JP2016516091A - 血管新生の誘導および調節のための組成物および方法、ならびに血管新生調節因子を同定する方法およびアッセイ - Google Patents

血管新生の誘導および調節のための組成物および方法、ならびに血管新生調節因子を同定する方法およびアッセイ Download PDF

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JP2016516091A
JP2016516091A JP2016506585A JP2016506585A JP2016516091A JP 2016516091 A JP2016516091 A JP 2016516091A JP 2016506585 A JP2016506585 A JP 2016506585A JP 2016506585 A JP2016506585 A JP 2016506585A JP 2016516091 A JP2016516091 A JP 2016516091A
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extract
angiogenesis
human
placental
protein
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JP2016516091A5 (cg-RX-API-DMAC10.html
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ピーター エス. マクフェトリッジ、
ピーター エス. マクフェトリッジ、
マーク シー. ムーア、
マーク シー. ムーア、
Original Assignee
ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド
ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド
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    • A—HUMAN NECESSITIES
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K38/19—Cytokines; Lymphokines; Interferons
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JP2016506585A 2013-04-02 2014-04-02 血管新生の誘導および調節のための組成物および方法、ならびに血管新生調節因子を同定する方法およびアッセイ Pending JP2016516091A (ja)

Applications Claiming Priority (3)

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US201361807401P 2013-04-02 2013-04-02
US61/807,401 2013-04-02
PCT/US2014/032696 WO2014165602A1 (en) 2013-04-02 2014-04-02 Compositions and methods for induction and modulation of angiogenesis and methods and assays for identifying angiogenesis modulators

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JP2016516091A true JP2016516091A (ja) 2016-06-02
JP2016516091A5 JP2016516091A5 (cg-RX-API-DMAC10.html) 2017-05-18

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US (2) US9821013B2 (cg-RX-API-DMAC10.html)
EP (1) EP2981273B1 (cg-RX-API-DMAC10.html)
JP (1) JP2016516091A (cg-RX-API-DMAC10.html)
KR (1) KR20150139569A (cg-RX-API-DMAC10.html)
AU (1) AU2014248198B2 (cg-RX-API-DMAC10.html)
CA (1) CA2908562A1 (cg-RX-API-DMAC10.html)
HK (1) HK1221402A1 (cg-RX-API-DMAC10.html)
WO (1) WO2014165602A1 (cg-RX-API-DMAC10.html)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5505760B2 (ja) 2005-09-27 2014-05-28 ティッシュテク・インコーポレーテッド 羊膜調製物及び精製組成物及びその使用方法
US9526770B2 (en) 2011-04-28 2016-12-27 Tissuetech, Inc. Methods of modulating bone remodeling
US9682044B2 (en) 2011-06-10 2017-06-20 Tissuetech, Inc. Methods of processing fetal support tissues, fetal support tissue powder products, and uses thereof
HK1221402A1 (zh) 2013-04-02 2017-06-02 University Of Florida Research Foundation, Inc. 用於诱导并调节血管生成的组合物和方法以及用於鉴别血管生成调节剂的方法和实验
TW201603818A (zh) 2014-06-03 2016-02-01 組織科技股份有限公司 組成物及方法
US20160243288A1 (en) 2015-02-23 2016-08-25 Tissuetech, Inc. Apparatuses and methods for treating ophthalmic diseases and disorders
US10342831B2 (en) 2015-05-20 2019-07-09 Tissuetech, Inc. Composition and methods for preventing the proliferation and epithelial-mesenchymal transition of epithelial cells
US12551509B2 (en) 2015-11-18 2026-02-17 Lucina Patent Holdco, Llc Acellular regenerative products and methods of their manufacture
TW201733600A (zh) 2016-01-29 2017-10-01 帝聖工業公司 胎兒扶持組織物及使用方法
WO2020036245A1 (ko) * 2018-08-17 2020-02-20 고려대학교 산학협력단 인간 신경줄기세포의 기능강화 및 생산을 위한 태반유래 세포 조건화 배지 및 이의 용도
US20210369630A1 (en) * 2018-10-17 2021-12-02 University Of Florida Research Foundation Magnetically responsive composite microparticles for triggered delivery of biologically active agents
WO2020201488A1 (en) 2019-04-04 2020-10-08 Hackethal Johannes A novel human-material-based platform technology for tissue engineering
EP4398888A1 (en) * 2021-09-07 2024-07-17 Plakous Therapeutics, Inc. Acellular placental therapies

