AU2014230822B2 - Heat-stable Respiratory Syncytial Virus prefusion F protein oligomers and their use in immunological compositions - Google Patents

Heat-stable Respiratory Syncytial Virus prefusion F protein oligomers and their use in immunological compositions Download PDF

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Publication number
AU2014230822B2
AU2014230822B2 AU2014230822A AU2014230822A AU2014230822B2 AU 2014230822 B2 AU2014230822 B2 AU 2014230822B2 AU 2014230822 A AU2014230822 A AU 2014230822A AU 2014230822 A AU2014230822 A AU 2014230822A AU 2014230822 B2 AU2014230822 B2 AU 2014230822B2
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AU2014230822A1 (en
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Cornelis Alexander Maria De Haan
Bert Jan Haijema
Petrus Josephus Marie Rottier
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Mucosis BV
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Mucosis BV
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/155Paramyxoviridae, e.g. parainfluenza virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/18011Paramyxoviridae
    • C12N2760/18511Pneumovirus, e.g. human respiratory syncytial virus
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/18011Paramyxoviridae
    • C12N2760/18511Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18534Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2014230822A 2013-03-14 2014-03-12 Heat-stable Respiratory Syncytial Virus prefusion F protein oligomers and their use in immunological compositions Ceased AU2014230822B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/828,667 2013-03-14
US13/828,667 US9060975B2 (en) 2013-03-14 2013-03-14 Heat-stable respiratory syncytial virus F protein oligomers and their use in immunological compositions
PCT/EP2014/054804 WO2014140083A1 (en) 2013-03-14 2014-03-12 Heat-stable respiratory syncytial virus prefusion f protein oligomers and their use in immunological compositions

Publications (2)

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AU2014230822A1 AU2014230822A1 (en) 2015-10-01
AU2014230822B2 true AU2014230822B2 (en) 2018-04-12

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AU2014230822A Ceased AU2014230822B2 (en) 2013-03-14 2014-03-12 Heat-stable Respiratory Syncytial Virus prefusion F protein oligomers and their use in immunological compositions

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US (2) US9060975B2 (https=)
EP (2) EP2970393B1 (https=)
JP (1) JP6285469B2 (https=)
CN (2) CN107029227A (https=)
AU (1) AU2014230822B2 (https=)
BR (1) BR112015022617A2 (https=)
CA (1) CA2905571A1 (https=)
WO (1) WO2014140083A1 (https=)

