JP2016516000A5 - - Google Patents
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- JP2016516000A5 JP2016516000A5 JP2015556140A JP2015556140A JP2016516000A5 JP 2016516000 A5 JP2016516000 A5 JP 2016516000A5 JP 2015556140 A JP2015556140 A JP 2015556140A JP 2015556140 A JP2015556140 A JP 2015556140A JP 2016516000 A5 JP2016516000 A5 JP 2016516000A5
- Authority
- JP
- Japan
- Prior art keywords
- tissue
- cancer tissue
- molecule
- cancer
- interest
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000001519 tissue Anatomy 0.000 claims 54
- 239000002872 contrast media Substances 0.000 claims 4
- 206010006187 Breast cancer Diseases 0.000 claims 3
- 208000026310 Breast neoplasm Diseases 0.000 claims 3
- 206010008342 Cervix carcinoma Diseases 0.000 claims 3
- 206010009944 Colon cancer Diseases 0.000 claims 3
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 3
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 3
- 206010033128 Ovarian cancer Diseases 0.000 claims 3
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 3
- 206010060862 Prostate cancer Diseases 0.000 claims 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 3
- 208000000453 Skin Neoplasms Diseases 0.000 claims 3
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 3
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 201000010881 cervical cancer Diseases 0.000 claims 3
- 201000004101 esophageal cancer Diseases 0.000 claims 3
- 201000010536 head and neck cancer Diseases 0.000 claims 3
- 208000014829 head and neck neoplasm Diseases 0.000 claims 3
- 201000005202 lung cancer Diseases 0.000 claims 3
- 208000020816 lung neoplasm Diseases 0.000 claims 3
- 210000001165 lymph node Anatomy 0.000 claims 3
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 3
- 201000001441 melanoma Diseases 0.000 claims 3
- 201000002528 pancreatic cancer Diseases 0.000 claims 3
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 3
- 201000000849 skin cancer Diseases 0.000 claims 3
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 3
- 208000017572 squamous cell neoplasm Diseases 0.000 claims 3
- 201000002510 thyroid cancer Diseases 0.000 claims 3
- 238000012800 visualization Methods 0.000 claims 2
- 238000003384 imaging method Methods 0.000 claims 1
- 230000007170 pathology Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361758680P | 2013-01-30 | 2013-01-30 | |
| US61/758,680 | 2013-01-30 | ||
| PCT/US2014/013942 WO2014120974A1 (en) | 2013-01-30 | 2014-01-30 | Selective delivery molecules and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016516000A JP2016516000A (ja) | 2016-06-02 |
| JP2016516000A5 true JP2016516000A5 (enExample) | 2017-03-09 |
| JP6508781B2 JP6508781B2 (ja) | 2019-05-08 |
Family
ID=51262954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015556140A Expired - Fee Related JP6508781B2 (ja) | 2013-01-30 | 2014-01-30 | 選択的な送達分子及びその使用方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US9782498B2 (enExample) |
| EP (1) | EP2951210A4 (enExample) |
| JP (1) | JP6508781B2 (enExample) |
| KR (2) | KR102278630B1 (enExample) |
| CN (1) | CN105102484B (enExample) |
| AU (1) | AU2014212308B2 (enExample) |
| CA (2) | CA3128911C (enExample) |
| EA (1) | EA031930B1 (enExample) |
| HK (1) | HK1217720A1 (enExample) |
| MX (1) | MX366375B (enExample) |
