US3598122A
(en)
|
1969-04-01 |
1971-08-10 |
Alza Corp |
Bandage for administering drugs
|
US4144317A
(en)
|
1975-05-30 |
1979-03-13 |
Alza Corporation |
Device consisting of copolymer having acetoxy groups for delivering drugs
|
US4262003A
(en)
|
1975-12-08 |
1981-04-14 |
Alza Corporation |
Method and therapeutic system for administering scopolamine transdermally
|
US4201211A
(en)
|
1977-07-12 |
1980-05-06 |
Alza Corporation |
Therapeutic system for administering clonidine transdermally
|
US4525586A
(en)
|
1980-02-28 |
1985-06-25 |
The Upjohn Company |
Composition and process
|
US4338457A
(en)
|
1980-02-28 |
1982-07-06 |
The Upjohn Company |
Composition and process
|
US4306075A
(en)
|
1980-03-28 |
1981-12-15 |
The Upjohn Company |
Composition and process
|
US4420632A
(en)
|
1980-04-15 |
1983-12-13 |
The Upjohn Company |
Composition and process
|
US4306076A
(en)
|
1980-04-23 |
1981-12-15 |
The Upjohn Company |
Inter-phenylene CBA compounds
|
US4349689A
(en)
|
1980-12-22 |
1982-09-14 |
The Upjohn Company |
Methano carbacyclin analogs
|
US4379454A
(en)
|
1981-02-17 |
1983-04-12 |
Alza Corporation |
Dosage for coadministering drug and percutaneous absorption enhancer
|
DE3333240A1
(de)
|
1983-09-12 |
1985-03-28 |
Schering AG, 1000 Berlin und 4709 Bergkamen |
Mittel zur transdermalen applikation von arzneimittelwirkstoffen
|
US4668814A
(en)
|
1984-03-08 |
1987-05-26 |
The Upjohn Company |
Interphenylene carbacyclin derivatives
|
US4683330A
(en)
|
1984-03-08 |
1987-07-28 |
The Upjohn Company |
Interphenylene carbacyclin derivatives
|
GB8814438D0
(en)
|
1988-06-17 |
1988-07-20 |
Wellcome Found |
Compounds for use in medicine
|
GB8824187D0
(en)
|
1988-10-14 |
1988-11-23 |
Wellcome Found |
Compounds for use in medicine
|
PT90888B
(pt)
|
1988-06-17 |
1994-12-30 |
Wellcome Found |
Processo para a preparacao de composicoes farmaceuticas contendo prostaglandinas
|
US5088977A
(en)
|
1988-12-21 |
1992-02-18 |
Drug Delivery Systems Inc. |
Electrical transdermal drug applicator with counteractor and method of drug delivery
|
GB9011588D0
(en)
*
|
1990-05-24 |
1990-07-11 |
Wellcome Found |
Prostaglandin analogues for use in medicine
|
CA2056039A1
(en)
|
1991-01-22 |
1992-07-23 |
Philip L. Fuchs |
Carbacyclin analogs
|
US5869505A
(en)
|
1993-02-02 |
1999-02-09 |
Keenan; Robert M. |
Nicotine metabolites and nicotine dependence
|
US5853751A
(en)
|
1993-06-23 |
1998-12-29 |
Masiz; John J. |
Molecular transdermal transport system
|
US5797898A
(en)
|
1996-07-02 |
1998-08-25 |
Massachusetts Institute Of Technology |
Microchip drug delivery devices
|
IN184589B
(US07585860-20090908-C00112.png)
|
1996-10-16 |
2000-09-09 |
Alza Corp |
|
CN1354622A
(zh)
|
1999-03-31 |
2002-06-19 |
联合治疗公司 |
前列腺素类化合物、组合物和治疗外周血管疾病和肺动脉高压的方法
|
US20020004065A1
(en)
|
2000-01-20 |
2002-01-10 |
David Kanios |
Compositions and methods to effect the release profile in the transdermal administration of active agents
