CN105392483B - 用于抑制磷酸盐转运的nhe3结合化合物和方法 - Google Patents

用于抑制磷酸盐转运的nhe3结合化合物和方法 Download PDF

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CN105392483B
CN105392483B CN201480030634.XA CN201480030634A CN105392483B CN 105392483 B CN105392483 B CN 105392483B CN 201480030634 A CN201480030634 A CN 201480030634A CN 105392483 B CN105392483 B CN 105392483B
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nhe
compound
small molecule
phosphate
alkyl
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CN105392483A (zh
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C.卡雷拉斯
D.沙尔莫
J.W.雅各布斯
E.拉邦特
J.G.路易斯
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Ardelyx Inc
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Ardelyx Inc
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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CN201480030634.XA 2013-04-12 2014-04-10 用于抑制磷酸盐转运的nhe3结合化合物和方法 Active CN105392483B (zh)

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US201361888879P 2013-10-09 2013-10-09
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PCT/US2014/033603 WO2014169094A2 (en) 2013-04-12 2014-04-10 Nhe3-binding compounds and methods for inhibiting phosphate transport

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CN105392483B (zh) 2013-04-12 2019-03-15 阿德利克斯公司 用于抑制磷酸盐转运的nhe3结合化合物和方法
CA2920856C (en) * 2013-08-09 2026-03-03 Ardelyx, Inc. Ph modulating compounds for inhibiting gastrointestinal phosphate uptake
WO2016013657A1 (ja) 2014-07-25 2016-01-28 大正製薬株式会社 ヘテロアリールで置換されたフェニルテトラヒドロイソキノリン化合物
JP6903923B2 (ja) * 2016-01-22 2021-07-14 大正製薬株式会社 ヘテロアリールで置換されたフェニルテトラヒドロイソキノリン化合物を有効成分として含有する医薬
KR20240090875A (ko) * 2017-01-09 2024-06-21 알데릭스, 인코포레이티드 위장관 장애를 치료하는 데 유용한 화합물
EA201991676A1 (ru) * 2017-01-09 2020-01-30 Арделикс, Инк. Ингибиторы nhe-опосредованного антипорта
WO2020051014A1 (en) 2018-09-04 2020-03-12 Teva Pharmaceuticals International Gmbh Processes for the preparation of tenapanor and intermediates thereof
JP2022509447A (ja) * 2018-10-25 2022-01-20 エアジェン ファーマ リミテッド 混合金属化合物による処置方法
CN111954669B (zh) 2019-03-14 2023-04-07 深圳仁泰医药科技有限公司 Nhe3抑制剂的晶型a及其制备方法和应用
ES2927100T3 (es) * 2019-05-16 2022-11-02 Lilly Co Eli Compuestos inhibidores del intercambiador de sodio-hidrógeno 3
JP2022533251A (ja) * 2019-05-21 2022-07-21 アルデリックス， インコーポレイテッド 患者において血清リン酸塩を低下させるための組み合わせ
CN112679427B (zh) * 2019-10-17 2023-05-12 江苏恒瑞医药股份有限公司 四氢异喹啉类衍生物、其制备方法及其在医药上的应用
EP4255397B1 (en) 2020-12-04 2026-02-18 Ardelyx, Inc. Oral formulations of tenapanor
CN114805202A (zh) * 2021-01-28 2022-07-29 江西济民可信集团有限公司 苯磺酰胺类化合物及其制备方法和应用

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