JP2016510983A5 - - Google Patents
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- Publication number
- JP2016510983A5 JP2016510983A5 JP2015562115A JP2015562115A JP2016510983A5 JP 2016510983 A5 JP2016510983 A5 JP 2016510983A5 JP 2015562115 A JP2015562115 A JP 2015562115A JP 2015562115 A JP2015562115 A JP 2015562115A JP 2016510983 A5 JP2016510983 A5 JP 2016510983A5
- Authority
- JP
- Japan
- Prior art keywords
- recombinant polypeptide
- thermostable
- polypeptide according
- immunogenic composition
- thermostable recombinant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims 19
- 102000004196 processed proteins & peptides Human genes 0.000 claims 19
- 230000002163 immunogen Effects 0.000 claims 7
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims 4
- 241000725643 Respiratory syncytial virus Species 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 3
- 238000005829 trimerization reaction Methods 0.000 claims 3
- 102000004961 Furin Human genes 0.000 claims 2
- 108090001126 Furin Proteins 0.000 claims 2
- 230000000890 antigenic effect Effects 0.000 claims 2
- 238000003776 cleavage reaction Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 230000007017 scission Effects 0.000 claims 2
- 108010011170 Ala-Trp-Arg-His-Pro-Gln-Phe-Gly-Gly Proteins 0.000 claims 1
- 101100107610 Arabidopsis thaliana ABCF4 gene Proteins 0.000 claims 1
- 102100024365 Arf-GAP domain and FG repeat-containing protein 1 Human genes 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- MSFSPUZXLOGKHJ-UHFFFAOYSA-N Muraminsaeure Natural products OC(=O)C(C)OC1C(N)C(O)OC(CO)C1O MSFSPUZXLOGKHJ-UHFFFAOYSA-N 0.000 claims 1
- 108010013639 Peptidoglycan Proteins 0.000 claims 1
- 206010061603 Respiratory syncytial virus infection Diseases 0.000 claims 1
- 101100068078 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GCN4 gene Proteins 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 230000001086 cytosolic effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 238000003259 recombinant expression Methods 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
- 210000003660 reticulum Anatomy 0.000 claims 1
- 239000013638 trimer Substances 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/828,667 | 2013-03-14 | ||
| US13/828,667 US9060975B2 (en) | 2013-03-14 | 2013-03-14 | Heat-stable respiratory syncytial virus F protein oligomers and their use in immunological compositions |
| PCT/EP2014/054804 WO2014140083A1 (en) | 2013-03-14 | 2014-03-12 | Heat-stable respiratory syncytial virus prefusion f protein oligomers and their use in immunological compositions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016510983A JP2016510983A (ja) | 2016-04-14 |
| JP2016510983A5 true JP2016510983A5 (https=) | 2017-02-23 |
| JP6285469B2 JP6285469B2 (ja) | 2018-02-28 |
Family
ID=50241453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015562115A Expired - Fee Related JP6285469B2 (ja) | 2013-03-14 | 2014-03-12 | 呼吸器合胞体ウイルスの熱安定な融合前ｆタンパク質オリゴマーおよび免疫組成物におけるその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9060975B2 (https=) |
| EP (2) | EP3178840A1 (https=) |
| JP (1) | JP6285469B2 (https=) |
| CN (2) | CN107029227A (https=) |
| AU (1) | AU2014230822B2 (https=) |
| BR (1) | BR112015022617A2 (https=) |
| CA (1) | CA2905571A1 (https=) |
| WO (1) | WO2014140083A1 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2900110A1 (en) | 2013-02-01 | 2014-08-07 | Medimmune, Llc | Respiratory syncytial virus f protein epitopes |
| EP3798310A1 (en) | 2013-03-14 | 2021-03-31 | Emory University | Recombinant rsv with silent mutations, vaccines, and methods related thereto |
| MX2018005462A (es) | 2015-10-29 | 2018-08-01 | Univ Emory | Composiciones inmunogénicas de rsv quimérico y métodos de uso. |
| IL262108B2 (en) * | 2016-04-05 | 2023-04-01 | Janssen Vaccines Prevention B V | Soluble pre-fusion rsv f proteins are stabilized |
| CN109311946A (zh) * | 2016-05-30 | 2019-02-05 | 扬森疫苗与预防公司 | 稳定化的融合前rsv f蛋白 |
| CN108300705B (zh) * | 2017-01-12 | 2021-10-22 | 厦门大学 | 稳定呼吸道合胞病毒融合蛋白的方法 |
| KR20260047644A (ko) | 2017-03-30 | 2026-04-08 | 더 유니버서티 어브 퀸슬랜드 | 키메라 분자 및 그의 용도 |