| WO (1) | WO2014120974A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2403964B1 (en) | 2009-03-02 | 2021-09-08 | Massachusetts Institute of Technology | Methods and products for in vivo enzyme profiling |
| ES2881535T3 (es) | 2011-03-15 | 2021-11-29 | Massachusetts Inst Technology | Detección multiplexada con indicadores codificados con isótopos |
| DK2736533T3 (en) | 2011-07-29 | 2018-08-06 | Avelas Biosciences Inc | SELECTIVE SUBMISSION MOLECULES AND METHODS OF USE |
| CN105102484B (zh) | 2013-01-30 | 2020-03-10 | 艾维拉斯生物科学公司 | 选择性递送分子及使用方法 |
| WO2014197840A1 (en) | 2013-06-07 | 2014-12-11 | Massachusetts Institute Of Technology | Affinity-based detection of ligand-encoded synthetic biomarkers |
| EP3337514B8 (en) | 2015-08-18 | 2022-04-06 | Rakuten Medical, Inc. | Composition comprising a conjugate comprising a phthalocyanine dye linked to a targeting molecule for photoimmunotherapy |
| AU2016308286B2 (en) | 2015-08-18 | 2022-04-07 | Rakuten Medical, Inc. | Phthalocyanine dye conjugates and their storage |
| EP3380487B1 (en) | 2015-11-23 | 2020-09-02 | Bristol-Myers Squibb Company | Additive systems for use in protein pegylation |
| EP3440013A4 (en) | 2016-04-08 | 2021-03-17 | Massachusetts Institute of Technology | METHOD FOR SPECIFIC PROFILING OF PROTEASE ACTIVITY ON LYMPH NODES |
| CA3022928A1 (en) | 2016-05-05 | 2017-11-09 | Massachusetts Institute Of Technology | Methods and uses for remotely triggered protease activity measurements |
| AU2018248327B2 (en) | 2017-04-07 | 2024-10-10 | Massachusetts Institute Of Technology | Methods to spatially profile protease activity in tissue and sections |
| WO2019204363A2 (en) * | 2018-04-16 | 2019-10-24 | Avelas Biosciences, Inc. | Selective delivery of therapeutic and imaging agents |
| JP7458998B2 (ja) | 2018-06-01 | 2024-04-01 | ラクテン・メディカル，インコーポレイテッド | フタロシアニン色素コンジュゲート組成物 |
| WO2020068920A2 (en) | 2018-09-25 | 2020-04-02 | Massachusetts Institute Of Technology | Lung protease nanosensors and uses thereof |
| WO2020150560A1 (en) | 2019-01-17 | 2020-07-23 | Massachusetts Institute Of Technology | Sensors for detecting and imaging of cancer metastasis |
| US20220160871A1 (en) | 2019-03-29 | 2022-05-26 | Rakuten Medical, Inc. | Methods for photoimmunotherapy and related biomarkers |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4452720A (en) | 1980-06-04 | 1984-06-05 | Teijin Limited | Fluorescent composition having the ability to change wavelengths of light, shaped article of said composition as a light wavelength converting element and device for converting optical energy to electrical energy using said element |
| US4439356A (en) | 1981-03-03 | 1984-03-27 | Syva Company | Unsymmetrical fluorescein derivatives |
| US4496542A (en) | 1981-03-30 | 1985-01-29 | Usv Pharmaceutical Corporation | N-substituted-amido-amino acids |
| US4507389A (en) | 1982-12-16 | 1985-03-26 | Monsanto Company | Determination of collagenase by reacting with peptide substrates |
| US4466919A (en) | 1982-12-16 | 1984-08-21 | Monsanto Company | Peptide substrates for mammalian collagenase |
| US5330900A (en) | 1987-12-31 | 1994-07-19 | Tropix, Inc. | Chemiluminescent 3-(substituted adamant-2'-ylidene) 1,2-dioxetanes |
| US5066580A (en) | 1988-08-31 | 1991-11-19 | Becton Dickinson And Company | Xanthene dyes that emit to the red of fluorescein |
| GB8927722D0 (en) | 1989-12-07 | 1990-02-07 | British Bio Technology | Proteins and nucleic acids |
