JP2016510808A5 - - Google Patents
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- JP2016510808A5 JP2016510808A5 JP2015562410A JP2015562410A JP2016510808A5 JP 2016510808 A5 JP2016510808 A5 JP 2016510808A5 JP 2015562410 A JP2015562410 A JP 2015562410A JP 2015562410 A JP2015562410 A JP 2015562410A JP 2016510808 A5 JP2016510808 A5 JP 2016510808A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- disease
- composition
- population
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 239000000203 mixture Substances 0.000 claims description 23
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 20
- 201000010099 disease Diseases 0.000 claims description 19
- 210000004027 cell Anatomy 0.000 claims description 17
- 210000002894 multi-fate stem cell Anatomy 0.000 claims description 11
- LZAXPYOBKSJSEX-UHFFFAOYSA-N blebbistatin Chemical compound C1CC2(O)C(=O)C3=CC(C)=CC=C3N=C2N1C1=CC=CC=C1 LZAXPYOBKSJSEX-UHFFFAOYSA-N 0.000 claims description 7
- 238000009168 stem cell therapy Methods 0.000 claims description 7
- 238000009580 stem-cell therapy Methods 0.000 claims description 7
- 210000003414 extremity Anatomy 0.000 claims description 5
- 210000000130 stem cell Anatomy 0.000 claims description 5
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 4
- 208000005764 Peripheral Arterial Disease Diseases 0.000 claims description 4
- 208000030831 Peripheral arterial occlusive disease Diseases 0.000 claims description 4
- 210000003423 ankle Anatomy 0.000 claims description 4
- 230000036772 blood pressure Effects 0.000 claims description 4
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims description 4
- 201000001320 Atherosclerosis Diseases 0.000 claims description 2
- 206010017711 Gangrene Diseases 0.000 claims description 2
- 206010040943 Skin Ulcer Diseases 0.000 claims description 2
- 206010012601 diabetes mellitus Diseases 0.000 claims description 2
- 208000035474 group of disease Diseases 0.000 claims description 2
- 230000000302 ischemic effect Effects 0.000 claims description 2
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims description 2
- 231100000019 skin ulcer Toxicity 0.000 claims description 2
- 210000002536 stromal cell Anatomy 0.000 claims description 2
- 208000019553 vascular disease Diseases 0.000 claims description 2
- 210000004271 bone marrow stromal cell Anatomy 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 1
- 239000005557 antagonist Substances 0.000 description 12
- 108010045128 Myosin Type II Proteins 0.000 description 11
- 102000005640 Myosin Type II Human genes 0.000 description 9
- 210000003205 muscle Anatomy 0.000 description 9
- 230000035876 healing Effects 0.000 description 3
- 108020004459 Small interfering RNA Proteins 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 150000004040 pyrrolidinones Chemical class 0.000 description 2
- 108020005544 Antisense RNA Proteins 0.000 description 1
- 229940126317 angiotensin II receptor antagonist Drugs 0.000 description 1
- 239000002333 angiotensin II receptor antagonist Substances 0.000 description 1
- 229940125364 angiotensin receptor blocker Drugs 0.000 description 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 description 1
- 239000003184 complementary RNA Substances 0.000 description 1
- FSEUPUDHEBLWJY-UHFFFAOYSA-N diacetylmonoxime Chemical compound CC(=O)C(C)=NO FSEUPUDHEBLWJY-UHFFFAOYSA-N 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 208000037906 ischaemic injury Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 108091070501 miRNA Proteins 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13159548.0A EP2777703B1 (en) | 2013-03-15 | 2013-03-15 | Compositions and methods for enhancing the therapeutic potential of stem cells |
| EP13159548.0 | 2013-03-15 | ||
| PCT/IB2014/001248 WO2014140930A2 (en) | 2013-03-15 | 2014-03-13 | Compostions and methods for enhancing the therapeutic potential of stem cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016510808A JP2016510808A (ja) | 2016-04-11 |
