JP2016515583A - オキュラー・インサートおよびその使用方法 - Google Patents

オキュラー・インサートおよびその使用方法 Download PDF

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Publication number
JP2016515583A
JP2016515583A JP2016505557A JP2016505557A JP2016515583A JP 2016515583 A JP2016515583 A JP 2016515583A JP 2016505557 A JP2016505557 A JP 2016505557A JP 2016505557 A JP2016505557 A JP 2016505557A JP 2016515583 A JP2016515583 A JP 2016515583A
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JP
Japan
Prior art keywords
composition
bimatoprost
polymer
curing
med
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2016505557A
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English (en)
Japanese (ja)
Other versions
JP2016515583A5 (enExample
Inventor
キャリー ライヒ，
キャリー ライヒ，
カルロス シュラー，
カルロス シュラー，
チャン イエ，
チャン イエ，
ローガン スターク，
ローガン スターク，
ラカナ ジェーン，
ラカナ ジェーン，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ForSight Vision5 Inc
Original Assignee
ForSight Vision5 Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ForSight Vision5 Inc filed Critical ForSight Vision5 Inc
Publication of JP2016515583A publication Critical patent/JP2016515583A/ja
Publication of JP2016515583A5 publication Critical patent/JP2016515583A5/ja
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts or implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/08—Mydriatics or cycloplegics
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
    • C08L83/04—Polysiloxanes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Composite Materials (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
JP2016505557A 2013-03-27 2014-03-27 オキュラー・インサートおよびその使用方法 Pending JP2016515583A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361805895P 2013-03-27 2013-03-27
US61/805,895 2013-03-27
PCT/US2014/031955 WO2014160828A1 (en) 2013-03-27 2014-03-27 Bimatoprost ocular silicone inserts and methods of use thereof

Publications (2)

Publication Number Publication Date
JP2016515583A true JP2016515583A (ja) 2016-05-30
JP2016515583A5 JP2016515583A5 (enExample) 2017-09-21

Family

ID=50896504

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016505557A Pending JP2016515583A (ja) 2013-03-27 2014-03-27 オキュラー・インサートおよびその使用方法

Country Status (6)

Country Link
US (3) US20160022695A1 (enExample)
EP (1) EP2978406A1 (enExample)
JP (1) JP2016515583A (enExample)
AU (1) AU2014241201A1 (enExample)
CA (1) CA2907881A1 (enExample)
WO (1) WO2014160828A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5505760B2 (ja) 2005-09-27 2014-05-28 ティッシュテク・インコーポレーテッド 羊膜調製物及び精製組成物及びその使用方法
WO2014066775A1 (en) 2012-10-26 2014-05-01 Forsight Vision5, Inc. Ophthalmic system for sustained release of drug to eye
EP3223793B1 (en) * 2014-11-25 2023-06-28 Eximore Ltd. Compositions and methods for delivering a bio-active agent or bio-active agents
US20160243288A1 (en) * 2015-02-23 2016-08-25 Tissuetech, Inc. Apparatuses and methods for treating ophthalmic diseases and disorders
EP3283004A4 (en) 2015-04-13 2018-12-05 Forsight Vision5, Inc. Ocular insert composition of semi-crystalline or crystalline pharmaceutically active agent
US12551509B2 (en) 2015-11-18 2026-02-17 Lucina Patent Holdco, Llc Acellular regenerative products and methods of their manufacture
WO2018169967A1 (en) 2017-03-14 2018-09-20 Allergan, Inc. Acorafloxacin in treating ocular infections
EP3840750A1 (en) 2018-08-21 2021-06-30 Allergan, Inc. The use of alpha-2-adrenergic receptor agonists for improving vision
US11077053B2 (en) 2018-08-21 2021-08-03 Allergan, Inc. Alpha-2-adrenergic receptor agonists for treatment of presbyopia, visual glare, visual starbursts, visual halos and night myopia
US11376432B2 (en) 2019-03-26 2022-07-05 Twenty Twenty Therapeutics Llc Non-invasive periocular device for dry-eye treatment
US11298537B2 (en) 2019-03-26 2022-04-12 Twenty Twenty Therapeutics Llc Non-invasive periocular device for dry-eye treatment and closed-loop methods for operating same
US20210260042A1 (en) 2020-02-20 2021-08-26 Allergan, Inc. Alpha-2-adrenergic receptor agonists for reducing redness and increasing whiteness in eyes and other ophthalmic purposes
JP2023514732A (ja) 2020-02-20 2023-04-07 アラーガン、インコーポレイテッド アルファ－２－アドレナリン受容体アゴニストの医薬組成物および視力を改善するためのその使用
CA3171976A1 (en) * 2020-03-20 2021-09-23 Carlos Schuler Implantable drug delivery devices for localized drug delivery
WO2022251710A2 (en) 2021-05-28 2022-12-01 Sight Sciences, Inc. Intraocular devices, systems, and methods
CN114224822B (zh) * 2022-01-28 2023-07-14 复旦大学附属眼耳鼻喉科医院 一种眼部缓释给药植入物及其制造方法