| US5674980A (en) | 1989-12-21 | 1997-10-07 | Biogen Inc | Fusion protein comprising tat-derived transport moiety |
| US6316003B1 (en) | 1989-12-21 | 2001-11-13 | Whitehead Institute For Biomedical Research | Tat-derived transport polypeptides |
| US5227487A (en) | 1990-04-16 | 1993-07-13 | Molecular Probes, Inc. | Certain tricyclic and pentacyclic-hetero nitrogen rhodol dyes |
| US5750409A (en) | 1991-11-18 | 1998-05-12 | Boehringer Mannheim Gmbh | Pentacyclic compounds and their use as absorption or fluorescent dyes |
| EP0800545B2 (en) | 1995-11-01 | 2011-03-02 | Bracco Research S.A. | Targeted magnetically labeled molecular marker systems for the nmr imaging |
| US5847162A (en) | 1996-06-27 | 1998-12-08 | The Perkin Elmer Corporation | 4, 7-Dichlororhodamine dyes |
| US6080852A (en) | 1996-06-27 | 2000-06-27 | The Perkin-Elmer Corporation | 4,7-dichlororhodamine dyes |
| US6214966B1 (en) * | 1996-09-26 | 2001-04-10 | Shearwater Corporation | Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution |
| GB9708265D0 (en) | 1997-04-24 | 1997-06-18 | Nycomed Imaging As | Contrast agents |
| CA2291074C (en) | 1997-05-21 | 2008-04-01 | The Board Of Trustees Of The Leland Stanford Junior University | Composition and method for enhancing transport across biological membranes |
| US6008379A (en) | 1997-10-01 | 1999-12-28 | The Perkin-Elmer Corporation | Aromatic-substituted xanthene dyes |
| US5936087A (en) | 1997-11-25 | 1999-08-10 | The Perkin-Elmer Corporation | Dibenzorhodamine dyes |
| US6592847B1 (en) | 1998-05-14 | 2003-07-15 | The General Hospital Corporation | Intramolecularly-quenched near infrared flourescent probes |
| US6083486A (en) | 1998-05-14 | 2000-07-04 | The General Hospital Corporation | Intramolecularly-quenched near infrared fluorescent probes |
| CA2328457A1 (en) | 1998-06-20 | 1999-12-29 | Washington University | Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy |
| DK1102785T3 (da) | 1999-06-07 | 2013-05-13 | Arrowhead Res Corp | Sammensætninger til lægemiddeltilførsel ved anvendelse af pH-følsomme molekyler |
| US6436703B1 (en) | 2000-03-31 | 2002-08-20 | Hyseq, Inc. | Nucleic acids and polypeptides |
| US20020009786A1 (en) | 2000-04-18 | 2002-01-24 | Tang Y. Tom | Novel nucleic acids and polypeptides |
| AU2002220082A1 (en) | 2000-10-19 | 2002-04-29 | The General Hospital Corporation | Imaging of enzymatic activity |
| US7179784B2 (en) | 2001-07-10 | 2007-02-20 | Massachusetts Institute Of Technology | Surfactant peptide nanostructures, and uses thereof |
| US20050042034A1 (en) | 2003-03-27 | 2005-02-24 | Longhorn Partners Pipeline, Lp | Pipeline trench system and method of encasing for spill containment |
| US7371364B2 (en) | 2003-08-15 | 2008-05-13 | Board Of Regents, The University Of Texas System | Cyclic peptide and imaging compound compositions and uses for targeted imaging and therapy |
| US7431915B2 (en) | 2003-10-31 | 2008-10-07 | The Regents Of The University Of California | Peptides whose uptake by cells is controllable |
| US9695251B2 (en) | 2003-10-31 | 2017-07-04 | The Regents Of The University Of California | Activatable cell penetrating peptides with quenched fluorophores |
| US7985401B2 (en) | 2003-10-31 | 2011-07-26 | The Regents Of The University Of California | Peptides whose uptake by cells is controllable |