|
US6242482B1
(en)
*
|
2000-06-05 |
2001-06-05 |
United Therapeutics Corporation |
Prostaglandin compounds and derivatives thereof, compositions containing the same and method of using the same for the treatment of congestive heart failure
|
US6635274B1
(en)
|
2000-10-27 |
2003-10-21 |
Biochemics, Inc. |
Solution-based transdermal drug delivery system
|
US6700025B2
(en)
|
2001-01-05 |
2004-03-02 |
United Therapeutics Corporation |
Process for stereoselective synthesis of prostacyclin derivatives
|
US20030108512A1
(en)
|
2001-12-10 |
2003-06-12 |
Robert Shorr |
Modified prostaglandin compounds and analogs thereof, compositions containing the same useful for the treatment of cancer
|
US6803386B2
(en)
|
2002-01-16 |
2004-10-12 |
United Therapeutics Corporation |
Prostacyclin derivative containing compositions and methods of using the same for the treatment of cancer
|
US8246979B2
(en)
|
2002-07-30 |
2012-08-21 |
Ucb Pharma Gmbh |
Transdermal delivery system for the administration of rotigotine
|
ES2622471T5
(es)
|
2003-05-22 |
2020-07-23 |
United Therapeutics Corp |
Compuestos y procedimientos para la administración de análogos de prostaciclina
|
CA2530407A1
(en)
|
2003-07-23 |
2005-02-03 |
The Regents Of The University Of California |
Penetration enhancer combinations for transdermal delivery
|
US7375139B2
(en)
|
2003-08-18 |
2008-05-20 |
Aldred Katherine M |
Transdermal method and apparatus
|
JP2005120069A
(ja)
|
2003-10-13 |
2005-05-12 |
Anges Mg Inc |
炎症性疾患治療薬
|
US7199157B2
(en)
|
2003-12-16 |
2007-04-03 |
United Therapeutics Corporation |
Use of treprostinil to improve kidney functions
|
CN1917866B
(zh)
|
2003-12-16 |
2010-12-15 |
联合治疗公司 |
曲前列环素或它的衍生物,或其药学上可接受的盐在制备治疗和预防缺血性损害的药物中的用途
|
DE602005020269D1
(de)
|
2004-04-12 |
2010-05-12 |
United Therapeutics Corp |
Verwendung von treprostinil zur behandlung von neuropathischen diabetischen fussgeschwüren
|
WO2006015299A2
(en)
|
2004-07-30 |
2006-02-09 |
Microchips, Inc. |
Multi-reservoir device for transdermal drug delivery and sensing
|
TW200628175A
(en)
|
2004-10-08 |
2006-08-16 |
Noven Pharma |
Transdermal drug delivert device including an occlusive backing
|
MX2007014990A
(es)
|
2005-06-02 |
2008-02-15 |
Univ Colorado |
Uso de analogos de prostaciclina.
|
KR20130114229A
(ko)
|
2005-06-03 |
2013-10-16 |
애크럭스 디디에스 피티와이 리미티드 |
경피 약물 전달 방법 및 조성물
|
EP1909772A4
(en)
|
2005-08-05 |
2011-07-13 |
Nuvo Res Inc |
TRANSDERMAL DRUG FORMULATION
|
BRPI0620216A2
(pt)
|
2005-12-20 |
2011-11-01 |
Teikoku Pharma Usa Inc |
métodos para administrar transdermicamente um agonista receptor de indol serotonina e composições transdérmicas para uso nos mesmos
|
PT1988910T
(pt)
|
2006-02-28 |
2018-02-07 |
Kodiak Sciences Inc |
Acriloiloxietilfosforilcolina contendo conjugados de polímeros e sua preparação
|
US9642912B2
(en)
|
2006-03-06 |
2017-05-09 |
Crescita Therapeutics Inc. |
Topical formulations for treating skin conditions
