JP2016512563A5 - - Google Patents
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- Publication number
- JP2016512563A5 JP2016512563A5 JP2016501988A JP2016501988A JP2016512563A5 JP 2016512563 A5 JP2016512563 A5 JP 2016512563A5 JP 2016501988 A JP2016501988 A JP 2016501988A JP 2016501988 A JP2016501988 A JP 2016501988A JP 2016512563 A5 JP2016512563 A5 JP 2016512563A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutical composition
- anticancer agent
- dihydrochloride
- butanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 16
- LRHPLDYGYMQRHN-UHFFFAOYSA-N n-butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims 10
- 239000002246 antineoplastic agent Substances 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- XEKOWRVHYACXOJ-UHFFFAOYSA-N acetic acid ethyl ester Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 3
- 238000010438 heat treatment Methods 0.000 claims 3
- 229910000041 hydrogen chloride Inorganic materials 0.000 claims 3
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M NaHCO3 Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000003472 neutralizing Effects 0.000 claims 2
- 238000010992 reflux Methods 0.000 claims 2
- ZMANZCXQSJIPKH-UHFFFAOYSA-N triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- BRADBAOVPACOQQ-UHFFFAOYSA-N hydron;methyl 1-benzyl-4-oxopiperidine-3-carboxylate;chloride Chemical compound Cl.C1CC(=O)C(C(=O)OC)CN1CC1=CC=CC=C1 BRADBAOVPACOQQ-UHFFFAOYSA-N 0.000 claims 1
- 150000007529 inorganic bases Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- PHTILULPLFUXPS-UHFFFAOYSA-N methyl 1-benzyl-4-oxopiperidine-3-carboxylate Chemical compound C1CC(=O)C(C(=O)OC)CN1CC1=CC=CC=C1 PHTILULPLFUXPS-UHFFFAOYSA-N 0.000 claims 1
- 150000007530 organic bases Chemical class 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361779828P | 2013-03-13 | 2013-03-13 | |
| US61/779,828 | 2013-03-13 | ||
| US201361904718P | 2013-11-15 | 2013-11-15 | |
| US61/904,718 | 2013-11-15 | ||
| PCT/US2014/025885 WO2014160130A1 (en) | 2013-03-13 | 2014-03-13 | Combination therapy with 7-benzyl-10-(2-methylbenzyl)-2,6,7,8,9,10-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(3h)-one |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018119005A Division JP2018184411A (ja) | 2013-03-13 | 2018-06-22 | 癌に対する薬剤併用療法のための化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016512563A JP2016512563A (ja) | 2016-04-28 |
| JP2016512563A5 true JP2016512563A5 (zh) | 2017-04-13 |
| JP6446025B2 JP6446025B2 (ja) | 2018-12-26 |
Family
ID=51527915
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016501988A Active JP6446025B2 (ja) | 2013-03-13 | 2014-03-13 | 癌に対する薬剤併用療法のための化合物 |
| JP2018119005A Pending JP2018184411A (ja) | 2013-03-13 | 2018-06-22 | 癌に対する薬剤併用療法のための化合物 |
| JP2020114024A Pending JP2020172510A (ja) | 2013-03-13 | 2020-07-01 | 癌に対する薬剤併用療法のための化合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018119005A Pending JP2018184411A (ja) | 2013-03-13 | 2018-06-22 | 癌に対する薬剤併用療法のための化合物 |
| JP2020114024A Pending JP2020172510A (ja) | 2013-03-13 | 2020-07-01 | 癌に対する薬剤併用療法のための化合物 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US9265765B2 (zh) |
| EP (2) | EP2968294B1 (zh) |
| JP (3) | JP6446025B2 (zh) |