| EP3434275A1 (en) | 2003-11-06 | 2019-01-30 | Seattle Genetics, Inc. | Assay for cancer cells based on the use of auristatin conjugates with antibodies |
| CN103755800B (zh) * | 2004-02-02 | 2016-02-24 | Ambrx公司 | 经修饰的人类生长激素多肽与其用途 |
| CA2583389A1 (en) | 2004-10-07 | 2006-04-20 | Emory University | Multifunctional nanoparticles conjugates and their use |
| NZ602170A (en) | 2008-02-08 | 2014-03-28 | Ambrx Inc | Modified leptin polypeptides and their uses |
| TW201004647A (en) | 2008-05-20 | 2010-02-01 | Sigma Tau Ind Farmaceuti | Novel dual targeting antitumoural conjugates |
| EP2344134B1 (en) * | 2008-09-23 | 2017-11-08 | The Regents of The University of California | Nanocarriers for drug delivery |
| PL2342223T3 (pl) * | 2008-09-26 | 2017-09-29 | Ambrx, Inc. | Zmodyfikowane polipeptydy zwierzęcej erytropoetyny i ich zastosowania |
| KR101095841B1 (ko) | 2009-02-19 | 2011-12-21 | 주식회사 나이벡 | 표적 선택적 세포／조직 투과기능 활성을 가지는 펩타이드 및 그 용도 |
| JP2012520856A (ja) | 2009-03-19 | 2012-09-10 | ゼネラル・エレクトリック・カンパニイ | 光学イメージング剤 |
| US8685372B2 (en) | 2009-04-15 | 2014-04-01 | The Regents Of The University Of California | Peptides and aptamers for targeting of neuron or nerves |
| EP2453926A4 (en) | 2009-07-15 | 2015-08-12 | Univ California | PEPTIDES WITH CONTROLLABLE CELLULAR RECORDING |
| JP5580625B2 (ja) | 2010-03-03 | 2014-08-27 | 住友化学株式会社 | メタンスルホン酸アルキルエステル溶液の製造方法 |
| JP5646923B2 (ja) | 2010-09-03 | 2014-12-24 | 矢崎総業株式会社 | 車両用表示装置及び車両用表示システム |
| EP2673003B1 (en) * | 2011-02-10 | 2018-11-07 | Ruprecht-Karls-Universität Heidelberg | Hydrophobic modified peptides for liver specific diagnosis |
| DK2736533T3 (en) * | 2011-07-29 | 2018-08-06 | Avelas Biosciences Inc | SELECTIVE SUBMISSION MOLECULES AND METHODS OF USE |
| US10029017B2 (en) | 2013-01-29 | 2018-07-24 | The Regents Of The University Of California | Pretargeted activatable cell penetrating peptide with intracellularly releasable prodrug |
| CN105102484B (zh) * | 2013-01-30 | 2020-03-10 | 艾维拉斯生物科学公司 | 选择性递送分子及使用方法 |
| HK1222122A1 (zh) | 2013-04-22 | 2017-06-23 | Avelas Biosciences, Inc. | 选择性药物递送组合物及使用方法 |
-
2014
- 2014-01-30 CN CN201480019153.9A patent/CN105102484B/zh not_active Expired - Fee Related
- 2014-01-30 US US14/764,681 patent/US9782498B2/en not_active Expired - Fee Related
- 2014-01-30 WO PCT/US2014/013942 patent/WO2014120974A1/en not_active Ceased
- 2014-01-30 AU AU2014212308A patent/AU2014212308B2/en not_active Ceased
- 2014-01-30 EP EP14746840.9A patent/EP2951210A4/en not_active Withdrawn
- 2014-01-30 MX MX2015009858A patent/MX366375B/es active IP Right Grant
- 2014-01-30 CA CA3128911A patent/CA3128911C/en active Active
- 2014-01-30 KR KR1020157022729A patent/KR102278630B1/ko not_active Expired - Fee Related
- 2014-01-30 HK HK16105781.4A patent/HK1217720A1/zh unknown
- 2014-01-30 JP JP2015556140A patent/JP6508781B2/ja not_active Expired - Fee Related
- 2014-01-30 EA EA201591284A patent/EA031930B1/ru unknown
- 2014-01-30 CA CA2899448A patent/CA2899448C/en active Active
- 2014-01-30 KR KR1020217021841A patent/KR102363779B1/ko not_active Expired - Fee Related
-
2017
- 2017-08-24 US US15/685,942 patent/US10226539B2/en active Active
-
2019
- 2019-01-31 US US16/264,296 patent/US11052160B2/en not_active Expired - Fee Related
-
2021
- 2021-05-03 US US17/302,453 patent/US20220257800A1/en not_active Abandoned
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