|
US9308181B2
(en)
|
2006-03-06 |
2016-04-12 |
Nuvo Research Inc. |
Topical formulations, systems and methods
|
US8747897B2
(en)
|
2006-04-27 |
2014-06-10 |
Supernus Pharmaceuticals, Inc. |
Osmotic drug delivery system
|
CA2654492C
(en)
|
2006-05-15 |
2017-06-27 |
United Therapeutics Corporation |
Treprostinil administration using a metered dose inhaler
|
WO2008002929A2
(en)
|
2006-06-26 |
2008-01-03 |
Inverseon, Inc. |
Heterologous cross-sensitization for improved agonist activity
|
US20090036465A1
(en)
|
2006-10-18 |
2009-02-05 |
United Therapeutics Corporation |
Combination therapy for pulmonary arterial hypertension
|
EP2491932A3
(en)
|
2007-02-09 |
2012-12-12 |
United Therapeutics Corporation |
Use of biomarkers for monitoring the course of treatment of a pulmonary disease upon treatment with treprostinil
|
WO2009009561A1
(en)
|
2007-07-11 |
2009-01-15 |
Lexicon Pharmaceuticals, Inc. |
Methods and compositions for treating pulmonary hypertension and related diseases and disorders
|
WO2009078965A1
(en)
|
2007-12-17 |
2009-06-25 |
United Therapeutics Corporation |
An improved process to prepare treprostinil, the active ingredient in remodulin
|
ES2689420T3
(es)
|
2008-03-31 |
2018-11-14 |
Nitto Denko Corporation |
Sistema de administración de permeante y métodos para su uso
|
WO2009152160A1
(en)
|
2008-06-10 |
2009-12-17 |
Gilead Sciences, Inc. |
Inhaled carbaprostacyclin and prostacyclin prodrugs for the treatment of pulmonary arterial hypertension
|
US20110212157A1
(en)
|
2008-06-26 |
2011-09-01 |
Anterios, Inc. |
Dermal delivery
|
US20110294815A1
(en)
|
2008-06-27 |
2011-12-01 |
Harbeson Scott L |
Prostacyclin analogs
|
MY178894A
(en)
|
2008-08-13 |
2020-10-21 |
Actelion Pharmaceuticals Ltd |
Therapeutic compositions containing macitentan
|
US8877710B2
(en)
|
2008-12-30 |
2014-11-04 |
Righospitalet |
Methods of identifying critically ill patients at increased risk of development of organ failure and compounds for the treatment hereof
|
CA2760499C
(en)
|
2009-05-07 |
2015-11-03 |
United Therapeutics Corporation |
Solid formulations of prostacyclin analogs
|
US8519178B2
(en)
|
2009-06-22 |
2013-08-27 |
Johnson Matthey Public Limited Company |
Method for the purification of prostaglandins
|
JP5877787B2
(ja)
|
2009-08-07 |
2016-03-08 |
サイファーム ソシエテ ア レスポンサビリテ リミテSciPharmS.a r.l. |
嚢胞性線維症の治療のための組成物
|
US9327105B2
(en)
|
2010-03-26 |
2016-05-03 |
Itrace Biomedical Inc. |
Active transdermal drug delivery system and the method thereof
|
WO2011123813A2
(en)
|
2010-04-02 |
2011-10-06 |
Amunix Operating Inc. |
Binding fusion proteins, binding fusion protein-drug conjugates, xten-drug conjugates and methods of making and using same
|
US8557961B2
(en)
|
2010-04-02 |
2013-10-15 |
Amunix Operating Inc. |
Alpha 1-antitrypsin compositions and methods of making and using same
|
EP2563369A2
(en)
|
2010-04-29 |
2013-03-06 |
Thrombologic APS |