| HUE073526T2 (hu) | 2017-04-04 | 2026-01-28 | Univ Washington | Önmagát összeállító fehérje nanostruktúrák, amelyek paramyxovírus és/vagy pneumovírus F fehérjéket jelenítenek meg és azok használata |
| WO2019063844A1 (en) * | 2017-09-29 | 2019-04-04 | Universiteit Antwerpen | VACCINATION AGAINST SYNCYTIAL RESPIRATORY VIRUS |
| BR112020015308A8 (pt) * | 2018-01-29 | 2023-02-07 | Merck Sharp & Dohme | Proteínas f de rsv estabilizadas e usos das mesmas |
| CN110684747B (zh) * | 2018-07-06 | 2024-05-24 | 厦门大学 | 灭活及保存呼吸道合胞病毒的方法 |
| KR102725189B1 (ko) * | 2018-11-01 | 2024-10-31 | 에스케이바이오사이언스(주) | 재조합 호흡기 세포융합 바이러스 f 단백질 및 이를 포함하는 백신 조성물 |
| CN109694400A (zh) * | 2019-01-31 | 2019-04-30 | 苏州高泓利康生物科技有限公司 | 一种表达呼吸道合胞病毒f蛋白及其制备方法 |
| CN114957407A (zh) * | 2019-04-02 | 2022-08-30 | 赛诺菲 | 抗原性多聚呼吸道合胞病毒多肽 |
| CN110054668B (zh) * | 2019-04-25 | 2021-09-10 | 北京交通大学 | 一种呼吸道合胞病毒融合前f蛋白及其应用 |
| EP4025587A1 (en) | 2019-09-04 | 2022-07-13 | University of Washington | Self-assembling protein nanostructures displaying paramyxovirus and/or pneumovirus f proteins and their use |
| CN111303245B (zh) * | 2020-02-21 | 2023-06-27 | 成都奥达生物科技有限公司 | 一种抗合胞病毒膜融合抑制剂 |
| JP7627447B2 (ja) * | 2020-04-22 | 2025-02-06 | ポステック・リサーチ・アンド・ビジネス・ディヴェロップメント・ファウンデイション | 三量体を形成するインフルエンザウイルス表面タンパク質由来組換え赤血球凝集素タンパク質およびその用途 |
| WO2021234579A1 (en) * | 2020-05-19 | 2021-11-25 | National Research Council Of Canada | Use of resistin as a trimerization partner for expression of trimeric proteins |
| CN112480217B (zh) * | 2020-11-30 | 2022-04-08 | 广州阿格纳生物医药制造有限公司 | 基于SARS-CoV-2的S抗原蛋白的疫苗和组合物 |
| KR20250140099A (ko) * | 2023-02-03 | 2025-09-24 | 노바백스, 인코포레이티드 | Rsv f 백신 제형 |
| WO2024192698A1 (zh) * | 2023-03-22 | 2024-09-26 | 中科牧维(南京)生物科技有限公司 | 靶向人呼吸道合胞病毒融合糖蛋白的多肽拮抗剂 |
| CN121464149A (zh) * | 2023-06-07 | 2026-02-03 | 四川三叶草生物制药有限公司 | Rsv疫苗组合物、方法及其用途 |
| US12383614B2 (en) | 2023-12-21 | 2025-08-12 | Yikang Biotech (Suzhou) Co., Ltd. | Mutants of respiratory syncytial virus fusion proteins |
| CN117886902B (zh) * | 2023-12-21 | 2024-11-26 | 易康生物(苏州)有限公司 | 改良的呼吸道合胞病毒融合f蛋白突变体及其应用 |
| CN121221752A (zh) * | 2025-02-14 | 2025-12-30 | 北京悦康科创医药科技股份有限公司 | 一种膜融合抑制多肽在抗副黏病毒科病毒感染中的应用 |
| CN120329390A (zh) * | 2025-03-03 | 2025-07-18 | 中国医学科学院医学生物学研究所 | 基于异源三聚体基序的蛋白的改造及应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0916726A1 (en) | 1997-11-13 | 1999-05-19 | Rijksuniversiteit te Groningen | Attaching substances to micro-organisms |
| DK1395648T3 (da) | 2001-06-11 | 2009-08-03 | Applied Nanosystems Bv | Fremgangsmåder til binding af AcmA-type proteinankerfusioner til cellevægsmateriale af mikroorganismer |
| EP1997830A1 (en) | 2007-06-01 | 2008-12-03 | AIMM Therapeutics B.V. | RSV specific binding molecules and means for producing them |
| EP2445527A2 (en) | 2009-06-24 | 2012-05-02 | ID Biomedical Corporation of Quebec | Vaccine |
| HUE028085T2 (en) | 2009-06-24 | 2016-11-28 | Glaxosmithkline Biologicals Sa | Recombinant RSV antigens |
| CA2768186A1 (en) * | 2009-07-15 | 2011-01-20 | Novartis Ag | Rsv f protein compositions and methods for making same |
| US8568726B2 (en) | 2009-10-06 | 2013-10-29 | Medimmune Limited | RSV specific binding molecule |
| US9585953B2 (en) | 2011-03-22 | 2017-03-07 | Mucosis B.V. | Immunogenic compositions in particulate form and methods for producing the same |
| CA2835644C (en) | 2011-05-13 | 2021-06-15 | Novartis Ag | Pre-fusion rsv f antigens |
-
2013
- 2013-03-14 US US13/828,667 patent/US9060975B2/en not_active Ceased
-
2014
- 2014-03-12 BR BR112015022617A patent/BR112015022617A2/pt not_active IP Right Cessation
- 2014-03-12 CN CN201710040168.9A patent/CN107029227A/zh active Pending
- 2014-03-12 WO PCT/EP2014/054804 patent/WO2014140083A1/en not_active Ceased
- 2014-03-12 CA CA2905571A patent/CA2905571A1/en not_active Abandoned
- 2014-03-12 JP JP2015562115A patent/JP6285469B2/ja not_active Expired - Fee Related
- 2014-03-12 CN CN201480022815.8A patent/CN105246910A/zh active Pending
- 2014-03-12 EP EP16200916.1A patent/EP3178840A1/en not_active Withdrawn
- 2014-03-12 EP EP14709318.1A patent/EP2970393B1/en not_active Not-in-force
- 2014-03-12 AU AU2014230822A patent/AU2014230822B2/en not_active Ceased
-
2016
- 2016-03-26 US US15/081,854 patent/USRE47471E1/en not_active Expired - Fee Related
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