JP2016510308A - 口内乾燥症候緩和用及び口内炎処置用の口腔局所用組成物 - Google Patents
口内乾燥症候緩和用及び口内炎処置用の口腔局所用組成物 Download PDFInfo
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- JP2016510308A JP2016510308A JP2015546975A JP2015546975A JP2016510308A JP 2016510308 A JP2016510308 A JP 2016510308A JP 2015546975 A JP2015546975 A JP 2015546975A JP 2015546975 A JP2015546975 A JP 2015546975A JP 2016510308 A JP2016510308 A JP 2016510308A
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- oral
- topical composition
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- oral topical
- fluoride
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Abstract
Description
口内乾燥又は口内乾燥症は、唾液腺の活性の低下によって引き起こされる。唾液の流れの減少は、不快感をもたらし、発話及び嚥下を妨げ、義歯の装着を困難にし、口臭を引き起こし、また口腔pHの低下と細菌増殖の増加とを引き起こすことによって口腔衛生を損なう可能性がある。長期間にわたる口内乾燥は、重度の虫歯及び口腔カンジダ症をもたらす可能性がある。口内乾燥は高齢者に共通の愁訴であり、老人の約20%は口内乾燥に冒されている。
本発明によって、タウリン、キシリトール及びプロパン−1,3−ジオールを含有する組成物を口の粘膜に局所的に適用すると口内乾燥に有益な効果を奏し、且つ口腔粘膜の再生を促進することが見出されている。
Claims (17)
- タウリン又はその塩、キシリトール及びプロパン−1,3−ジオールを含む口腔局所用組成物。
- タウリン又はその塩の濃度が0.01〜5.0重量%である、請求項1記載の口腔局所用組成物。
- キシリトールの濃度が0.1〜10.0重量%である、請求項1又は2記載の口腔局所用組成物。
- プロパン−1,3−ジオールの濃度が0.1〜30.0重量%である、請求項1〜3のいずれか一項記載の口腔局所用組成物。
- ヒアルロン酸ナトリウムをさらに含む、請求項1〜4のいずれか一項記載の口腔局所用組成物。
- ミネラル補給剤をさらに含む、請求項1〜5のいずれか一項記載の口腔局所用組成物。
- 前記ミネラル補給剤が、フッ化カリウム、フッ化ナトリウム、モノフルオロリン酸ナトリウム、フッ化スズ、アミンフッ化物(ヘキサデシルアミンヒドロフルオリド、ビス−(ヒドロキシエチル)アミノプロピル−N−ヒドロキシエチル−オクタデシルアミンジヒドロフルオリド、N−N’,N’−トリ(ポリオキシエチレン)−N−ヘキサデシル−プロピレンジアミンジヒドロフルオリド又はオクタデセニルアミンヒドロフルオリド)、リン酸カリウム、ピロリン酸カリウム、クエン酸三カリウム、乳酸カルシウム、パントテン酸カルシウム及び炭酸カルシウムなどの、フッ化物アニオン、リン酸アニオン、ナトリウムカチオン及びカリウムカチオンからなる群より選択される、請求項6記載の口腔局所用組成物。
- 前記ミネラル補給剤がモノフルオロリン酸ナトリウム又はフッ化ナトリウムである、請求項7記載の口腔局所用組成物。
- 浸透圧保護剤をさらに含む、請求項1〜8のいずれか一項記載の口腔局所用組成物。
- 前記浸透圧保護剤がベタインである、請求項9記載の口腔局所用組成物。
- 潤滑剤をさらに含む、請求項1〜10のいずれか一項記載の口腔局所用組成物。
- 前記潤滑剤がポリビニルピロリドンである、請求項11記載の口腔局所用組成物。
- 唾液の流れを刺激するための化合物をさらに含む、請求項1〜12のいずれか一項記載の口腔局所用組成物。
- 唾液の流れを刺激するための前記化合物がクエン酸塩又はクエン酸である、請求項13記載の口腔局所用組成物。
- ゲル、スプレー、練り歯磨き、洗口剤、口腔パッチ剤、チューインガム及び錠剤の形態である、請求項1〜14のいずれか一項記載の口腔局所用組成物。
- 口内乾燥の症候を緩和又は解消するための、請求項1〜15のいずれか一項記載の口腔局所用組成物。
- 口腔潰瘍を予防又は治療するための、請求項1〜15のいずれか一項記載の口腔局所用組成物。
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EP12197696.3A EP2745836B1 (en) | 2012-12-18 | 2012-12-18 | Topical oral composition for alleviating dry mouth symptoms and for treating mouth ulcers |
PCT/EP2013/076080 WO2014095489A1 (en) | 2012-12-18 | 2013-12-10 | Topical oral composition for alleviating dry mouth symptoms and for treating mouth ulcers |
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CA2895249A1 (en) | 2014-06-26 |
CN104955447A (zh) | 2015-09-30 |
CN104955447B (zh) | 2019-02-22 |
US20150320701A1 (en) | 2015-11-12 |
US9895326B2 (en) | 2018-02-20 |
JP6461002B2 (ja) | 2019-01-30 |
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EP2745836A1 (en) | 2014-06-25 |
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