Methods of treatment of patients at increased risk of development of ischemic events and compounds hereof
|
EP2576492B1
(en)
*
|
2010-06-03 |
2017-09-20 |
United Therapeutics Corporation |
Treprostinil production
|
WO2012006273A1
(en)
|
2010-07-09 |
2012-01-12 |
United Therapeutics Corporation |
Combination therapies with cox-2 inhibitors and treprostinil
|
CA2710726C
(en)
|
2010-07-22 |
2016-02-23 |
Alphora Research Inc. |
Synthesis of treprostinil and intermediates useful therein
|
US20130261177A1
(en)
|
2010-10-01 |
2013-10-03 |
Rigshospitalet |
Compounds capable of modulating/preserving endothelial integrity for use in prevention or treatment of acute traumatic coagulopathy and resuscitated cardiac arrest
|
CA2726599C
(en)
|
2010-12-30 |
2017-07-25 |
Alphora Research Inc. |
Process for treprostinil salt preparation
|
CN103379907B
(zh)
|
2011-01-13 |
2018-01-09 |
塞法姆公司 |
增强造血干细胞移入的方法
|
WO2012103037A1
(en)
|
2011-01-24 |
2012-08-02 |
Anterios, Inc. |
Oil compositions
|
DK2672957T3
(da)
|
2011-02-07 |
2017-02-06 |
Scipharm Sàrl |
Hidtil ukendt sammensætning til behandling af cystisk fibrose
|
WO2012107364A1
(en)
|
2011-02-07 |
2012-08-16 |
Scipharm Sàrl |
Novel composition for the treatment of cystic fibrosis
|
US20140044797A1
(en)
|
2011-04-19 |
2014-02-13 |
Rigshospitalet |
Prostacyclin and analogs thereof administered during surgery for prevention and treatment of capillary leakage
|
EP2739613A4
(en)
|
2011-08-05 |
2015-01-07 |
Cardero Therapeutics Inc |
flavonoid
|
WO2013024053A1
(en)
|
2011-08-12 |
2013-02-21 |
Ascendis Pharma A/S |
Carrier-linked prodrugs having reversible carboxylic ester linkages
|
JP2014522878A
(ja)
|
2011-08-12 |
2014-09-08 |
アセンディス ファーマ エー/エス |
プロスタサイクリンの徐放組成物
|
JP6092867B2
(ja)
|
2011-08-12 |
2017-03-08 |
アセンディス ファーマ エー/エス |
担体連結しているトレプロスチニルプロドラッグ
|
US8524939B2
(en)
|
2011-08-24 |
2013-09-03 |
Chirogate International Inc. |
Intermediates for the synthesis of benzindene prostaglandins and preparations thereof
|
CN103193626B
(zh)
|
2012-01-10 |
2016-05-11 |
上海天伟生物制药有限公司 |
一种前列腺素类似物的晶型及其制备方法和用途
|
US9387214B2
(en)
|
2012-01-13 |
2016-07-12 |
United Therapeutics Corporation |
Method of identifying therapies for pulmonary hypertension
|
WO2013143548A1
(en)
|
2012-03-30 |
2013-10-03 |
Rigshospitalet |
Compounds capable of modulating/preserving endothelial integrity for use in prevention or treatment of acute traumatic coagulopathy and resuscitated cardiac arrest
|
AU2013254756B2
(en)
|
2012-04-25 |
2017-03-30 |
Ascendis Pharma A/S |
Prodrugs of hydroxyl-comprising drugs
|
LT2674413T
(lt)
|
2012-06-15 |
2017-09-25 |
Scipharm Sąrl |
Treprostinilo ir jo darinių gavimo būdas
|
WO2014022373A1
(en)
|
2012-08-01 |
2014-02-06 |
United Therapeutics Corporation |
Treatment of pulmonary arterial hypertension with mesenchymal stem cells
|
MX369094B
(es)
|
2012-12-07 |
2019-10-29 |
Cayman Chemical Co Inc |
Metodos para sintetizar un analogo de prostaciclina.