| KR (2) | KR20220123335A (zh) |
| CN (1) | CN105530937A (zh) |
| AU (3) | AU2014244117B2 (zh) |
| BR (1) | BR112015023256A2 (zh) |
| CA (2) | CA3204801A1 (zh) |
| CY (1) | CY1121735T1 (zh) |
| DK (1) | DK2968294T3 (zh) |
| EA (1) | EA037937B1 (zh) |
| ES (1) | ES2734568T3 (zh) |
| HK (1) | HK1217653A1 (zh) |
| HR (1) | HRP20191181T1 (zh) |
| HU (1) | HUE044238T2 (zh) |
| IL (2) | IL241452B (zh) |
| LT (1) | LT2968294T (zh) |
| ME (1) | ME03470B (zh) |
| MX (2) | MX2015012636A (zh) |
| NZ (2) | NZ711948A (zh) |
| PL (1) | PL2968294T3 (zh) |
| PT (1) | PT2968294T (zh) |
| RS (1) | RS59013B1 (zh) |
| SG (2) | SG11201507247WA (zh) |
| SI (1) | SI2968294T1 (zh) |
| WO (1) | WO2014160130A1 (zh) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4335511A3 (en) | 2011-04-29 | 2024-05-15 | The Penn State Research Foundation | Small molecule trail gene induction by normal and tumor cells as an anticancer therapy |
| US9376437B2 (en) | 2013-03-13 | 2016-06-28 | Oncoceutics, Inc | 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, salts thereof and methods of using the same in combination therapy |
| JP6446025B2 (ja) | 2013-03-13 | 2018-12-26 | オンコシューティクス インコーポレイテッドＯｎｃｏｃｅｕｔｉｃｓ，Ｉｎｃ． | 癌に対する薬剤併用療法のための化合物 |
| US20160067337A1 (en) | 2013-03-14 | 2016-03-10 | Bristol-Myers Squibb Company | Combination of dr5 agonist and anti-pd-1 antagonist and methods of use |
| CA3129892A1 (en) | 2014-03-12 | 2015-09-17 | Yeda Research And Development Co. Ltd. | Reducing systemic regulatory t cell levels or activity for treatment of disease and injury of the cns |
| US10519237B2 (en) | 2014-03-12 | 2019-12-31 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| US10618963B2 (en) | 2014-03-12 | 2020-04-14 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| US9394365B1 (en) | 2014-03-12 | 2016-07-19 | Yeda Research And Development Co., Ltd | Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease |
| JP6756435B2 (ja) * | 2014-03-31 | 2020-09-16 | ザ スクリプス リサーチ インスティテュート | Ｔｒａｉｌ誘導のためのファーマコフォア |
| CA3209519A1 (en) * | 2015-01-30 | 2016-08-04 | Oncoceutics, Inc. | 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo [1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, analogs thereof, and salts thereof and methods for their use in therapy |
| CN104860948B (zh) | 2015-05-15 | 2017-09-26 | 南京盖特医药技术有限公司 | 咪唑并嘧啶酮类化合物及其制备方法和应用 |
| SI3640345T1 (sl) | 2015-08-17 | 2022-01-31 | Kura Oncology, Inc. | Postopki za zdravljenje rakavih pacientov z inhibitorji farneziltransferaze |
| KR20170037260A (ko) | 2015-09-25 | 2017-04-04 | 현대자동차주식회사 | 차량용 배터리 시스템 및 그 제어 방법 |
| MX2018009227A (es) | 2016-01-29 | 2018-11-09 | Oncoceutics Inc | Modulacion del receptor acoplado a proteina g (gpcr) por imipridones. |
| LT3423105T (lt) | 2016-03-02 | 2021-09-10 | Eisai R&D Management Co., Ltd. | Antikūno-vaisto konjugatai eribulino pagrindu ir jų panaudojimo būdai |
| KR20170110520A (ko) * | 2016-03-23 | 2017-10-11 | 고려대학교 산학협력단 | mTOR 억제제 및 N-아세틸시스테인을 포함하는 간섬유화 억제용 조성물 |
| US11559510B2 (en) | 2016-04-06 | 2023-01-24 | Noxopharm Limited | Isoflavonoid composition with improved pharmacokinetics |
| AU2017247006B2 (en) * | 2016-04-06 | 2022-05-12 | Noxopharm Limited | Radiotherapy improvements |
