JP2016512748A - 複数チャンバ式の注射デバイス - Google Patents
複数チャンバ式の注射デバイス Download PDFInfo
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- JP2016512748A JP2016512748A JP2016502910A JP2016502910A JP2016512748A JP 2016512748 A JP2016512748 A JP 2016512748A JP 2016502910 A JP2016502910 A JP 2016502910A JP 2016502910 A JP2016502910 A JP 2016502910A JP 2016512748 A JP2016512748 A JP 2016512748A
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- syringe
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- 238000002347 injection Methods 0.000 title abstract description 75
- 239000007924 injection Substances 0.000 title abstract description 75
- 229940079593 drug Drugs 0.000 claims abstract description 31
- 239000003814 drug Substances 0.000 claims abstract description 31
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 5
- 206010020751 Hypersensitivity Diseases 0.000 claims description 9
- 239000000739 antihistaminic agent Substances 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 8
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 claims description 7
- 229930182837 (R)-adrenaline Natural products 0.000 claims description 7
- 229960005139 epinephrine Drugs 0.000 claims description 7
- 239000012530 fluid Substances 0.000 claims description 7
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims description 6
- 230000001387 anti-histamine Effects 0.000 claims description 6
- 239000003246 corticosteroid Substances 0.000 claims description 6
- 239000000645 desinfectant Substances 0.000 claims description 5
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 4
- 239000003416 antiarrhythmic agent Substances 0.000 claims description 4
- 238000004891 communication Methods 0.000 claims description 4
- VHRSUDSXCMQTMA-PJHHCJLFSA-N 6alpha-methylprednisolone Chemical compound C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)CO)CC[C@H]21 VHRSUDSXCMQTMA-PJHHCJLFSA-N 0.000 claims description 3
- 208000030961 allergic reaction Diseases 0.000 claims description 3
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 claims description 2
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims description 2
- 230000000903 blocking effect Effects 0.000 claims description 2
- 229960003957 dexamethasone Drugs 0.000 claims description 2
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims description 2
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 claims description 2
- 229960000520 diphenhydramine Drugs 0.000 claims description 2
- 229960004194 lidocaine Drugs 0.000 claims description 2
- 229960004584 methylprednisolone Drugs 0.000 claims description 2
- 229960002748 norepinephrine Drugs 0.000 claims description 2
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 claims description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 2
- 230000003028 elevating effect Effects 0.000 claims 2
- 208000010125 myocardial infarction Diseases 0.000 claims 2
- 229940124572 antihypotensive agent Drugs 0.000 claims 1
- 235000010855 food raising agent Nutrition 0.000 claims 1
- 239000005526 vasoconstrictor agent Substances 0.000 claims 1
- 230000001681 protective effect Effects 0.000 description 7
- 230000008901 benefit Effects 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 238000011282 treatment Methods 0.000 description 5
- UCTWMZQNUQWSLP-UHFFFAOYSA-N adrenaline Chemical compound CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 description 4
- 208000003455 anaphylaxis Diseases 0.000 description 4
- 206010002198 Anaphylactic reaction Diseases 0.000 description 3
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- 230000009471 action Effects 0.000 description 3
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- 150000001875 compounds Chemical class 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 229940125715 antihistaminic agent Drugs 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000012459 cleaning agent Substances 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 239000011888 foil Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 150000003431 steroids Chemical class 0.000 description 2
- FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 description 1
- 206010002199 Anaphylactic shock Diseases 0.000 description 1
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 description 1
- MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 229960001334 corticosteroids Drugs 0.000 description 1
- 229960004544 cortisone Drugs 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000011221 initial treatment Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000011866 long-term treatment Methods 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 229940064748 medrol Drugs 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229960004618 prednisone Drugs 0.000 description 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
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- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/22—Valves or arrangement of valves
- A61M39/223—Multiway valves
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- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
