JP2016510808A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016510808A5 JP2016510808A5 JP2015562410A JP2015562410A JP2016510808A5 JP 2016510808 A5 JP2016510808 A5 JP 2016510808A5 JP 2015562410 A JP2015562410 A JP 2015562410A JP 2015562410 A JP2015562410 A JP 2015562410A JP 2016510808 A5 JP2016510808 A5 JP 2016510808A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- disease
- composition
- population
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 23
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 20
- 201000010099 disease Diseases 0.000 claims description 19
- 210000004027 cell Anatomy 0.000 claims description 17
- 210000002894 multi-fate stem cell Anatomy 0.000 claims description 11
- LZAXPYOBKSJSEX-UHFFFAOYSA-N blebbistatin Chemical compound C1CC2(O)C(=O)C3=CC(C)=CC=C3N=C2N1C1=CC=CC=C1 LZAXPYOBKSJSEX-UHFFFAOYSA-N 0.000 claims description 7
- 238000009168 stem cell therapy Methods 0.000 claims description 7
- 238000009580 stem-cell therapy Methods 0.000 claims description 7
- 210000003414 extremity Anatomy 0.000 claims description 5
- 210000000130 stem cell Anatomy 0.000 claims description 5
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 4
- 208000005764 Peripheral Arterial Disease Diseases 0.000 claims description 4
- 208000030831 Peripheral arterial occlusive disease Diseases 0.000 claims description 4
- 210000003423 ankle Anatomy 0.000 claims description 4
- 230000036772 blood pressure Effects 0.000 claims description 4
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims description 4
- 201000001320 Atherosclerosis Diseases 0.000 claims description 2
- 206010017711 Gangrene Diseases 0.000 claims description 2
- 206010040943 Skin Ulcer Diseases 0.000 claims description 2
- 206010012601 diabetes mellitus Diseases 0.000 claims description 2
- 208000035474 group of disease Diseases 0.000 claims description 2
- 230000000302 ischemic effect Effects 0.000 claims description 2
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims description 2
- 231100000019 skin ulcer Toxicity 0.000 claims description 2
- 210000002536 stromal cell Anatomy 0.000 claims description 2
- 208000019553 vascular disease Diseases 0.000 claims description 2
- 210000004271 bone marrow stromal cell Anatomy 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 1
- 239000005557 antagonist Substances 0.000 description 12
- 108010045128 Myosin Type II Proteins 0.000 description 11
- 102000005640 Myosin Type II Human genes 0.000 description 9
- 210000003205 muscle Anatomy 0.000 description 9
- 230000035876 healing Effects 0.000 description 3
- 108020004459 Small interfering RNA Proteins 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 150000004040 pyrrolidinones Chemical class 0.000 description 2
- 108020005544 Antisense RNA Proteins 0.000 description 1
- 229940126317 angiotensin II receptor antagonist Drugs 0.000 description 1
- 239000002333 angiotensin II receptor antagonist Substances 0.000 description 1
- 229940125364 angiotensin receptor blocker Drugs 0.000 description 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 description 1
- 239000003184 complementary RNA Substances 0.000 description 1
- FSEUPUDHEBLWJY-UHFFFAOYSA-N diacetylmonoxime Chemical compound CC(=O)C(C)=NO FSEUPUDHEBLWJY-UHFFFAOYSA-N 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 208000037906 ischaemic injury Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 108091070501 miRNA Proteins 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13159548.0A EP2777703B1 (en) | 2013-03-15 | 2013-03-15 | Compositions and methods for enhancing the therapeutic potential of stem cells |
| EP13159548.0 | 2013-03-15 | ||
| PCT/IB2014/001248 WO2014140930A2 (en) | 2013-03-15 | 2014-03-13 | Compostions and methods for enhancing the therapeutic potential of stem cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016510808A JP2016510808A (ja) | 2016-04-11 |
| JP2016510808A5 true JP2016510808A5 (enExample) | 2017-04-13 |
| JP6399410B2 JP6399410B2 (ja) | 2018-10-03 |
Family
ID=47900872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015562410A Active JP6399410B2 (ja) | 2013-03-15 | 2014-03-13 | 幹細胞の治療可能性を高めるための組成物および方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US20160030482A1 (enExample) |
| EP (1) | EP2777703B1 (enExample) |
| JP (1) | JP6399410B2 (enExample) |
| KR (1) | KR102203925B1 (enExample) |
| CN (1) | CN105050597A (enExample) |
| AU (1) | AU2014229502B2 (enExample) |
| BR (1) | BR112015022565A2 (enExample) |
| CA (1) | CA2905650C (enExample) |
| ES (1) | ES2602078T3 (enExample) |
| WO (1) | WO2014140930A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111405898B (zh) * | 2018-01-29 | 2022-09-13 | 中国科学院动物研究所 | 一种破坏细胞机械稳态以及促进组织器官的再生修复的方法及其应用 |
| HU231285B1 (hu) | 2018-04-18 | 2022-08-28 | Printnet Kereskedelmi És Szolgáltató Kft. | A miozin-2-izoformákat szelektíven gátló, gyógyászatilag hatásos vegyületek |