| CN109789144B (zh) * | 2016-08-12 | 2022-04-15 | 马德拉医疗公司 | 蛋白激酶调节剂 |
| EP3838275A1 (en) | 2016-11-03 | 2021-06-23 | Kura Oncology, Inc. | Farnesyltransferase inhibitors for use in methods of treating cancer |
| EP3565548A4 (en) * | 2017-01-04 | 2020-10-14 | The Board of Trustees of the Leland Stanford Junior University | TARGET GENES IN MYC-INDUCED NEOPLASIA |
| MX2019008458A (es) | 2017-01-17 | 2019-12-02 | Heparegenix Gmbh | Inhibidores de proteina cinasa para promover la regeneracion hepatica o reducir o prevenir la muerte de hepatocitos. |
| US10172862B2 (en) * | 2017-01-30 | 2019-01-08 | Oncoceutics, Inc. | Imipridones for gliomas |
| IT201800004082A1 (it) * | 2018-03-29 | 2019-09-29 | Berlin Chemie Ag | Composizioni farmaceutiche antitumorali per terapia combinata |
| US20200046703A1 (en) * | 2018-08-09 | 2020-02-13 | Asymmetric Therapeutics, Llc | Compositions and methods for treatment of the side-effects associated with administration of therapeutic agents |
| US11633399B2 (en) | 2018-12-25 | 2023-04-25 | Sol-Gel Technologies Ltd. | Treatment of skin disorders with compositions comprising an EGFR inhibitor |
| CN113286594B (zh) * | 2019-01-18 | 2023-12-15 | 南京明德新药研发有限公司 | 吡啶并嘧啶类化合物在制备治疗鼻咽癌药物中的应用 |
| EP3725370A1 (en) | 2019-04-19 | 2020-10-21 | ImmunoBrain Checkpoint, Inc. | Modified anti-pd-l1 antibodies and methods and uses for treating a neurodegenerative disease |
| AU2020390236A1 (en) * | 2019-11-28 | 2022-07-14 | Inxmed (Nanjing) Co., Ltd. | Use of BI853520 in cancer treatment |
| AU2021247415A1 (en) | 2020-03-30 | 2022-09-29 | Noxopharm Limited | Methods for the treatment of inflammation associated with infection |
| CN117599041B (zh) * | 2024-01-22 | 2024-05-03 | 中国人民解放军军事科学院军事医学研究院 | 去氢雌马酚及其衍生物作为新型辐射防护剂和细胞保护剂的医药用途 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2150062A1 (de) | 1971-10-07 | 1973-04-12 | Boehringer Sohn Ingelheim | Imidazo- eckige klammer auf 1,2-a eckige klammer zu -pyrido- eckige klammer auf 4,3-d eckige klammer zu -pyrimidine, deren saeureadditionssalze und verfahren zu deren herstellung |
| US4642345A (en) | 1980-08-14 | 1987-02-10 | Mead Johnson & Company | 6,7-dihydro-3H-imidazo[1,2-a]-purine-9(4H)-ones |
| US7635690B2 (en) | 1999-01-22 | 2009-12-22 | Emory University | HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine |
| US7351729B2 (en) | 2002-03-08 | 2008-04-01 | Signal Pharmaceuticals, Llc | JNK inhibitors for use in combination therapy for treating or managing proliferative disorders and cancers |
| US20050043233A1 (en) | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
| KR101914254B1 (ko) | 2005-02-18 | 2018-11-02 | 아브락시스 바이오사이언스, 엘엘씨 | 치료제의 조합 및 투여 방식, 및 조합 요법 |
| US20080221135A1 (en) | 2005-05-13 | 2008-09-11 | Bristol-Myers Squibb Company | Combination therapy |
| US20110287001A1 (en) | 2008-09-22 | 2011-11-24 | Tetralogic Pharmaceuticals | Method of treatment |
| WO2010068925A1 (en) | 2008-12-11 | 2010-06-17 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
| US9724337B2 (en) | 2009-04-21 | 2017-08-08 | University Of Kentucky Research Foundation | AG-205 for the treatment of breast cancer |