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62129222A (ja) * 1985-08-30 1987-06-11 アメリカ合衆国 細胞培養組成物およびその用途
JPS63152322A (ja) * 1986-09-30 1988-06-24 Ichimaru Pharcos Co Ltd プラセンタ−組織由来フイブロネクチン含有溶液
JPS63501953A (ja) * 1985-12-17 1988-08-04 サイナ−ゲン,インコ−ポレ−テツド 毛管内皮細胞プロテア−ゼ合成、dna合成および遊走を促進することの出来るヒト胎盤血管形成誘導因子
JPH0931100A (ja) * 1995-07-24 1997-02-04 Nippon Ham Kk 変性コラーゲン及びその製造方法
WO2003082305A1 (en) * 2002-04-03 2003-10-09 Naohide Yamashita Drug containing human placenta-origin mesenchymal cells and process for producing vegf using the cells
JP2004517117A (ja) * 2001-01-05 2004-06-10 バイロメッド・リミテッド 抗血管新生タンパク質をコードする遺伝子またはその部分を含む慢性関節リウマチ治療用医薬組成物
JP2005065661A (ja) * 2003-08-20 2005-03-17 Akihiro Yamaguchi ヒト血管内皮細胞のVEGF誘導性活性化及び血管新生におけるIdの役割
JP2009510091A (ja) * 2005-09-27 2009-03-12 ティッシュテク・インコーポレーテッド 羊膜調製物及び精製組成物及びその使用方法
JP2010539938A (ja) * 2007-09-24 2010-12-24 ノーティス,インク. 灌流可能な微小血管システムを作製するための方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4994559A (en) 1985-12-17 1991-02-19 Synergen, Inc. Human basic fibroblast growth factor
CA2005600A1 (en) 1988-12-20 1990-06-20 Cal-Henrik Heldin Endothelial cell growth factor
AUPM425294A0 (en) * 1994-03-04 1994-03-31 Australian National University, The In-vitro angiogenesis assay
US5770565A (en) 1994-04-13 1998-06-23 La Jolla Cancer Research Center Peptides for reducing or inhibiting bone resorption
EP1183358A1 (en) 1999-06-07 2002-03-06 Edwards Lifesciences Corporation Targeted angiogenesis
US7163681B2 (en) 2000-08-07 2007-01-16 Centocor, Inc. Anti-integrin antibodies, compositions, methods and uses
CN1658848A (zh) 2002-04-12 2005-08-24 细胞基因公司 血管生成调节剂的鉴定方法,由此发现的化合物和使用该化合物的治疗方法
US8940292B2 (en) * 2003-01-28 2015-01-27 Wake Forest University Health Sciences Enhancement of angiogenesis to grafts using cells engineered to produce growth factors
US8192348B2 (en) * 2003-07-01 2012-06-05 Regents Of The University Of Minnesota Engineered blood vessels
US7775965B2 (en) 2004-03-09 2010-08-17 The Board Of Regents Of The University Of Oklahoma Decellularized grafts from umbilical cord vessels and process for preparing and using same
US8187639B2 (en) * 2005-09-27 2012-05-29 Tissue Tech, Inc. Amniotic membrane preparations and purified compositions and anti-angiogenesis treatment
US20080131522A1 (en) 2006-10-03 2008-06-05 Qing Liu Use of placental biomaterial for ocular surgery
KR20200136051A (ko) 2007-09-26 2020-12-04 안트로제네시스 코포레이션 인간 태반 관류액으로부터의 혈관형성 세포
WO2009100128A1 (en) * 2008-02-04 2009-08-13 Massachusetts Institute Of Technology Particulate delivery vehicles for embryoid bodies
WO2009116951A2 (en) * 2008-03-17 2009-09-24 Agency For Science, Technology And Research Microcarriers for stem cell culture
US8685634B2 (en) * 2009-03-06 2014-04-01 University of Pittsburgh—of the Commonwealth System of Higher Education Neural scaffolds
US9186365B2 (en) 2009-07-31 2015-11-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Antiangiogenic small molecules and methods of use
KR101118017B1 (ko) 2009-09-04 2012-02-24 (주)차바이오앤디오스텍 태반 추출물을 제조하는 방법 및 태반 추출물
CN102822521B (zh) * 2010-03-30 2016-01-27 西门子公司 具有间接蒸发的太阳能热发电站和运行这种太阳能热发电站的方法
KR20140071813A (ko) 2012-12-04 2014-06-12 삼성전자주식회사 파이버 상에 형성된 저항성 메모리 소자 및 그 제종 방법
HK1221402A1 (zh) 2013-04-02 2017-06-02 University Of Florida Research Foundation, Inc. 用於诱导并调节血管生成的组合物和方法以及用於鉴别血管生成调节剂的方法和实验

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62129222A (ja) * 1985-08-30 1987-06-11 アメリカ合衆国 細胞培養組成物およびその用途
JPS63501953A (ja) * 1985-12-17 1988-08-04 サイナ−ゲン,インコ−ポレ−テツド 毛管内皮細胞プロテア−ゼ合成、dna合成および遊走を促進することの出来るヒト胎盤血管形成誘導因子
JPS63152322A (ja) * 1986-09-30 1988-06-24 Ichimaru Pharcos Co Ltd プラセンタ−組織由来フイブロネクチン含有溶液
JPH0931100A (ja) * 1995-07-24 1997-02-04 Nippon Ham Kk 変性コラーゲン及びその製造方法
JP2004517117A (ja) * 2001-01-05 2004-06-10 バイロメッド・リミテッド 抗血管新生タンパク質をコードする遺伝子またはその部分を含む慢性関節リウマチ治療用医薬組成物
WO2003082305A1 (en) * 2002-04-03 2003-10-09 Naohide Yamashita Drug containing human placenta-origin mesenchymal cells and process for producing vegf using the cells
JP2005065661A (ja) * 2003-08-20 2005-03-17 Akihiro Yamaguchi ヒト血管内皮細胞のVEGF誘導性活性化及び血管新生におけるIdの役割
JP2009510091A (ja) * 2005-09-27 2009-03-12 ティッシュテク・インコーポレーテッド 羊膜調製物及び精製組成物及びその使用方法
JP2010539938A (ja) * 2007-09-24 2010-12-24 ノーティス,インク. 灌流可能な微小血管システムを作製するための方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BIOSCIENCE REPORTS, vol. 5, JPN6017049123, 1985, pages 783 - 790, ISSN: 0004008859 *
日本創傷治癒学会プログラム・抄録集, vol. 42nd, JPN6017049125, 2012, pages 152 - 094, ISSN: 0004008860 *

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