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LT2950886T (lt) 2013-02-01 2020-07-10 Medimmune, Llc Respiracinio sincitinio viruso f baltymo epitopai
CN113322264B (zh) 2013-03-14 2024-05-31 爱默蕾大学 具有沉默突变的重组rsv、其相关疫苗和方法
MX2018005462A (es) * 2015-10-29 2018-08-01 Univ Emory Composiciones inmunogénicas de rsv quimérico y métodos de uso.
PH12022552125A1 (en) * 2016-04-05 2023-04-12 Janssen Vaccines & Prevention Bv Stabilized soluble pre-fusion rsv f proteins
IL264119B2 (en) * 2016-05-30 2023-04-01 Janssen Vaccines Prevention B V f proteins of rsv are stabilized before fusion
WO2018130072A1 (zh) * 2017-01-12 2018-07-19 厦门大学 稳定呼吸道合胞病毒融合蛋白的方法
MX2019011599A (es) 2017-03-30 2019-12-19 Univ Queensland Moleculas quimericas y usos de las mismas.
KR102774312B1 (ko) 2017-04-04 2025-03-05 유니버시티 오브 워싱톤 파라믹소바이러스 및/또는 뉴모바이러스 f 단백질을 표시하는 자가-조립 단백질 나노구조체 및 이의 용도
WO2019063844A1 (en) * 2017-09-29 2019-04-04 Universiteit Antwerpen VACCINATION AGAINST SYNCYTIAL RESPIRATORY VIRUS
MA51230A (fr) * 2018-01-29 2021-05-05 Merck Sharp & Dohme Protéines f rsv stabilisées et leurs utilisations
CN110684747B (zh) * 2018-07-06 2024-05-24 厦门大学 灭活及保存呼吸道合胞病毒的方法
KR102725189B1 (ko) * 2018-11-01 2024-10-31 에스케이바이오사이언스(주) 재조합 호흡기 세포융합 바이러스 f 단백질 및 이를 포함하는 백신 조성물
CN109694400A (zh) * 2019-01-31 2019-04-30 苏州高泓利康生物科技有限公司 一种表达呼吸道合胞病毒f蛋白及其制备方法
CN114957407A (zh) 2019-04-02 2022-08-30 赛诺菲 抗原性多聚呼吸道合胞病毒多肽
CN110054668B (zh) * 2019-04-25 2021-09-10 北京交通大学 一种呼吸道合胞病毒融合前f蛋白及其应用
CN114502572A (zh) 2019-09-04 2022-05-13 华盛顿大学 展示副粘病毒和/或肺炎病毒f蛋白的自组装蛋白纳米结构及其用途
CN111303245B (zh) * 2020-02-21 2023-06-27 成都奥达生物科技有限公司 一种抗合胞病毒膜融合抑制剂
EP4141121A4 (en) * 2020-04-22 2024-07-10 POSTECH Research and Business Development Foundation RECOMBINANT HEMAGGLUTININ PROTEIN DERIVED FROM TRIMER-FORMING INFLUENZA VIRUS SURFACE PROTEIN AND USE THEREOF
WO2021234579A1 (en) * 2020-05-19 2021-11-25 National Research Council Of Canada Use of resistin as a trimerization partner for expression of trimeric proteins
CN112480217B (zh) * 2020-11-30 2022-04-08 广州阿格纳生物医药制造有限公司 基于SARS-CoV-2的S抗原蛋白的疫苗和组合物
EP4658308A2 (en) * 2023-02-03 2025-12-10 Novavax, Inc. Rsv f vaccine formulations
WO2024192698A1 (zh) * 2023-03-22 2024-09-26 中科牧维(南京)生物科技有限公司 靶向人呼吸道合胞病毒融合糖蛋白的多肽拮抗剂
AU2024287014A1 (en) * 2023-06-07 2026-01-22 Sichuan Clover Biopharmaceuticals, Inc. Rsv vaccine composition, method and use thereof
US12383614B2 (en) 2023-12-21 2025-08-12 Yikang Biotech (Suzhou) Co., Ltd. Mutants of respiratory syncytial virus fusion proteins
CN117886902B (zh) * 2023-12-21 2024-11-26 易康生物(苏州)有限公司 改良的呼吸道合胞病毒融合f蛋白突变体及其应用
CN121221752A (zh) * 2025-02-14 2025-12-30 北京悦康科创医药科技股份有限公司 一种膜融合抑制多肽在抗副黏病毒科病毒感染中的应用
CN120329390A (zh) * 2025-03-03 2025-07-18 中国医学科学院医学生物学研究所 基于异源三聚体基序的蛋白的改造及应用

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WO2012158613A1 (en) * 2011-05-13 2012-11-22 Novartis Ag Pre-fusion rsv f antigens

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AU2002314626B2 (en) 2001-06-11 2008-01-03 Applied Nanosystems B.V. Methods for binding AcmA-type protein anchor fusions to cell-wall material of micro-organisms
EP1997830A1 (en) 2007-06-01 2008-12-03 AIMM Therapeutics B.V. RSV specific binding molecules and means for producing them
MX2012000035A (es) 2009-06-24 2012-02-28 Id Biomedical Corp Quebec Antigenos de virus de sincicio respiratorio recombinantes.
US8568726B2 (en) 2009-10-06 2013-10-29 Medimmune Limited RSV specific binding molecule
BR112013024157A2 (pt) 2011-03-22 2016-12-06 Mucosis Bv composições imunogênicas em forma particulada e métodos para produção destas

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WO2010149743A2 (en) * 2009-06-24 2010-12-29 Id Biomedical Corporation Of Quebec Vaccine
WO2011008974A2 (en) * 2009-07-15 2011-01-20 Novartis Ag Rsv f protein compositions and methods for making same
WO2012158613A1 (en) * 2011-05-13 2012-11-22 Novartis Ag Pre-fusion rsv f antigens

Non-Patent Citations (1)

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Ruiz-Argüello et al. "Thermostability of the human respiratory syncytial virus fusion protein before and after activation: implications for the membrane-fusion mechanism." Journal of general virology, 2004, 85(12), pp. 3677-3687. *

Also Published As

Publication number Publication date
CN105246910A (zh) 2016-01-13
JP6285469B2 (ja) 2018-02-28
AU2014230822A1 (en) 2015-10-01
EP2970393A1 (en) 2016-01-20
WO2014140083A1 (en) 2014-09-18
CA2905571A1 (en) 2014-09-18
US20140271696A1 (en) 2014-09-18
EP3178840A1 (en) 2017-06-14
JP2016510983A (ja) 2016-04-14
US9060975B2 (en) 2015-06-23
BR112015022617A2 (pt) 2017-10-31
EP2970393B1 (en) 2017-01-11
CN107029227A (zh) 2017-08-11
USRE47471E1 (en) 2019-07-02

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