JP6377121B2 - 低分子ヘパリンの経口製剤を改善するための添加剤としての吸収エンハンサ - Google Patents

低分子ヘパリンの経口製剤を改善するための添加剤としての吸収エンハンサ Download PDF

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Publication number
JP6377121B2
JP6377121B2 JP2016500174A JP2016500174A JP6377121B2 JP 6377121 B2 JP6377121 B2 JP 6377121B2 JP 2016500174 A JP2016500174 A JP 2016500174A JP 2016500174 A JP2016500174 A JP 2016500174A JP 6377121 B2 JP6377121 B2 JP 6377121B2
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Japan
Prior art keywords
chitosan
bromelain
molecular weight
range
low molecular
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JP2016500174A
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Japanese (ja)
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JP2016512244A5 (enExample
JP2016512244A (ja
Inventor
トレセック,ペーター
ヴァイダ,スザンヌ
Original Assignee
バクサルタ インコーポレイテッド
バクサルタ インコーポレイテッド
バクサルタ ゲーエムベーハー
バクサルタ ゲーエムベーハー
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727Heparin; Heparan
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716Glucans
    • A61K31/722Chitin, chitosan
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4873Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Botany (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2016500174A 2013-03-12 2014-01-21 低分子ヘパリンの経口製剤を改善するための添加剤としての吸収エンハンサ Expired - Fee Related JP6377121B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361778113P 2013-03-12 2013-03-12
US61/778,113 2013-03-12
PCT/US2014/012360 WO2014158321A1 (en) 2013-03-12 2014-01-21 Resorption enhancers as additives to improve the oral formulation of low molecular weight heparins

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018138582A Division JP2018184445A (ja) 2013-03-12 2018-07-24 低分子ヘパリンの経口製剤を改善するための添加剤としての吸収エンハンサ

Publications (3)

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JP2016512244A JP2016512244A (ja) 2016-04-25
JP2016512244A5 JP2016512244A5 (enExample) 2017-02-09
JP6377121B2 true JP6377121B2 (ja) 2018-08-22

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JP2016500174A Expired - Fee Related JP6377121B2 (ja) 2013-03-12 2014-01-21 低分子ヘパリンの経口製剤を改善するための添加剤としての吸収エンハンサ
JP2018138582A Pending JP2018184445A (ja) 2013-03-12 2018-07-24 低分子ヘパリンの経口製剤を改善するための添加剤としての吸収エンハンサ

Family Applications After (1)

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JP2018138582A Pending JP2018184445A (ja) 2013-03-12 2018-07-24 低分子ヘパリンの経口製剤を改善するための添加剤としての吸収エンハンサ

Country Status (7)

Country Link
US (1) US9265791B2 (enExample)
EP (2) EP2968400B1 (enExample)
JP (2) JP6377121B2 (enExample)
AU (1) AU2014242354B2 (enExample)
DK (1) DK2968400T3 (enExample)
ES (1) ES2732659T3 (enExample)
WO (1) WO2014158321A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111983207A (zh) * 2019-05-23 2020-11-24 宁德市医院 一种血栓弹力图仪全血质控品及配制方法
CN111658658B (zh) * 2020-06-17 2023-08-11 上海大学 低聚木糖在制备抗深静脉血栓的药物中的应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL79254A0 (en) 1986-06-26 1986-09-30 Hadassah Med Org Compositions for preventing graft rejection
US5831005A (en) 1992-09-24 1998-11-03 Chiron Corporation Synthesis of N-substituted oligomers
US5877278A (en) 1992-09-24 1999-03-02 Chiron Corporation Synthesis of N-substituted oligomers
JP3714426B2 (ja) 1994-02-01 2005-11-09 株式会社糖鎖工学研究所 フコイダンオリゴ糖組成物含有癌転移抑制剤
FR2754183A1 (fr) 1996-10-08 1998-04-10 Lefebvre Jean Marie Composition visqueuse hemostatique, notamment a l'etat de gel
JP3371124B2 (ja) 1996-12-24 2003-01-27 正邦 田幸 養殖オキナワモズクを原料とするアセチルフコイダンおよ びそれの製造法
JP3580206B2 (ja) 2000-02-01 2004-10-20 日本電気株式会社 携帯電話装置及び携帯電話装置の表示動作方法並びに携帯電話装置の表示動作プログラムを記録した記憶媒体
JP4768142B2 (ja) 2001-03-08 2011-09-07 協同乳業株式会社 フコイダンの簡易製造方法
CN1173997C (zh) 2001-04-28 2004-11-03 武汉大学 高纯度魔芋葡甘聚糖的提取工艺
CN1344565A (zh) 2001-10-19 2002-04-17 汤洁 岩藻多糖酯作为抗病毒及免疫调节剂及其制备方法
US20050282775A1 (en) 2004-06-16 2005-12-22 Paringenix, Inc. Method and medicament for sulfated polysaccharide treatment of inflammation without inducing platelet activation and heparin-induced thrombocytopenia syndrome
US8114842B1 (en) 2004-10-05 2012-02-14 Gp Medical, Inc. Nanoparticles for drug delivery
WO2008090631A1 (ja) 2007-01-26 2008-07-31 Suntory Holdings Limited フコイダン由来オリゴ糖
CA2838793C (en) 2011-07-19 2019-08-06 Baxter International Inc. Resorption enhancers as additives to improve the oral formulation of non-anticoagulant sulfated polysaccharides

Also Published As

Publication number Publication date
EP2968400A1 (en) 2016-01-20
EP3578184A1 (en) 2019-12-11
US20140271608A1 (en) 2014-09-18
ES2732659T3 (es) 2019-11-25
US9265791B2 (en) 2016-02-23
JP2018184445A (ja) 2018-11-22
DK2968400T3 (da) 2019-07-29
AU2014242354B2 (en) 2016-07-07
WO2014158321A1 (en) 2014-10-02
EP2968400B1 (en) 2019-05-08
EP2968400A4 (en) 2016-08-10
AU2014242354A1 (en) 2015-04-02
JP2016512244A (ja) 2016-04-25

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