|
EP3878452B1
(en)
|
2013-01-09 |
2023-09-20 |
United Therapeutics Corporation |
Treatment of vasculopathy with prostacyclin and mesenchymal stem cells
|
JP6542128B2
(ja)
|
2013-01-11 |
2019-07-10 |
コルセア ファーマ インコーポレイテッド |
トレプロスチニルのプロドラッグ
|
US9203373B2
(en)
*
|
2013-01-11 |
2015-12-01 |
Qualcomm Incorporated |
Diplexer design using through glass via technology
|
US9505737B2
(en)
|
2013-01-11 |
2016-11-29 |
Corsair Pharma, Inc. |
Treprostinil derivative compounds and methods of using same
|
CA2904598C
(en)
|
2013-03-15 |
2021-10-05 |
United Therapeutics Corporation |
Salts of treprostinil
|
EP2978313B1
(en)
|
2013-03-25 |
2018-02-21 |
United Therapeutics Corporation |
Process of making prostacyclin compounds with linker thiol and pegylated forms
|
EP2991639A4
(en)
|
2013-04-30 |
2016-11-30 |
United Therapeutics Corp |
PHARMACEUTICAL FORMULATIONS WITH CONTROLLED RELEASE
|
WO2014203278A2
(en)
|
2013-06-19 |
2014-12-24 |
Msn Laboratories Private Limited |
NOVEL PROCESS FOR THE PREPARATION OF (1R,2R,3aS,9aS)-[[2,3,3a,4,9,9a-HEXAHYDRO-2-HYDROXY-1-[(3S)-3-HYDROXYOCTYL]-1H-BENZ[f]INDEN-5-YL]OXY]ACETIC ACID
|
FR3008320B1
(fr)
|
2013-07-15 |
2018-04-20 |
Centre Hospitalier Univ Grenoble |
Dispositif de prevention ou de traitement d'une ulceration cutanee
|
MX2020004912A
(es)
|
2013-10-25 |
2021-05-21 |
Insmed Inc |
Compuestos derivados de prostaciclinas, y el uso de los mismo para el tratamiento de la hipertension pulmonar.
|
JP6373378B2
(ja)
|
2013-11-13 |
2018-08-15 |
ケイマン ケミカル カンパニー, インコーポレーテッド |
プロスタサイクリン類似体のアミン塩
|
WO2015138423A1
(en)
|
2014-03-11 |
2015-09-17 |
Insmed Incorporated |
Prostacylin compositions and methods for using the same
|
TWI685348B
(zh)
|
2014-05-08 |
2020-02-21 |
美國禮來大藥廠 |
速效胰島素組合物
|
WO2016010538A1
(en)
|
2014-07-16 |
2016-01-21 |
Corsair Pharma, Inc. |
Treprostinil derivative compounds and methods of using same
|
US20160045470A1
(en)
|
2014-08-12 |
2016-02-18 |
Dr. Reddy's Laboratories Limited |
Amorphous solid dispersion of treprostinil diethanolamine
|
HU231184B1
(hu)
|
2014-10-08 |
2021-07-28 |
CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. |
Treprostinil-nátrium-monohidrát és eljárás ennek előállítására
|
CA2967385C
(en)
|
2014-11-18 |
2023-05-16 |
Insmed Incorporated |
Methods of manufacturing treprostinil and treprostinil derivative prodrugs
|
TWI540121B
(zh)
|
2014-12-01 |
2016-07-01 |
臺灣永光化學工業股份有限公司 |
曲前列環素二乙醇胺之合成方法及新穎中間體
|
US20180021347A1
(en)
|
2015-01-27 |
2018-01-25 |
Scipharm Sàrl |
Composition for the treatment of hepatic veno-occlusive disease
|
US20160243064A1
(en)
|
2015-02-21 |
2016-08-25 |
Gavis Pharmaceuticals |
Novel oral pharmaceutical compositions of treprostinil
|
WO2016176555A1
(en)
|
2015-04-29 |
2016-11-03 |
Insmed Incorporated |
Prostacyclin compounds, compositions and methods of use thereof
|
US9394227B1
(en)
|
2015-06-17 |
2016-07-19 |
Corsair Pharma, Inc. |
Treprostinil derivatives and compositions and uses thereof
|
US9643911B2
(en)
|
2015-06-17 |
2017-05-09 |
Corsair Pharma, Inc. |
Treprostinil derivatives and compositions and uses thereof
|
WO2018106632A1
(en)
|
2016-12-05 |
2018-06-14 |
Corsair Pharma, Inc. |
Dermal and transdermal administration of treprostinil and salts thereof
|
JP6556217B2
(ja)
*
|
2017-12-20 |
2019-08-07 |
三菱電機株式会社 |
流量検出装置
|
JP2020011957A
(ja)
|
2019-07-22 |
2020-01-23 |
コルセア ファーマ インコーポレイテッド |
トレプロスチニル誘導体化合物およびその使用方法
|