剤及び治療用器具 |
| US20110118827A1 (en) | 2005-06-06 | 2011-05-19 | Dr. Tim Wu | Biodegradable stent formed with polymer-bioceramic nanoparticle composite and method of making the same |
| US20070178138A1 (en) | 2006-02-01 | 2007-08-02 | Allergan, Inc. | Biodegradable non-opthalmic implants and related methods |
| WO2007127488A1 (en) * | 2006-04-27 | 2007-11-08 | Shenoy Narmada R | Compositions and methods for treating or preventing diseases of body passageways |
| JP2007313009A (ja) * | 2006-05-25 | 2007-12-06 | Terumo Corp | ステント |
| WO2008076383A2 (en) * | 2006-12-18 | 2008-06-26 | Med Institute Inc. | Stent graft with releasable therapeutic agent |
| KR100904207B1 (ko) | 2007-06-01 | 2009-06-25 | (주) 태웅메디칼 | 스텐트용 약물 방출 코팅제, 그의 제조방법 및 이 코팅제로 코팅된 약물 방출 스텐트 |
| AU2008202283B2 (en) | 2007-06-01 | 2011-01-20 | Kyong-Min Shin | Coating agent for drug releasing stent, preparation method thereof and drug releasing stent coated therewith |
| KR100988816B1 (ko) | 2008-01-29 | 2010-10-20 | 신경민 | 담즙관용 이중 피막형 스텐트 |
| NZ593343A (en) * | 2008-12-11 | 2013-04-26 | Abraxis Bioscience Llc | Combination cancer treatment conprising Abraxane and an inflamatory inhibitor |
| US20110045055A1 (en) * | 2009-08-21 | 2011-02-24 | Boston Scientific Scimed, Inc. | Medical devices containing therapeutic agents |
| CA2797110C (en) * | 2010-04-22 | 2020-07-21 | Micell Technologies, Inc. | Stents and other devices having extracellular matrix coating |
| US20120150282A1 (en) | 2010-12-10 | 2012-06-14 | Biotronik Ag | Implant having a paclitaxel-releasing coating |
| EP2696815B1 (en) | 2011-04-13 | 2019-03-20 | Micell Technologies, Inc. | Stents having controlled elution |
| EP2725103A3 (en) | 2011-11-14 | 2016-01-06 | Silenseed Ltd | Methods and compositions for treating prostate cancer |
| CN102727944A (zh) * | 2011-11-14 | 2012-10-17 | 上海市第一人民医院 | 抗胆管良、恶性狭窄的药物涂层支架及制备方法 |
| US8834902B2 (en) * | 2012-03-09 | 2014-09-16 | Q3 Medical Devices Limited | Biodegradable supporting device |
| CA2944480C (en) * | 2013-04-10 | 2021-05-18 | Massachusetts Institute Of Technology | Local drug delivery devices and methods for treating cancer |
-
2014
- 2014-04-10 CA CA2944480A patent/CA2944480C/en active Active
- 2014-04-10 WO PCT/US2014/033671 patent/WO2014169137A1/en not_active Ceased
- 2014-04-10 EP EP14727109.2A patent/EP2983730B1/en active Active
- 2014-04-10 ES ES14727109T patent/ES2762555T3/es active Active
- 2014-04-10 JP JP2016507662A patent/JP6431528B2/ja active Active
- 2014-04-10 US US14/250,025 patent/US9301926B2/en active Active
-
2016
- 2016-02-26 US US15/055,012 patent/US11167066B2/en active Active
-
2018
- 2018-11-02 JP JP2018207608A patent/JP2019034962A/ja active Pending
-
2021
- 2021-11-08 US US17/520,891 patent/US20220054719A1/en active Pending
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