JP2016512244A5 - - Google Patents
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- Publication number
- JP2016512244A5 JP2016512244A5 JP2016500174A JP2016500174A JP2016512244A5 JP 2016512244 A5 JP2016512244 A5 JP 2016512244A5 JP 2016500174 A JP2016500174 A JP 2016500174A JP 2016500174 A JP2016500174 A JP 2016500174A JP 2016512244 A5 JP2016512244 A5 JP 2016512244A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- oral administration
- epithelial barrier
- gastrointestinal epithelial
- barrier permeation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004082 barrier epithelial cell Anatomy 0.000 claims 15
- 230000004890 epithelial barrier function Effects 0.000 claims 15
- 230000002496 gastric effect Effects 0.000 claims 15
- 229920001661 Chitosan Polymers 0.000 claims 12
- 239000004365 Protease Substances 0.000 claims 11
- 239000003623 enhancer Substances 0.000 claims 11
- 108010004032 Bromelains Proteins 0.000 claims 9
- 235000019835 bromelain Nutrition 0.000 claims 9
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims 6
- 150000004676 glycans Chemical class 0.000 claims 6
- 229920001282 polysaccharide Polymers 0.000 claims 6
- 239000005017 polysaccharide Substances 0.000 claims 6
- 239000003055 low molecular weight heparin Substances 0.000 claims 5
- 229940127215 low-molecular weight heparin Drugs 0.000 claims 5
- 102000000591 Tight Junction Proteins Human genes 0.000 claims 4
- 108010002321 Tight Junction Proteins Proteins 0.000 claims 4
- 210000001578 tight junction Anatomy 0.000 claims 4
- 108091005804 Peptidases Proteins 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 102000035195 Peptidases Human genes 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- 239000003613 bile acid Substances 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 235000019419 proteases Nutrition 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361778113P | 2013-03-12 | 2013-03-12 | |
| US61/778,113 | 2013-03-12 | ||
| PCT/US2014/012360 WO2014158321A1 (en) | 2013-03-12 | 2014-01-21 | Resorption enhancers as additives to improve the oral formulation of low molecular weight heparins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018138582A Division JP2018184445A (ja) | 2013-03-12 | 2018-07-24 | 低分子ヘパリンの経口製剤を改善するための添加剤としての吸収エンハンサ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016512244A JP2016512244A (ja) | 2016-04-25 |
| JP2016512244A5 true JP2016512244A5 (enExample) | 2017-02-09 |
| JP6377121B2 JP6377121B2 (ja) | 2018-08-22 |
Family
ID=51527951
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016500174A Expired - Fee Related JP6377121B2 (ja) | 2013-03-12 | 2014-01-21 | 低分子ヘパリンの経口製剤を改善するための添加剤としての吸収エンハンサ |
| JP2018138582A Pending JP2018184445A (ja) | 2013-03-12 | 2018-07-24 | 低分子ヘパリンの経口製剤を改善するための添加剤としての吸収エンハンサ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018138582A Pending JP2018184445A (ja) | 2013-03-12 | 2018-07-24 | 低分子ヘパリンの経口製剤を改善するための添加剤としての吸収エンハンサ |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9265791B2 (enExample) |
| EP (2) | EP2968400B1 (enExample) |
| JP (2) | JP6377121B2 (enExample) |
| AU (1) | AU2014242354B2 (enExample) |
| DK (1) | DK2968400T3 (enExample) |
| ES (1) | ES2732659T3 (enExample) |
| WO (1) | WO2014158321A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111983207A (zh) * | 2019-05-23 | 2020-11-24 | 宁德市医院 | 一种血栓弹力图仪全血质控品及配制方法 |
| CN111658658B (zh) * | 2020-06-17 | 2023-08-11 | 上海大学 | 低聚木糖在制备抗深静脉血栓的药物中的应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL79254A0 (en) | 1986-06-26 | 1986-09-30 | Hadassah Med Org | Compositions for preventing graft rejection |
| US5831005A (en) | 1992-09-24 | 1998-11-03 | Chiron Corporation | Synthesis of N-substituted oligomers |
| US5877278A (en) | 1992-09-24 | 1999-03-02 | Chiron Corporation | Synthesis of N-substituted oligomers |
| JP3714426B2 (ja) | 1994-02-01 | 2005-11-09 | 株式会社糖鎖工学研究所 | フコイダンオリゴ糖組成物含有癌転移抑制剤 |
| FR2754183A1 (fr) | 1996-10-08 | 1998-04-10 | Lefebvre Jean Marie | Composition visqueuse hemostatique, notamment a l'etat de gel |
| JP3371124B2 (ja) | 1996-12-24 | 2003-01-27 | 正邦 田幸 | 養殖オキナワモズクを原料とするアセチルフコイダンおよ びそれの製造法 |
| JP3580206B2 (ja) | 2000-02-01 | 2004-10-20 | 日本電気株式会社 | 携帯電話装置及び携帯電話装置の表示動作方法並びに携帯電話装置の表示動作プログラムを記録した記憶媒体 |
| JP4768142B2 (ja) | 2001-03-08 | 2011-09-07 | 協同乳業株式会社 | フコイダンの簡易製造方法 |
| CN1173997C (zh) | 2001-04-28 | 2004-11-03 | 武汉大学 | 高纯度魔芋葡甘聚糖的提取工艺 |
| CN1344565A (zh) | 2001-10-19 | 2002-04-17 | 汤洁 | 岩藻多糖酯作为抗病毒及免疫调节剂及其制备方法 |
| US20050282775A1 (en) | 2004-06-16 | 2005-12-22 | Paringenix, Inc. | Method and medicament for sulfated polysaccharide treatment of inflammation without inducing platelet activation and heparin-induced thrombocytopenia syndrome |
| US8114842B1 (en) | 2004-10-05 | 2012-02-14 | Gp Medical, Inc. | Nanoparticles for drug delivery |
| WO2008090631A1 (ja) | 2007-01-26 | 2008-07-31 | Suntory Holdings Limited | フコイダン由来オリゴ糖 |
| CA2838793C (en) | 2011-07-19 | 2019-08-06 | Baxter International Inc. | Resorption enhancers as additives to improve the oral formulation of non-anticoagulant sulfated polysaccharides |
-
2014
- 2014-01-21 EP EP14774362.9A patent/EP2968400B1/en active Active
- 2014-01-21 ES ES14774362T patent/ES2732659T3/es active Active
- 2014-01-21 WO PCT/US2014/012360 patent/WO2014158321A1/en not_active Ceased
- 2014-01-21 AU AU2014242354A patent/AU2014242354B2/en not_active Ceased
- 2014-01-21 US US14/160,235 patent/US9265791B2/en not_active Expired - Fee Related
- 2014-01-21 JP JP2016500174A patent/JP6377121B2/ja not_active Expired - Fee Related
- 2014-01-21 EP EP19173011.8A patent/EP3578184A1/en not_active Withdrawn
- 2014-01-21 DK DK14774362.9T patent/DK2968400T3/da active
-
2018
- 2018-07-24 JP JP2018138582A patent/JP2018184445A/ja active Pending
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