| JP2016510808A5 true JP2016510808A5 (enExample) | 2017-04-13 |
| JP6399410B2 JP6399410B2 (ja) | 2018-10-03 |
Family
ID=47900872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015562410A Active JP6399410B2 (ja) | 2013-03-15 | 2014-03-13 | 幹細胞の治療可能性を高めるための組成物および方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US20160030482A1 (enExample) |
| EP (1) | EP2777703B1 (enExample) |
| JP (1) | JP6399410B2 (enExample) |
| KR (1) | KR102203925B1 (enExample) |
| CN (1) | CN105050597A (enExample) |
| AU (1) | AU2014229502B2 (enExample) |
| BR (1) | BR112015022565A2 (enExample) |
| CA (1) | CA2905650C (enExample) |
| ES (1) | ES2602078T3 (enExample) |
| WO (1) | WO2014140930A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7542258B2 (ja) | 2018-01-29 | 2024-08-30 | 中国科学院動物研究所 | 細胞の機械的恒常性を破壊し、組織器官の再生と修復を促進する方法、およびその使用 |
| HU231285B1 (hu) * | 2018-04-18 | 2022-08-28 | Printnet Kereskedelmi És Szolgáltató Kft. | A miozin-2-izoformákat szelektíven gátló, gyógyászatilag hatásos vegyületek |
| CN108728410B (zh) * | 2018-06-19 | 2020-04-21 | 中国医学科学院阜外医院 | 基于药物预处理的间充质干细胞来源外泌体的制备方法 |
| JP7230409B2 (ja) * | 2018-10-02 | 2023-03-01 | カシオ計算機株式会社 | 判定装置、判定方法及び判定プログラム |
| BR112021017799A2 (pt) | 2019-03-08 | 2021-11-23 | Commw Scient Ind Res Org | Célula vegetal, planta ou uma parte da mesma, polipeptídeo de fusão nifd ou produto clivado do mesmo, combinação do polipeptídeo de fusão nifd ou produto clivado do mesmo e um polipeptídeo de fusão nifd que compreende um mtp fundido translacionalmente para um polipeptídeo de nifk (nk) ou um produto clivado de mpp do mesmo, polinucleotídeo, vetor, uso de um polinucleotídeo, método de produção uma planta transgênica, método de produção de semente transgênica, método de produção de farinha, farinha integral, amido, óleo, farinha de sementes ou outro produto obtido a partir de sementes, produto produzido a partir da planta transgênica ou parte da mesma, método de preparação de um produto alimentício, e processo de alimentação de um animal |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7732445B2 (en) | 2006-07-21 | 2010-06-08 | Northwestern University | Myosin light chain kinase inhibitor compounds, compostions and related methods of use |
| CN101125146B (zh) * | 2007-07-02 | 2011-05-04 | 中国药科大学 | 一种防治炎症相关心脑血管疾病的药物靶标及其抑制剂 |
| EP2249837A4 (en) * | 2008-01-31 | 2011-06-15 | Univ Monash | METHOD FOR TREATING THROMBOEMBOLIC ILLNESSES |
| JP6189581B2 (ja) | 2009-02-20 | 2017-08-30 | セルラー ダイナミクス インターナショナル， インコーポレイテッド | 幹細胞の分化のための方法および組成物 |
| CN102395672A (zh) * | 2009-04-13 | 2012-03-28 | 加利福尼亚大学董事会 | 用于干细胞培养的方法和组合物 |
| US20130295669A1 (en) | 2010-11-09 | 2013-11-07 | Lonza Cologne Gmbh | Method for controlling binding of cells to a substrate |
| CN102940631B (zh) * | 2012-11-02 | 2015-04-15 | 清华大学 | Blebbistatin在促进干细胞存活和维持干细胞干性中的应用 |
-
2013
- 2013-03-15 ES ES13159548.0T patent/ES2602078T3/es active Active
- 2013-03-15 EP EP13159548.0A patent/EP2777703B1/en active Active
-
2014
- 2014-03-13 US US14/777,352 patent/US20160030482A1/en not_active Abandoned
- 2014-03-13 BR BR112015022565A patent/BR112015022565A2/pt not_active Application Discontinuation
- 2014-03-13 AU AU2014229502A patent/AU2014229502B2/en active Active
- 2014-03-13 CA CA2905650A patent/CA2905650C/en active Active
- 2014-03-13 WO PCT/IB2014/001248 patent/WO2014140930A2/en not_active Ceased
- 2014-03-13 CN CN201480015952.9A patent/CN105050597A/zh active Pending
- 2014-03-13 KR KR1020157029741A patent/KR102203925B1/ko active Active
- 2014-03-13 JP JP2015562410A patent/JP6399410B2/ja active Active
-
2017
- 2017-08-28 US US15/688,148 patent/US20180055888A1/en not_active Abandoned
-
2020
- 2020-01-09 US US16/738,495 patent/US20200147142A1/en not_active Abandoned
-
2024
- 2024-06-05 US US18/734,900 patent/US20240316111A1/en active Pending
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