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007535537A (ja) * 2004-04-30 2007-12-06 アラーガン、インコーポレイテッド プロスタミド含有生分解性眼内インプラント
JP2010513555A (ja) * 2006-12-19 2010-04-30 アラーガン、インコーポレイテッド 眼内使用のための環状脂質インプラントの製造法
US20100278898A1 (en) * 2004-04-30 2010-11-04 Allergan, Inc. Intraocular pressure reduction with intracameral bimatoprost implants
JP2010538696A (ja) * 2007-09-07 2010-12-16 キューエルティー プラグ デリバリー，インク． 治療薬剤の持続放出のための薬物コア
JP2011520805A (ja) * 2008-05-09 2011-07-21 キューエルティー プラグ デリバリー，インク． 緑内障および高眼圧症治療のための活性剤の持続送達
JP2012512904A (ja) * 2008-12-18 2012-06-07 アエリエ・ファーマシューティカルズ・インコーポレーテッド 治療薬の送達のための薬物送達装置
JP2012528695A (ja) * 2009-06-03 2012-11-15 フォーサイト・ラブス・エルエルシイ 前眼部薬物供給
WO2013040426A2 (en) * 2011-09-14 2013-03-21 Forsight Labs, Llc Ocular insert apparatus and methods

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4452776A (en) * 1979-08-20 1984-06-05 Eye Research Institute Of Retina Foundation Hydrogel implant article and method
IL143477A (en) 2001-05-31 2009-07-20 Finetech Pharmaceutical Ltd Process for the preparation of 17-phenyl-18,19,20-trinor-pgf2?? and its derivatives
UY30883A1 (es) * 2007-01-31 2008-05-31 Alcon Res Tapones punctales y metodos de liberacion de agentes terapeuticos
KR20120081227A (ko) * 2009-11-02 2012-07-18 샹하이 테크웰 바이오파마슈티컬 컴퍼니, 리미티드 비마토프로스트 결정 및 그의 제조방법과 용도

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007535537A (ja) * 2004-04-30 2007-12-06 アラーガン、インコーポレイテッド プロスタミド含有生分解性眼内インプラント
US20100278898A1 (en) * 2004-04-30 2010-11-04 Allergan, Inc. Intraocular pressure reduction with intracameral bimatoprost implants
JP2012121927A (ja) * 2004-04-30 2012-06-28 Allergan Inc プロスタミド含有生分解性眼内インプラント
JP2010513555A (ja) * 2006-12-19 2010-04-30 アラーガン、インコーポレイテッド 眼内使用のための環状脂質インプラントの製造法
JP2010538696A (ja) * 2007-09-07 2010-12-16 キューエルティー プラグ デリバリー，インク． 治療薬剤の持続放出のための薬物コア
JP2011520805A (ja) * 2008-05-09 2011-07-21 キューエルティー プラグ デリバリー，インク． 緑内障および高眼圧症治療のための活性剤の持続送達
JP2012512904A (ja) * 2008-12-18 2012-06-07 アエリエ・ファーマシューティカルズ・インコーポレーテッド 治療薬の送達のための薬物送達装置
JP2012528695A (ja) * 2009-06-03 2012-11-15 フォーサイト・ラブス・エルエルシイ 前眼部薬物供給
WO2013040426A2 (en) * 2011-09-14 2013-03-21 Forsight Labs, Llc Ocular insert apparatus and methods

Also Published As

Publication number Publication date
US20160022695A1 (en) 2016-01-28
US20180092926A1 (en) 2018-04-05
WO2014160828A1 (en) 2014-10-02
US20220331335A1 (en) 2022-10-20
AU2014241201A1 (en) 2015-10-15
EP2978406A1 (en) 2016-02-03
CA2907881A1 (en) 2014-10-02

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