| DE102010014426A1 (de) * | 2010-04-01 | 2011-10-06 | Bayer Schering Pharma Aktiengesellschaft | Verwendung neuer pan-CDK-Inhibitoren zur Behandlung von Tumoren |
| EP4335511A3 (en) * | 2011-04-29 | 2024-05-15 | The Penn State Research Foundation | Small molecule trail gene induction by normal and tumor cells as an anticancer therapy |
| US8377946B1 (en) | 2011-12-30 | 2013-02-19 | Pharmacyclics, Inc. | Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors |
| JP6446025B2 (ja) | 2013-03-13 | 2018-12-26 | オンコシューティクス インコーポレイテッドＯｎｃｏｃｅｕｔｉｃｓ，Ｉｎｃ． | 癌に対する薬剤併用療法のための化合物 |
| JP6756435B2 (ja) | 2014-03-31 | 2020-09-16 | ザ スクリプス リサーチ インスティテュート | Ｔｒａｉｌ誘導のためのファーマコフォア |
-
2014
- 2014-03-13 JP JP2016501988A patent/JP6446025B2/ja active Active
- 2014-03-13 KR KR1020227029471A patent/KR20220123335A/ko not_active Application Discontinuation
- 2014-03-13 RS RS20190874A patent/RS59013B1/sr unknown
- 2014-03-13 EA EA201591715A patent/EA037937B1/ru unknown
- 2014-03-13 NZ NZ711948A patent/NZ711948A/en unknown
- 2014-03-13 NZ NZ751509A patent/NZ751509A/en active IP Right Revival
- 2014-03-13 EP EP14775569.8A patent/EP2968294B1/en active Active
- 2014-03-13 WO PCT/US2014/025885 patent/WO2014160130A1/en active Application Filing
- 2014-03-13 HU HUE14775569 patent/HUE044238T2/hu unknown
- 2014-03-13 AU AU2014244117A patent/AU2014244117B2/en not_active Ceased
- 2014-03-13 EP EP19171477.3A patent/EP3572083A1/en not_active Withdrawn
- 2014-03-13 SG SG11201507247WA patent/SG11201507247WA/en unknown
- 2014-03-13 MX MX2015012636A patent/MX2015012636A/es active IP Right Grant
- 2014-03-13 PT PT14775569T patent/PT2968294T/pt unknown
- 2014-03-13 LT LTEP14775569.8T patent/LT2968294T/lt unknown
- 2014-03-13 ES ES14775569T patent/ES2734568T3/es active Active
- 2014-03-13 KR KR1020157028393A patent/KR102438135B1/ko active IP Right Grant
- 2014-03-13 SI SI201431257T patent/SI2968294T1/sl unknown
- 2014-03-13 US US14/208,657 patent/US9265765B2/en active Active
- 2014-03-13 DK DK14775569.8T patent/DK2968294T3/da active
- 2014-03-13 CN CN201480022856.7A patent/CN105530937A/zh active Pending
- 2014-03-13 PL PL14775569T patent/PL2968294T3/pl unknown
- 2014-03-13 SG SG10201808496VA patent/SG10201808496VA/en unknown
- 2014-03-13 ME MEP-2019-197A patent/ME03470B/me unknown
- 2014-03-13 CA CA3204801A patent/CA3204801A1/en active Pending
- 2014-03-13 CA CA2905037A patent/CA2905037C/en active Active
- 2014-03-13 BR BR112015023256A patent/BR112015023256A2/pt not_active Application Discontinuation
-
2015
- 2015-09-10 IL IL241452A patent/IL241452B/en active IP Right Grant
- 2015-09-11 MX MX2019013643A patent/MX2019013643A/es unknown
-
2016
- 2016-05-19 HK HK16105766.3A patent/HK1217653A1/zh unknown
-
2018
- 2018-06-22 JP JP2018119005A patent/JP2018184411A/ja active Pending
-
2019
- 2019-03-19 AU AU2019201896A patent/AU2019201896A1/en not_active Abandoned
- 2019-07-01 HR HRP20191181TT patent/HRP20191181T1/hr unknown
- 2019-07-01 CY CY20191100687T patent/CY1121735T1/el unknown
-
2020
- 2020-06-23 IL IL275623A patent/IL275623A/en unknown
- 2020-07-01 JP JP2020114024A patent/JP2020172510A/ja active Pending
- 2020-09-14 AU AU2020233606A patent/AU2020233606A1/en not_active Abandoned
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