| CN108728410B (zh) * | 2018-06-19 | 2020-04-21 | 中国医学科学院阜外医院 | 基于药物预处理的间充质干细胞来源外泌体的制备方法 |
| JP7230409B2 (ja) * | 2018-10-02 | 2023-03-01 | カシオ計算機株式会社 | 判定装置、判定方法及び判定プログラム |
| KR102932345B1 (ko) | 2019-03-08 | 2026-02-27 | 커먼웰쓰 사이언티픽 앤 인더스트리알 리서치 오거니제이션 | 식물 세포에서 니트로게나제 폴리펩티드의 발현 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008011176A2 (en) | 2006-07-21 | 2008-01-24 | Northwestern University | Myosin light chain kinase inhibitor compounds, compositions and related methods of use |
| CN101125146B (zh) * | 2007-07-02 | 2011-05-04 | 中国药科大学 | 一种防治炎症相关心脑血管疾病的药物靶标及其抑制剂 |
| AU2009208391A1 (en) * | 2008-01-31 | 2009-08-06 | Monash University | Methods of treating thromboembolic disorders |
| EP2398897B1 (en) | 2009-02-20 | 2017-06-28 | Cellular Dynamics International, Inc. | Methods and compositions for the differentiation of stem cells |
| AU2010236632A1 (en) * | 2009-04-13 | 2011-09-15 | The Regents Of The University Of California | Methods and compositions for stem cell cultures |
| CN103201377A (zh) | 2010-11-09 | 2013-07-10 | 隆萨科隆有限公司 | 控制细胞与基质结合的方法 |
| CN102940631B (zh) * | 2012-11-02 | 2015-04-15 | 清华大学 | Blebbistatin在促进干细胞存活和维持干细胞干性中的应用 |
-
2013
- 2013-03-15 ES ES13159548.0T patent/ES2602078T3/es active Active
- 2013-03-15 EP EP13159548.0A patent/EP2777703B1/en active Active
-
2014
- 2014-03-13 BR BR112015022565A patent/BR112015022565A2/pt not_active Application Discontinuation
- 2014-03-13 AU AU2014229502A patent/AU2014229502B2/en active Active
- 2014-03-13 JP JP2015562410A patent/JP6399410B2/ja active Active
- 2014-03-13 KR KR1020157029741A patent/KR102203925B1/ko active Active
- 2014-03-13 CA CA2905650A patent/CA2905650C/en active Active
- 2014-03-13 CN CN201480015952.9A patent/CN105050597A/zh active Pending
- 2014-03-13 US US14/777,352 patent/US20160030482A1/en not_active Abandoned
- 2014-03-13 WO PCT/IB2014/001248 patent/WO2014140930A2/en not_active Ceased
-
2017
- 2017-08-28 US US15/688,148 patent/US20180055888A1/en not_active Abandoned
-
2020
- 2020-01-09 US US16/738,495 patent/US20200147142A1/en not_active Abandoned
-
2024
- 2024-06-05 US US18/734,900 patent/US20240316111A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Shi et al. | Angiotensin II induces vascular endothelial growth factor synthesis in mesenchymal stem cells | |
| Suzuki et al. | Adipose tissue-derived stem cells as a therapeutic tool for cardiovascular disease | |
| CA2747794A1 (en) | Treatment of lung and pulmonary diseases and disorders | |
| De Girolamo et al. | Stemness and osteogenic and adipogenic potential are differently impaired in subcutaneous and visceral adipose derived stem cells (ASCs) isolated from obese donors | |
| Yea et al. | Comparison of mesenchymal stem cells from bone marrow, umbilical cord blood, and umbilical cord tissue in regeneration of a full-thickness tendon defect in vitro and in vivo | |
| Bamshad et al. | Human umbilical cord-derived mesenchymal stem cells-harvested mitochondrial transplantation improved motor function in TBI models through rescuing neuronal cells from apoptosis and alleviating astrogliosis and microglia activation | |
| Heyboer III et al. | CD34+/CD45-dim stem cell mobilization by hyperbaric oxygen—changes with oxygen dosage | |
| Verina et al. | Pluripotent possibilities: human umbilical cord blood cell treatment after neonatal brain injury | |
| WO2011049414A3 (ko) | 지방조직 유래 성체 줄기세포 이동을 유도하는 방법 | |
| Pascucci et al. | Membrane vesicles mediate pro-angiogenic activity of equine adipose-derived mesenchymal stromal cells | |
| US10383895B2 (en) | Stimulation of therapeutic angiogenesis by T regulatory cells | |
| JP2012512911A5 (enExample) | ||
| WO2007149548A3 (en) | Treatment of erectile dysfunction by stem cell therapy | |
| JP2010540662A5 (enExample) | ||
| Wang et al. | Adipose-derived stem cell transplantation improves learning and memory via releasing neurotrophins in rat model of temporal lobe epilepsy | |
| RS53039B (sr) | Postupak ekspanzije za adultne stem ćelije iz krvi, naročito periferne krvi, i odgovarajuća primena u oblasti medicine | |
| JP2016508123A5 (enExample) | ||
| JP6865933B2 (ja) | 勃起不全治療剤 | |
| CN105934155A (zh) | 在调节疼痛和/或纤维化中使用脂肪组织来源的细胞的方法 | |
| Ji et al. | Decellularized matrix of adipose-derived mesenchymal stromal cells enhanced retinal progenitor cell proliferation via the Akt/Erk pathway and neuronal differentiation | |
| JP2015525787A (ja) | 神経成長因子が中高年男性の性機能低下症候群を治療するための薬物の調製における応用 | |
| BR112015022565A2 (pt) | composições e métodos para aumentar o potencial terapêutico das células tronco | |
| Sadik et al. | Local renin-angiotensin system regulates the differentiation of mesenchymal stem cells into insulin-producing cells through angiotensin type 2 receptor | |
| KR101843952B1 (ko) | 지방조직-유래 기질혈관분획의 분리 방법 | |
| KR102280199B1 (ko) | 중간엽 줄기세포의 면역조절 활성 증진용 조성물 |