JP2016516779A5 - - Google Patents

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JP2016516779A5
JP2016516779A5 JP2016507652A JP2016507652A JP2016516779A5 JP 2016516779 A5 JP2016516779 A5 JP 2016516779A5 JP 2016507652 A JP2016507652 A JP 2016507652A JP 2016507652 A JP2016507652 A JP 2016507652A JP 2016516779 A5 JP2016516779 A5 JP 2016516779A5
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Japan
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nhe
optionally substituted
alkyl
small molecule
binding small
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JP2016507652A
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Japanese (ja)
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JP2016516779A (ja
JP6377132B2 (ja
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Priority claimed from PCT/US2014/033603 external-priority patent/WO2014169094A2/en
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Publication of JP2016516779A5 publication Critical patent/JP2016516779A5/ja
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JP2016507652A 2013-04-12 2014-04-10 Nhe3結合化合物およびリン酸輸送の阻害方法 Active JP6377132B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361811613P 2013-04-12 2013-04-12
US61/811,613 2013-04-12
US201361888879P 2013-10-09 2013-10-09
US61/888,879 2013-10-09
PCT/US2014/033603 WO2014169094A2 (en) 2013-04-12 2014-04-10 Nhe3-binding compounds and methods for inhibiting phosphate transport

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018109684A Division JP6588600B2 (ja) 2013-04-12 2018-06-07 Nhe3結合化合物およびリン酸輸送の阻害方法

Publications (3)

Publication Number Publication Date
JP2016516779A JP2016516779A (ja) 2016-06-09
JP2016516779A5 true JP2016516779A5 (enExample) 2017-05-18
JP6377132B2 JP6377132B2 (ja) 2018-08-22

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Family Applications (6)

Application Number Title Priority Date Filing Date
JP2016507652A Active JP6377132B2 (ja) 2013-04-12 2014-04-10 Nhe3結合化合物およびリン酸輸送の阻害方法
JP2018109684A Active JP6588600B2 (ja) 2013-04-12 2018-06-07 Nhe3結合化合物およびリン酸輸送の阻害方法
JP2019166022A Withdrawn JP2020007350A (ja) 2013-04-12 2019-09-12 Nhe3結合化合物およびリン酸輸送の阻害方法
JP2021150682A Pending JP2021193129A (ja) 2013-04-12 2021-09-16 Nhe3結合化合物およびリン酸輸送の阻害方法
JP2023180663A Pending JP2024010040A (ja) 2013-04-12 2023-10-20 Nhe3結合化合物およびリン酸輸送の阻害方法
JP2025277433A Pending JP2026053537A (ja) 2013-04-12 2025-12-23 Nhe3結合化合物およびリン酸輸送の阻害方法

Family Applications After (5)

Application Number Title Priority Date Filing Date
JP2018109684A Active JP6588600B2 (ja) 2013-04-12 2018-06-07 Nhe3結合化合物およびリン酸輸送の阻害方法
JP2019166022A Withdrawn JP2020007350A (ja) 2013-04-12 2019-09-12 Nhe3結合化合物およびリン酸輸送の阻害方法
JP2021150682A Pending JP2021193129A (ja) 2013-04-12 2021-09-16 Nhe3結合化合物およびリン酸輸送の阻害方法
JP2023180663A Pending JP2024010040A (ja) 2013-04-12 2023-10-20 Nhe3結合化合物およびリン酸輸送の阻害方法
JP2025277433A Pending JP2026053537A (ja) 2013-04-12 2025-12-23 Nhe3結合化合物およびリン酸輸送の阻害方法

Country Status (27)

Country Link
US (4) US10272079B2 (enExample)
EP (3) EP3552630A1 (enExample)
JP (6) JP6377132B2 (enExample)
KR (4) KR20230132619A (enExample)
CN (2) CN105392483B (enExample)
AU (2) AU2014250956B2 (enExample)
BR (1) BR112015025805A2 (enExample)
CA (1) CA2909169A1 (enExample)
CY (1) CY1121929T1 (enExample)
DK (1) DK2983667T3 (enExample)
ES (1) ES2735992T3 (enExample)
HR (1) HRP20191000T1 (enExample)
HU (1) HUE044550T2 (enExample)
IL (3) IL284624B2 (enExample)
LT (1) LT2983667T (enExample)
MX (2) MX382203B (enExample)
NZ (1) NZ752535A (enExample)
PL (1) PL2983667T3 (enExample)
PT (1) PT2983667T (enExample)
RS (1) RS58969B1 (enExample)
RU (1) RU2675364C2 (enExample)
SI (1) SI2983667T1 (enExample)
SM (1) SMT201900386T1 (enExample)
TW (3) TWI724332B (enExample)
UY (1) UY35532A (enExample)
WO (1) WO2014169094A2 (enExample)
ZA (1) ZA201508006B (enExample)

Families Citing this family (15)

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US10543207B2 (en) 2008-12-31 2020-01-28 Ardelyx, Inc. Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
SMT201900386T1 (it) * 2013-04-12 2019-09-09 Ardelyx Inc Composti nhe3-leganti e metodi per l'inibizione del trasporto di fosfato
KR20160042039A (ko) 2013-08-09 2016-04-18 알데릭스, 인코포레이티드 인산염 수송을 억제하기 위한 화합물 및 방법
CN106536502B (zh) * 2014-07-25 2019-03-05 大正制药株式会社 被杂芳基取代的苯基四氢异喹啉化合物
JP6903923B2 (ja) * 2016-01-22 2021-07-14 大正製薬株式会社 ヘテロアリールで置換されたフェニルテトラヒドロイソキノリン化合物を有効成分として含有する医薬
JP2020505333A (ja) 2017-01-09 2020-02-20 アルデリックス, インコーポレイテッド Nhe媒介性アンチポートの阻害薬
AU2018205400C1 (en) 2017-01-09 2026-01-15 Ardelyx, Inc. Compounds useful for treating gastrointestinal tract disorders
WO2020051014A1 (en) 2018-09-04 2020-03-12 Teva Pharmaceuticals International Gmbh Processes for the preparation of tenapanor and intermediates thereof
CN113164515A (zh) * 2018-10-25 2021-07-23 艾尔金制药有限公司 用混合金属化合物治疗的方法
WO2020181555A1 (zh) * 2019-03-14 2020-09-17 深圳仁泰医药科技有限公司 Nhe3抑制剂的晶型a及其制备方法和应用
ES2927100T3 (es) 2019-05-16 2022-11-02 Lilly Co Eli Compuestos inhibidores del intercambiador de sodio-hidrógeno 3
WO2020237096A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Combination for lowering serum phosphate in a patient
CN112679427B (zh) * 2019-10-17 2023-05-12 江苏恒瑞医药股份有限公司 四氢异喹啉类衍生物、其制备方法及其在医药上的应用
AU2021391949A1 (en) 2020-12-04 2023-07-06 Ardelyx, Inc. Oral formulations of tenapanor
CN114805202A (zh) * 2021-01-28 2022-07-29 江西济民可信集团有限公司 苯磺酰胺类化合物及其制备方法和应用

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