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- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
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- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
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- A61M5/31515—Connection of piston with piston rod
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
- A61M5/321—Means for protection against accidental injuries by used needles
- A61M5/3213—Caps placed axially onto the needle, e.g. equipped with finger protection guards
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M2005/1787—Syringes for sequential delivery of fluids, e.g. first medicament and then flushing liquid
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- A—HUMAN NECESSITIES
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
- A61M2005/3107—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle for needles
- A61M2005/3109—Caps sealing the needle bore by use of, e.g. air-hardening adhesive, elastomer or epoxy resin
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3128—Incorporating one-way valves, e.g. pressure-relief or non-return valves
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- A—HUMAN NECESSITIES
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31501—Means for blocking or restricting the movement of the rod or piston
- A61M2005/31508—Means for blocking or restricting the movement of the rod or piston provided on the piston-rod
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- A—HUMAN NECESSITIES
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- A61M5/178—Syringes
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- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
- A61M2005/31518—Piston or piston-rod constructions, e.g. connection of piston with piston-rod designed to reduce the overall size of an injection device, e.g. using flexible or pivotally connected chain-like rod members
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- A61M2205/6081—Colour codes
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- Environmental & Geological Engineering (AREA)
- Pulmonology (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
この出願は、2013年3月15日に出願され、「Multi−Chamber Injection Device」と題された同時係属の米国仮特許出願第61/801,275号の利益を主張するものである。米国仮特許出願第61/801,275号は、それの全体が参照によって本明細書に組み込まれる。
出願は、特定の構造上の特徴、化合物/組成物、及び/または方法論的な動作を有する実施態様を説明するが、特許請求の範囲は、説明された特定の特徴または動作に必ずしも限定されないことが理解されることになる。むしろ、特定の特徴及び動作は、出願の特許請求の範囲内にある単に例示的ないくつかの実施態様に過ぎない。
Claims (30)
- 複数チャンバ注射器であって、
互いに垂直に及び中心軸に垂直に配備された3つ以上のチャンバと、
前記チャンバのそれぞれと関連されるプランジャーと、
出口本体であって、前記出口本体の少なくとも一部分が、前記中心軸の周りに回転して、出口を前記チャンバの1つと流体連通して位置付ける一方で、他のチャンバからの流体の放出をブロックするように、前記チャンバに回転可能に接続された、出口本体と、を備える、複数チャンバ注射器。 - 前記チャンバの2つ以上が、同じ医学的状態を治療するために共に使用可能である異なる薬品を含有する、請求項1に記載の注射器。
- 前記他のチャンバに及び前記中心軸に垂直に配備された第4のチャンバを更に備え、前記第4のチャンバが、エピネフリンを含有する、請求項1に記載の注射器。
- 前記チャンバの1つ以上の容積が、約1mLから約140mLである、請求項1または3に記載の注射器。
- 前記3つ以上のチャンバが、材料の単一の部分から形成される、請求項1または3のいずれかに記載の注射器。
- 前記3つ以上のチャンバが、材料の2つ以上の部分から形成され、前記チャンバが、前記出口本体への取り付けによって互いに対して適所に固定される、請求項1または3のいずれかに記載の注射器。
- 前記出口本体が、ただ1つの出口を有する、請求項1または3のいずれかに記載の注射器。
- 前記出口本体が、前記チャンバに固定して取り付けられた第1の部分と、前記第1の部分に回転可能に結合された及び前記中心軸の周りに前記第1の部分に対して回転するように構成された第2の部分と、を有する、請求項1または3のいずれかに記載の注射器。
- 前記出口が、中空針を備える、請求項1または3のいずれかに記載の注射器。
- 前記出口が、ルアーコネクタを備える、請求項1または3のいずれかに記載の注射器。
- 前記医学的状態が、アレルギー反応であり、第1のチャンバが、エピネフリンを含有し、第2のチャンバが、抗ヒスタミン剤を含有し、第3のチャンバが、コルチコステロイドを含有する、請求項1または3のいずれかに記載の注射器。
- 第4のチャンバが、エピネフリンを含有する、請求項11に記載の注射器。
- 前記抗ヒスタミン剤が、ジフェンヒドラミンを含む、請求項11に記載の注射器。
- 前記コルチコステロイドが、デキサメタゾン、メチルプレドニゾロン、または両方を含む、請求項11に記載の注射器。
- 前記医学的状態が、心臓発作であり、第1のチャンバが、抗不整脈薬を含有し、第2のチャンバが、昇圧剤を含有し、第3のチャンバが、pH昇降剤を含有する、請求項1のいずれかに記載の注射器。
- 前記抗不整脈薬が、リドカインを含む、請求項15に記載の注射器。
- 前記昇圧剤が、ノルエピネフリンを含む、請求項15に記載の注射器。
- 前記pH昇降剤が、重炭酸ナトリウムを含む、請求項15のいずれかに記載の注射器。
- 前記プランジャーのうちの少なくとも1つの不慮の動作を防止するためのプランジャーロックを更に備える、請求項1または3のいずれかに記載の注射器。
- 前記出口を取り外し可能に覆う蓋を更に備える、請求項1または3のいずれかに記載の注射器。
- 前記蓋が、1つ以上の針のための収納部を備える、請求項20に記載の注射器。
- 前記蓋が、消毒剤を含有するスポンジを備える、請求項20に記載の注射器。
- デバイスであって、
チャンバ、前記チャンバと関連したプランジャー、及び前記チャンバと流体連通した中空針をそれぞれ有する複数の注射器と、
前記複数の注射器を収容するように構成された容器と、
前記容器内に前記注射器を前記注射器の長さの次元で互いに平行に配向させて保持するように構成された前記容器内のホルダーと、を備え、前記複数の注射器の少なくとも2つの別個のものが、同じ医学的状態を治療するために共に使用可能な異なる薬品を予め充填される、デバイス。 - 前記複数の注射器が、3つ以上の注射器を備える、請求項23に記載のデバイス。
- 前記複数の注射器が、4つ以上の注射器を備える、請求項24に記載のデバイス。
- 前記複数の注射器が、前記容器内に線形に装着される、請求項23、24、または25に記載のデバイス。
- 前記複数の注射器が、前記容器内に円形に装着される、請求項23、24、または25に記載のデバイス。
- 前記複数の注射器が、ホルダー内に取り外し可能に装着される、請求項23、24、または25に記載のデバイス。
- 前記医学的状態が、アレルギー反応であり、第1の注射器が、エピネフリンを含有し、第2の注射器が、抗ヒスタミン剤を含有し、第3の注射器が、コルチコステロイドを含有する、請求項23、24、または25に記載のデバイス。
- 前記医学的状態が、心臓発作であり、第1の注射器が、抗不整脈薬を含有し、第2の注射器が、昇圧剤を含有し、第3の注射器が、pH昇降剤を含有する、請求項23、24、または25に記載のデバイス。
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US61/801,275 | 2013-03-15 | ||
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CN105050639A (zh) | 2015-11-11 |
WO2014144416A1 (en) | 2014-09-18 |
JP6422479B2 (ja) | 2018-11-14 |
CA2903832C (en) | 2022-03-22 |
RU2684037C2 (ru) | 2019-04-03 |
US20160030671A1 (en) | 2016-02-04 |
EP2968762B1 (en) | 2021-04-21 |
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SG10201707147RA (en) | 2017-10-30 |
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BR112015023007B1 (pt) | 2022-03-15 |
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